YKR095W / MLP1

Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR095W / MLP1

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:3.38|P-value:1.73E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.81|P-value:2.71E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-2.94|P-value:8.00E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.68|P-value:4.99E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:6.74|P-value:4.20E-13 ID:SGTC_162|Compound:k030-0015|FD-Score:4.21|P-value:4.08E-6 ID:SGTC_164|Compound:4100-3994|FD-Score:3.11|P-value:4.98E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.14|P-value:3.85E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.98|P-value:1.29E-5 ID:SGTC_262|Compound:fenpropimorph|FD-Score:-3.00|P-value:6.54E-4 ID:SGTC_508|Compound:roscovitine|FD-Score:3.01|P-value:7.47E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:5.12|P-value:2.86E-8 ID:SGTC_609|Compound:0986-0026|FD-Score:-3.16|P-value:3.48E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.91|P-value:1.41E-5 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.30|P-value:2.05E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-3.19|P-value:3.16E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:2.96|P-value:8.95E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.32|P-value:2.21E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:3.44|P-value:1.36E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.85|P-value:1.88E-5 ID:SGTC_935|Compound:2996-0153|FD-Score:3.28|P-value:2.58E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.56|P-value:5.50E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:2.95|P-value:9.29E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-3.12|P-value:4.15E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:4.17|P-value:5.04E-6 ID:SGTC_1471|Compound:k673-0312|FD-Score:-3.25|P-value:2.50E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-2.96|P-value:7.59E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.64|P-value:6.00E-5 ID:SGTC_1712|Compound:st032288|FD-Score:5.09|P-value:3.51E-8 ID:SGTC_1718|Compound:roemerine|FD-Score:3.10|P-value:5.19E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.66|P-value:4.44E-5 ID:SGTC_1754|Compound:st042065|FD-Score:3.76|P-value:3.54E-5 ID:SGTC_1800|Compound:st050079|FD-Score:5.04|P-value:4.74E-8 ID:SGTC_1801|Compound:st050089|FD-Score:4.91|P-value:9.93E-8 ID:SGTC_1818|Compound:st052136|FD-Score:4.11|P-value:6.76E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.30|P-value:2.64E-6 ID:SGTC_2021|Compound:4019055|FD-Score:4.72|P-value:2.86E-7 ID:SGTC_2050|Compound:5263056|FD-Score:3.17|P-value:4.07E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.10|P-value:5.29E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-2.98|P-value:6.89E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.02|P-value:7.20E-4 ID:SGTC_2442|Compound:5158906|FD-Score:4.16|P-value:5.37E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.03|P-value:4.21E-14 ID:SGTC_2688|Compound:kanamycin b|FD-Score:2.93|P-value:9.95E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.01|P-value:7.40E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.12|P-value:4.79E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.48|P-value:1.17E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.17|P-value:4.11E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.39|P-value:1.41E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.82|P-value:2.68E-5 ID:SGTC_3037|Compound:9091026|FD-Score:5.24|P-value:1.41E-8 ID:SGTC_37|Compound:0566-0070|FD-Score:3.38|P-value:1.73E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.81|P-value:2.71E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-2.94|P-value:8.00E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.68|P-value:4.99E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:6.74|P-value:4.20E-13 ID:SGTC_162|Compound:k030-0015|FD-Score:4.21|P-value:4.08E-6 ID:SGTC_164|Compound:4100-3994|FD-Score:3.11|P-value:4.98E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.14|P-value:3.85E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.98|P-value:1.29E-5 ID:SGTC_262|Compound:fenpropimorph|FD-Score:-3.00|P-value:6.54E-4 ID:SGTC_508|Compound:roscovitine|FD-Score:3.01|P-value:7.47E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:5.12|P-value:2.86E-8 ID:SGTC_609|Compound:0986-0026|FD-Score:-3.16|P-value:3.48E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.91|P-value:1.41E-5 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.30|P-value:2.05E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-3.19|P-value:3.16E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:2.96|P-value:8.95E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.32|P-value:2.21E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:3.44|P-value:1.36E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.85|P-value:1.88E-5 ID:SGTC_935|Compound:2996-0153|FD-Score:3.28|P-value:2.58E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.56|P-value:5.50E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:2.95|P-value:9.29E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-3.12|P-value:4.15E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:4.17|P-value:5.04E-6 ID:SGTC_1471|Compound:k673-0312|FD-Score:-3.25|P-value:2.50E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-2.96|P-value:7.59E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.64|P-value:6.00E-5 ID:SGTC_1712|Compound:st032288|FD-Score:5.09|P-value:3.51E-8 ID:SGTC_1718|Compound:roemerine|FD-Score:3.10|P-value:5.19E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.66|P-value:4.44E-5 ID:SGTC_1754|Compound:st042065|FD-Score:3.76|P-value:3.54E-5 ID:SGTC_1800|Compound:st050079|FD-Score:5.04|P-value:4.74E-8 ID:SGTC_1801|Compound:st050089|FD-Score:4.91|P-value:9.93E-8 ID:SGTC_1818|Compound:st052136|FD-Score:4.11|P-value:6.76E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.30|P-value:2.64E-6 ID:SGTC_2021|Compound:4019055|FD-Score:4.72|P-value:2.86E-7 ID:SGTC_2050|Compound:5263056|FD-Score:3.17|P-value:4.07E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.10|P-value:5.29E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-2.98|P-value:6.89E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.02|P-value:7.20E-4 ID:SGTC_2442|Compound:5158906|FD-Score:4.16|P-value:5.37E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.03|P-value:4.21E-14 ID:SGTC_2688|Compound:kanamycin b|FD-Score:2.93|P-value:9.95E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.01|P-value:7.40E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.12|P-value:4.79E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.48|P-value:1.17E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.17|P-value:4.11E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.39|P-value:1.41E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.82|P-value:2.68E-5 ID:SGTC_3037|Compound:9091026|FD-Score:5.24|P-value:1.41E-8

Top fitness defect scores for YKR095W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2679 rapamycin 7.03 1.0 nM 4.21E-14 58 1.00E-12
2 SGTC_146 3448-8650 6.74 53.1 µM 4.20E-13 NEO1-PIK1 43 7.71E-12
3 SGTC_3037 9091026 5.24 49.5 µM 1.41E-8 NEO1-PIK1 64 8.08E-8
4 SGTC_528 3492-0019 5.12 172.0 µM 2.86E-8 calcium & mitochondrial duress 151 1.52E-7
5 SGTC_1712 st032288 5.09 53.4 µM 3.51E-8 calcium & mitochondrial duress 113 1.82E-7
6 SGTC_1800 st050079 5.04 29.1 µM 4.74E-8 NEO1-PIK1 73 2.38E-7
7 SGTC_1801 st050089 4.91 28.4 µM 9.93E-8 NEO1-PIK1 77 4.60E-7
8 SGTC_2021 4019055 4.72 173.0 µM 2.86E-7 endomembrane recycling 75 1.18E-6
9 SGTC_1844 rapamycin 4.30 4.0 nM 2.64E-6 138 8.53E-6
10 SGTC_162 k030-0015 4.21 37.8 µM 4.08E-6 iron homeostasis 20 1.26E-5
11 SGTC_1386 3228-0095 4.17 33.8 µM 5.04E-6 17 1.52E-5
12 SGTC_2442 5158906 4.16 48.5 µM 5.37E-6 15 1.61E-5
13 SGTC_1818 st052136 4.11 56.3 µM 6.76E-6 NEO1-PIK1 44 1.97E-5
14 SGTC_221 trifluoperazine 3.98 10.3 µM 1.29E-5 NEO1-PIK1 208 3.52E-5
15 SGTC_2974 9094440 3.82 9.7 µM 2.68E-5 ergosterol biosynthesis 50 6.75E-5
16 SGTC_43 0570-0105 3.81 72.5 µM 2.71E-5 ERG2 105 6.83E-5
17 SGTC_1754 st042065 3.76 16.1 µM 3.54E-5 NEO1-PIK1 196 8.66E-5
18 SGTC_103 0844-0104 3.68 51.8 µM 4.99E-5 ERAD & cell cycle 157 1.18E-4
19 SGTC_1525 8-methoxypsoralen 3.64 92.5 µM 6.00E-5 DNA damage response 40 1.39E-4
20 SGTC_2839 9003951 3.48 26.0 µM 1.17E-4 21 2.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.326 4.87E-84 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.311 1.98E-76 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.311 5.62E-76 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.308 9.17E-75 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.305 3.08E-73 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.295 3.50E-68 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.291 1.49E-66 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.281 3.58E-62 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.279 8.15E-61 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.271 1.45E-57 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.261 3.57E-53 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.259 1.78E-52 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.256 3.60E-51 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.254 1.32E-50 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.248 2.36E-48 YNL288W CAF40 hom Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p