YKR071C / DRE2

Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKR071C / DRE2

Click on Significant Values for Screen Details ID:SGTC_84|Compound:0443-0269|FD-Score:-4.62|P-value:3.35E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:4.21|P-value:1.57E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:-4.88|P-value:1.24E-5 ID:SGTC_468|Compound:gf-109203x|FD-Score:-3.68|P-value:7.37E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.72|P-value:7.34E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.80|P-value:1.95E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:3.66|P-value:8.72E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.73|P-value:6.30E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.63|P-value:9.64E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:-4.22|P-value:1.35E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.89|P-value:4.32E-4 ID:SGTC_2018|Compound:5133068|FD-Score:7.34|P-value:1.54E-10 ID:SGTC_2024|Compound:5144227|FD-Score:-5.01|P-value:7.45E-6 ID:SGTC_2143|Compound:5623677|FD-Score:-3.91|P-value:3.66E-4 ID:SGTC_2178|Compound:5812956|FD-Score:3.92|P-value:3.95E-4 ID:SGTC_2291|Compound:7917025|FD-Score:4.00|P-value:3.13E-4 ID:SGTC_2324|Compound:6149169|FD-Score:-4.02|P-value:2.53E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.96|P-value:3.52E-4 ID:SGTC_2439|Compound:5492030|FD-Score:-5.08|P-value:5.83E-6 ID:SGTC_2440|Compound:5628896|FD-Score:5.01|P-value:8.74E-6 ID:SGTC_2850|Compound:9015429|FD-Score:-4.28|P-value:1.08E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.72|P-value:6.43E-4 ID:SGTC_2929|Compound:9013348|FD-Score:5.78|P-value:3.57E-7 ID:SGTC_2940|Compound:9060638|FD-Score:4.86|P-value:1.54E-5 ID:SGTC_3096|Compound:9117468|FD-Score:-3.97|P-value:3.04E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-4.36|P-value:8.39E-5 ID:SGTC_3226|Compound:9131256|FD-Score:-4.23|P-value:1.27E-4 ID:SGTC_3230|Compound:9131665|FD-Score:-3.81|P-value:4.95E-4 ID:SGTC_3253|Compound:9135987|FD-Score:-3.77|P-value:5.61E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-3.75|P-value:5.90E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.47|P-value:6.54E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:-4.62|P-value:3.35E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:4.21|P-value:1.57E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:-4.88|P-value:1.24E-5 ID:SGTC_468|Compound:gf-109203x|FD-Score:-3.68|P-value:7.37E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.72|P-value:7.34E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.80|P-value:1.95E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:3.66|P-value:8.72E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.73|P-value:6.30E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.63|P-value:9.64E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:-4.22|P-value:1.35E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.89|P-value:4.32E-4 ID:SGTC_2018|Compound:5133068|FD-Score:7.34|P-value:1.54E-10 ID:SGTC_2024|Compound:5144227|FD-Score:-5.01|P-value:7.45E-6 ID:SGTC_2143|Compound:5623677|FD-Score:-3.91|P-value:3.66E-4 ID:SGTC_2178|Compound:5812956|FD-Score:3.92|P-value:3.95E-4 ID:SGTC_2291|Compound:7917025|FD-Score:4.00|P-value:3.13E-4 ID:SGTC_2324|Compound:6149169|FD-Score:-4.02|P-value:2.53E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.96|P-value:3.52E-4 ID:SGTC_2439|Compound:5492030|FD-Score:-5.08|P-value:5.83E-6 ID:SGTC_2440|Compound:5628896|FD-Score:5.01|P-value:8.74E-6 ID:SGTC_2850|Compound:9015429|FD-Score:-4.28|P-value:1.08E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.72|P-value:6.43E-4 ID:SGTC_2929|Compound:9013348|FD-Score:5.78|P-value:3.57E-7 ID:SGTC_2940|Compound:9060638|FD-Score:4.86|P-value:1.54E-5 ID:SGTC_3096|Compound:9117468|FD-Score:-3.97|P-value:3.04E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-4.36|P-value:8.39E-5 ID:SGTC_3226|Compound:9131256|FD-Score:-4.23|P-value:1.27E-4 ID:SGTC_3230|Compound:9131665|FD-Score:-3.81|P-value:4.95E-4 ID:SGTC_3253|Compound:9135987|FD-Score:-3.77|P-value:5.61E-4 ID:SGTC_3254|Compound:9136651|FD-Score:-3.75|P-value:5.90E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.47|P-value:6.54E-5

Top fitness defect scores for YKR071C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2018 5133068 7.34 143.0 µM 1.54E-10 1 1.08E-13 0.95
2 SGTC_2929 9013348 5.78 24.6 µM 3.57E-7 1 3.66E-9 1.14
3 SGTC_2440 5628896 5.01 157.8 µM 8.74E-6 4 2.68E-7 0.92
4 SGTC_2940 9060638 4.86 45.9 µM 1.54E-5 amide catabolism 3 5.74E-7 0.21
5 SGTC_528 3492-0019 4.80 172.0 µM 1.95E-5 calcium & mitochondrial duress 14 7.86E-7 0.16
6 SGTC_3293 9120939 4.47 62.0 µM 6.54E-5 7 3.97E-6 0.25
7 SGTC_165 k038-0023 4.21 64.4 µM 1.57E-4 ubiquinone biosynthesis & proteasome 22 1.28E-5 0.34
8 SGTC_2291 7917025 4.00 104.3 µM 3.13E-4 iron homeostasis 11 3.23E-5 0.13
9 SGTC_2438 5259590 3.96 200.0 µM 3.52E-4 4 3.77E-5 0.34
10 SGTC_2178 5812956 3.92 200.0 µM 3.95E-4 5 4.39E-5 0.43
11 SGTC_1819 st053448 3.89 58.6 µM 4.32E-4 amide catabolism 1 4.95E-5 0.23
12 SGTC_475 α-linolenic acid 3.72 10.0 µM 7.34E-4 excess fatty acid 7 1.00E-4 0.02
13 SGTC_799 1310-0557 3.66 151.0 µM 8.72E-4 superoxide 7 1.26E-4 0.18
14 SGTC_1170 0310-0127 3.63 64.8 µM 9.64E-4 12 1.44E-4 0.10
15 SGTC_583 1488-1091 3.60 88.9 µM 0.00105 7 1.61E-4 0.06
16 SGTC_999 4022-0066 3.59 22.7 µM 0.00106 Golgi 18 1.64E-4 0.06
17 SGTC_3085 9117376 3.52 49.5 µM 0.00132 12 2.19E-4 0.24
18 SGTC_1179 1021-1431 3.46 9.3 µM 0.00155 9 2.72E-4 0.04
19 SGTC_2016 5121758 3.40 140.0 µM 0.00181 redox potentiating 28 3.34E-4 0.10
20 SGTC_1159 4092-0538 3.32 61.2 µM 0.00228 14 4.55E-4 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.67E-15 YDR244W PEX5 hom Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions
0.134 7.00E-15 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.106 7.95E-10 YMR026C PEX12 hom C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder
0.104 1.32E-9 YBL028C YBL028C hom Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.096 2.19E-8 YLR328W NMA1 hom Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication
0.095 3.17E-8 YOL014W_p YOL014W_p hom Putative protein of unknown function
0.095 3.38E-8 YLR144C ACF2 hom Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress
0.095 3.70E-8 YDR266C HEL2 hom RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor
0.093 6.73E-8 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.091 1.32E-7 YOR176W HEM15 het Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
0.090 2.04E-7 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.089 2.42E-7 YJR061W_p YJR061W_p hom Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication
0.088 3.39E-7 YDL045C FAD1 het Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
0.085 7.53E-7 YIL166C_p YIL166C_p hom Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
0.085 9.14E-7 YPR073C LTP1 hom Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine