YLL002W / RTT109

Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL002W / RTT109

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:3.61|P-value:2.39E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:4.26|P-value:1.92E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.58|P-value:2.65E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:5.13|P-value:3.57E-7 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.88|P-value:8.67E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:3.39|P-value:5.16E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.34|P-value:6.31E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:-3.50|P-value:3.66E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.20|P-value:9.65E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:4.09|P-value:3.78E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:3.27|P-value:7.68E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:3.66|P-value:2.00E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.30|P-value:7.09E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.24|P-value:8.67E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.38|P-value:5.30E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.15|P-value:2.99E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.83|P-value:1.05E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.12|P-value:3.31E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.50|P-value:3.48E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.58|P-value:2.65E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.53|P-value:5.92E-6 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.08|P-value:3.89E-5 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.29|P-value:7.20E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.42|P-value:4.68E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-3.46|P-value:4.24E-4 ID:SGTC_1665|Compound:st014639|FD-Score:4.88|P-value:1.15E-6 ID:SGTC_1673|Compound:st016611|FD-Score:3.28|P-value:7.57E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.31|P-value:6.73E-4 ID:SGTC_1707|Compound:st032323|FD-Score:4.95|P-value:8.60E-7 ID:SGTC_1942|Compound:st076330|FD-Score:5.52|P-value:4.67E-8 ID:SGTC_2146|Compound:5545642|FD-Score:3.61|P-value:2.40E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.28|P-value:7.47E-4 ID:SGTC_2180|Compound:6301957|FD-Score:-4.37|P-value:1.23E-5 ID:SGTC_2240|Compound:6690706|FD-Score:3.44|P-value:4.40E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-3.47|P-value:4.13E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.93|P-value:7.56E-5 ID:SGTC_2350|Compound:9023895|FD-Score:7.48|P-value:2.37E-13 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-3.35|P-value:6.17E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.42|P-value:4.85E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.59|P-value:2.60E-4 ID:SGTC_2469|Compound:5655019|FD-Score:-3.27|P-value:8.11E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.76|P-value:1.38E-4 ID:SGTC_2472|Compound:5377652|FD-Score:-3.43|P-value:4.72E-4 ID:SGTC_2487|Compound:5918373|FD-Score:4.15|P-value:2.97E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.48|P-value:3.82E-4 ID:SGTC_2671|Compound:danthron|FD-Score:3.73|P-value:1.55E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.83|P-value:1.12E-4 ID:SGTC_2955|Compound:9076254|FD-Score:4.53|P-value:5.76E-6 ID:SGTC_2957|Compound:9076800|FD-Score:6.50|P-value:1.67E-10 ID:SGTC_3124|Compound:9127567|FD-Score:3.50|P-value:3.55E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.26|P-value:7.93E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.29|P-value:7.44E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.61|P-value:2.39E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:4.26|P-value:1.92E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.58|P-value:2.65E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:5.13|P-value:3.57E-7 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.88|P-value:8.67E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:3.39|P-value:5.16E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.34|P-value:6.31E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:-3.50|P-value:3.66E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.20|P-value:9.65E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:4.09|P-value:3.78E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:3.27|P-value:7.68E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:3.66|P-value:2.00E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.30|P-value:7.09E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.24|P-value:8.67E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.38|P-value:5.30E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.15|P-value:2.99E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.83|P-value:1.05E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.12|P-value:3.31E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.50|P-value:3.48E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.58|P-value:2.65E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.53|P-value:5.92E-6 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.08|P-value:3.89E-5 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.29|P-value:7.20E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.42|P-value:4.68E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-3.46|P-value:4.24E-4 ID:SGTC_1665|Compound:st014639|FD-Score:4.88|P-value:1.15E-6 ID:SGTC_1673|Compound:st016611|FD-Score:3.28|P-value:7.57E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.31|P-value:6.73E-4 ID:SGTC_1707|Compound:st032323|FD-Score:4.95|P-value:8.60E-7 ID:SGTC_1942|Compound:st076330|FD-Score:5.52|P-value:4.67E-8 ID:SGTC_2146|Compound:5545642|FD-Score:3.61|P-value:2.40E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.28|P-value:7.47E-4 ID:SGTC_2180|Compound:6301957|FD-Score:-4.37|P-value:1.23E-5 ID:SGTC_2240|Compound:6690706|FD-Score:3.44|P-value:4.40E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-3.47|P-value:4.13E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.93|P-value:7.56E-5 ID:SGTC_2350|Compound:9023895|FD-Score:7.48|P-value:2.37E-13 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-3.35|P-value:6.17E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.42|P-value:4.85E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.59|P-value:2.60E-4 ID:SGTC_2469|Compound:5655019|FD-Score:-3.27|P-value:8.11E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.76|P-value:1.38E-4 ID:SGTC_2472|Compound:5377652|FD-Score:-3.43|P-value:4.72E-4 ID:SGTC_2487|Compound:5918373|FD-Score:4.15|P-value:2.97E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.48|P-value:3.82E-4 ID:SGTC_2671|Compound:danthron|FD-Score:3.73|P-value:1.55E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.83|P-value:1.12E-4 ID:SGTC_2955|Compound:9076254|FD-Score:4.53|P-value:5.76E-6 ID:SGTC_2957|Compound:9076800|FD-Score:6.50|P-value:1.67E-10 ID:SGTC_3124|Compound:9127567|FD-Score:3.50|P-value:3.55E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.26|P-value:7.93E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.29|P-value:7.44E-4

Top fitness defect scores for YLL002W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2350 9023895 7.48 38.9 µM 2.37E-13 ergosterol biosynthesis 5 3.72E-14
2 SGTC_2957 9076800 6.50 11.5 µM 1.67E-10 3 4.12E-11
3 SGTC_1942 st076330 5.52 65.2 µM 4.67E-8 7 1.69E-8
4 SGTC_200 k038-0079 5.13 37.5 µM 3.57E-7 ubiquinone biosynthesis & proteasome 37 1.49E-7
5 SGTC_1707 st032323 4.95 6.3 µM 8.60E-7 DNA damage response 36 3.79E-7
6 SGTC_1665 st014639 4.88 11.4 µM 1.15E-6 NEO1 13 5.19E-7
7 SGTC_2955 9076254 4.53 12.2 µM 5.76E-6 8 2.89E-6
8 SGTC_1374 2889-5571 4.53 141.0 µM 5.92E-6 RSC complex & mRNA processing 22 2.97E-6
9 SGTC_93 0109-0045 4.26 59.2 µM 1.92E-5 DNA damage response 30 1.04E-5
10 SGTC_2487 5918373 4.15 44.0 µM 2.97E-5 11 1.66E-5
11 SGTC_1038 k292-0204 4.15 154.0 µM 2.99E-5 14 1.67E-5
12 SGTC_1137 ixabepilone 4.12 100.0 µM 3.31E-5 19 1.86E-5
13 SGTC_756 0508-1999 4.09 28.3 µM 3.78E-5 RPP1 & pyrimidine depletion 20 2.15E-5
14 SGTC_1409 3909-8004 4.08 61.9 µM 3.89E-5 17 2.22E-5
15 SGTC_219 mitoxanthrone 3.88 164.4 µM 8.67E-5 DNA intercalators 54 5.20E-5
16 SGTC_1107 amlodipine 3.83 47.0 µM 1.05E-4 36 6.36E-5
17 SGTC_2471 5466956 3.76 24.8 µM 1.38E-4 mitochondrial processes 14 8.54E-5
18 SGTC_2671 danthron 3.73 100.0 µM 1.55E-4 DNA damage response 52 9.68E-5
19 SGTC_949 1165-0505 3.66 146.0 µM 2.00E-4 26 1.27E-4
20 SGTC_36 0335-0881 3.61 14.2 µM 2.39E-4 ubiquinone biosynthesis & proteasome 140 1.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 4.41E-13 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.111 1.40E-10 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.110 1.97E-10 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.109 2.17E-10 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.108 3.46E-10 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.101 4.65E-9 YGL240W DOC1 hom Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain
0.096 2.72E-8 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.091 1.23E-7 YJL072C PSF2 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.091 1.41E-7 YNL250W RAD50 hom Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress
0.091 1.40E-7 YJR039W_p YJR039W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.089 2.23E-7 YML110C COQ5 hom 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
0.087 4.13E-7 YJL092W SRS2 hom DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability
0.087 4.26E-7 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.087 5.00E-7 YPL139C UME1 hom Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p
0.086 5.65E-7 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2