YJL105W / SET4

Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL105W / SET4

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.96|P-value:5.12E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:4.89|P-value:8.90E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:3.72|P-value:1.41E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:4.32|P-value:1.20E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:3.69|P-value:1.60E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.56|P-value:2.43E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.28|P-value:6.85E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:5.60|P-value:2.24E-8 ID:SGTC_368|Compound:fentichlor|FD-Score:6.27|P-value:4.37E-10 ID:SGTC_432|Compound:NS 1619|FD-Score:3.55|P-value:2.69E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:5.98|P-value:2.53E-9 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.37|P-value:4.84E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.40|P-value:4.51E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.67|P-value:1.72E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:4.54|P-value:4.70E-6 ID:SGTC_885|Compound:0865-0106|FD-Score:4.26|P-value:1.57E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:4.40|P-value:8.49E-6 ID:SGTC_919|Compound:tnp00227|FD-Score:6.22|P-value:5.99E-10 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.82|P-value:9.17E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:5.55|P-value:2.99E-8 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.17|P-value:9.97E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.40|P-value:4.27E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.97|P-value:5.40E-5 ID:SGTC_1534|Compound:6-azauridine|FD-Score:7.30|P-value:4.78E-13 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.50|P-value:3.14E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.53|P-value:4.79E-6 ID:SGTC_1619|Compound:st003326|FD-Score:3.39|P-value:4.73E-4 ID:SGTC_1626|Compound:st003712|FD-Score:4.03|P-value:4.20E-5 ID:SGTC_1659|Compound:st012954|FD-Score:3.48|P-value:3.39E-4 ID:SGTC_1770|Compound:st043884|FD-Score:6.02|P-value:1.98E-9 ID:SGTC_1774|Compound:st048371|FD-Score:3.84|P-value:8.81E-5 ID:SGTC_1838|Compound:st055369|FD-Score:6.39|P-value:2.20E-10 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:6.30|P-value:3.84E-10 ID:SGTC_1870|Compound:st057514|FD-Score:5.05|P-value:4.00E-7 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.58|P-value:3.90E-6 ID:SGTC_1879|Compound:gemcitabine|FD-Score:4.97|P-value:5.95E-7 ID:SGTC_1964|Compound:st076914|FD-Score:5.57|P-value:2.58E-8 ID:SGTC_1967|Compound:st070177|FD-Score:-3.90|P-value:6.61E-5 ID:SGTC_1984|Compound:st072354|FD-Score:3.36|P-value:5.16E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.50|P-value:3.22E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.35|P-value:5.35E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.84|P-value:8.80E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.35|P-value:5.46E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.34|P-value:5.65E-4 ID:SGTC_2414|Compound:st077232|FD-Score:4.59|P-value:3.71E-6 ID:SGTC_2446|Compound:5162541|FD-Score:3.59|P-value:2.29E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:11.90|P-value:1.44E-31 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:5.43|P-value:5.54E-8 ID:SGTC_2533|Compound:agelasine|FD-Score:3.47|P-value:3.51E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.72|P-value:1.33E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.36|P-value:5.22E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.01|P-value:4.56E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.67|P-value:1.69E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:6.07|P-value:1.51E-9 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.69|P-value:1.60E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:5.39|P-value:7.06E-8 ID:SGTC_2867|Compound:9039098|FD-Score:3.79|P-value:1.07E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.55|P-value:2.64E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.31|P-value:6.27E-4 ID:SGTC_2965|Compound:9082772|FD-Score:4.19|P-value:2.17E-5 ID:SGTC_3047|Compound:9092122|FD-Score:3.58|P-value:2.35E-4 ID:SGTC_3052|Compound:9092717|FD-Score:5.03|P-value:4.45E-7 ID:SGTC_3110|Compound:9122132|FD-Score:3.54|P-value:2.79E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.52|P-value:2.91E-4 ID:SGTC_3114|Compound:9122766|FD-Score:9.23|P-value:8.99E-20 ID:SGTC_3304|Compound:9125678|FD-Score:4.08|P-value:3.41E-5 ID:SGTC_3337|Compound:9144342|FD-Score:3.59|P-value:2.30E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.96|P-value:5.12E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:4.89|P-value:8.90E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:3.72|P-value:1.41E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:4.32|P-value:1.20E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:3.69|P-value:1.60E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.56|P-value:2.43E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.28|P-value:6.85E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:5.60|P-value:2.24E-8 ID:SGTC_368|Compound:fentichlor|FD-Score:6.27|P-value:4.37E-10 ID:SGTC_432|Compound:NS 1619|FD-Score:3.55|P-value:2.69E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:5.98|P-value:2.53E-9 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.37|P-value:4.84E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.40|P-value:4.51E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.67|P-value:1.72E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:4.54|P-value:4.70E-6 ID:SGTC_885|Compound:0865-0106|FD-Score:4.26|P-value:1.57E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:4.40|P-value:8.49E-6 ID:SGTC_919|Compound:tnp00227|FD-Score:6.22|P-value:5.99E-10 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.82|P-value:9.17E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:5.55|P-value:2.99E-8 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.17|P-value:9.97E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.40|P-value:4.27E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.97|P-value:5.40E-5 ID:SGTC_1534|Compound:6-azauridine|FD-Score:7.30|P-value:4.78E-13 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.50|P-value:3.14E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.53|P-value:4.79E-6 ID:SGTC_1619|Compound:st003326|FD-Score:3.39|P-value:4.73E-4 ID:SGTC_1626|Compound:st003712|FD-Score:4.03|P-value:4.20E-5 ID:SGTC_1659|Compound:st012954|FD-Score:3.48|P-value:3.39E-4 ID:SGTC_1770|Compound:st043884|FD-Score:6.02|P-value:1.98E-9 ID:SGTC_1774|Compound:st048371|FD-Score:3.84|P-value:8.81E-5 ID:SGTC_1838|Compound:st055369|FD-Score:6.39|P-value:2.20E-10 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:6.30|P-value:3.84E-10 ID:SGTC_1870|Compound:st057514|FD-Score:5.05|P-value:4.00E-7 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.58|P-value:3.90E-6 ID:SGTC_1879|Compound:gemcitabine|FD-Score:4.97|P-value:5.95E-7 ID:SGTC_1964|Compound:st076914|FD-Score:5.57|P-value:2.58E-8 ID:SGTC_1967|Compound:st070177|FD-Score:-3.90|P-value:6.61E-5 ID:SGTC_1984|Compound:st072354|FD-Score:3.36|P-value:5.16E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.50|P-value:3.22E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.35|P-value:5.35E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.84|P-value:8.80E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.35|P-value:5.46E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.34|P-value:5.65E-4 ID:SGTC_2414|Compound:st077232|FD-Score:4.59|P-value:3.71E-6 ID:SGTC_2446|Compound:5162541|FD-Score:3.59|P-value:2.29E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:11.90|P-value:1.44E-31 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:5.43|P-value:5.54E-8 ID:SGTC_2533|Compound:agelasine|FD-Score:3.47|P-value:3.51E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.72|P-value:1.33E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.36|P-value:5.22E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.01|P-value:4.56E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.67|P-value:1.69E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:6.07|P-value:1.51E-9 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.69|P-value:1.60E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:5.39|P-value:7.06E-8 ID:SGTC_2867|Compound:9039098|FD-Score:3.79|P-value:1.07E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.55|P-value:2.64E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.31|P-value:6.27E-4 ID:SGTC_2965|Compound:9082772|FD-Score:4.19|P-value:2.17E-5 ID:SGTC_3047|Compound:9092122|FD-Score:3.58|P-value:2.35E-4 ID:SGTC_3052|Compound:9092717|FD-Score:5.03|P-value:4.45E-7 ID:SGTC_3110|Compound:9122132|FD-Score:3.54|P-value:2.79E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.52|P-value:2.91E-4 ID:SGTC_3114|Compound:9122766|FD-Score:9.23|P-value:8.99E-20 ID:SGTC_3304|Compound:9125678|FD-Score:4.08|P-value:3.41E-5 ID:SGTC_3337|Compound:9144342|FD-Score:3.59|P-value:2.30E-4

Top fitness defect scores for YJL105W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2528 xanthyletin 11.90 44.8 µM 1.44E-31 1 6.20E-33
2 SGTC_3114 9122766 9.23 49.5 µM 8.99E-20 1 1.32E-20
3 SGTC_1534 6-azauridine 7.30 81.6 µM 4.78E-13 RNA pol III & RNase P/MRP 3 1.41E-13
4 SGTC_1838 st055369 6.39 84.5 µM 2.20E-10 3 8.55E-11
5 SGTC_1869 3',7'-dimethoxyflavone 6.30 40.3 µM 3.84E-10 2 1.53E-10
6 SGTC_368 fentichlor 6.27 4.6 µM 4.37E-10 1 1.76E-10
7 SGTC_919 tnp00227 6.22 403.6 nM 5.99E-10 RNA pol III & RNase P/MRP 8 2.44E-10
8 SGTC_2604 4'-hydroxychalcone 6.07 11.3 µM 1.51E-9 6 6.41E-10
9 SGTC_1770 st043884 6.02 66.3 µM 1.98E-9 2 8.49E-10
10 SGTC_695 3505-6186 5.98 243.0 µM 2.53E-9 2 1.10E-9
11 SGTC_364 0083-0097 5.60 67.7 µM 2.24E-8 8 1.08E-8
12 SGTC_1964 st076914 5.57 61.0 µM 2.58E-8 RPP1 & pyrimidine depletion 3 1.24E-8
13 SGTC_1075 aripiprazole 5.55 15.2 µM 2.99E-8 6 1.45E-8
14 SGTC_2529 gangaleoidin 5.43 93.6 µM 5.54E-8 5 2.76E-8
15 SGTC_2616 abietic acid 5.39 100.0 µM 7.06E-8 14 3.56E-8
16 SGTC_1870 st057514 5.05 26.5 µM 4.00E-7 RSC & ERG11 9 2.18E-7
17 SGTC_3052 9092717 5.03 49.5 µM 4.45E-7 10 2.44E-7
18 SGTC_1879 gemcitabine 4.97 100.0 µM 5.95E-7 2 3.30E-7
19 SGTC_64 000l-0018 4.89 272.1 µM 8.90E-7 ubiquinone biosynthesis & proteasome 113 5.03E-7
20 SGTC_2414 st077232 4.59 92.9 µM 3.71E-6 13 2.23E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 5.47E-10 YBL097W BRN1 het Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission
0.101 4.82E-9 YOR247W SRL1 hom Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication
0.094 5.43E-8 YKR058W GLG1 hom Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication
0.094 5.76E-8 YDR183W PLP1 hom Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators
0.089 2.17E-7 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.086 6.11E-7 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.084 1.17E-6 YGL089C MF(ALPHA)2 hom Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
0.082 2.17E-6 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.081 2.47E-6 YNR063W_p YNR063W_p hom Putative zinc-cluster protein of unknown function
0.078 6.10E-6 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.078 6.25E-6 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.078 6.55E-6 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.078 6.86E-6 YLR021W IRC25 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.077 8.66E-6 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.077 9.19E-6 YOR178C GAC1 hom Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock