YML097C / VPS9

A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin

Zygosity: Homozygous strain
fixedexpanded
Profile for YML097C / VPS9

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-3.49|P-value:5.48E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:6.64|P-value:9.60E-11 ID:SGTC_124|Compound:0136-0217|FD-Score:3.81|P-value:1.18E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.92|P-value:7.86E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:9.07|P-value:2.03E-18 ID:SGTC_168|Compound:3970-0862|FD-Score:6.30|P-value:7.44E-10 ID:SGTC_174|Compound:3553-0389|FD-Score:3.64|P-value:2.22E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.13|P-value:5.25E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:4.31|P-value:1.69E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:8.89|P-value:8.76E-18 ID:SGTC_245|Compound:methotrexate|FD-Score:3.26|P-value:8.12E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.65|P-value:3.77E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.75|P-value:2.24E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.43|P-value:4.61E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:4.19|P-value:2.73E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:7.42|P-value:5.85E-13 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.67|P-value:1.96E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:7.11|P-value:4.84E-12 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.78|P-value:1.33E-4 ID:SGTC_459|Compound:nigericin|FD-Score:5.24|P-value:2.43E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:5.36|P-value:1.31E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:3.52|P-value:3.36E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:3.65|P-value:2.11E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:-3.37|P-value:8.16E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.94|P-value:7.19E-5 ID:SGTC_620|Compound:0109-0052|FD-Score:3.36|P-value:5.86E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.65|P-value:2.88E-8 ID:SGTC_748|Compound:0136-0228|FD-Score:3.35|P-value:5.94E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.43|P-value:4.55E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.34|P-value:1.44E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:4.97|P-value:8.85E-7 ID:SGTC_879|Compound:0831-1030|FD-Score:3.38|P-value:5.51E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.74|P-value:1.55E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.90|P-value:8.35E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:3.40|P-value:5.14E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.73|P-value:1.58E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:4.13|P-value:3.50E-5 ID:SGTC_1084|Compound:voriconazole|FD-Score:5.35|P-value:1.38E-7 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.20|P-value:9.86E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:4.11|P-value:3.79E-5 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.69|P-value:1.85E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:6.73|P-value:5.45E-11 ID:SGTC_1160|Compound:4092-0570|FD-Score:-3.86|P-value:1.49E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.84|P-value:1.05E-8 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.50|P-value:6.21E-8 ID:SGTC_1306|Compound:1185-0270|FD-Score:13.50|P-value:1.53E-38 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.48|P-value:3.91E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.85|P-value:1.01E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.83|P-value:1.12E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.53|P-value:5.50E-8 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.79|P-value:1.30E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:5.60|P-value:3.78E-8 ID:SGTC_1608|Compound:st001473|FD-Score:3.44|P-value:4.47E-4 ID:SGTC_1658|Compound:st012944|FD-Score:7.30|P-value:1.36E-12 ID:SGTC_1660|Compound:st012960|FD-Score:7.12|P-value:4.42E-12 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.60|P-value:2.54E-4 ID:SGTC_1687|Compound:st020778|FD-Score:12.60|P-value:1.23E-33 ID:SGTC_1731|Compound:st035964|FD-Score:4.38|P-value:1.23E-5 ID:SGTC_1753|Compound:st043925|FD-Score:-3.78|P-value:1.97E-4 ID:SGTC_1754|Compound:st042065|FD-Score:31.10|P-value:1.24E-192 ID:SGTC_1757|Compound:st041620|FD-Score:-8.78|P-value:5.23E-17 ID:SGTC_1760|Compound:st045453|FD-Score:49.10|P-value:0 ID:SGTC_1761|Compound:st044296|FD-Score:-5.09|P-value:8.34E-7 ID:SGTC_1765|Compound:st044815|FD-Score:3.61|P-value:2.42E-4 ID:SGTC_1773|Compound:st048542|FD-Score:7.03|P-value:7.84E-12 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.88|P-value:8.96E-5 ID:SGTC_1800|Compound:st050079|FD-Score:6.97|P-value:1.20E-11 ID:SGTC_1801|Compound:st050089|FD-Score:8.13|P-value:3.64E-15 ID:SGTC_1803|Compound:st050068|FD-Score:13.70|P-value:1.30E-39 ID:SGTC_1818|Compound:st052136|FD-Score:5.54|P-value:5.31E-8 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.21|P-value:2.45E-12 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.63|P-value:2.27E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.04|P-value:4.89E-5 ID:SGTC_2077|Compound:5212015|FD-Score:6.20|P-value:1.33E-9 ID:SGTC_2090|Compound:5301565|FD-Score:3.73|P-value:1.61E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.68|P-value:1.94E-4 ID:SGTC_2167|Compound:5876490|FD-Score:5.65|P-value:2.89E-8 ID:SGTC_2290|Compound:7904846|FD-Score:-3.43|P-value:6.69E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.47|P-value:3.99E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.67|P-value:2.00E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.93|P-value:7.65E-5 ID:SGTC_2526|Compound:patulin|FD-Score:5.31|P-value:1.71E-7 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.14|P-value:3.27E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.16|P-value:3.51E-7 ID:SGTC_2586|Compound:curcumin|FD-Score:3.86|P-value:1.00E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.32|P-value:6.59E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.46|P-value:7.97E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:3.36|P-value:5.78E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.28|P-value:7.55E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.77|P-value:2.26E-6 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.74|P-value:2.51E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:4.37|P-value:1.28E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.88|P-value:1.37E-4 ID:SGTC_2816|Compound:7982706|FD-Score:10.60|P-value:1.99E-24 ID:SGTC_2818|Compound:7996756|FD-Score:-5.03|P-value:1.11E-6 ID:SGTC_2821|Compound:7996764|FD-Score:-8.37|P-value:1.31E-15 ID:SGTC_2827|Compound:7993847|FD-Score:5.63|P-value:3.20E-8 ID:SGTC_2841|Compound:9004761|FD-Score:-4.05|P-value:7.28E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-4.76|P-value:3.77E-6 ID:SGTC_2949|Compound:9072542|FD-Score:4.85|P-value:1.54E-6 ID:SGTC_2985|Compound:9022375|FD-Score:5.76|P-value:1.62E-8 ID:SGTC_3037|Compound:9091026|FD-Score:3.52|P-value:3.40E-4 ID:SGTC_3133|Compound:9127736|FD-Score:5.16|P-value:3.51E-7 ID:SGTC_3142|Compound:9086498|FD-Score:4.48|P-value:8.15E-6 ID:SGTC_3143|Compound:9086658|FD-Score:-3.76|P-value:2.09E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.58|P-value:2.72E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.33|P-value:6.38E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.49|P-value:5.48E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:6.64|P-value:9.60E-11 ID:SGTC_124|Compound:0136-0217|FD-Score:3.81|P-value:1.18E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.92|P-value:7.86E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:9.07|P-value:2.03E-18 ID:SGTC_168|Compound:3970-0862|FD-Score:6.30|P-value:7.44E-10 ID:SGTC_174|Compound:3553-0389|FD-Score:3.64|P-value:2.22E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.13|P-value:5.25E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:4.31|P-value:1.69E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:8.89|P-value:8.76E-18 ID:SGTC_245|Compound:methotrexate|FD-Score:3.26|P-value:8.12E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.65|P-value:3.77E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.75|P-value:2.24E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.43|P-value:4.61E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:4.19|P-value:2.73E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:7.42|P-value:5.85E-13 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.67|P-value:1.96E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:7.11|P-value:4.84E-12 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.78|P-value:1.33E-4 ID:SGTC_459|Compound:nigericin|FD-Score:5.24|P-value:2.43E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:5.36|P-value:1.31E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:3.52|P-value:3.36E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:3.65|P-value:2.11E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:-3.37|P-value:8.16E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.94|P-value:7.19E-5 ID:SGTC_620|Compound:0109-0052|FD-Score:3.36|P-value:5.86E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.65|P-value:2.88E-8 ID:SGTC_748|Compound:0136-0228|FD-Score:3.35|P-value:5.94E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.43|P-value:4.55E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.34|P-value:1.44E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:4.97|P-value:8.85E-7 ID:SGTC_879|Compound:0831-1030|FD-Score:3.38|P-value:5.51E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.74|P-value:1.55E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.90|P-value:8.35E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:3.40|P-value:5.14E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.73|P-value:1.58E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:4.13|P-value:3.50E-5 ID:SGTC_1084|Compound:voriconazole|FD-Score:5.35|P-value:1.38E-7 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.20|P-value:9.86E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:4.11|P-value:3.79E-5 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.69|P-value:1.85E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:6.73|P-value:5.45E-11 ID:SGTC_1160|Compound:4092-0570|FD-Score:-3.86|P-value:1.49E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.84|P-value:1.05E-8 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.50|P-value:6.21E-8 ID:SGTC_1306|Compound:1185-0270|FD-Score:13.50|P-value:1.53E-38 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.48|P-value:3.91E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.85|P-value:1.01E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.83|P-value:1.12E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.53|P-value:5.50E-8 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.79|P-value:1.30E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:5.60|P-value:3.78E-8 ID:SGTC_1608|Compound:st001473|FD-Score:3.44|P-value:4.47E-4 ID:SGTC_1658|Compound:st012944|FD-Score:7.30|P-value:1.36E-12 ID:SGTC_1660|Compound:st012960|FD-Score:7.12|P-value:4.42E-12 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.60|P-value:2.54E-4 ID:SGTC_1687|Compound:st020778|FD-Score:12.60|P-value:1.23E-33 ID:SGTC_1731|Compound:st035964|FD-Score:4.38|P-value:1.23E-5 ID:SGTC_1753|Compound:st043925|FD-Score:-3.78|P-value:1.97E-4 ID:SGTC_1754|Compound:st042065|FD-Score:31.10|P-value:1.24E-192 ID:SGTC_1757|Compound:st041620|FD-Score:-8.78|P-value:5.23E-17 ID:SGTC_1760|Compound:st045453|FD-Score:49.10|P-value:0 ID:SGTC_1761|Compound:st044296|FD-Score:-5.09|P-value:8.34E-7 ID:SGTC_1765|Compound:st044815|FD-Score:3.61|P-value:2.42E-4 ID:SGTC_1773|Compound:st048542|FD-Score:7.03|P-value:7.84E-12 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.88|P-value:8.96E-5 ID:SGTC_1800|Compound:st050079|FD-Score:6.97|P-value:1.20E-11 ID:SGTC_1801|Compound:st050089|FD-Score:8.13|P-value:3.64E-15 ID:SGTC_1803|Compound:st050068|FD-Score:13.70|P-value:1.30E-39 ID:SGTC_1818|Compound:st052136|FD-Score:5.54|P-value:5.31E-8 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.21|P-value:2.45E-12 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.63|P-value:2.27E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.04|P-value:4.89E-5 ID:SGTC_2077|Compound:5212015|FD-Score:6.20|P-value:1.33E-9 ID:SGTC_2090|Compound:5301565|FD-Score:3.73|P-value:1.61E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.68|P-value:1.94E-4 ID:SGTC_2167|Compound:5876490|FD-Score:5.65|P-value:2.89E-8 ID:SGTC_2290|Compound:7904846|FD-Score:-3.43|P-value:6.69E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.47|P-value:3.99E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.67|P-value:2.00E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.93|P-value:7.65E-5 ID:SGTC_2526|Compound:patulin|FD-Score:5.31|P-value:1.71E-7 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.14|P-value:3.27E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.16|P-value:3.51E-7 ID:SGTC_2586|Compound:curcumin|FD-Score:3.86|P-value:1.00E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.32|P-value:6.59E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.46|P-value:7.97E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:3.36|P-value:5.78E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.28|P-value:7.55E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.77|P-value:2.26E-6 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.74|P-value:2.51E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:4.37|P-value:1.28E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.88|P-value:1.37E-4 ID:SGTC_2816|Compound:7982706|FD-Score:10.60|P-value:1.99E-24 ID:SGTC_2818|Compound:7996756|FD-Score:-5.03|P-value:1.11E-6 ID:SGTC_2821|Compound:7996764|FD-Score:-8.37|P-value:1.31E-15 ID:SGTC_2827|Compound:7993847|FD-Score:5.63|P-value:3.20E-8 ID:SGTC_2841|Compound:9004761|FD-Score:-4.05|P-value:7.28E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-4.76|P-value:3.77E-6 ID:SGTC_2949|Compound:9072542|FD-Score:4.85|P-value:1.54E-6 ID:SGTC_2985|Compound:9022375|FD-Score:5.76|P-value:1.62E-8 ID:SGTC_3037|Compound:9091026|FD-Score:3.52|P-value:3.40E-4 ID:SGTC_3133|Compound:9127736|FD-Score:5.16|P-value:3.51E-7 ID:SGTC_3142|Compound:9086498|FD-Score:4.48|P-value:8.15E-6 ID:SGTC_3143|Compound:9086658|FD-Score:-3.76|P-value:2.09E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.58|P-value:2.72E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.33|P-value:6.38E-4

Top fitness defect scores for YML097C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1760 st045453 49.10 10.4 µM 0 NEO1-PIK1 1 0
2 SGTC_1754 st042065 31.10 16.1 µM 1.24E-192 NEO1-PIK1 1 5.42E-212
3 SGTC_1803 st050068 13.70 52.4 µM 1.30E-39 NEO1-PIK1 4 2.97E-43
4 SGTC_1306 1185-0270 13.50 9.0 µM 1.53E-38 Golgi 7 4.50E-42
5 SGTC_1687 st020778 12.60 55.4 µM 1.23E-33 34 1.13E-36
6 SGTC_2816 7982706 10.60 58.4 µM 1.99E-24 azole & statin 3 1.50E-26
7 SGTC_159 3970-0959 9.07 50.0 µM 2.03E-18 9 6.00E-20
8 SGTC_221 trifluoperazine 8.89 10.3 µM 8.76E-18 NEO1-PIK1 74 2.98E-19
9 SGTC_1801 st050089 8.13 28.4 µM 3.64E-15 NEO1-PIK1 26 2.23E-16
10 SGTC_377 3970-0964 7.42 33.1 µM 5.85E-13 5 5.84E-14
11 SGTC_1658 st012944 7.30 20.0 µM 1.36E-12 iron homeostasis 14 1.47E-13
12 SGTC_1844 rapamycin 7.21 4.0 nM 2.45E-12 70 2.81E-13
13 SGTC_1660 st012960 7.12 28.1 µM 4.42E-12 iron homeostasis 1 5.35E-13
14 SGTC_439 amiodarone 7.11 34.4 µM 4.84E-12 NEO1-PIK1 28 5.91E-13
15 SGTC_1773 st048542 7.03 73.6 µM 7.84E-12 11 1.00E-12
16 SGTC_1800 st050079 6.97 29.1 µM 1.20E-11 NEO1-PIK1 24 1.60E-12
17 SGTC_1157 4092-0394 6.73 27.6 µM 5.45E-11 2 8.38E-12
18 SGTC_70 0141-0289 6.64 43.3 µM 9.60E-11 mitochondrial stress 60 1.56E-11
19 SGTC_168 3970-0862 6.30 530.5 µM 7.44E-10 37 1.46E-10
20 SGTC_2077 5212015 6.20 200.0 µM 1.33E-9 22 2.78E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.583 3.73E-305 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.496 1.10E-207 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.492 7.18E-204 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.465 1.19E-179 YOR089C VPS21 hom Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication
0.461 5.29E-176 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.432 1.00E-152 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.415 8.44E-140 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.412 7.46E-138 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.401 5.97E-130 YDR491C_d YDR491C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.393 4.11E-124 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.376 6.40E-113 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.375 4.12E-112 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.370 3.24E-109 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.354 7.16E-100 YDR492W IZH1 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.344 5.59E-94 YAR042W SWH1 hom Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction