YML059C / NTE1

Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes

Zygosity: Homozygous strain
fixedexpanded
Profile for YML059C / NTE1

Click on Significant Values for Screen Details ID:SGTC_309|Compound:k408-0051|FD-Score:3.81|P-value:6.14E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:3.30|P-value:4.35E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-4.68|P-value:1.10E-6 ID:SGTC_570|Compound:0987-0065|FD-Score:6.05|P-value:5.06E-10 ID:SGTC_574|Compound:1315-0397|FD-Score:-5.03|P-value:1.81E-7 ID:SGTC_725|Compound:1497-0963|FD-Score:3.28|P-value:4.79E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.54|P-value:1.79E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.32|P-value:4.05E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:6.30|P-value:1.04E-10 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.12|P-value:1.63E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:-4.21|P-value:1.03E-5 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.20|P-value:6.32E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.24|P-value:5.46E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.22|P-value:5.96E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.63|P-value:1.29E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.17|P-value:7.07E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.29|P-value:4.60E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.96|P-value:3.31E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.30|P-value:4.35E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.73|P-value:8.53E-5 ID:SGTC_1706|Compound:st031321|FD-Score:-3.59|P-value:1.43E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.41|P-value:2.97E-4 ID:SGTC_2002|Compound:4023503|FD-Score:4.31|P-value:7.06E-6 ID:SGTC_2339|Compound:9000433|FD-Score:-3.25|P-value:5.01E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.20|P-value:6.21E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:-3.51|P-value:1.94E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.07|P-value:9.74E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.75|P-value:7.90E-5 ID:SGTC_3294|Compound:9122953|FD-Score:-3.65|P-value:1.10E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.81|P-value:6.14E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:3.30|P-value:4.35E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-4.68|P-value:1.10E-6 ID:SGTC_570|Compound:0987-0065|FD-Score:6.05|P-value:5.06E-10 ID:SGTC_574|Compound:1315-0397|FD-Score:-5.03|P-value:1.81E-7 ID:SGTC_725|Compound:1497-0963|FD-Score:3.28|P-value:4.79E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.54|P-value:1.79E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.32|P-value:4.05E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:6.30|P-value:1.04E-10 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.12|P-value:1.63E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:-4.21|P-value:1.03E-5 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.20|P-value:6.32E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.24|P-value:5.46E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.22|P-value:5.96E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.63|P-value:1.29E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.17|P-value:7.07E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.29|P-value:4.60E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.96|P-value:3.31E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.30|P-value:4.35E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.73|P-value:8.53E-5 ID:SGTC_1706|Compound:st031321|FD-Score:-3.59|P-value:1.43E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.41|P-value:2.97E-4 ID:SGTC_2002|Compound:4023503|FD-Score:4.31|P-value:7.06E-6 ID:SGTC_2339|Compound:9000433|FD-Score:-3.25|P-value:5.01E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.20|P-value:6.21E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:-3.51|P-value:1.94E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.07|P-value:9.74E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.75|P-value:7.90E-5 ID:SGTC_3294|Compound:9122953|FD-Score:-3.65|P-value:1.10E-4

Top fitness defect scores for YML059C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1124 fisetin 6.30 1.2 µM 1.04E-10 5 1.49E-10
2 SGTC_570 0987-0065 6.05 62.6 µM 5.06E-10 60S ribosome export 1 7.05E-10
3 SGTC_2002 4023503 4.31 131.0 µM 7.06E-6 mitochondrial processes 22 8.32E-6
4 SGTC_1191 1487-1166 4.12 10.6 µM 1.63E-5 azole & statin 28 1.90E-5
5 SGTC_1642 st009582 3.96 77.7 µM 3.31E-5 RPP1 & pyrimidine depletion 15 3.79E-5
6 SGTC_309 k408-0051 3.81 1.5 µM 6.14E-5 56 6.97E-5
7 SGTC_2807 7945238 3.75 52.0 µM 7.90E-5 27 8.93E-5
8 SGTC_1685 st024049 3.73 53.1 µM 8.53E-5 TSC3-RPN4 16 9.64E-5
9 SGTC_1508 1080-0625 3.63 72.9 µM 1.29E-4 28 1.44E-4
10 SGTC_813 k007-0158 3.54 173.0 µM 1.79E-4 fatty acid desaturase (OLE1) 63 1.99E-4
11 SGTC_1708 st033234 3.41 31.8 µM 2.97E-4 30 3.28E-4
12 SGTC_817 1391-0715 3.32 46.0 µM 4.05E-4 34 4.45E-4
13 SGTC_1681 tripelennamine 3.30 100.0 µM 4.35E-4 38 4.78E-4
14 SGTC_383 2324-0395 3.30 7.4 µM 4.35E-4 azole & statin 67 4.78E-4
15 SGTC_1611 st001856 3.29 99.4 µM 4.60E-4 44 5.05E-4
16 SGTC_725 1497-0963 3.28 19.0 µM 4.79E-4 copper-dependent oxidative stress 43 5.26E-4
17 SGTC_1238 0333-0287 3.24 48.8 µM 5.46E-4 Golgi 52 5.98E-4
18 SGTC_1251 0490-5699 3.22 265.0 µM 5.96E-4 71 6.52E-4
19 SGTC_2595 hexamethylquercetagetin 3.20 100.0 µM 6.21E-4 55 6.78E-4
20 SGTC_1201 1889-3372 3.20 45.9 µM 6.32E-4 Golgi 25 6.90E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.05E-15 YBR263W SHM1 hom Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine
0.130 4.34E-14 YJL153C INO1 hom Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
0.120 3.49E-12 YOL053W AIM39 hom Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
0.105 9.36E-10 YER187W_p YER187W_p hom Putative protein of unknown function; induced in respiratory-deficient cells
0.105 1.03E-9 YML058W SML1 hom Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
0.100 6.02E-9 YLR177W_p YLR177W_p hom Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication
0.098 1.45E-8 YDR031W MIC14 hom Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.094 4.53E-8 YJL157C FAR1 hom Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.092 1.01E-7 YOL147C PEX11 hom Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p
0.089 2.44E-7 YIL003W CFD1 het Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol
0.085 7.43E-7 YGR213C RTA1 hom Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
0.085 7.85E-7 YFL051C_p YFL051C_p hom Putative protein of unknown function; YFL051C is not an essential gene
0.085 7.94E-7 YDL229W SSB1 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication
0.084 1.12E-6 YFL044C OTU1 hom Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress
0.083 1.37E-6 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication