YJL109C / UTP10

Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL109C / UTP10

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.23|P-value:5.27E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:6.67|P-value:6.43E-12 ID:SGTC_41|Compound:0478-0632|FD-Score:3.53|P-value:1.73E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:6.04|P-value:4.39E-10 ID:SGTC_146|Compound:3448-8650|FD-Score:3.15|P-value:6.84E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-4.60|P-value:1.45E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.49|P-value:1.97E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.69|P-value:9.21E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:-3.14|P-value:7.08E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.72|P-value:7.90E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:4.61|P-value:1.46E-6 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.44|P-value:2.45E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:-7.21|P-value:1.20E-13 ID:SGTC_1228|Compound:0124-0032|FD-Score:-4.27|P-value:7.11E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.96|P-value:2.95E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.44|P-value:2.38E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.06|P-value:9.26E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.55|P-value:1.52E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.06|P-value:9.35E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:4.09|P-value:1.63E-5 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.17|P-value:6.38E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.85|P-value:4.76E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.80|P-value:5.66E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.83|P-value:4.74E-7 ID:SGTC_1700|Compound:st030840|FD-Score:3.66|P-value:9.99E-5 ID:SGTC_1747|Compound:st037496|FD-Score:-3.84|P-value:4.86E-5 ID:SGTC_2008|Compound:4012253|FD-Score:3.37|P-value:3.11E-4 ID:SGTC_2012|Compound:4023501|FD-Score:6.20|P-value:1.54E-10 ID:SGTC_2054|Compound:5233173|FD-Score:-3.59|P-value:1.32E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.04|P-value:9.90E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-8.14|P-value:6.58E-17 ID:SGTC_2295|Compound:7971645|FD-Score:5.58|P-value:7.52E-9 ID:SGTC_2301|Compound:7769476|FD-Score:-3.87|P-value:4.29E-5 ID:SGTC_2397|Compound:5161689|FD-Score:-3.32|P-value:3.76E-4 ID:SGTC_2434|Compound:5670830|FD-Score:-3.39|P-value:2.84E-4 ID:SGTC_2469|Compound:5655019|FD-Score:3.32|P-value:3.71E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.02|P-value:2.22E-5 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.20|P-value:5.81E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-3.85|P-value:4.61E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.12|P-value:7.68E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.47|P-value:2.13E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.37|P-value:3.19E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.79|P-value:5.97E-5 ID:SGTC_3171|Compound:9103192|FD-Score:-3.04|P-value:9.94E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.13|P-value:7.28E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.05|P-value:9.93E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.23|P-value:5.27E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:6.67|P-value:6.43E-12 ID:SGTC_41|Compound:0478-0632|FD-Score:3.53|P-value:1.73E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:6.04|P-value:4.39E-10 ID:SGTC_146|Compound:3448-8650|FD-Score:3.15|P-value:6.84E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-4.60|P-value:1.45E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.49|P-value:1.97E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.69|P-value:9.21E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:-3.14|P-value:7.08E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.72|P-value:7.90E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:4.61|P-value:1.46E-6 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.44|P-value:2.45E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:-7.21|P-value:1.20E-13 ID:SGTC_1228|Compound:0124-0032|FD-Score:-4.27|P-value:7.11E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.96|P-value:2.95E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.44|P-value:2.38E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.06|P-value:9.26E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.55|P-value:1.52E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.06|P-value:9.35E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:4.09|P-value:1.63E-5 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.17|P-value:6.38E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.85|P-value:4.76E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.80|P-value:5.66E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.83|P-value:4.74E-7 ID:SGTC_1700|Compound:st030840|FD-Score:3.66|P-value:9.99E-5 ID:SGTC_1747|Compound:st037496|FD-Score:-3.84|P-value:4.86E-5 ID:SGTC_2008|Compound:4012253|FD-Score:3.37|P-value:3.11E-4 ID:SGTC_2012|Compound:4023501|FD-Score:6.20|P-value:1.54E-10 ID:SGTC_2054|Compound:5233173|FD-Score:-3.59|P-value:1.32E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.04|P-value:9.90E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-8.14|P-value:6.58E-17 ID:SGTC_2295|Compound:7971645|FD-Score:5.58|P-value:7.52E-9 ID:SGTC_2301|Compound:7769476|FD-Score:-3.87|P-value:4.29E-5 ID:SGTC_2397|Compound:5161689|FD-Score:-3.32|P-value:3.76E-4 ID:SGTC_2434|Compound:5670830|FD-Score:-3.39|P-value:2.84E-4 ID:SGTC_2469|Compound:5655019|FD-Score:3.32|P-value:3.71E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.02|P-value:2.22E-5 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.20|P-value:5.81E-4 ID:SGTC_2810|Compound:7959871|FD-Score:-3.85|P-value:4.61E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.12|P-value:7.68E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.47|P-value:2.13E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.37|P-value:3.19E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.79|P-value:5.97E-5 ID:SGTC_3171|Compound:9103192|FD-Score:-3.04|P-value:9.94E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.13|P-value:7.28E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.05|P-value:9.93E-4

Top fitness defect scores for YJL109C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_39 0986-0283 6.67 58.4 µM 6.43E-12 calcium & mitochondrial duress 4 1.28E-11 0.27
2 SGTC_2012 4023501 6.20 200.0 µM 1.54E-10 2 2.80E-10 0.19
3 SGTC_46 0329-0187a 6.04 2.2 µM 4.39E-10 2 7.75E-10 1.09
4 SGTC_2295 7971645 5.58 200.0 µM 7.52E-9 2 1.22E-8 0.07
5 SGTC_1680 diphenhydramine 4.83 100.0 µM 4.74E-7 NEO1 8 6.84E-7 0.11
6 SGTC_717 1532-0246 4.61 73.2 µM 1.46E-6 Golgi 3 2.04E-6 0.28
7 SGTC_1489 4065-0444 4.09 182.0 µM 1.63E-5 3 2.12E-5 0.18
8 SGTC_2533 agelasine 4.02 13.7 µM 2.22E-5 ERG2 13 2.86E-5 0.02
9 SGTC_1230 0170-0365 3.96 3.8 µM 2.95E-5 endomembrane recycling 24 3.78E-5 0.11
10 SGTC_1526 st051518 3.85 75.0 µM 4.76E-5 7 6.02E-5 0.16
11 SGTC_1635 st007035 3.80 42.4 µM 5.66E-5 21 7.12E-5 0.04
12 SGTC_631 k072-0230 3.72 41.5 µM 7.90E-5 60S ribosome export 8 9.85E-5 0.00
13 SGTC_554 4483-2211 3.69 187.0 µM 9.21E-5 3 1.14E-4 0.24
14 SGTC_1700 st030840 3.66 7.9 µM 9.99E-5 PDR1 13 1.24E-4 0.09
15 SGTC_41 0478-0632 3.53 82.6 µM 1.73E-4 16 2.11E-4 0.17
16 SGTC_1198 1612-1005 3.44 86.7 µM 2.45E-4 3 2.96E-4 0.02
17 SGTC_2008 4012253 3.37 172.0 µM 3.11E-4 16 3.73E-4 0.11
18 SGTC_2955 9076254 3.37 12.2 µM 3.19E-4 9 3.83E-4 0.13
19 SGTC_2469 5655019 3.32 90.8 µM 3.71E-4 4 4.43E-4 0.06
20 SGTC_38 0929-0051 3.23 58.3 µM 5.27E-4 10 6.23E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.228 1.31E-40 YJR011C_p YJR011C_p hom Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
0.144 4.50E-17 YKL099C UTP11 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.143 9.78E-17 YDR029W_d YDR029W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.133 1.32E-14 YOR105W_p YOR105W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.130 4.43E-14 YDR426C_d YDR426C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41
0.126 2.92E-13 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.124 5.33E-13 YBR104W YMC2 hom Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication
0.121 2.40E-12 YGR161W-C_p YGR161W-C_p hom Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
0.120 2.94E-12 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.119 4.81E-12 YLR276C DBP9 het DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
0.116 1.77E-11 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.115 2.39E-11 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.114 4.20E-11 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.114 4.28E-11 YGL122C NAB2 het Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress
0.112 7.72E-11 YKL139W CTK1 hom Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13