YJR148W / BAT2

Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR148W / BAT2

Click on Significant Values for Screen Details ID:SGTC_333|Compound:3486-0131|FD-Score:2.94|P-value:8.89E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.02|P-value:6.58E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.21|P-value:3.16E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-2.91|P-value:9.90E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:2.93|P-value:9.06E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:-4.03|P-value:8.88E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:3.01|P-value:6.87E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.15|P-value:4.00E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.28|P-value:2.46E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:3.13|P-value:4.26E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:4.46|P-value:1.06E-6 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.43|P-value:1.31E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.33|P-value:1.94E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:-3.15|P-value:4.00E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.79|P-value:2.75E-5 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.36|P-value:1.78E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.35|P-value:1.83E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.21|P-value:3.70E-6 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.15|P-value:4.06E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:-3.04|P-value:6.01E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:2.96|P-value:8.18E-4 ID:SGTC_1699|Compound:st031318|FD-Score:4.70|P-value:2.76E-7 ID:SGTC_1700|Compound:st030840|FD-Score:-2.97|P-value:7.93E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.17|P-value:3.74E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.11|P-value:4.67E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.47|P-value:1.10E-4 ID:SGTC_1774|Compound:st048371|FD-Score:4.53|P-value:7.09E-7 ID:SGTC_1777|Compound:st045864|FD-Score:3.23|P-value:2.96E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-3.93|P-value:1.43E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.18|P-value:3.56E-4 ID:SGTC_1845|Compound:st056753|FD-Score:-3.38|P-value:1.62E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.01|P-value:6.74E-4 ID:SGTC_2035|Compound:5154463|FD-Score:-3.80|P-value:2.68E-5 ID:SGTC_2043|Compound:5101342|FD-Score:-2.95|P-value:8.46E-4 ID:SGTC_2304|Compound:7443016|FD-Score:3.38|P-value:1.61E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.54|P-value:6.92E-7 ID:SGTC_2696|Compound:st077691|FD-Score:3.09|P-value:5.00E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.03|P-value:9.12E-6 ID:SGTC_2908|Compound:7930301|FD-Score:3.18|P-value:3.49E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.15|P-value:4.07E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.70|P-value:4.14E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.04|P-value:6.15E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-2.91|P-value:9.87E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.67|P-value:4.70E-5 ID:SGTC_3060|Compound:1327-0027|FD-Score:-3.03|P-value:6.26E-4 ID:SGTC_3062|Compound:9077494|FD-Score:3.67|P-value:4.71E-5 ID:SGTC_3069|Compound:9117009|FD-Score:-3.14|P-value:4.23E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.28|P-value:2.43E-4 ID:SGTC_3121|Compound:9125696|FD-Score:3.61|P-value:6.20E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.23|P-value:2.97E-4 ID:SGTC_3198|Compound:9112019|FD-Score:-3.27|P-value:2.50E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.30|P-value:2.25E-4 ID:SGTC_3211|Compound:9128781|FD-Score:7.58|P-value:3.69E-16 ID:SGTC_333|Compound:3486-0131|FD-Score:2.94|P-value:8.89E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.02|P-value:6.58E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.21|P-value:3.16E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-2.91|P-value:9.90E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:2.93|P-value:9.06E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:-4.03|P-value:8.88E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:3.01|P-value:6.87E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.15|P-value:4.00E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.28|P-value:2.46E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:3.13|P-value:4.26E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:4.46|P-value:1.06E-6 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.43|P-value:1.31E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.33|P-value:1.94E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:-3.15|P-value:4.00E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.79|P-value:2.75E-5 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.36|P-value:1.78E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.35|P-value:1.83E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.21|P-value:3.70E-6 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.15|P-value:4.06E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:-3.04|P-value:6.01E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:2.96|P-value:8.18E-4 ID:SGTC_1699|Compound:st031318|FD-Score:4.70|P-value:2.76E-7 ID:SGTC_1700|Compound:st030840|FD-Score:-2.97|P-value:7.93E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.17|P-value:3.74E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.11|P-value:4.67E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.47|P-value:1.10E-4 ID:SGTC_1774|Compound:st048371|FD-Score:4.53|P-value:7.09E-7 ID:SGTC_1777|Compound:st045864|FD-Score:3.23|P-value:2.96E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-3.93|P-value:1.43E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.18|P-value:3.56E-4 ID:SGTC_1845|Compound:st056753|FD-Score:-3.38|P-value:1.62E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.01|P-value:6.74E-4 ID:SGTC_2035|Compound:5154463|FD-Score:-3.80|P-value:2.68E-5 ID:SGTC_2043|Compound:5101342|FD-Score:-2.95|P-value:8.46E-4 ID:SGTC_2304|Compound:7443016|FD-Score:3.38|P-value:1.61E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.54|P-value:6.92E-7 ID:SGTC_2696|Compound:st077691|FD-Score:3.09|P-value:5.00E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.03|P-value:9.12E-6 ID:SGTC_2908|Compound:7930301|FD-Score:3.18|P-value:3.49E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.15|P-value:4.07E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.70|P-value:4.14E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.04|P-value:6.15E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-2.91|P-value:9.87E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.67|P-value:4.70E-5 ID:SGTC_3060|Compound:1327-0027|FD-Score:-3.03|P-value:6.26E-4 ID:SGTC_3062|Compound:9077494|FD-Score:3.67|P-value:4.71E-5 ID:SGTC_3069|Compound:9117009|FD-Score:-3.14|P-value:4.23E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.28|P-value:2.43E-4 ID:SGTC_3121|Compound:9125696|FD-Score:3.61|P-value:6.20E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.23|P-value:2.97E-4 ID:SGTC_3198|Compound:9112019|FD-Score:-3.27|P-value:2.50E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.30|P-value:2.25E-4 ID:SGTC_3211|Compound:9128781|FD-Score:7.58|P-value:3.69E-16

Top fitness defect scores for YJR148W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3211 9128781 7.58 49.5 µM 3.69E-16 12 1.77E-14
2 SGTC_1699 st031318 4.70 29.1 µM 2.76E-7 14 1.27E-6
3 SGTC_2316 5844804 4.54 197.4 µM 6.92E-7 11 2.87E-6
4 SGTC_1774 st048371 4.53 48.5 µM 7.09E-7 RNA processing & uracil transport 7 2.94E-6
5 SGTC_965 1291-5240 4.46 308.0 µM 1.06E-6 21 4.19E-6
6 SGTC_1331 1472-0049 4.21 76.2 µM 3.70E-6 14 1.27E-5
7 SGTC_2750 bromebric acid 4.03 70.2 µM 9.12E-6 28 2.83E-5
8 SGTC_1188 1403-0014 3.79 4.6 µM 2.75E-5 mitochondrial stress 59 7.56E-5
9 SGTC_2942 9052777 3.70 62.2 µM 4.14E-5 44 1.09E-4
10 SGTC_3062 9077494 3.67 49.5 µM 4.71E-5 mitochondrial response to ROS 42 1.22E-4
11 SGTC_3121 9125696 3.61 49.5 µM 6.20E-5 6 1.56E-4
12 SGTC_1742 st038235 3.47 28.9 µM 1.10E-4 mitochondrial stress 140 2.58E-4
13 SGTC_1156 4092-0367 3.43 4.9 µM 1.31E-4 38 3.02E-4
14 SGTC_2304 7443016 3.38 91.4 µM 1.61E-4 34 3.62E-4
15 SGTC_1159 4092-0538 3.33 61.2 µM 1.94E-4 54 4.28E-4
16 SGTC_3209 9113616 3.30 49.5 µM 2.25E-4 57 4.90E-4
17 SGTC_3080 9117754 3.28 49.5 µM 2.43E-4 43 5.24E-4
18 SGTC_1777 st045864 3.23 34.8 µM 2.96E-4 25 6.24E-4
19 SGTC_3197 9113331 3.23 49.5 µM 2.97E-4 67 6.27E-4
20 SGTC_418 lividomycin a 3.21 100.0 µM 3.16E-4 33 6.62E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.187 1.15E-27 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.166 4.16E-22 YBR265W TSC10 het 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
0.141 2.57E-16 YGR122C-A_d YGR122C-A_d hom Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
0.138 8.73E-16 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.113 4.46E-11 YPL260W YPL260W hom Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress
0.106 6.58E-10 YJL151C SNA3 hom Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles
0.104 1.33E-9 YDR197W CBS2 hom Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
0.100 6.56E-9 YJR152W DAL5 hom Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
0.099 8.44E-9 YDR513W GRX2 hom Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication
0.096 2.99E-8 YDL118W_d YDL118W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein
0.094 4.39E-8 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.089 2.28E-7 YJL088W ARG3 hom Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine
0.088 3.46E-7 YGL075C MPS2 het Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
0.088 3.59E-7 YKL151C YKL151C hom NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.087 3.93E-7 YDR063W AIM7 hom Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss