YLR390W / ECM19

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR390W / ECM19

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.52|P-value:8.09E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.00|P-value:1.69E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:3.62|P-value:5.91E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.19|P-value:8.57E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:4.47|P-value:3.12E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:4.22|P-value:7.69E-5 ID:SGTC_594|Compound:1487-1584|FD-Score:3.46|P-value:9.66E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:-3.68|P-value:4.50E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-3.95|P-value:1.82E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:4.45|P-value:3.28E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:4.73|P-value:1.11E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.46|P-value:9.67E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:3.89|P-value:2.46E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:7.55|P-value:6.29E-12 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.59|P-value:5.97E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.81|P-value:3.17E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.47|P-value:9.55E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:-3.75|P-value:3.56E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:-4.01|P-value:1.47E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.93|P-value:1.93E-4 ID:SGTC_1677|Compound:st019204|FD-Score:4.20|P-value:8.43E-5 ID:SGTC_1691|Compound:st019933|FD-Score:5.81|P-value:9.46E-8 ID:SGTC_1702|Compound:st027038|FD-Score:-3.53|P-value:7.27E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.63|P-value:5.85E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-3.57|P-value:6.36E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.84|P-value:2.95E-4 ID:SGTC_1993|Compound:st073995|FD-Score:-3.69|P-value:4.36E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.96|P-value:1.77E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.59|P-value:6.43E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.99|P-value:1.77E-4 ID:SGTC_2215|Compound:7188065|FD-Score:3.48|P-value:9.25E-4 ID:SGTC_2288|Compound:7946289|FD-Score:4.22|P-value:7.72E-5 ID:SGTC_2296|Compound:7971656|FD-Score:4.46|P-value:3.19E-5 ID:SGTC_2334|Compound:9017922|FD-Score:-3.43|P-value:9.63E-4 ID:SGTC_2335|Compound:9018011|FD-Score:5.53|P-value:3.62E-7 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.64|P-value:5.52E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.89|P-value:2.19E-4 ID:SGTC_2907|Compound:7721985|FD-Score:4.04|P-value:1.48E-4 ID:SGTC_2910|Compound:7948405|FD-Score:3.66|P-value:5.26E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.87|P-value:2.64E-4 ID:SGTC_2969|Compound:9091408|FD-Score:4.28|P-value:6.35E-5 ID:SGTC_2971|Compound:9092186|FD-Score:5.71|P-value:1.53E-7 ID:SGTC_2977|Compound:9011197|FD-Score:5.99|P-value:3.86E-8 ID:SGTC_3003|Compound:9075612|FD-Score:4.11|P-value:1.15E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.76|P-value:3.85E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.51|P-value:8.33E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-3.42|P-value:9.92E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-4.28|P-value:5.54E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:3.52|P-value:8.09E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.00|P-value:1.69E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:3.62|P-value:5.91E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.19|P-value:8.57E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:4.47|P-value:3.12E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:4.22|P-value:7.69E-5 ID:SGTC_594|Compound:1487-1584|FD-Score:3.46|P-value:9.66E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:-3.68|P-value:4.50E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-3.95|P-value:1.82E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:4.45|P-value:3.28E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:4.73|P-value:1.11E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.46|P-value:9.67E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:3.89|P-value:2.46E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:7.55|P-value:6.29E-12 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.59|P-value:5.97E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.81|P-value:3.17E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.47|P-value:9.55E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:-3.75|P-value:3.56E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:-4.01|P-value:1.47E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.93|P-value:1.93E-4 ID:SGTC_1677|Compound:st019204|FD-Score:4.20|P-value:8.43E-5 ID:SGTC_1691|Compound:st019933|FD-Score:5.81|P-value:9.46E-8 ID:SGTC_1702|Compound:st027038|FD-Score:-3.53|P-value:7.27E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.63|P-value:5.85E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-3.57|P-value:6.36E-4 ID:SGTC_1870|Compound:st057514|FD-Score:3.84|P-value:2.95E-4 ID:SGTC_1993|Compound:st073995|FD-Score:-3.69|P-value:4.36E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.96|P-value:1.77E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.59|P-value:6.43E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.99|P-value:1.77E-4 ID:SGTC_2215|Compound:7188065|FD-Score:3.48|P-value:9.25E-4 ID:SGTC_2288|Compound:7946289|FD-Score:4.22|P-value:7.72E-5 ID:SGTC_2296|Compound:7971656|FD-Score:4.46|P-value:3.19E-5 ID:SGTC_2334|Compound:9017922|FD-Score:-3.43|P-value:9.63E-4 ID:SGTC_2335|Compound:9018011|FD-Score:5.53|P-value:3.62E-7 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.64|P-value:5.52E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.89|P-value:2.19E-4 ID:SGTC_2907|Compound:7721985|FD-Score:4.04|P-value:1.48E-4 ID:SGTC_2910|Compound:7948405|FD-Score:3.66|P-value:5.26E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.87|P-value:2.64E-4 ID:SGTC_2969|Compound:9091408|FD-Score:4.28|P-value:6.35E-5 ID:SGTC_2971|Compound:9092186|FD-Score:5.71|P-value:1.53E-7 ID:SGTC_2977|Compound:9011197|FD-Score:5.99|P-value:3.86E-8 ID:SGTC_3003|Compound:9075612|FD-Score:4.11|P-value:1.15E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.76|P-value:3.85E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.51|P-value:8.33E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-3.42|P-value:9.92E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-4.28|P-value:5.54E-5

Top fitness defect scores for YLR390W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_827 3253-0474 7.55 693.0 µM 6.29E-12 1 2.21E-14
2 SGTC_2977 9011197 5.99 71.4 µM 3.86E-8 6 1.04E-9
3 SGTC_1691 st019933 5.81 84.6 µM 9.46E-8 3 3.15E-9
4 SGTC_2971 9092186 5.71 9.9 µM 1.53E-7 ergosterol biosynthesis 10 5.69E-9
5 SGTC_2335 9018011 5.53 154.2 µM 3.62E-7 8 1.65E-8
6 SGTC_729 4092-0585 4.73 94.1 µM 1.11E-5 10 1.12E-6
7 SGTC_496 calpeptin 4.47 138.0 µM 3.12E-5 9 3.96E-6
8 SGTC_2296 7971656 4.46 126.5 µM 3.19E-5 33 4.07E-6
9 SGTC_726 3448-4391 4.45 34.2 µM 3.28E-5 6 4.20E-6
10 SGTC_2969 9091408 4.28 28.7 µM 6.35E-5 19 9.48E-6
11 SGTC_574 1315-0397 4.22 40.0 µM 7.69E-5 25 1.20E-5
12 SGTC_2288 7946289 4.22 167.3 µM 7.72E-5 21 1.20E-5
13 SGTC_1677 st019204 4.20 53.9 µM 8.43E-5 12 1.34E-5
14 SGTC_245 methotrexate 4.19 289.6 µM 8.57E-5 40 1.37E-5
15 SGTC_3003 9075612 4.11 71.4 µM 1.15E-4 19 1.96E-5
16 SGTC_2907 7721985 4.04 69.9 µM 1.48E-4 17 2.67E-5
17 SGTC_18 0111-0177 4.00 500.0 nM 1.69E-4 71 3.15E-5
18 SGTC_2211 7117706 3.99 200.0 µM 1.77E-4 11 3.33E-5
19 SGTC_812 4251-0442 3.89 148.0 µM 2.46E-4 9 4.98E-5
20 SGTC_2966 9084041 3.87 48.0 µM 2.64E-4 36 5.45E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.085 7.37E-7 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.085 7.92E-7 YHL008C_p YHL008C_p hom Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.082 2.22E-6 YHR088W RPF1 het Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA
0.077 7.00E-6 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.070 5.03E-5 YJL029C VPS53 hom Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting
0.069 6.04E-5 YML023C NSE5 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
0.068 7.89E-5 YER144C UBP5 hom Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck
0.066 1.24E-4 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.066 1.26E-4 YJR012C_p YJR012C_p het Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W
0.066 1.30E-4 YDR493W MZM1 hom Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog
0.066 1.30E-4 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.064 2.28E-4 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.063 2.36E-4 YGL238W CSE1 het Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation
0.063 2.34E-4 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.062 3.38E-4 YOR286W RDL2 hom Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss