YJL196C / ELO1

Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL196C / ELO1

Click on Significant Values for Screen Details ID:SGTC_196|Compound:k015-0023|FD-Score:-2.98|P-value:3.37E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:-3.45|P-value:4.15E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:3.45|P-value:4.35E-5 ID:SGTC_280|Compound:3448-3607|FD-Score:2.83|P-value:6.48E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.04|P-value:2.76E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-2.88|P-value:5.04E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.35|P-value:7.11E-5 ID:SGTC_846|Compound:0335-0850|FD-Score:3.41|P-value:5.38E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:3.45|P-value:4.29E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:-2.73|P-value:9.09E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.07|P-value:2.42E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.29|P-value:9.35E-5 ID:SGTC_1646|Compound:st011709|FD-Score:2.98|P-value:3.55E-4 ID:SGTC_1653|Compound:st012112|FD-Score:2.89|P-value:5.09E-4 ID:SGTC_1749|Compound:st037932|FD-Score:2.97|P-value:3.71E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.17|P-value:1.59E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.01|P-value:3.07E-4 ID:SGTC_1821|Compound:st053465|FD-Score:-2.82|P-value:6.34E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.21|P-value:1.31E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.62|P-value:1.93E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.41|P-value:5.24E-5 ID:SGTC_2320|Compound:7373003|FD-Score:-2.87|P-value:5.29E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-2.93|P-value:4.06E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-3.57|P-value:2.27E-5 ID:SGTC_2348|Compound:9022543|FD-Score:-6.13|P-value:1.35E-12 ID:SGTC_2349|Compound:9023730|FD-Score:6.22|P-value:7.49E-13 ID:SGTC_2428|Compound:5615643|FD-Score:3.26|P-value:1.07E-4 ID:SGTC_2485|Compound:5633444|FD-Score:5.42|P-value:3.38E-10 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.00|P-value:3.31E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:4.07|P-value:1.83E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:2.90|P-value:4.86E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.82|P-value:6.64E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.56|P-value:2.52E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-2.89|P-value:4.82E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:2.74|P-value:9.08E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:2.96|P-value:3.79E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:2.74|P-value:9.24E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:-2.81|P-value:6.73E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-2.80|P-value:6.95E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.35|P-value:7.01E-5 ID:SGTC_2882|Compound:9058044|FD-Score:-3.30|P-value:8.33E-5 ID:SGTC_2884|Compound:9058502|FD-Score:4.48|P-value:1.78E-7 ID:SGTC_2967|Compound:9089538|FD-Score:-3.03|P-value:2.68E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-4.98|P-value:6.65E-9 ID:SGTC_3101|Compound:9120531|FD-Score:2.97|P-value:3.65E-4 ID:SGTC_3144|Compound:9087057|FD-Score:2.89|P-value:5.03E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.41|P-value:5.26E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-2.74|P-value:8.86E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:-2.98|P-value:3.37E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:-3.45|P-value:4.15E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:3.45|P-value:4.35E-5 ID:SGTC_280|Compound:3448-3607|FD-Score:2.83|P-value:6.48E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.04|P-value:2.76E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-2.88|P-value:5.04E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.35|P-value:7.11E-5 ID:SGTC_846|Compound:0335-0850|FD-Score:3.41|P-value:5.38E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:3.45|P-value:4.29E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:-2.73|P-value:9.09E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.07|P-value:2.42E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.29|P-value:9.35E-5 ID:SGTC_1646|Compound:st011709|FD-Score:2.98|P-value:3.55E-4 ID:SGTC_1653|Compound:st012112|FD-Score:2.89|P-value:5.09E-4 ID:SGTC_1749|Compound:st037932|FD-Score:2.97|P-value:3.71E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.17|P-value:1.59E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.01|P-value:3.07E-4 ID:SGTC_1821|Compound:st053465|FD-Score:-2.82|P-value:6.34E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.21|P-value:1.31E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.62|P-value:1.93E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.41|P-value:5.24E-5 ID:SGTC_2320|Compound:7373003|FD-Score:-2.87|P-value:5.29E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-2.93|P-value:4.06E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-3.57|P-value:2.27E-5 ID:SGTC_2348|Compound:9022543|FD-Score:-6.13|P-value:1.35E-12 ID:SGTC_2349|Compound:9023730|FD-Score:6.22|P-value:7.49E-13 ID:SGTC_2428|Compound:5615643|FD-Score:3.26|P-value:1.07E-4 ID:SGTC_2485|Compound:5633444|FD-Score:5.42|P-value:3.38E-10 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.00|P-value:3.31E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:4.07|P-value:1.83E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:2.90|P-value:4.86E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.82|P-value:6.64E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.56|P-value:2.52E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-2.89|P-value:4.82E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:2.74|P-value:9.08E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:2.96|P-value:3.79E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:2.74|P-value:9.24E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:-2.81|P-value:6.73E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-2.80|P-value:6.95E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.35|P-value:7.01E-5 ID:SGTC_2882|Compound:9058044|FD-Score:-3.30|P-value:8.33E-5 ID:SGTC_2884|Compound:9058502|FD-Score:4.48|P-value:1.78E-7 ID:SGTC_2967|Compound:9089538|FD-Score:-3.03|P-value:2.68E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-4.98|P-value:6.65E-9 ID:SGTC_3101|Compound:9120531|FD-Score:2.97|P-value:3.65E-4 ID:SGTC_3144|Compound:9087057|FD-Score:2.89|P-value:5.03E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.41|P-value:5.26E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-2.74|P-value:8.86E-4

Top fitness defect scores for YJL196C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2349 9023730 6.22 187.1 µM 7.49E-13 3 2.55E-10
2 SGTC_2485 5633444 5.42 17.8 µM 3.38E-10 redox potentiating 18 2.92E-8
3 SGTC_2884 9058502 4.48 52.0 µM 1.78E-7 17 3.81E-6
4 SGTC_2559 tetrahydrosappanone a trimethyl ether 4.07 100.0 µM 1.83E-6 11 2.35E-5
5 SGTC_1999 st074831 3.62 12.5 µM 1.93E-5 plasma membrane duress 45 1.48E-4
6 SGTC_2587 piperic acid 3.56 92.2 µM 2.52E-5 32 1.82E-4
7 SGTC_870 0573-2213 3.45 57.6 µM 4.29E-5 ERG2 34 2.77E-4
8 SGTC_278 4092-0821 3.45 23.9 µM 4.35E-5 plasma membrane duress 61 2.80E-4
9 SGTC_2303 7774051 3.41 200.0 µM 5.24E-5 39 3.24E-4
10 SGTC_3191 9110352 3.41 49.5 µM 5.26E-5 25 3.24E-4
11 SGTC_846 0335-0850 3.41 148.0 µM 5.38E-5 ubiquinone biosynthesis & proteasome 47 3.30E-4
12 SGTC_2791 5663188 3.35 71.4 µM 7.01E-5 RPP1 & pyrimidine depletion 44 4.06E-4
13 SGTC_724 3910-0327 3.35 137.0 µM 7.11E-5 ERG2 41 4.11E-4
14 SGTC_1355 1499-0035 3.29 1.7 µM 9.35E-5 42 5.09E-4
15 SGTC_2428 5615643 3.26 7.8 µM 1.07E-4 50 5.65E-4
16 SGTC_1889 st059080 3.21 5.2 µM 1.31E-4 48 6.61E-4
17 SGTC_1757 st041620 3.17 31.8 µM 1.59E-4 57 7.71E-4
18 SGTC_1083 didemethylchlorpromazine sulfoxide 3.07 707.4 nM 2.42E-4 redox potentiating 142 0.00107
19 SGTC_397 arbidol 3.04 50.0 µM 2.76E-4 cell wall 60 0.00119
20 SGTC_1820 st053765 3.01 18.6 µM 3.07E-4 RPP1 & pyrimidine depletion 65 0.00129

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 6.48E-10 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.103 2.35E-9 YLL042C ATG10 hom Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy
0.098 1.09E-8 YAL054C ACS1 hom Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
0.098 1.32E-8 YLR419W_p YLR419W_p hom Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene
0.092 8.49E-8 YOR266W PNT1 hom Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine
0.091 1.11E-7 YAR019C CDC15 het Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress
0.090 1.70E-7 YBR156C SLI15 hom Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly
0.083 1.32E-6 YHR033W_p YHR033W_p hom Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication
0.080 3.04E-6 YDR412W RRP17 het Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5′ end processing of pre-60S ribosomal RNA
0.078 5.69E-6 YPL186C UIP4 hom Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
0.077 7.33E-6 YMR240C CUS1 het Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p
0.076 1.03E-5 YKL010C UFD4 hom Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress
0.076 1.14E-5 YFL034C-B MOB2 het Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p
0.073 2.27E-5 YML074C FPR3 hom Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
0.072 2.96E-5 YDL028C MPS1 het Dual-specificity kinase; required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p