YLR134W / PDC5

Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR134W / PDC5

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:-3.41|P-value:1.97E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.22|P-value:4.41E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.28|P-value:3.30E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.25|P-value:3.96E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:9.59|P-value:1.61E-23 ID:SGTC_135|Compound:0933-0004|FD-Score:5.26|P-value:2.61E-8 ID:SGTC_229|Compound:benomyl|FD-Score:4.23|P-value:6.00E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:7.97|P-value:7.66E-17 ID:SGTC_280|Compound:3448-3607|FD-Score:3.70|P-value:6.46E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:5.12|P-value:5.75E-8 ID:SGTC_356|Compound:1634-0012|FD-Score:5.80|P-value:9.69E-10 ID:SGTC_359|Compound:0081-0058|FD-Score:4.20|P-value:6.88E-6 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.12|P-value:6.08E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:5.61|P-value:3.29E-9 ID:SGTC_400|Compound:oxethazaine|FD-Score:-4.44|P-value:2.04E-6 ID:SGTC_420|Compound:mitomycin C|FD-Score:4.33|P-value:3.74E-6 ID:SGTC_543|Compound:3844-1095|FD-Score:4.06|P-value:1.37E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:3.28|P-value:3.52E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.15|P-value:5.59E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.22|P-value:4.40E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-4.62|P-value:8.34E-7 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.44|P-value:1.79E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-6.54|P-value:5.73E-12 ID:SGTC_799|Compound:1310-0557|FD-Score:3.72|P-value:5.92E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.35|P-value:2.56E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.41|P-value:1.99E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:4.64|P-value:8.11E-7 ID:SGTC_923|Compound:1900-2434|FD-Score:3.15|P-value:5.75E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.54|P-value:1.26E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.41|P-value:2.08E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.12|P-value:6.41E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:4.02|P-value:1.63E-5 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.17|P-value:5.21E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.32|P-value:2.96E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.44|P-value:9.25E-9 ID:SGTC_1836|Compound:st055642|FD-Score:-3.37|P-value:2.36E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.62|P-value:9.08E-5 ID:SGTC_2126|Compound:5251174|FD-Score:-3.20|P-value:4.39E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:-3.91|P-value:2.49E-5 ID:SGTC_2182|Compound:6325192|FD-Score:3.82|P-value:3.89E-5 ID:SGTC_2246|Compound:7293507|FD-Score:-3.93|P-value:2.26E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.10|P-value:6.67E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.14|P-value:5.81E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.05|P-value:8.19E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.34|P-value:2.74E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.16|P-value:5.37E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.94|P-value:2.29E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.83|P-value:3.80E-5 ID:SGTC_3043|Compound:9092303|FD-Score:-3.55|P-value:1.14E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-4.09|P-value:1.11E-5 ID:SGTC_3140|Compound:9094243|FD-Score:-3.38|P-value:2.29E-4 ID:SGTC_3235|Compound:9132602|FD-Score:-2.99|P-value:9.65E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.41|P-value:1.97E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.22|P-value:4.41E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.28|P-value:3.30E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.25|P-value:3.96E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:9.59|P-value:1.61E-23 ID:SGTC_135|Compound:0933-0004|FD-Score:5.26|P-value:2.61E-8 ID:SGTC_229|Compound:benomyl|FD-Score:4.23|P-value:6.00E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:7.97|P-value:7.66E-17 ID:SGTC_280|Compound:3448-3607|FD-Score:3.70|P-value:6.46E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:5.12|P-value:5.75E-8 ID:SGTC_356|Compound:1634-0012|FD-Score:5.80|P-value:9.69E-10 ID:SGTC_359|Compound:0081-0058|FD-Score:4.20|P-value:6.88E-6 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.12|P-value:6.08E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:5.61|P-value:3.29E-9 ID:SGTC_400|Compound:oxethazaine|FD-Score:-4.44|P-value:2.04E-6 ID:SGTC_420|Compound:mitomycin C|FD-Score:4.33|P-value:3.74E-6 ID:SGTC_543|Compound:3844-1095|FD-Score:4.06|P-value:1.37E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:3.28|P-value:3.52E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.15|P-value:5.59E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.22|P-value:4.40E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-4.62|P-value:8.34E-7 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.44|P-value:1.79E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-6.54|P-value:5.73E-12 ID:SGTC_799|Compound:1310-0557|FD-Score:3.72|P-value:5.92E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.35|P-value:2.56E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.41|P-value:1.99E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:4.64|P-value:8.11E-7 ID:SGTC_923|Compound:1900-2434|FD-Score:3.15|P-value:5.75E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.54|P-value:1.26E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.41|P-value:2.08E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.12|P-value:6.41E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:4.02|P-value:1.63E-5 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.17|P-value:5.21E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.32|P-value:2.96E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.44|P-value:9.25E-9 ID:SGTC_1836|Compound:st055642|FD-Score:-3.37|P-value:2.36E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.62|P-value:9.08E-5 ID:SGTC_2126|Compound:5251174|FD-Score:-3.20|P-value:4.39E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:-3.91|P-value:2.49E-5 ID:SGTC_2182|Compound:6325192|FD-Score:3.82|P-value:3.89E-5 ID:SGTC_2246|Compound:7293507|FD-Score:-3.93|P-value:2.26E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.10|P-value:6.67E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.14|P-value:5.81E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.05|P-value:8.19E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.34|P-value:2.74E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.16|P-value:5.37E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.94|P-value:2.29E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.83|P-value:3.80E-5 ID:SGTC_3043|Compound:9092303|FD-Score:-3.55|P-value:1.14E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-4.09|P-value:1.11E-5 ID:SGTC_3140|Compound:9094243|FD-Score:-3.38|P-value:2.29E-4 ID:SGTC_3235|Compound:9132602|FD-Score:-2.99|P-value:9.65E-4

Top fitness defect scores for YLR134W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_134 0269-0018 9.59 6.9 µM 1.61E-23 42 4.52E-22
2 SGTC_236 1509-0011 7.97 5.3 µM 7.66E-17 252 7.68E-16
3 SGTC_356 1634-0012 5.80 32.5 µM 9.69E-10 4 3.29E-9
4 SGTC_386 1509-0011 5.61 3.1 µM 3.29E-9 96 1.03E-8
5 SGTC_1635 st007035 5.44 42.4 µM 9.25E-9 150 2.71E-8
6 SGTC_135 0933-0004 5.26 26.4 µM 2.61E-8 60S ribosome export 6 7.14E-8
7 SGTC_343 4130-2827 5.12 29.8 µM 5.75E-8 14 1.49E-7
8 SGTC_811 0416-0114 4.64 265.0 µM 8.11E-7 8 1.78E-6
9 SGTC_420 mitomycin C 4.33 81.9 mM 3.74E-6 13 7.43E-6
10 SGTC_229 benomyl 4.23 22.9 µM 6.00E-6 tubulin folding & SWR complex 27 1.16E-5
11 SGTC_359 0081-0058 4.20 15.9 µM 6.88E-6 60S ribosome export 35 1.31E-5
12 SGTC_543 3844-1095 4.06 191.0 µM 1.37E-5 ERG2 48 2.50E-5
13 SGTC_1426 4048-4480 4.02 71.7 µM 1.63E-5 60S ribosome export 14 2.95E-5
14 SGTC_2887 9044784 3.94 58.4 µM 2.29E-5 fatty acid desaturase (OLE1) 27 4.06E-5
15 SGTC_2896 9052656 3.83 71.4 µM 3.80E-5 endomembrane recycling 123 6.51E-5
16 SGTC_2182 6325192 3.82 200.0 µM 3.89E-5 Golgi 17 6.65E-5
17 SGTC_799 1310-0557 3.72 151.0 µM 5.92E-5 superoxide 30 9.86E-5
18 SGTC_280 3448-3607 3.70 3.0 µM 6.46E-5 60S ribosome export 12 1.07E-4
19 SGTC_1908 st060353 3.62 56.5 µM 9.08E-5 RPP1 & pyrimidine depletion 53 1.47E-4
20 SGTC_957 1187-1561 3.54 14.1 µM 1.26E-4 35 2.01E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.414 4.55E-139 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.411 5.93E-137 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.402 1.32E-130 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.390 2.76E-122 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.383 1.16E-117 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.377 1.20E-113 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.376 4.89E-113 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.374 1.14E-111 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.369 1.25E-108 YDL107W MSS2 hom Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
0.368 2.69E-108 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.364 2.64E-105 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.357 1.40E-101 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.356 5.02E-101 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.354 2.01E-99 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.353 4.72E-99 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p