YKR026C / GCN3

Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR026C / GCN3

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:8.12|P-value:2.60E-12 ID:SGTC_14|Compound:0354-0009|FD-Score:3.73|P-value:8.22E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:8.05|P-value:3.97E-12 ID:SGTC_24|Compound:0417-1663|FD-Score:5.94|P-value:2.35E-7 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:4.73|P-value:3.13E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:4.93|P-value:1.48E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:8.10|P-value:2.97E-12 ID:SGTC_51|Compound:1013-0126|FD-Score:6.64|P-value:8.86E-9 ID:SGTC_68|Compound:0986-0284|FD-Score:6.98|P-value:1.53E-9 ID:SGTC_79|Compound:0052-0007|FD-Score:10.20|P-value:2.70E-18 ID:SGTC_152|Compound:4469-0003|FD-Score:5.65|P-value:8.43E-7 ID:SGTC_167|Compound:3672-0051|FD-Score:8.49|P-value:2.65E-13 ID:SGTC_176|Compound:1486-1328|FD-Score:8.94|P-value:1.45E-14 ID:SGTC_180|Compound:1486-1293|FD-Score:15.90|P-value:2.43E-42 ID:SGTC_194|Compound:1486-1323|FD-Score:3.70|P-value:8.91E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:3.68|P-value:9.36E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:4.52|P-value:6.63E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-4.91|P-value:1.16E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:3.81|P-value:6.55E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:-5.85|P-value:2.38E-7 ID:SGTC_278|Compound:4092-0821|FD-Score:7.53|P-value:7.80E-11 ID:SGTC_285|Compound:1486-1325|FD-Score:5.29|P-value:3.72E-6 ID:SGTC_308|Compound:4092-1169|FD-Score:4.33|P-value:1.23E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:4.55|P-value:5.93E-5 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.91|P-value:4.81E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:6.09|P-value:1.19E-7 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:7.82|P-value:1.57E-11 ID:SGTC_412|Compound:gemfibrozil|FD-Score:4.03|P-value:3.28E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:6.05|P-value:1.45E-7 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.23|P-value:1.73E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:4.57|P-value:5.43E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:10.30|P-value:7.53E-19 ID:SGTC_523|Compound:1934-0222|FD-Score:5.43|P-value:2.10E-6 ID:SGTC_526|Compound:4469-0568|FD-Score:7.06|P-value:1.04E-9 ID:SGTC_541|Compound:4513-1321|FD-Score:4.01|P-value:3.54E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:11.10|P-value:2.02E-21 ID:SGTC_568|Compound:1193-0097|FD-Score:4.39|P-value:1.04E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:5.42|P-value:2.14E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:8.19|P-value:1.66E-12 ID:SGTC_583|Compound:1488-1091|FD-Score:6.07|P-value:1.29E-7 ID:SGTC_585|Compound:0kpi-0023|FD-Score:8.98|P-value:1.16E-14 ID:SGTC_596|Compound:1155-0152|FD-Score:6.47|P-value:2.03E-8 ID:SGTC_601|Compound:0986-0029|FD-Score:9.13|P-value:4.11E-15 ID:SGTC_609|Compound:0986-0026|FD-Score:6.96|P-value:1.72E-9 ID:SGTC_636|Compound:0kpi-0074|FD-Score:4.41|P-value:9.58E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:4.82|P-value:2.28E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:6.34|P-value:3.66E-8 ID:SGTC_651|Compound:3253-0966|FD-Score:11.10|P-value:2.13E-21 ID:SGTC_657|Compound:3534-0529|FD-Score:4.59|P-value:5.20E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:7.64|P-value:4.25E-11 ID:SGTC_661|Compound:1304-0007|FD-Score:4.09|P-value:2.70E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:6.73|P-value:5.57E-9 ID:SGTC_668|Compound:1682-0499|FD-Score:5.55|P-value:1.25E-6 ID:SGTC_677|Compound:0929-0063|FD-Score:6.19|P-value:7.73E-8 ID:SGTC_689|Compound:0833-0039|FD-Score:4.00|P-value:3.64E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:4.88|P-value:1.81E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:4.39|P-value:1.01E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:8.70|P-value:6.96E-14 ID:SGTC_748|Compound:0136-0228|FD-Score:8.30|P-value:8.71E-13 ID:SGTC_762|Compound:1165-0429|FD-Score:4.63|P-value:4.53E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:11.50|P-value:7.68E-23 ID:SGTC_768|Compound:0384-0033|FD-Score:19.90|P-value:6.72E-65 ID:SGTC_779|Compound:1360-0071|FD-Score:3.71|P-value:8.65E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:5.41|P-value:2.27E-6 ID:SGTC_813|Compound:k007-0158|FD-Score:3.70|P-value:9.05E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:8.95|P-value:1.35E-14 ID:SGTC_823|Compound:0417-1665|FD-Score:7.14|P-value:6.79E-10 ID:SGTC_834|Compound:0312-0008|FD-Score:8.23|P-value:1.35E-12 ID:SGTC_849|Compound:0386-0493|FD-Score:-4.22|P-value:1.37E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:4.35|P-value:1.18E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:4.36|P-value:1.14E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:4.70|P-value:3.47E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:4.85|P-value:2.03E-5 ID:SGTC_892|Compound:0929-0076|FD-Score:6.95|P-value:1.79E-9 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:6.85|P-value:2.96E-9 ID:SGTC_1005|Compound:4092-0690|FD-Score:13.20|P-value:1.30E-29 ID:SGTC_1011|Compound:4112-3381|FD-Score:6.90|P-value:2.35E-9 ID:SGTC_1019|Compound:4262-0212|FD-Score:8.40|P-value:4.78E-13 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.13|P-value:2.41E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.76|P-value:7.54E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:4.45|P-value:8.37E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:5.11|P-value:7.62E-6 ID:SGTC_1072|Compound:oxiconazole|FD-Score:6.11|P-value:1.12E-7 ID:SGTC_1076|Compound:itraconazole|FD-Score:5.92|P-value:2.63E-7 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.73|P-value:6.34E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:7.07|P-value:9.71E-10 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.99|P-value:3.75E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.37|P-value:1.08E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.93|P-value:4.47E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:8.21|P-value:1.50E-12 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.83|P-value:3.41E-9 ID:SGTC_1219|Compound:1469-0211|FD-Score:8.24|P-value:1.25E-12 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.77|P-value:7.20E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:7.39|P-value:1.78E-10 ID:SGTC_1304|Compound:1165-0502|FD-Score:4.56|P-value:5.62E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:5.99|P-value:1.88E-7 ID:SGTC_1335|Compound:1486-0900|FD-Score:5.16|P-value:6.20E-6 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.54|P-value:6.06E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.96|P-value:4.07E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.79|P-value:6.94E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:9.22|P-value:2.19E-15 ID:SGTC_1455|Compound:4262-0120|FD-Score:5.09|P-value:8.02E-6 ID:SGTC_1482|Compound:3346-2049|FD-Score:8.26|P-value:1.08E-12 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.92|P-value:4.61E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:5.32|P-value:3.21E-6 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:13.40|P-value:1.45E-30 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:16.20|P-value:1.54E-43 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:16.60|P-value:1.07E-45 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:5.18|P-value:5.65E-6 ID:SGTC_1600|Compound:coumarin 106|FD-Score:5.51|P-value:1.53E-6 ID:SGTC_1617|Compound:st002906|FD-Score:7.40|P-value:1.61E-10 ID:SGTC_1636|Compound:st007707|FD-Score:10.30|P-value:8.54E-19 ID:SGTC_1638|Compound:st008370|FD-Score:4.06|P-value:3.02E-4 ID:SGTC_1649|Compound:st011737|FD-Score:10.20|P-value:2.18E-18 ID:SGTC_1658|Compound:st012944|FD-Score:7.00|P-value:1.41E-9 ID:SGTC_1673|Compound:st016611|FD-Score:8.34|P-value:6.79E-13 ID:SGTC_1715|Compound:st032160|FD-Score:11.70|P-value:1.30E-23 ID:SGTC_1740|Compound:st038286|FD-Score:3.76|P-value:7.44E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.68|P-value:7.27E-4 ID:SGTC_1750|Compound:st081859|FD-Score:10.30|P-value:7.91E-19 ID:SGTC_1757|Compound:st041620|FD-Score:5.42|P-value:2.16E-6 ID:SGTC_1797|Compound:st048695|FD-Score:11.70|P-value:8.49E-24 ID:SGTC_1818|Compound:st052136|FD-Score:-4.31|P-value:1.01E-4 ID:SGTC_1881|Compound:5652484|FD-Score:8.21|P-value:1.50E-12 ID:SGTC_1882|Compound:5615643|FD-Score:8.09|P-value:3.04E-12 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:10.60|P-value:9.97E-20 ID:SGTC_1909|Compound:st060837|FD-Score:3.99|P-value:3.69E-4 ID:SGTC_1937|Compound:st074714|FD-Score:4.97|P-value:1.30E-5 ID:SGTC_1999|Compound:st074831|FD-Score:7.16|P-value:6.10E-10 ID:SGTC_2015|Compound:5119600|FD-Score:11.10|P-value:2.31E-21 ID:SGTC_2021|Compound:4019055|FD-Score:3.83|P-value:5.99E-4 ID:SGTC_2024|Compound:5144227|FD-Score:27.50|P-value:5.59E-122 ID:SGTC_2036|Compound:5160441|FD-Score:4.31|P-value:1.32E-4 ID:SGTC_2038|Compound:4100038|FD-Score:10.10|P-value:3.30E-18 ID:SGTC_2049|Compound:5262831|FD-Score:3.76|P-value:7.54E-4 ID:SGTC_2050|Compound:5263056|FD-Score:7.17|P-value:5.82E-10 ID:SGTC_2056|Compound:5235370|FD-Score:5.08|P-value:8.33E-6 ID:SGTC_2093|Compound:5331342|FD-Score:8.85|P-value:2.69E-14 ID:SGTC_2118|Compound:5526350|FD-Score:7.62|P-value:4.81E-11 ID:SGTC_2126|Compound:5251174|FD-Score:4.58|P-value:5.38E-5 ID:SGTC_2128|Compound:5255449|FD-Score:-5.26|P-value:2.94E-6 ID:SGTC_2136|Compound:5328288|FD-Score:-3.62|P-value:8.61E-4 ID:SGTC_2137|Compound:5261020|FD-Score:4.63|P-value:4.43E-5 ID:SGTC_2175|Compound:5807670|FD-Score:4.16|P-value:2.17E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:9.81|P-value:3.48E-17 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.25|P-value:5.83E-8 ID:SGTC_2286|Compound:7945697|FD-Score:11.70|P-value:1.50E-23 ID:SGTC_2288|Compound:7946289|FD-Score:9.59|P-value:1.71E-16 ID:SGTC_2301|Compound:7769476|FD-Score:5.65|P-value:8.31E-7 ID:SGTC_2376|Compound:9072922|FD-Score:3.94|P-value:4.42E-4 ID:SGTC_2384|Compound:9036245|FD-Score:18.70|P-value:1.19E-57 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.00|P-value:3.58E-4 ID:SGTC_2428|Compound:5615643|FD-Score:11.70|P-value:9.04E-24 ID:SGTC_2437|Compound:5741531|FD-Score:9.59|P-value:1.78E-16 ID:SGTC_2445|Compound:5742597|FD-Score:11.20|P-value:9.01E-22 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:5.94|P-value:2.34E-7 ID:SGTC_2472|Compound:5377652|FD-Score:8.91|P-value:1.83E-14 ID:SGTC_2478|Compound:5763493|FD-Score:11.10|P-value:2.10E-21 ID:SGTC_2486|Compound:5283202|FD-Score:8.86|P-value:2.42E-14 ID:SGTC_2488|Compound:5268135|FD-Score:12.90|P-value:2.36E-28 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:7.27|P-value:3.40E-10 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:5.92|P-value:2.56E-7 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:18.60|P-value:7.03E-57 ID:SGTC_2551|Compound:apiole|FD-Score:4.33|P-value:1.24E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:4.73|P-value:3.12E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:8.87|P-value:2.30E-14 ID:SGTC_2618|Compound:avocadyne|FD-Score:6.06|P-value:1.35E-7 ID:SGTC_2620|Compound:irigenin|FD-Score:3.83|P-value:6.17E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:7.90|P-value:9.78E-12 ID:SGTC_2650|Compound:prasterone|FD-Score:12.50|P-value:9.47E-27 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.68|P-value:3.75E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.79|P-value:6.77E-4 ID:SGTC_2669|Compound:eugenol|FD-Score:4.90|P-value:1.64E-5 ID:SGTC_2678|Compound:equilin|FD-Score:5.22|P-value:4.93E-6 ID:SGTC_2684|Compound:capsaicin|FD-Score:4.49|P-value:7.23E-5 ID:SGTC_2696|Compound:st077691|FD-Score:4.24|P-value:1.66E-4 ID:SGTC_2699|Compound:st077704|FD-Score:7.22|P-value:4.41E-10 ID:SGTC_2717|Compound:st081029|FD-Score:4.20|P-value:1.92E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:12.10|P-value:2.28E-25 ID:SGTC_2733|Compound:amorolfine|FD-Score:4.00|P-value:3.63E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.86|P-value:1.95E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:12.40|P-value:2.26E-26 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.44|P-value:8.60E-5 ID:SGTC_2789|Compound:5281112|FD-Score:6.23|P-value:6.20E-8 ID:SGTC_2802|Compound:7925815|FD-Score:5.13|P-value:6.84E-6 ID:SGTC_2816|Compound:7982706|FD-Score:5.80|P-value:4.29E-7 ID:SGTC_2910|Compound:7948405|FD-Score:4.24|P-value:1.66E-4 ID:SGTC_2948|Compound:9070189|FD-Score:13.70|P-value:1.53E-31 ID:SGTC_3083|Compound:9117465|FD-Score:5.74|P-value:5.55E-7 ID:SGTC_3200|Compound:9114385|FD-Score:-4.37|P-value:8.26E-5 ID:SGTC_3236|Compound:9132701|FD-Score:4.28|P-value:1.47E-4 ID:SGTC_3308|Compound:9128332|FD-Score:9.27|P-value:1.56E-15 ID:SGTC_3319|Compound:9138450|FD-Score:4.39|P-value:1.03E-4 ID:SGTC_3337|Compound:9144342|FD-Score:6.37|P-value:3.26E-8 ID:SGTC_10|Compound:0279-0212|FD-Score:8.12|P-value:2.60E-12 ID:SGTC_14|Compound:0354-0009|FD-Score:3.73|P-value:8.22E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:8.05|P-value:3.97E-12 ID:SGTC_24|Compound:0417-1663|FD-Score:5.94|P-value:2.35E-7 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:4.73|P-value:3.13E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:4.93|P-value:1.48E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:8.10|P-value:2.97E-12 ID:SGTC_51|Compound:1013-0126|FD-Score:6.64|P-value:8.86E-9 ID:SGTC_68|Compound:0986-0284|FD-Score:6.98|P-value:1.53E-9 ID:SGTC_79|Compound:0052-0007|FD-Score:10.20|P-value:2.70E-18 ID:SGTC_152|Compound:4469-0003|FD-Score:5.65|P-value:8.43E-7 ID:SGTC_167|Compound:3672-0051|FD-Score:8.49|P-value:2.65E-13 ID:SGTC_176|Compound:1486-1328|FD-Score:8.94|P-value:1.45E-14 ID:SGTC_180|Compound:1486-1293|FD-Score:15.90|P-value:2.43E-42 ID:SGTC_194|Compound:1486-1323|FD-Score:3.70|P-value:8.91E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:3.68|P-value:9.36E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:4.52|P-value:6.63E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-4.91|P-value:1.16E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:3.81|P-value:6.55E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:-5.85|P-value:2.38E-7 ID:SGTC_278|Compound:4092-0821|FD-Score:7.53|P-value:7.80E-11 ID:SGTC_285|Compound:1486-1325|FD-Score:5.29|P-value:3.72E-6 ID:SGTC_308|Compound:4092-1169|FD-Score:4.33|P-value:1.23E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:4.55|P-value:5.93E-5 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.91|P-value:4.81E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:6.09|P-value:1.19E-7 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:7.82|P-value:1.57E-11 ID:SGTC_412|Compound:gemfibrozil|FD-Score:4.03|P-value:3.28E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:6.05|P-value:1.45E-7 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.23|P-value:1.73E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:4.57|P-value:5.43E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:10.30|P-value:7.53E-19 ID:SGTC_523|Compound:1934-0222|FD-Score:5.43|P-value:2.10E-6 ID:SGTC_526|Compound:4469-0568|FD-Score:7.06|P-value:1.04E-9 ID:SGTC_541|Compound:4513-1321|FD-Score:4.01|P-value:3.54E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:11.10|P-value:2.02E-21 ID:SGTC_568|Compound:1193-0097|FD-Score:4.39|P-value:1.04E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:5.42|P-value:2.14E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:8.19|P-value:1.66E-12 ID:SGTC_583|Compound:1488-1091|FD-Score:6.07|P-value:1.29E-7 ID:SGTC_585|Compound:0kpi-0023|FD-Score:8.98|P-value:1.16E-14 ID:SGTC_596|Compound:1155-0152|FD-Score:6.47|P-value:2.03E-8 ID:SGTC_601|Compound:0986-0029|FD-Score:9.13|P-value:4.11E-15 ID:SGTC_609|Compound:0986-0026|FD-Score:6.96|P-value:1.72E-9 ID:SGTC_636|Compound:0kpi-0074|FD-Score:4.41|P-value:9.58E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:4.82|P-value:2.28E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:6.34|P-value:3.66E-8 ID:SGTC_651|Compound:3253-0966|FD-Score:11.10|P-value:2.13E-21 ID:SGTC_657|Compound:3534-0529|FD-Score:4.59|P-value:5.20E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:7.64|P-value:4.25E-11 ID:SGTC_661|Compound:1304-0007|FD-Score:4.09|P-value:2.70E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:6.73|P-value:5.57E-9 ID:SGTC_668|Compound:1682-0499|FD-Score:5.55|P-value:1.25E-6 ID:SGTC_677|Compound:0929-0063|FD-Score:6.19|P-value:7.73E-8 ID:SGTC_689|Compound:0833-0039|FD-Score:4.00|P-value:3.64E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:4.88|P-value:1.81E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:4.39|P-value:1.01E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:8.70|P-value:6.96E-14 ID:SGTC_748|Compound:0136-0228|FD-Score:8.30|P-value:8.71E-13 ID:SGTC_762|Compound:1165-0429|FD-Score:4.63|P-value:4.53E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:11.50|P-value:7.68E-23 ID:SGTC_768|Compound:0384-0033|FD-Score:19.90|P-value:6.72E-65 ID:SGTC_779|Compound:1360-0071|FD-Score:3.71|P-value:8.65E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:5.41|P-value:2.27E-6 ID:SGTC_813|Compound:k007-0158|FD-Score:3.70|P-value:9.05E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:8.95|P-value:1.35E-14 ID:SGTC_823|Compound:0417-1665|FD-Score:7.14|P-value:6.79E-10 ID:SGTC_834|Compound:0312-0008|FD-Score:8.23|P-value:1.35E-12 ID:SGTC_849|Compound:0386-0493|FD-Score:-4.22|P-value:1.37E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:4.35|P-value:1.18E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:4.36|P-value:1.14E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:4.70|P-value:3.47E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:4.85|P-value:2.03E-5 ID:SGTC_892|Compound:0929-0076|FD-Score:6.95|P-value:1.79E-9 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:6.85|P-value:2.96E-9 ID:SGTC_1005|Compound:4092-0690|FD-Score:13.20|P-value:1.30E-29 ID:SGTC_1011|Compound:4112-3381|FD-Score:6.90|P-value:2.35E-9 ID:SGTC_1019|Compound:4262-0212|FD-Score:8.40|P-value:4.78E-13 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.13|P-value:2.41E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.76|P-value:7.54E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:4.45|P-value:8.37E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:5.11|P-value:7.62E-6 ID:SGTC_1072|Compound:oxiconazole|FD-Score:6.11|P-value:1.12E-7 ID:SGTC_1076|Compound:itraconazole|FD-Score:5.92|P-value:2.63E-7 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.73|P-value:6.34E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:7.07|P-value:9.71E-10 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.99|P-value:3.75E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.37|P-value:1.08E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.93|P-value:4.47E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:8.21|P-value:1.50E-12 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.83|P-value:3.41E-9 ID:SGTC_1219|Compound:1469-0211|FD-Score:8.24|P-value:1.25E-12 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.77|P-value:7.20E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:7.39|P-value:1.78E-10 ID:SGTC_1304|Compound:1165-0502|FD-Score:4.56|P-value:5.62E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:5.99|P-value:1.88E-7 ID:SGTC_1335|Compound:1486-0900|FD-Score:5.16|P-value:6.20E-6 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.54|P-value:6.06E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.96|P-value:4.07E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.79|P-value:6.94E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:9.22|P-value:2.19E-15 ID:SGTC_1455|Compound:4262-0120|FD-Score:5.09|P-value:8.02E-6 ID:SGTC_1482|Compound:3346-2049|FD-Score:8.26|P-value:1.08E-12 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.92|P-value:4.61E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:5.32|P-value:3.21E-6 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:13.40|P-value:1.45E-30 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:16.20|P-value:1.54E-43 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:16.60|P-value:1.07E-45 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:5.18|P-value:5.65E-6 ID:SGTC_1600|Compound:coumarin 106|FD-Score:5.51|P-value:1.53E-6 ID:SGTC_1617|Compound:st002906|FD-Score:7.40|P-value:1.61E-10 ID:SGTC_1636|Compound:st007707|FD-Score:10.30|P-value:8.54E-19 ID:SGTC_1638|Compound:st008370|FD-Score:4.06|P-value:3.02E-4 ID:SGTC_1649|Compound:st011737|FD-Score:10.20|P-value:2.18E-18 ID:SGTC_1658|Compound:st012944|FD-Score:7.00|P-value:1.41E-9 ID:SGTC_1673|Compound:st016611|FD-Score:8.34|P-value:6.79E-13 ID:SGTC_1715|Compound:st032160|FD-Score:11.70|P-value:1.30E-23 ID:SGTC_1740|Compound:st038286|FD-Score:3.76|P-value:7.44E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.68|P-value:7.27E-4 ID:SGTC_1750|Compound:st081859|FD-Score:10.30|P-value:7.91E-19 ID:SGTC_1757|Compound:st041620|FD-Score:5.42|P-value:2.16E-6 ID:SGTC_1797|Compound:st048695|FD-Score:11.70|P-value:8.49E-24 ID:SGTC_1818|Compound:st052136|FD-Score:-4.31|P-value:1.01E-4 ID:SGTC_1881|Compound:5652484|FD-Score:8.21|P-value:1.50E-12 ID:SGTC_1882|Compound:5615643|FD-Score:8.09|P-value:3.04E-12 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:10.60|P-value:9.97E-20 ID:SGTC_1909|Compound:st060837|FD-Score:3.99|P-value:3.69E-4 ID:SGTC_1937|Compound:st074714|FD-Score:4.97|P-value:1.30E-5 ID:SGTC_1999|Compound:st074831|FD-Score:7.16|P-value:6.10E-10 ID:SGTC_2015|Compound:5119600|FD-Score:11.10|P-value:2.31E-21 ID:SGTC_2021|Compound:4019055|FD-Score:3.83|P-value:5.99E-4 ID:SGTC_2024|Compound:5144227|FD-Score:27.50|P-value:5.59E-122 ID:SGTC_2036|Compound:5160441|FD-Score:4.31|P-value:1.32E-4 ID:SGTC_2038|Compound:4100038|FD-Score:10.10|P-value:3.30E-18 ID:SGTC_2049|Compound:5262831|FD-Score:3.76|P-value:7.54E-4 ID:SGTC_2050|Compound:5263056|FD-Score:7.17|P-value:5.82E-10 ID:SGTC_2056|Compound:5235370|FD-Score:5.08|P-value:8.33E-6 ID:SGTC_2093|Compound:5331342|FD-Score:8.85|P-value:2.69E-14 ID:SGTC_2118|Compound:5526350|FD-Score:7.62|P-value:4.81E-11 ID:SGTC_2126|Compound:5251174|FD-Score:4.58|P-value:5.38E-5 ID:SGTC_2128|Compound:5255449|FD-Score:-5.26|P-value:2.94E-6 ID:SGTC_2136|Compound:5328288|FD-Score:-3.62|P-value:8.61E-4 ID:SGTC_2137|Compound:5261020|FD-Score:4.63|P-value:4.43E-5 ID:SGTC_2175|Compound:5807670|FD-Score:4.16|P-value:2.17E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:9.81|P-value:3.48E-17 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.25|P-value:5.83E-8 ID:SGTC_2286|Compound:7945697|FD-Score:11.70|P-value:1.50E-23 ID:SGTC_2288|Compound:7946289|FD-Score:9.59|P-value:1.71E-16 ID:SGTC_2301|Compound:7769476|FD-Score:5.65|P-value:8.31E-7 ID:SGTC_2376|Compound:9072922|FD-Score:3.94|P-value:4.42E-4 ID:SGTC_2384|Compound:9036245|FD-Score:18.70|P-value:1.19E-57 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.00|P-value:3.58E-4 ID:SGTC_2428|Compound:5615643|FD-Score:11.70|P-value:9.04E-24 ID:SGTC_2437|Compound:5741531|FD-Score:9.59|P-value:1.78E-16 ID:SGTC_2445|Compound:5742597|FD-Score:11.20|P-value:9.01E-22 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:5.94|P-value:2.34E-7 ID:SGTC_2472|Compound:5377652|FD-Score:8.91|P-value:1.83E-14 ID:SGTC_2478|Compound:5763493|FD-Score:11.10|P-value:2.10E-21 ID:SGTC_2486|Compound:5283202|FD-Score:8.86|P-value:2.42E-14 ID:SGTC_2488|Compound:5268135|FD-Score:12.90|P-value:2.36E-28 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:7.27|P-value:3.40E-10 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:5.92|P-value:2.56E-7 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:18.60|P-value:7.03E-57 ID:SGTC_2551|Compound:apiole|FD-Score:4.33|P-value:1.24E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:4.73|P-value:3.12E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:8.87|P-value:2.30E-14 ID:SGTC_2618|Compound:avocadyne|FD-Score:6.06|P-value:1.35E-7 ID:SGTC_2620|Compound:irigenin|FD-Score:3.83|P-value:6.17E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:7.90|P-value:9.78E-12 ID:SGTC_2650|Compound:prasterone|FD-Score:12.50|P-value:9.47E-27 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.68|P-value:3.75E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.79|P-value:6.77E-4 ID:SGTC_2669|Compound:eugenol|FD-Score:4.90|P-value:1.64E-5 ID:SGTC_2678|Compound:equilin|FD-Score:5.22|P-value:4.93E-6 ID:SGTC_2684|Compound:capsaicin|FD-Score:4.49|P-value:7.23E-5 ID:SGTC_2696|Compound:st077691|FD-Score:4.24|P-value:1.66E-4 ID:SGTC_2699|Compound:st077704|FD-Score:7.22|P-value:4.41E-10 ID:SGTC_2717|Compound:st081029|FD-Score:4.20|P-value:1.92E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:12.10|P-value:2.28E-25 ID:SGTC_2733|Compound:amorolfine|FD-Score:4.00|P-value:3.63E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.86|P-value:1.95E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:12.40|P-value:2.26E-26 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.44|P-value:8.60E-5 ID:SGTC_2789|Compound:5281112|FD-Score:6.23|P-value:6.20E-8 ID:SGTC_2802|Compound:7925815|FD-Score:5.13|P-value:6.84E-6 ID:SGTC_2816|Compound:7982706|FD-Score:5.80|P-value:4.29E-7 ID:SGTC_2910|Compound:7948405|FD-Score:4.24|P-value:1.66E-4 ID:SGTC_2948|Compound:9070189|FD-Score:13.70|P-value:1.53E-31 ID:SGTC_3083|Compound:9117465|FD-Score:5.74|P-value:5.55E-7 ID:SGTC_3200|Compound:9114385|FD-Score:-4.37|P-value:8.26E-5 ID:SGTC_3236|Compound:9132701|FD-Score:4.28|P-value:1.47E-4 ID:SGTC_3308|Compound:9128332|FD-Score:9.27|P-value:1.56E-15 ID:SGTC_3319|Compound:9138450|FD-Score:4.39|P-value:1.03E-4 ID:SGTC_3337|Compound:9144342|FD-Score:6.37|P-value:3.26E-8

Top fitness defect scores for YKR026C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2024 5144227 27.50 134.0 µM 5.59E-122 1 9.02E-167
2 SGTC_768 0384-0033 19.90 77.3 µM 6.72E-65 fatty acid desaturase (OLE1) 4 1.75E-88
3 SGTC_2384 9036245 18.70 200.0 µM 1.19E-57 2 1.54E-78
4 SGTC_2540 epiandrosterone 18.60 100.0 µM 7.03E-57 2 1.76E-77
5 SGTC_1597 7-benzyloxygramine 16.60 47.5 µM 1.07E-45 calcium & mitochondrial duress 7 3.85E-62
6 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 16.20 54.9 µM 1.54E-43 redox potentiating 4 3.49E-59
7 SGTC_180 1486-1293 15.90 102.8 µM 2.43E-42 6 1.54E-57
8 SGTC_2948 9070189 13.70 9.4 µM 1.53E-31 plasma membrane duress 4 1.00E-42
9 SGTC_1572 epiandrosterone 13.40 68.9 µM 1.45E-30 3 2.20E-41
10 SGTC_1005 4092-0690 13.20 4.4 µM 1.30E-29 plasma membrane duress 4 4.43E-40
11 SGTC_2488 5268135 12.90 45.7 µM 2.36E-28 6 2.36E-38
12 SGTC_2650 prasterone 12.50 100.0 µM 9.47E-27 3 3.73E-36
13 SGTC_2758 dehydroepiandrosterone 12.40 69.3 µM 2.26E-26 10 1.23E-35
14 SGTC_2725 haloperidol 12.10 53.2 µM 2.28E-25 plasma membrane duress 7 2.93E-34
15 SGTC_1797 st048695 11.70 56.8 µM 8.49E-24 NEO1 13 4.18E-32
16 SGTC_2428 5615643 11.70 7.8 µM 9.04E-24 1 4.56E-32
17 SGTC_1715 st032160 11.70 10.2 µM 1.30E-23 3 7.52E-32
18 SGTC_2286 7945697 11.70 125.0 µM 1.50E-23 2 9.16E-32
19 SGTC_767 0929-0023 11.50 86.0 µM 7.68E-23 TRP & mitochondrial translation 2 8.59E-31
20 SGTC_2445 5742597 11.20 35.6 µM 9.01E-22 2 2.51E-29

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.642 0 YEL009C GCN4 hom Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
0.638 0 YGL026C TRP5 hom Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis
0.634 0 YDR283C GCN2 hom Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control
0.609 0 YDR007W TRP1 hom Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
0.587 7.93E-309 YDR008C_d YDR008C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.556 8.11E-271 YDR354W TRP4 hom Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
0.554 1.75E-268 YFR009W GCN20 hom Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
0.530 2.32E-241 YDR127W ARO1 hom Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
0.501 2.32E-212 YGL117W_p YGL117W_p hom Putative protein of unknown function
0.491 2.54E-202 YKL211C TRP3 hom Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.486 5.31E-198 YDR035W ARO3 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan
0.448 3.20E-164 YER090W TRP2 hom Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
0.362 2.10E-104 YGL148W ARO2 hom Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress
0.224 2.63E-39 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.219 1.01E-37 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication