YKL069W

Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL069W / YKL069W

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:3.18|P-value:3.09E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.64|P-value:4.17E-5 ID:SGTC_112|Compound:phenothiazine|FD-Score:2.88|P-value:9.91E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.64|P-value:4.22E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:3.71|P-value:3.06E-5 ID:SGTC_328|Compound:k915-0120|FD-Score:4.00|P-value:7.50E-6 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.34|P-value:1.03E-4 ID:SGTC_401|Compound:neomycin|FD-Score:3.59|P-value:5.34E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.20|P-value:1.84E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.62|P-value:4.67E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:-2.81|P-value:8.59E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:-3.12|P-value:2.62E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:-2.92|P-value:5.75E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.19|P-value:1.91E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.22|P-value:2.62E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-2.82|P-value:8.44E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:-2.79|P-value:9.25E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:-3.30|P-value:1.20E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.42|P-value:7.29E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.88|P-value:1.39E-5 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.51|P-value:5.16E-7 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.68|P-value:3.57E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:6.05|P-value:2.46E-11 ID:SGTC_1206|Compound:3978-0017|FD-Score:2.94|P-value:7.91E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.59|P-value:5.31E-5 ID:SGTC_1486|Compound:3970-0793|FD-Score:-3.40|P-value:7.82E-5 ID:SGTC_1526|Compound:st051518|FD-Score:3.61|P-value:4.91E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.31|P-value:1.81E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.02|P-value:5.81E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.41|P-value:7.38E-5 ID:SGTC_1739|Compound:st037196|FD-Score:-2.80|P-value:8.89E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.95|P-value:9.86E-6 ID:SGTC_1779|Compound:st039427|FD-Score:3.97|P-value:8.71E-6 ID:SGTC_1868|Compound:st057644|FD-Score:7.31|P-value:9.47E-16 ID:SGTC_1967|Compound:st070177|FD-Score:2.93|P-value:7.97E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.01|P-value:5.94E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.70|P-value:3.17E-5 ID:SGTC_2038|Compound:4100038|FD-Score:4.98|P-value:3.38E-8 ID:SGTC_2075|Compound:5212009|FD-Score:-3.02|P-value:3.92E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.42|P-value:1.14E-4 ID:SGTC_2162|Compound:5663267|FD-Score:2.93|P-value:8.01E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.99|P-value:7.83E-6 ID:SGTC_2345|Compound:9052315|FD-Score:3.12|P-value:3.94E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-2.78|P-value:9.74E-4 ID:SGTC_2421|Compound:5690543|FD-Score:4.77|P-value:1.21E-7 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.35|P-value:1.51E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:4.76|P-value:1.23E-7 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.87|P-value:6.40E-8 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.32|P-value:1.11E-4 ID:SGTC_2585|Compound:alliin|FD-Score:-3.58|P-value:3.54E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.25|P-value:6.30E-9 ID:SGTC_2610|Compound:ononetin|FD-Score:3.17|P-value:3.20E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.92|P-value:4.79E-8 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.24|P-value:2.41E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.38|P-value:1.35E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.44|P-value:1.03E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.21|P-value:1.75E-4 ID:SGTC_3095|Compound:9117207|FD-Score:2.87|P-value:9.97E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.04|P-value:5.34E-4 ID:SGTC_3143|Compound:9086658|FD-Score:2.88|P-value:9.67E-4 ID:SGTC_3237|Compound:9133362|FD-Score:-2.77|P-value:9.87E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.01|P-value:5.91E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.18|P-value:3.09E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.64|P-value:4.17E-5 ID:SGTC_112|Compound:phenothiazine|FD-Score:2.88|P-value:9.91E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.64|P-value:4.22E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:3.71|P-value:3.06E-5 ID:SGTC_328|Compound:k915-0120|FD-Score:4.00|P-value:7.50E-6 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.34|P-value:1.03E-4 ID:SGTC_401|Compound:neomycin|FD-Score:3.59|P-value:5.34E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.20|P-value:1.84E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.62|P-value:4.67E-5 ID:SGTC_566|Compound:0958-0068|FD-Score:-2.81|P-value:8.59E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:-3.12|P-value:2.62E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:-2.92|P-value:5.75E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.19|P-value:1.91E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.22|P-value:2.62E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-2.82|P-value:8.44E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:-2.79|P-value:9.25E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:-3.30|P-value:1.20E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.42|P-value:7.29E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.88|P-value:1.39E-5 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.51|P-value:5.16E-7 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.68|P-value:3.57E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:6.05|P-value:2.46E-11 ID:SGTC_1206|Compound:3978-0017|FD-Score:2.94|P-value:7.91E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.59|P-value:5.31E-5 ID:SGTC_1486|Compound:3970-0793|FD-Score:-3.40|P-value:7.82E-5 ID:SGTC_1526|Compound:st051518|FD-Score:3.61|P-value:4.91E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.31|P-value:1.81E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.02|P-value:5.81E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.41|P-value:7.38E-5 ID:SGTC_1739|Compound:st037196|FD-Score:-2.80|P-value:8.89E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.95|P-value:9.86E-6 ID:SGTC_1779|Compound:st039427|FD-Score:3.97|P-value:8.71E-6 ID:SGTC_1868|Compound:st057644|FD-Score:7.31|P-value:9.47E-16 ID:SGTC_1967|Compound:st070177|FD-Score:2.93|P-value:7.97E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.01|P-value:5.94E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.70|P-value:3.17E-5 ID:SGTC_2038|Compound:4100038|FD-Score:4.98|P-value:3.38E-8 ID:SGTC_2075|Compound:5212009|FD-Score:-3.02|P-value:3.92E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.42|P-value:1.14E-4 ID:SGTC_2162|Compound:5663267|FD-Score:2.93|P-value:8.01E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.99|P-value:7.83E-6 ID:SGTC_2345|Compound:9052315|FD-Score:3.12|P-value:3.94E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-2.78|P-value:9.74E-4 ID:SGTC_2421|Compound:5690543|FD-Score:4.77|P-value:1.21E-7 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.35|P-value:1.51E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:4.76|P-value:1.23E-7 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.87|P-value:6.40E-8 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.32|P-value:1.11E-4 ID:SGTC_2585|Compound:alliin|FD-Score:-3.58|P-value:3.54E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.25|P-value:6.30E-9 ID:SGTC_2610|Compound:ononetin|FD-Score:3.17|P-value:3.20E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.92|P-value:4.79E-8 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.24|P-value:2.41E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.38|P-value:1.35E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.44|P-value:1.03E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.21|P-value:1.75E-4 ID:SGTC_3095|Compound:9117207|FD-Score:2.87|P-value:9.97E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.04|P-value:5.34E-4 ID:SGTC_3143|Compound:9086658|FD-Score:2.88|P-value:9.67E-4 ID:SGTC_3237|Compound:9133362|FD-Score:-2.77|P-value:9.87E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.01|P-value:5.91E-4

Top fitness defect scores for YKL069W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1868 st057644 7.31 42.7 µM 9.47E-16 4 1.36E-13
2 SGTC_1179 1021-1431 6.05 9.3 µM 2.46E-11 15 7.13E-10
3 SGTC_2604 4'-hydroxychalcone 5.25 11.3 µM 6.30E-9 12 7.71E-8
4 SGTC_2038 4100038 4.98 31.0 µM 3.38E-8 plasma membrane duress 27 3.20E-7
5 SGTC_2636 apigenin dimethyl ether 4.92 100.0 µM 4.79E-8 17 4.29E-7
6 SGTC_2575 plumbagin 4.87 510.0 nM 6.40E-8 superoxide 20 5.48E-7
7 SGTC_2421 5690543 4.77 90.7 µM 1.21E-7 7 9.39E-7
8 SGTC_2507 purpurin 4.76 79.7 µM 1.23E-7 copper-dependent oxidative stress 24 9.53E-7
9 SGTC_1072 oxiconazole 4.51 14.9 nM 5.16E-7 ergosterol depletion effects on membrane 40 3.22E-6
10 SGTC_328 k915-0120 4.00 63.5 µM 7.50E-6 TSC3-RPN4 20 3.12E-5
11 SGTC_2297 7971671 3.99 152.3 µM 7.83E-6 RNA processing & uracil transport 23 3.24E-5
12 SGTC_1779 st039427 3.97 55.0 µM 8.71E-6 28 3.55E-5
13 SGTC_1765 st044815 3.95 90.4 µM 9.86E-6 25 3.94E-5
14 SGTC_1021 4476-0760 3.88 85.3 µM 1.39E-5 29 5.26E-5
15 SGTC_322 k048-0136 3.71 19.3 µM 3.06E-5 RSC & ERG11 18 1.04E-4
16 SGTC_2029 5175081 3.70 200.0 µM 3.17E-5 24 1.06E-4
17 SGTC_1178 0988-0033 3.68 191.0 µM 3.57E-5 37 1.18E-4
18 SGTC_47 0149-0135 3.64 24.2 µM 4.17E-5 TSC3-RPN4 26 1.35E-4
19 SGTC_246 cycloheximide 3.64 667.0 µM 4.22E-5 19 1.36E-4
20 SGTC_453 enantio-paf c16 3.62 10.0 µM 4.67E-5 174 1.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.68E-13 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.095 3.38E-8 YBL050W SEC17 het Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP
0.086 6.36E-7 YBR031W RPL4A hom Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication
0.085 8.33E-7 YJL028W YJL028W hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments
0.085 9.13E-7 YMR317W_p YMR317W_p hom Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene
0.083 1.32E-6 YOL025W LAG2 hom Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1
0.083 1.39E-6 YGR265W_d YGR265W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
0.083 1.69E-6 YKR033C_d YKR033C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80
0.082 2.09E-6 YAL038W CDC19 het Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication
0.082 2.05E-6 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081 2.70E-6 YNL034W_p YNL034W_p hom Putative protein of unknown function; YNL034W is not an essential gene
0.080 3.96E-6 YOR366W_d YOR366W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C
0.077 8.08E-6 YLR138W NHA1 hom Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH
0.077 8.21E-6 YLR064W PER33 hom Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress
0.076 1.10E-5 YHR204W MNL1 hom Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation