YLR314C / CDC3

Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR314C / CDC3

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:2.94|P-value:8.91E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:4.15|P-value:5.38E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.07|P-value:1.03E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:-2.99|P-value:9.05E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.96|P-value:1.36E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:3.08|P-value:5.35E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.44|P-value:1.66E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:-3.07|P-value:6.80E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:-3.31|P-value:2.71E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.09|P-value:5.20E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:5.14|P-value:2.61E-8 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.33|P-value:2.09E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.63|P-value:7.38E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.70|P-value:5.64E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-4.54|P-value:1.01E-6 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.71|P-value:4.27E-5 ID:SGTC_1659|Compound:st012954|FD-Score:2.96|P-value:8.24E-4 ID:SGTC_1998|Compound:st075797|FD-Score:-3.81|P-value:3.40E-5 ID:SGTC_2027|Compound:5150920|FD-Score:-3.20|P-value:4.27E-4 ID:SGTC_2041|Compound:5107442|FD-Score:-3.36|P-value:2.31E-4 ID:SGTC_2047|Compound:4141938|FD-Score:-3.18|P-value:4.63E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.30|P-value:2.27E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.78|P-value:3.07E-5 ID:SGTC_2290|Compound:7904846|FD-Score:-3.27|P-value:3.20E-4 ID:SGTC_2319|Compound:6033012|FD-Score:3.24|P-value:2.87E-4 ID:SGTC_2332|Compound:7982454|FD-Score:4.65|P-value:4.18E-7 ID:SGTC_2338|Compound:7999974|FD-Score:3.27|P-value:2.60E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.10|P-value:6.05E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.13|P-value:6.07E-6 ID:SGTC_2404|Compound:5161160|FD-Score:6.23|P-value:2.24E-11 ID:SGTC_2433|Compound:5607874|FD-Score:-3.17|P-value:4.69E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.05|P-value:8.98E-6 ID:SGTC_2551|Compound:apiole|FD-Score:3.46|P-value:1.22E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-4.53|P-value:1.08E-6 ID:SGTC_2781|Compound:5567276|FD-Score:3.45|P-value:1.26E-4 ID:SGTC_2833|Compound:9001315|FD-Score:6.58|P-value:1.79E-12 ID:SGTC_2871|Compound:9038510|FD-Score:3.08|P-value:5.39E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.09|P-value:5.16E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.34|P-value:1.98E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-3.20|P-value:4.18E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.22|P-value:3.92E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.69|P-value:4.48E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-5.51|P-value:4.08E-9 ID:SGTC_3138|Compound:9097216|FD-Score:4.00|P-value:1.12E-5 ID:SGTC_3192|Compound:9110362|FD-Score:3.79|P-value:2.98E-5 ID:SGTC_3255|Compound:9139072|FD-Score:-3.41|P-value:1.83E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-4.01|P-value:1.41E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-3.09|P-value:6.34E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:2.94|P-value:8.91E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:4.15|P-value:5.38E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.07|P-value:1.03E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:-2.99|P-value:9.05E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.96|P-value:1.36E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:3.08|P-value:5.35E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.44|P-value:1.66E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:-3.07|P-value:6.80E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:-3.31|P-value:2.71E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.09|P-value:5.20E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:5.14|P-value:2.61E-8 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.33|P-value:2.09E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.63|P-value:7.38E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.70|P-value:5.64E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-4.54|P-value:1.01E-6 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.71|P-value:4.27E-5 ID:SGTC_1659|Compound:st012954|FD-Score:2.96|P-value:8.24E-4 ID:SGTC_1998|Compound:st075797|FD-Score:-3.81|P-value:3.40E-5 ID:SGTC_2027|Compound:5150920|FD-Score:-3.20|P-value:4.27E-4 ID:SGTC_2041|Compound:5107442|FD-Score:-3.36|P-value:2.31E-4 ID:SGTC_2047|Compound:4141938|FD-Score:-3.18|P-value:4.63E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.30|P-value:2.27E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.78|P-value:3.07E-5 ID:SGTC_2290|Compound:7904846|FD-Score:-3.27|P-value:3.20E-4 ID:SGTC_2319|Compound:6033012|FD-Score:3.24|P-value:2.87E-4 ID:SGTC_2332|Compound:7982454|FD-Score:4.65|P-value:4.18E-7 ID:SGTC_2338|Compound:7999974|FD-Score:3.27|P-value:2.60E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.10|P-value:6.05E-4 ID:SGTC_2401|Compound:5128683|FD-Score:4.13|P-value:6.07E-6 ID:SGTC_2404|Compound:5161160|FD-Score:6.23|P-value:2.24E-11 ID:SGTC_2433|Compound:5607874|FD-Score:-3.17|P-value:4.69E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.05|P-value:8.98E-6 ID:SGTC_2551|Compound:apiole|FD-Score:3.46|P-value:1.22E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-4.53|P-value:1.08E-6 ID:SGTC_2781|Compound:5567276|FD-Score:3.45|P-value:1.26E-4 ID:SGTC_2833|Compound:9001315|FD-Score:6.58|P-value:1.79E-12 ID:SGTC_2871|Compound:9038510|FD-Score:3.08|P-value:5.39E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.09|P-value:5.16E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.34|P-value:1.98E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-3.20|P-value:4.18E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.22|P-value:3.92E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.69|P-value:4.48E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-5.51|P-value:4.08E-9 ID:SGTC_3138|Compound:9097216|FD-Score:4.00|P-value:1.12E-5 ID:SGTC_3192|Compound:9110362|FD-Score:3.79|P-value:2.98E-5 ID:SGTC_3255|Compound:9139072|FD-Score:-3.41|P-value:1.83E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-4.01|P-value:1.41E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-3.09|P-value:6.34E-4

Top fitness defect scores for YLR314C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2833 9001315 6.58 45.5 µM 1.79E-12 amide catabolism 2 2.37E-11 0.14
2 SGTC_2404 5161160 6.23 200.0 µM 2.24E-11 2 2.30E-10 0.43
3 SGTC_1163 k060-0048 5.14 49.9 µM 2.61E-8 1 1.34E-7 1.81
4 SGTC_2332 7982454 4.65 138.9 µM 4.18E-7 6 1.63E-6 0.00
5 SGTC_52 0329-0193 4.15 875.0 nM 5.38E-6 TSC3-RPN4 7 1.63E-5 0.40
6 SGTC_2401 5128683 4.13 200.0 µM 6.07E-6 6 1.82E-5 0.12
7 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.05 3.7 µM 8.98E-6 12 2.59E-5 0.09
8 SGTC_3138 9097216 4.00 49.5 µM 1.12E-5 6 3.17E-5 0.18
9 SGTC_423 5-fluorouracil 3.96 457.0 µM 1.36E-5 exosome 29 3.76E-5 0.21
10 SGTC_3192 9110362 3.79 49.5 µM 2.98E-5 mitochondrial processes 9 7.63E-5 0.50
11 SGTC_2258 7960471 3.78 200.0 µM 3.07E-5 4 7.83E-5 0.03
12 SGTC_1587 estradiol valerate 3.71 56.1 µM 4.27E-5 4 1.06E-4 0.05
13 SGTC_2938 9059746 3.69 27.3 µM 4.48E-5 fatty acid desaturase (OLE1) 12 1.10E-4 0.07
14 SGTC_2551 apiole 3.46 73.9 µM 1.22E-4 3 2.72E-4 0.49
15 SGTC_2781 5567276 3.45 71.4 µM 1.26E-4 16 2.80E-4 0.22
16 SGTC_2922 7999257 3.34 32.5 µM 1.98E-4 11 4.20E-4 0.03
17 SGTC_1170 0310-0127 3.33 64.8 µM 2.09E-4 19 4.42E-4 0.02
18 SGTC_2048 5246248 3.30 200.0 µM 2.27E-4 5 4.76E-4 0.16
19 SGTC_2338 7999974 3.27 200.0 µM 2.60E-4 17 5.39E-4 0.08
20 SGTC_2319 6033012 3.24 152.6 µM 2.87E-4 tubulin folding & SWR complex 8 5.87E-4 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 3.85E-18 YDL029W ARP2 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.132 1.77E-14 YKL173W SNU114 het GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
0.129 5.98E-14 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.128 1.28E-13 YLR026C SED5 het cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
0.118 6.80E-12 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.113 5.13E-11 YEL001C IRC22 hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
0.110 1.77E-10 YBL020W RFT1 het Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein
0.110 1.92E-10 YOR269W PAC1 hom Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly
0.103 1.96E-9 YGR198W YPP1 het Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene
0.098 1.17E-8 YDL031W DBP10 het Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis
0.097 1.78E-8 YDL212W SHR3 het Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
0.095 3.28E-8 YOR272W YTM1 het Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats
0.093 6.20E-8 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.091 1.42E-7 YBR076W ECM8 hom Non-essential protein of unknown function
0.091 1.50E-7 YML069W POB3 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress