YLR441C / RPS1A

Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR441C / RPS1A

Click on Significant Values for Screen Details ID:SGTC_94|Compound:0334-0113|FD-Score:4.75|P-value:5.68E-6 ID:SGTC_190|Compound:3970-0790|FD-Score:3.75|P-value:2.70E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-4.75|P-value:4.76E-6 ID:SGTC_204|Compound:1543-0184|FD-Score:4.47|P-value:1.84E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:3.42|P-value:7.97E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.97|P-value:1.04E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.62|P-value:4.26E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.48|P-value:6.66E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:4.24|P-value:4.56E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:4.44|P-value:2.05E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:4.25|P-value:4.35E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.09|P-value:8.00E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:3.58|P-value:4.71E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:4.85|P-value:3.73E-6 ID:SGTC_992|Compound:3909-8734|FD-Score:3.68|P-value:3.45E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.16|P-value:6.09E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.64|P-value:3.89E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:5.30|P-value:4.77E-7 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.86|P-value:1.84E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.83|P-value:2.04E-4 ID:SGTC_1563|Compound:conessine|FD-Score:4.49|P-value:1.69E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.36|P-value:8.48E-4 ID:SGTC_1729|Compound:st035615|FD-Score:4.73|P-value:6.17E-6 ID:SGTC_1767|Compound:st044992|FD-Score:-3.68|P-value:2.94E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.29|P-value:3.79E-5 ID:SGTC_1807|Compound:st050092|FD-Score:4.68|P-value:7.67E-6 ID:SGTC_1878|Compound:temozolomide|FD-Score:-3.76|P-value:2.20E-4 ID:SGTC_2007|Compound:4011539|FD-Score:4.08|P-value:8.15E-5 ID:SGTC_2028|Compound:5153890|FD-Score:4.18|P-value:5.73E-5 ID:SGTC_2038|Compound:4100038|FD-Score:-4.78|P-value:4.21E-6 ID:SGTC_2127|Compound:5253358|FD-Score:-3.45|P-value:6.31E-4 ID:SGTC_2132|Compound:5317594|FD-Score:4.52|P-value:1.46E-5 ID:SGTC_2171|Compound:5739187|FD-Score:4.03|P-value:1.00E-4 ID:SGTC_2359|Compound:9039622|FD-Score:4.21|P-value:5.08E-5 ID:SGTC_2414|Compound:st077232|FD-Score:4.36|P-value:2.83E-5 ID:SGTC_2447|Compound:5741742|FD-Score:-4.64|P-value:7.53E-6 ID:SGTC_2451|Compound:5856223|FD-Score:-4.30|P-value:3.02E-5 ID:SGTC_2518|Compound:prenyletin|FD-Score:-3.75|P-value:2.34E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.40|P-value:2.44E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.79|P-value:4.39E-8 ID:SGTC_2789|Compound:5281112|FD-Score:4.59|P-value:1.14E-5 ID:SGTC_2842|Compound:9000675|FD-Score:3.50|P-value:6.30E-4 ID:SGTC_2855|Compound:9016525|FD-Score:4.07|P-value:8.48E-5 ID:SGTC_3021|Compound:9087658|FD-Score:5.47|P-value:2.15E-7 ID:SGTC_3027|Compound:9089541|FD-Score:-3.88|P-value:1.48E-4 ID:SGTC_3033|Compound:9090887|FD-Score:-8.05|P-value:3.29E-14 ID:SGTC_3038|Compound:9091290|FD-Score:-3.44|P-value:6.57E-4 ID:SGTC_3043|Compound:9092303|FD-Score:4.52|P-value:1.49E-5 ID:SGTC_3124|Compound:9127567|FD-Score:3.74|P-value:2.80E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-4.04|P-value:8.08E-5 ID:SGTC_3201|Compound:9113999|FD-Score:4.37|P-value:2.73E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-3.41|P-value:7.16E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:4.75|P-value:5.68E-6 ID:SGTC_190|Compound:3970-0790|FD-Score:3.75|P-value:2.70E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-4.75|P-value:4.76E-6 ID:SGTC_204|Compound:1543-0184|FD-Score:4.47|P-value:1.84E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:3.42|P-value:7.97E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.97|P-value:1.04E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.62|P-value:4.26E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.48|P-value:6.66E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:4.24|P-value:4.56E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:4.44|P-value:2.05E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:4.25|P-value:4.35E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.09|P-value:8.00E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:3.58|P-value:4.71E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:4.85|P-value:3.73E-6 ID:SGTC_992|Compound:3909-8734|FD-Score:3.68|P-value:3.45E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.16|P-value:6.09E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.64|P-value:3.89E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:5.30|P-value:4.77E-7 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.86|P-value:1.84E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.83|P-value:2.04E-4 ID:SGTC_1563|Compound:conessine|FD-Score:4.49|P-value:1.69E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.36|P-value:8.48E-4 ID:SGTC_1729|Compound:st035615|FD-Score:4.73|P-value:6.17E-6 ID:SGTC_1767|Compound:st044992|FD-Score:-3.68|P-value:2.94E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.29|P-value:3.79E-5 ID:SGTC_1807|Compound:st050092|FD-Score:4.68|P-value:7.67E-6 ID:SGTC_1878|Compound:temozolomide|FD-Score:-3.76|P-value:2.20E-4 ID:SGTC_2007|Compound:4011539|FD-Score:4.08|P-value:8.15E-5 ID:SGTC_2028|Compound:5153890|FD-Score:4.18|P-value:5.73E-5 ID:SGTC_2038|Compound:4100038|FD-Score:-4.78|P-value:4.21E-6 ID:SGTC_2127|Compound:5253358|FD-Score:-3.45|P-value:6.31E-4 ID:SGTC_2132|Compound:5317594|FD-Score:4.52|P-value:1.46E-5 ID:SGTC_2171|Compound:5739187|FD-Score:4.03|P-value:1.00E-4 ID:SGTC_2359|Compound:9039622|FD-Score:4.21|P-value:5.08E-5 ID:SGTC_2414|Compound:st077232|FD-Score:4.36|P-value:2.83E-5 ID:SGTC_2447|Compound:5741742|FD-Score:-4.64|P-value:7.53E-6 ID:SGTC_2451|Compound:5856223|FD-Score:-4.30|P-value:3.02E-5 ID:SGTC_2518|Compound:prenyletin|FD-Score:-3.75|P-value:2.34E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.40|P-value:2.44E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.79|P-value:4.39E-8 ID:SGTC_2789|Compound:5281112|FD-Score:4.59|P-value:1.14E-5 ID:SGTC_2842|Compound:9000675|FD-Score:3.50|P-value:6.30E-4 ID:SGTC_2855|Compound:9016525|FD-Score:4.07|P-value:8.48E-5 ID:SGTC_3021|Compound:9087658|FD-Score:5.47|P-value:2.15E-7 ID:SGTC_3027|Compound:9089541|FD-Score:-3.88|P-value:1.48E-4 ID:SGTC_3033|Compound:9090887|FD-Score:-8.05|P-value:3.29E-14 ID:SGTC_3038|Compound:9091290|FD-Score:-3.44|P-value:6.57E-4 ID:SGTC_3043|Compound:9092303|FD-Score:4.52|P-value:1.49E-5 ID:SGTC_3124|Compound:9127567|FD-Score:3.74|P-value:2.80E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-4.04|P-value:8.08E-5 ID:SGTC_3201|Compound:9113999|FD-Score:4.37|P-value:2.73E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-3.41|P-value:7.16E-4

Top fitness defect scores for YLR441C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 5.79 96.7 µM 4.39E-8 calcium & mitochondrial duress 168 3.60E-9
2 SGTC_3021 9087658 5.47 49.5 µM 2.15E-7 1 2.27E-8
3 SGTC_1281 0884-0031 5.30 11.8 µM 4.77E-7 fatty acid desaturase (OLE1) 9 5.73E-8
4 SGTC_965 1291-5240 4.85 308.0 µM 3.73E-6 14 6.21E-7
5 SGTC_94 0334-0113 4.75 514.8 µM 5.68E-6 10 1.01E-6
6 SGTC_1729 st035615 4.73 46.0 µM 6.17E-6 19 1.11E-6
7 SGTC_1807 st050092 4.68 58.9 µM 7.67E-6 60S ribosome export 4 1.43E-6
8 SGTC_2789 5281112 4.59 71.4 µM 1.14E-5 18 2.26E-6
9 SGTC_2132 5317594 4.52 122.7 µM 1.46E-5 SWF1 & branched chain AA biosynthesis 20 3.03E-6
10 SGTC_3043 9092303 4.52 49.5 µM 1.49E-5 6 3.09E-6
11 SGTC_1563 conessine 4.49 56.1 µM 1.69E-5 9 3.58E-6
12 SGTC_204 1543-0184 4.47 62.4 µM 1.84E-5 TRP & mitochondrial translation 22 3.94E-6
13 SGTC_750 4073-0104 4.44 132.0 µM 2.05E-5 5 4.49E-6
14 SGTC_2614 arthonioic acid 4.40 13.4 µM 2.44E-5 14 5.49E-6
15 SGTC_3201 9113999 4.37 49.5 µM 2.73E-5 24 6.25E-6
16 SGTC_2414 st077232 4.36 92.9 µM 2.83E-5 17 6.50E-6
17 SGTC_1781 st038725 4.29 66.3 µM 3.79E-5 NEO1 90 9.11E-6
18 SGTC_791 1348-1292 4.25 225.0 µM 4.35E-5 28 1.07E-5
19 SGTC_679 0422-0091 4.24 41.4 µM 4.56E-5 Golgi 24 1.13E-5
20 SGTC_2359 9039622 4.21 200.0 µM 5.08E-5 endomembrane recycling 20 1.28E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.08E-12 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.122 1.45E-12 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.117 9.30E-12 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.111 1.09E-10 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.093 6.72E-8 YLR264W RPS28B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication
0.093 7.63E-8 YGR118W RPS23A hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.092 1.00E-7 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.091 1.29E-7 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.087 4.60E-7 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.086 5.76E-7 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.085 7.72E-7 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.084 1.01E-6 YAL056C-A_d YAL056C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.083 1.33E-6 YDL052C SLC1 hom 1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes
0.081 2.30E-6 YPL239W YAR1 hom Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
0.081 2.33E-6 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases