YLR251W / SYM1

Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR251W / SYM1

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:3.62|P-value:6.72E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:5.09|P-value:3.95E-8 ID:SGTC_143|Compound:4032-1194|FD-Score:4.47|P-value:1.18E-6 ID:SGTC_169|Compound:k015-0017|FD-Score:3.09|P-value:5.59E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:2.99|P-value:7.88E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:4.02|P-value:1.11E-5 ID:SGTC_620|Compound:0109-0052|FD-Score:3.02|P-value:7.02E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.07|P-value:5.87E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:-2.94|P-value:9.45E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.85|P-value:2.40E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:3.74|P-value:3.96E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:3.13|P-value:4.68E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:-3.84|P-value:2.46E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:-4.14|P-value:6.22E-6 ID:SGTC_912|Compound:3474-0017|FD-Score:3.79|P-value:3.09E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:3.21|P-value:3.48E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.97|P-value:8.44E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.23|P-value:3.28E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.13|P-value:4.75E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.45|P-value:1.37E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.48|P-value:1.21E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.50|P-value:1.09E-4 ID:SGTC_1621|Compound:st003705|FD-Score:3.95|P-value:1.49E-5 ID:SGTC_1623|Compound:st003709|FD-Score:3.05|P-value:6.37E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.28|P-value:2.65E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.72|P-value:4.28E-5 ID:SGTC_1930|Compound:st074634|FD-Score:-3.02|P-value:7.19E-4 ID:SGTC_2239|Compound:6685329|FD-Score:2.96|P-value:8.75E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.07|P-value:6.01E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.22|P-value:3.36E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.29|P-value:2.97E-6 ID:SGTC_2370|Compound:9071495|FD-Score:-3.57|P-value:8.28E-5 ID:SGTC_2379|Compound:9035213|FD-Score:6.88|P-value:1.89E-13 ID:SGTC_2389|Compound:9091542|FD-Score:3.50|P-value:1.11E-4 ID:SGTC_2426|Compound:5582046|FD-Score:5.25|P-value:1.52E-8 ID:SGTC_2448|Compound:5185112|FD-Score:-3.21|P-value:3.46E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.06|P-value:6.25E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.63|P-value:6.27E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.79|P-value:3.21E-5 ID:SGTC_2804|Compound:7954240|FD-Score:3.77|P-value:3.49E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:3.62|P-value:6.72E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:5.09|P-value:3.95E-8 ID:SGTC_143|Compound:4032-1194|FD-Score:4.47|P-value:1.18E-6 ID:SGTC_169|Compound:k015-0017|FD-Score:3.09|P-value:5.59E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:2.99|P-value:7.88E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:4.02|P-value:1.11E-5 ID:SGTC_620|Compound:0109-0052|FD-Score:3.02|P-value:7.02E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.07|P-value:5.87E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:-2.94|P-value:9.45E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.85|P-value:2.40E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:3.74|P-value:3.96E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:3.13|P-value:4.68E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:-3.84|P-value:2.46E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:-4.14|P-value:6.22E-6 ID:SGTC_912|Compound:3474-0017|FD-Score:3.79|P-value:3.09E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:3.21|P-value:3.48E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.97|P-value:8.44E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.23|P-value:3.28E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.13|P-value:4.75E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.45|P-value:1.37E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.48|P-value:1.21E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.50|P-value:1.09E-4 ID:SGTC_1621|Compound:st003705|FD-Score:3.95|P-value:1.49E-5 ID:SGTC_1623|Compound:st003709|FD-Score:3.05|P-value:6.37E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.28|P-value:2.65E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.72|P-value:4.28E-5 ID:SGTC_1930|Compound:st074634|FD-Score:-3.02|P-value:7.19E-4 ID:SGTC_2239|Compound:6685329|FD-Score:2.96|P-value:8.75E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.07|P-value:6.01E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.22|P-value:3.36E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.29|P-value:2.97E-6 ID:SGTC_2370|Compound:9071495|FD-Score:-3.57|P-value:8.28E-5 ID:SGTC_2379|Compound:9035213|FD-Score:6.88|P-value:1.89E-13 ID:SGTC_2389|Compound:9091542|FD-Score:3.50|P-value:1.11E-4 ID:SGTC_2426|Compound:5582046|FD-Score:5.25|P-value:1.52E-8 ID:SGTC_2448|Compound:5185112|FD-Score:-3.21|P-value:3.46E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.06|P-value:6.25E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.63|P-value:6.27E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.79|P-value:3.21E-5 ID:SGTC_2804|Compound:7954240|FD-Score:3.77|P-value:3.49E-5

Top fitness defect scores for YLR251W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2379 9035213 6.88 200.0 µM 1.89E-13 1 3.01E-12
2 SGTC_2426 5582046 5.25 32.2 µM 1.52E-8 8 7.79E-8
3 SGTC_69 0096-0274 5.09 206.7 µM 3.95E-8 mitochondrial processes 16 1.84E-7
4 SGTC_143 4032-1194 4.47 15.7 µM 1.18E-6 40 3.91E-6
5 SGTC_2331 7980721 4.29 200.0 µM 2.97E-6 20 8.97E-6
6 SGTC_616 4092-0450 4.02 108.0 µM 1.11E-5 14 2.94E-5
7 SGTC_1621 st003705 3.95 32.4 µM 1.49E-5 calcium & mitochondrial duress 25 3.84E-5
8 SGTC_644 1498-1197 3.85 63.3 µM 2.40E-5 24 5.90E-5
9 SGTC_912 3474-0017 3.79 2.2 µM 3.09E-5 27 7.42E-5
10 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 3.79 100.0 µM 3.21E-5 39 7.67E-5
11 SGTC_2804 7954240 3.77 19.5 µM 3.49E-5 40 8.26E-5
12 SGTC_716 1683-5115 3.74 658.0 µM 3.96E-5 26 9.27E-5
13 SGTC_1742 st038235 3.72 28.9 µM 4.28E-5 mitochondrial stress 124 9.95E-5
14 SGTC_2586 curcumin 3.63 80.0 µM 6.27E-5 iron homeostasis 66 1.40E-4
15 SGTC_49 0717-0965 3.62 32.1 µM 6.72E-5 60S ribosome export 30 1.49E-4
16 SGTC_1619 st003326 3.50 88.7 µM 1.09E-4 60S ribosome export 29 2.32E-4
17 SGTC_2389 9091542 3.50 195.5 µM 1.11E-4 iron homeostasis 50 2.35E-4
18 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 3.48 67.5 µM 1.21E-4 65 2.55E-4
19 SGTC_1568 digitonin 3.45 820.0 nM 1.37E-4 sphingolipid biosynthesis & PDR1 48 2.84E-4
20 SGTC_1472 k841-0093 3.23 193.0 µM 3.28E-4 39 6.25E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 5.98E-17 YNL130C-A_p DGR1_p hom Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose
0.129 5.73E-14 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.114 3.08E-11 YJR099W YUH1 hom Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
0.110 1.82E-10 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.100 6.87E-9 YJR123W RPS5 het Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7
0.098 1.50E-8 YOR161C-C_p YOR161C-C_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.096 2.18E-8 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.096 2.68E-8 YDL026W_d YDL026W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.095 3.55E-8 YIR016W_p YIR016W_p hom Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication
0.091 1.46E-7 YHR020W YHR020W het Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments
0.090 2.03E-7 YKL124W SSH4 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
0.090 2.04E-7 YER015W FAA2 hom Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome
0.089 2.24E-7 YCR034W FEN1 hom Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication
0.089 2.50E-7 YNL045W LAP2 hom Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.088 2.90E-7 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes