YJR044C / VPS55

Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR044C / VPS55

Click on Significant Values for Screen Details ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.98|P-value:5.53E-5 ID:SGTC_290|Compound:2043-6722|FD-Score:3.69|P-value:1.71E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.28|P-value:8.63E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.42|P-value:4.39E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.61|P-value:2.28E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.40|P-value:4.84E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.43|P-value:4.31E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:5.39|P-value:8.78E-8 ID:SGTC_720|Compound:r052-1644|FD-Score:-3.51|P-value:3.93E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:4.33|P-value:1.32E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:4.17|P-value:2.55E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:4.83|P-value:1.42E-6 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.52|P-value:5.84E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.68|P-value:1.73E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.25|P-value:8.03E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:4.47|P-value:7.25E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-4.03|P-value:5.64E-5 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.53|P-value:3.00E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.28|P-value:7.18E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.18|P-value:9.98E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.52|P-value:3.16E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.70|P-value:1.63E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.80|P-value:1.11E-4 ID:SGTC_1611|Compound:st001856|FD-Score:-3.68|P-value:2.15E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.60|P-value:2.38E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:7.00|P-value:6.21E-12 ID:SGTC_1642|Compound:st009582|FD-Score:3.30|P-value:6.61E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.32|P-value:6.22E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.82|P-value:1.25E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.22|P-value:2.08E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.27|P-value:7.45E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.33|P-value:7.19E-4 ID:SGTC_2382|Compound:9035899|FD-Score:4.11|P-value:3.34E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.41|P-value:4.56E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.62|P-value:2.18E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.38|P-value:5.17E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.45|P-value:4.74E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.56|P-value:2.76E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.70|P-value:2.62E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:7.46|P-value:2.67E-13 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.78|P-value:1.45E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.26|P-value:7.57E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.31|P-value:1.79E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:7.23|P-value:1.32E-12 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.18|P-value:9.86E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.56|P-value:2.70E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.51|P-value:6.03E-6 ID:SGTC_2764|Compound:methyldopa|FD-Score:4.16|P-value:2.73E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:6.37|P-value:3.45E-10 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.54|P-value:3.55E-4 ID:SGTC_2807|Compound:7945238|FD-Score:5.70|P-value:1.70E-8 ID:SGTC_2815|Compound:7968870|FD-Score:3.85|P-value:9.26E-5 ID:SGTC_2951|Compound:9072950|FD-Score:3.99|P-value:5.47E-5 ID:SGTC_3123|Compound:9126162|FD-Score:-3.91|P-value:9.06E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-3.41|P-value:5.53E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.26|P-value:2.26E-5 ID:SGTC_3224|Compound:9130643|FD-Score:4.23|P-value:2.06E-5 ID:SGTC_3269|Compound:9137823|FD-Score:3.54|P-value:2.94E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.18|P-value:9.90E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.98|P-value:5.53E-5 ID:SGTC_290|Compound:2043-6722|FD-Score:3.69|P-value:1.71E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.28|P-value:8.63E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.42|P-value:4.39E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.61|P-value:2.28E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.40|P-value:4.84E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.43|P-value:4.31E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:5.39|P-value:8.78E-8 ID:SGTC_720|Compound:r052-1644|FD-Score:-3.51|P-value:3.93E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:4.33|P-value:1.32E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:4.17|P-value:2.55E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:4.83|P-value:1.42E-6 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.52|P-value:5.84E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.68|P-value:1.73E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.25|P-value:8.03E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:4.47|P-value:7.25E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-4.03|P-value:5.64E-5 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.53|P-value:3.00E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.28|P-value:7.18E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.18|P-value:9.98E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.52|P-value:3.16E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.70|P-value:1.63E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.80|P-value:1.11E-4 ID:SGTC_1611|Compound:st001856|FD-Score:-3.68|P-value:2.15E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.60|P-value:2.38E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:7.00|P-value:6.21E-12 ID:SGTC_1642|Compound:st009582|FD-Score:3.30|P-value:6.61E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.32|P-value:6.22E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.82|P-value:1.25E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.22|P-value:2.08E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.27|P-value:7.45E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.33|P-value:7.19E-4 ID:SGTC_2382|Compound:9035899|FD-Score:4.11|P-value:3.34E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.41|P-value:4.56E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.62|P-value:2.18E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.38|P-value:5.17E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.45|P-value:4.74E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.56|P-value:2.76E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.70|P-value:2.62E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:7.46|P-value:2.67E-13 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.78|P-value:1.45E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.26|P-value:7.57E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.31|P-value:1.79E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:7.23|P-value:1.32E-12 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.18|P-value:9.86E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.56|P-value:2.70E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.51|P-value:6.03E-6 ID:SGTC_2764|Compound:methyldopa|FD-Score:4.16|P-value:2.73E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:6.37|P-value:3.45E-10 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.54|P-value:3.55E-4 ID:SGTC_2807|Compound:7945238|FD-Score:5.70|P-value:1.70E-8 ID:SGTC_2815|Compound:7968870|FD-Score:3.85|P-value:9.26E-5 ID:SGTC_2951|Compound:9072950|FD-Score:3.99|P-value:5.47E-5 ID:SGTC_3123|Compound:9126162|FD-Score:-3.91|P-value:9.06E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-3.41|P-value:5.53E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.26|P-value:2.26E-5 ID:SGTC_3224|Compound:9130643|FD-Score:4.23|P-value:2.06E-5 ID:SGTC_3269|Compound:9137823|FD-Score:3.54|P-value:2.94E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.18|P-value:9.90E-4

Top fitness defect scores for YJR044C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2581 avocatin a 7.46 64.0 µM 2.67E-13 sphingolipid biosynthesis & PDR1 7 4.43E-14
2 SGTC_2630 antimycin a 7.23 100.0 µM 1.32E-12 mitochondrial processes 7 2.46E-13
3 SGTC_1631 benzylvanillin 7.00 81.9 µM 6.21E-12 Golgi 2 1.28E-12
4 SGTC_2775 cyproheptadine 6.37 69.6 µM 3.45E-10 2 9.43E-11
5 SGTC_2807 7945238 5.70 52.0 µM 1.70E-8 5 6.09E-9
6 SGTC_717 1532-0246 5.39 73.2 µM 8.78E-8 Golgi 7 3.51E-8
7 SGTC_966 1300-0360 4.83 30.2 µM 1.42E-6 heme requiring 11 6.84E-7
8 SGTC_2538 3',7'-epoxycaryophyllan-6-one 4.70 100.0 µM 2.62E-6 14 1.32E-6
9 SGTC_1040 k898-0338 4.52 155.0 µM 5.84E-6 12 3.10E-6
10 SGTC_2763 lisinopril 4.51 49.3 µM 6.03E-6 9 3.21E-6
11 SGTC_1123 mangostin 4.47 811.3 nM 7.25E-6 mitochondrial response to ROS 24 3.90E-6
12 SGTC_779 1360-0071 4.33 233.0 µM 1.32E-5 fatty acid desaturase (OLE1) 20 7.41E-6
13 SGTC_3224 9130643 4.23 49.5 µM 2.06E-5 RPP1 & pyrimidine depletion 20 1.19E-5
14 SGTC_2331 7980721 4.22 200.0 µM 2.08E-5 23 1.20E-5
15 SGTC_965 1291-5240 4.17 308.0 µM 2.55E-5 29 1.49E-5
16 SGTC_2764 methyldopa 4.16 94.7 µM 2.73E-5 16 1.61E-5
17 SGTC_2382 9035899 4.11 200.0 µM 3.34E-5 60S ribosome export 13 1.99E-5
18 SGTC_2951 9072950 3.99 58.1 µM 5.47E-5 ERG2 22 3.36E-5
19 SGTC_243 5hr heat shock (37°C) + splitomicin 3.98 1.0 µM 5.53E-5 heat shock/prefoldin 50 3.41E-5
20 SGTC_2815 7968870 3.85 71.4 µM 9.26E-5 25 5.89E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.70E-10 YGL192W IME4 hom Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids
0.102 3.06E-9 YMR136W GAT2 hom Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
0.099 7.86E-9 YOL153C YOL153C hom Hypothetical protein
0.097 1.65E-8 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.089 2.54E-7 YCL049C_p YCL049C_p hom Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene
0.088 2.96E-7 YGR269W_d YGR269W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C
0.088 3.69E-7 YML080W DUS1 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17
0.086 5.80E-7 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.086 6.09E-7 YFR031C-A RPL2A hom Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication
0.083 1.62E-6 YPL114W_d YPL114W_d hom Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index
0.082 1.97E-6 YLR184W_d YLR184W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 2.20E-6 YPR002W PDH1 hom Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
0.080 3.31E-6 YJL163C_p YJL163C_p hom Putative protein of unknown function
0.078 5.49E-6 YHR190W ERG9 het Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway
0.075 1.37E-5 YJL042W MHP1 hom Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins