YJL177W / RPL17B

Ribosomal 60S subunit protein L17B; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL177W / RPL17B

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:5.71|P-value:1.22E-8 ID:SGTC_123|Compound:0083-0120|FD-Score:4.19|P-value:1.86E-5 ID:SGTC_389|Compound:tpck|FD-Score:3.14|P-value:9.30E-4 ID:SGTC_442|Compound:cape|FD-Score:3.13|P-value:9.58E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-5.62|P-value:5.44E-8 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.32|P-value:1.08E-5 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.30|P-value:5.43E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-5.74|P-value:2.79E-8 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.54|P-value:2.40E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:-4.06|P-value:6.91E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:3.18|P-value:8.23E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.13|P-value:9.62E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.38|P-value:4.13E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.64|P-value:1.63E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.75|P-value:1.09E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.38|P-value:4.23E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.41|P-value:3.74E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.38|P-value:8.00E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-3.40|P-value:7.52E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.13|P-value:2.48E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.19|P-value:7.89E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.82|P-value:8.42E-5 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.85|P-value:7.39E-5 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.61|P-value:1.81E-4 ID:SGTC_1620|Compound:st003704|FD-Score:4.60|P-value:3.19E-6 ID:SGTC_1675|Compound:st018485|FD-Score:6.46|P-value:1.43E-10 ID:SGTC_1728|Compound:st035614|FD-Score:3.74|P-value:1.16E-4 ID:SGTC_1730|Compound:st033808|FD-Score:5.31|P-value:1.01E-7 ID:SGTC_2317|Compound:5986382|FD-Score:-3.49|P-value:5.55E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-4.21|P-value:3.87E-5 ID:SGTC_2340|Compound:7987427|FD-Score:3.33|P-value:5.01E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-4.46|P-value:1.33E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.53|P-value:4.73E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.27|P-value:6.04E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.13|P-value:9.77E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.48|P-value:1.61E-13 ID:SGTC_2957|Compound:9076800|FD-Score:-3.55|P-value:4.46E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-3.46|P-value:6.02E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-4.55|P-value:9.07E-6 ID:SGTC_2999|Compound:9069765|FD-Score:4.28|P-value:1.30E-5 ID:SGTC_3104|Compound:9120930|FD-Score:-3.39|P-value:7.70E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.53|P-value:2.43E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-4.15|P-value:4.87E-5 ID:SGTC_3189|Compound:9110682|FD-Score:-4.66|P-value:5.68E-6 ID:SGTC_3217|Compound:9129673|FD-Score:4.14|P-value:2.30E-5 ID:SGTC_3220|Compound:9131269|FD-Score:-3.76|P-value:2.12E-4 ID:SGTC_3269|Compound:9137823|FD-Score:4.52|P-value:4.60E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:5.71|P-value:1.22E-8 ID:SGTC_123|Compound:0083-0120|FD-Score:4.19|P-value:1.86E-5 ID:SGTC_389|Compound:tpck|FD-Score:3.14|P-value:9.30E-4 ID:SGTC_442|Compound:cape|FD-Score:3.13|P-value:9.58E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-5.62|P-value:5.44E-8 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.32|P-value:1.08E-5 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.30|P-value:5.43E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-5.74|P-value:2.79E-8 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.54|P-value:2.40E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:-4.06|P-value:6.91E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:3.18|P-value:8.23E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.13|P-value:9.62E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.38|P-value:4.13E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.64|P-value:1.63E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.75|P-value:1.09E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.38|P-value:4.23E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.41|P-value:3.74E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.38|P-value:8.00E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-3.40|P-value:7.52E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.13|P-value:2.48E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.19|P-value:7.89E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.82|P-value:8.42E-5 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.85|P-value:7.39E-5 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.61|P-value:1.81E-4 ID:SGTC_1620|Compound:st003704|FD-Score:4.60|P-value:3.19E-6 ID:SGTC_1675|Compound:st018485|FD-Score:6.46|P-value:1.43E-10 ID:SGTC_1728|Compound:st035614|FD-Score:3.74|P-value:1.16E-4 ID:SGTC_1730|Compound:st033808|FD-Score:5.31|P-value:1.01E-7 ID:SGTC_2317|Compound:5986382|FD-Score:-3.49|P-value:5.55E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-4.21|P-value:3.87E-5 ID:SGTC_2340|Compound:7987427|FD-Score:3.33|P-value:5.01E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-4.46|P-value:1.33E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.53|P-value:4.73E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.27|P-value:6.04E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.13|P-value:9.77E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.48|P-value:1.61E-13 ID:SGTC_2957|Compound:9076800|FD-Score:-3.55|P-value:4.46E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-3.46|P-value:6.02E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-4.55|P-value:9.07E-6 ID:SGTC_2999|Compound:9069765|FD-Score:4.28|P-value:1.30E-5 ID:SGTC_3104|Compound:9120930|FD-Score:-3.39|P-value:7.70E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.53|P-value:2.43E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-4.15|P-value:4.87E-5 ID:SGTC_3189|Compound:9110682|FD-Score:-4.66|P-value:5.68E-6 ID:SGTC_3217|Compound:9129673|FD-Score:4.14|P-value:2.30E-5 ID:SGTC_3220|Compound:9131269|FD-Score:-3.76|P-value:2.12E-4 ID:SGTC_3269|Compound:9137823|FD-Score:4.52|P-value:4.60E-6

Top fitness defect scores for YJL177W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 7.48 96.7 µM 1.61E-13 calcium & mitochondrial duress 87 3.65E-14
2 SGTC_1675 st018485 6.46 24.5 µM 1.43E-10 60S ribosome export 5 5.07E-11
3 SGTC_118 0083-0097 5.71 135.3 µM 1.22E-8 translation 34 5.74E-9
4 SGTC_1730 st033808 5.31 45.1 µM 1.01E-7 7 5.46E-8
5 SGTC_1620 st003704 4.60 16.5 µM 3.19E-6 8 2.11E-6
6 SGTC_3269 9137823 4.52 49.5 µM 4.60E-6 60S ribosome export 9 3.11E-6
7 SGTC_450 aminopyrene 4.32 156.0 nM 1.08E-5 24 7.67E-6
8 SGTC_2999 9069765 4.28 71.4 µM 1.30E-5 amide catabolism 17 9.36E-6
9 SGTC_123 0083-0120 4.19 66.7 µM 1.86E-5 43 1.37E-5
10 SGTC_3217 9129673 4.14 49.5 µM 2.30E-5 34 1.70E-5
11 SGTC_1409 3909-8004 4.13 61.9 µM 2.48E-5 14 1.85E-5
12 SGTC_1435 4092-0789 3.85 56.7 µM 7.39E-5 plasma membrane duress 14 5.85E-5
13 SGTC_1430 4049-0248 3.82 69.1 µM 8.42E-5 22 6.71E-5
14 SGTC_1107 amlodipine 3.75 47.0 µM 1.09E-4 47 8.80E-5
15 SGTC_1728 st035614 3.74 33.8 µM 1.16E-4 62 9.38E-5
16 SGTC_1050 3232-1156 3.64 69.3 µM 1.63E-4 RSC complex & mRNA processing 28 1.35E-4
17 SGTC_1551 6-bromo-3'-methylflavone 3.61 63.5 µM 1.81E-4 29 1.51E-4
18 SGTC_473 2-arachidonoylglycerol 3.54 10.0 µM 2.40E-4 27 2.03E-4
19 SGTC_3127 9126946 3.53 49.5 µM 2.43E-4 ERG2 28 2.05E-4
20 SGTC_1160 4092-0570 3.41 10.5 µM 3.74E-4 plasma membrane duress 63 3.22E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 1.49E-20 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.129 7.05E-14 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.127 1.51E-13 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.123 7.07E-13 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.123 9.17E-13 YDR241W_d BUD26_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.117 1.24E-11 YOR312C RPL20B hom Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication
0.116 1.79E-11 YLR185W RPL37A hom Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication
0.114 3.93E-11 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.106 6.93E-10 YBL071C-B_p YBL071C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.105 1.11E-9 YKL143W LTV1 hom Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature
0.104 1.28E-9 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.103 2.13E-9 YLR264W RPS28B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication
0.102 3.24E-9 YLR264C-A_p YLR264C-A_p hom Putative protein of unknown function
0.102 3.80E-9 YMR230W RPS10B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication
0.101 4.15E-9 YDR418W RPL12B hom Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication