YKL070W_p

Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL070W / YKL070W

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:3.46|P-value:1.16E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:5.02|P-value:5.56E-8 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.72|P-value:6.84E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.15|P-value:6.43E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.52|P-value:9.07E-5 ID:SGTC_197|Compound:4544-0043|FD-Score:-3.46|P-value:1.96E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.20|P-value:4.13E-6 ID:SGTC_381|Compound:3461-2219|FD-Score:3.05|P-value:5.71E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.09|P-value:7.86E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.10|P-value:4.77E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.45|P-value:1.20E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-4.15|P-value:9.79E-6 ID:SGTC_818|Compound:4072-2707|FD-Score:-4.49|P-value:1.94E-6 ID:SGTC_822|Compound:1487-0950|FD-Score:3.69|P-value:4.48E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.77|P-value:3.08E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:2.94|P-value:8.42E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:2.91|P-value:9.42E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.01|P-value:1.88E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.77|P-value:3.08E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:3.14|P-value:4.08E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.50|P-value:9.54E-7 ID:SGTC_1945|Compound:st075991|FD-Score:3.09|P-value:4.96E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.26|P-value:3.17E-6 ID:SGTC_1954|Compound:st077032|FD-Score:4.20|P-value:4.20E-6 ID:SGTC_2044|Compound:5102272|FD-Score:2.91|P-value:9.38E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.83|P-value:2.40E-5 ID:SGTC_2248|Compound:tofa|FD-Score:3.58|P-value:6.95E-5 ID:SGTC_2304|Compound:7443016|FD-Score:-3.33|P-value:3.25E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.04|P-value:5.92E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.49|P-value:1.05E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:2.98|P-value:7.32E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:3.13|P-value:4.32E-4 ID:SGTC_3104|Compound:9120930|FD-Score:-3.03|P-value:9.71E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.35|P-value:1.85E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.23|P-value:2.94E-4 ID:SGTC_3162|Compound:9099653|FD-Score:2.99|P-value:6.98E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.46|P-value:1.16E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:5.02|P-value:5.56E-8 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.72|P-value:6.84E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.15|P-value:6.43E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.52|P-value:9.07E-5 ID:SGTC_197|Compound:4544-0043|FD-Score:-3.46|P-value:1.96E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.20|P-value:4.13E-6 ID:SGTC_381|Compound:3461-2219|FD-Score:3.05|P-value:5.71E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.09|P-value:7.86E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.10|P-value:4.77E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.45|P-value:1.20E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-4.15|P-value:9.79E-6 ID:SGTC_818|Compound:4072-2707|FD-Score:-4.49|P-value:1.94E-6 ID:SGTC_822|Compound:1487-0950|FD-Score:3.69|P-value:4.48E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.77|P-value:3.08E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:2.94|P-value:8.42E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:2.91|P-value:9.42E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.01|P-value:1.88E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.77|P-value:3.08E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:3.14|P-value:4.08E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.50|P-value:9.54E-7 ID:SGTC_1945|Compound:st075991|FD-Score:3.09|P-value:4.96E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.26|P-value:3.17E-6 ID:SGTC_1954|Compound:st077032|FD-Score:4.20|P-value:4.20E-6 ID:SGTC_2044|Compound:5102272|FD-Score:2.91|P-value:9.38E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.83|P-value:2.40E-5 ID:SGTC_2248|Compound:tofa|FD-Score:3.58|P-value:6.95E-5 ID:SGTC_2304|Compound:7443016|FD-Score:-3.33|P-value:3.25E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.04|P-value:5.92E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.49|P-value:1.05E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:2.98|P-value:7.32E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:3.13|P-value:4.32E-4 ID:SGTC_3104|Compound:9120930|FD-Score:-3.03|P-value:9.71E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.35|P-value:1.85E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.23|P-value:2.94E-4 ID:SGTC_3162|Compound:9099653|FD-Score:2.99|P-value:6.98E-4

Top fitness defect scores for YKL070W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_53 0973-0023 5.02 40.0 µM 5.56E-8 RNA processing & uracil transport 7 2.62E-7
2 SGTC_1676 st018489 4.50 23.4 µM 9.54E-7 60S ribosome export 21 3.46E-6
3 SGTC_1948 st076329 4.26 66.6 µM 3.17E-6 20 1.03E-5
4 SGTC_358 0075-0058 4.20 9.4 µM 4.13E-6 52 1.31E-5
5 SGTC_1954 st077032 4.20 68.9 µM 4.20E-6 15 1.33E-5
6 SGTC_2106 5357045 3.83 167.3 µM 2.40E-5 20 6.46E-5
7 SGTC_1445 4239-0156 3.77 97.7 µM 3.08E-5 32 8.09E-5
8 SGTC_1009 4106-0057 3.77 9.9 µM 3.08E-5 16 8.10E-5
9 SGTC_822 1487-0950 3.69 154.0 µM 4.48E-5 20 1.14E-4
10 SGTC_2248 tofa 3.58 1.1 µM 6.95E-5 sphingolipid biosynthesis & PDR1 49 1.69E-4
11 SGTC_164 4100-3994 3.52 89.6 µM 9.07E-5 46 2.16E-4
12 SGTC_2594 a-mangostin 3.49 100.0 µM 1.05E-4 47 2.46E-4
13 SGTC_50 0929-0078 3.46 56.4 µM 1.16E-4 69 2.69E-4
14 SGTC_726 3448-4391 3.45 34.2 µM 1.20E-4 28 2.78E-4
15 SGTC_3106 9121286 3.35 49.5 µM 1.85E-4 30 4.11E-4
16 SGTC_3124 9127567 3.23 49.5 µM 2.94E-4 DNA damage response 38 6.27E-4
17 SGTC_1578 josamycin 3.14 24.2 µM 4.08E-4 36 8.43E-4
18 SGTC_2740 felodipine 3.13 17.1 µM 4.32E-4 37 8.89E-4
19 SGTC_593 1203-0218 3.10 61.7 µM 4.77E-4 37 9.73E-4
20 SGTC_1945 st075991 3.09 56.6 µM 4.96E-4 60S ribosome export 55 0.00101

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.40E-12 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.122 1.56E-12 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
0.114 4.05E-11 YOL071W EMI5 hom Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.106 6.82E-10 YER105C NUP157 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog, NUP170, that arose from the whole genome duplication
0.100 7.27E-9 YMR184W ADD37 hom Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress
0.100 7.74E-9 YKR054C DYN1 hom Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
0.097 2.06E-8 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.096 2.37E-8 YPR195C_d YPR195C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.096 2.37E-8 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.095 3.74E-8 YML120C NDI1 hom NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID
0.090 1.66E-7 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.090 1.78E-7 YGL112C TAF6 het Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
0.089 2.17E-7 YJR059W PTK2 hom Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
0.087 3.96E-7 YGL091C NBP35 het Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases
0.087 4.64E-7 YKL086W SRX1 hom Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress