YML114C / TAF8

TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YML114C / TAF8

Click on Significant Values for Screen Details ID:SGTC_138|Compound:0850-0259|FD-Score:-3.55|P-value:1.81E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:5.20|P-value:8.05E-8 ID:SGTC_167|Compound:3672-0051|FD-Score:4.48|P-value:3.23E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:7.46|P-value:2.80E-14 ID:SGTC_297|Compound:0986-0032|FD-Score:-3.16|P-value:7.38E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.63|P-value:1.25E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.21|P-value:5.95E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.50|P-value:2.07E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.53|P-value:1.84E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.23|P-value:5.65E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.53|P-value:1.88E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.31|P-value:4.29E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:5.98|P-value:8.61E-10 ID:SGTC_514|Compound:4466-0038|FD-Score:3.79|P-value:6.70E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:6.30|P-value:1.07E-10 ID:SGTC_584|Compound:0986-0246|FD-Score:3.22|P-value:5.82E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:-3.33|P-value:3.99E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.88|P-value:4.58E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:3.85|P-value:5.11E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.19|P-value:6.58E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.70|P-value:1.06E-6 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.16|P-value:7.13E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.19|P-value:6.44E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.44|P-value:2.66E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.26|P-value:5.00E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.18|P-value:6.93E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.83|P-value:5.66E-5 ID:SGTC_1616|Compound:st002734|FD-Score:4.19|P-value:1.18E-5 ID:SGTC_1623|Compound:st003709|FD-Score:-4.51|P-value:2.85E-6 ID:SGTC_1642|Compound:st009582|FD-Score:-3.33|P-value:3.99E-4 ID:SGTC_1666|Compound:st014829|FD-Score:5.23|P-value:6.69E-8 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.17|P-value:7.08E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.38|P-value:3.27E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.47|P-value:2.35E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-3.17|P-value:7.27E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:6.86|P-value:2.48E-12 ID:SGTC_2136|Compound:5328288|FD-Score:4.83|P-value:5.70E-7 ID:SGTC_2226|Compound:7298446|FD-Score:3.07|P-value:9.73E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-3.24|P-value:5.58E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.30|P-value:4.47E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.74|P-value:8.00E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:-3.28|P-value:4.77E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.18|P-value:6.77E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:-3.62|P-value:1.37E-4 ID:SGTC_3341|Compound:9147222|FD-Score:-3.99|P-value:2.99E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.55|P-value:1.81E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:5.20|P-value:8.05E-8 ID:SGTC_167|Compound:3672-0051|FD-Score:4.48|P-value:3.23E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:7.46|P-value:2.80E-14 ID:SGTC_297|Compound:0986-0032|FD-Score:-3.16|P-value:7.38E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.63|P-value:1.25E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.21|P-value:5.95E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.50|P-value:2.07E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.53|P-value:1.84E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.23|P-value:5.65E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.53|P-value:1.88E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.31|P-value:4.29E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:5.98|P-value:8.61E-10 ID:SGTC_514|Compound:4466-0038|FD-Score:3.79|P-value:6.70E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:6.30|P-value:1.07E-10 ID:SGTC_584|Compound:0986-0246|FD-Score:3.22|P-value:5.82E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:-3.33|P-value:3.99E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.88|P-value:4.58E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:3.85|P-value:5.11E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.19|P-value:6.58E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.70|P-value:1.06E-6 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.16|P-value:7.13E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.19|P-value:6.44E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.44|P-value:2.66E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.26|P-value:5.00E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.18|P-value:6.93E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.83|P-value:5.66E-5 ID:SGTC_1616|Compound:st002734|FD-Score:4.19|P-value:1.18E-5 ID:SGTC_1623|Compound:st003709|FD-Score:-4.51|P-value:2.85E-6 ID:SGTC_1642|Compound:st009582|FD-Score:-3.33|P-value:3.99E-4 ID:SGTC_1666|Compound:st014829|FD-Score:5.23|P-value:6.69E-8 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.17|P-value:7.08E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.38|P-value:3.27E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.47|P-value:2.35E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-3.17|P-value:7.27E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:6.86|P-value:2.48E-12 ID:SGTC_2136|Compound:5328288|FD-Score:4.83|P-value:5.70E-7 ID:SGTC_2226|Compound:7298446|FD-Score:3.07|P-value:9.73E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-3.24|P-value:5.58E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.30|P-value:4.47E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.74|P-value:8.00E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:-3.28|P-value:4.77E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.18|P-value:6.77E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:-3.62|P-value:1.37E-4 ID:SGTC_3341|Compound:9147222|FD-Score:-3.99|P-value:2.99E-5

Top fitness defect scores for YML114C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_168 3970-0862 7.46 530.5 µM 2.80E-14 11 4.30E-14 0.14
2 SGTC_2129 girgensonine 6.86 121.0 µM 2.48E-12 heme biosynthesis & mitochondrial translocase 9 3.56E-12 1.10
3 SGTC_547 1120-0019 6.30 610.0 nM 1.07E-10 azole & statin 3 1.46E-10 1.01
4 SGTC_457 grayanotoxin iii 5.98 135.0 µM 8.61E-10 10 1.14E-9 0.62
5 SGTC_1666 st014829 5.23 29.0 µM 6.69E-8 calcium & mitochondrial duress 1 8.33E-8 0.56
6 SGTC_165 k038-0023 5.20 64.4 µM 8.05E-8 ubiquinone biosynthesis & proteasome 13 1.00E-7 0.01
7 SGTC_2136 5328288 4.83 199.3 µM 5.70E-7 5 6.89E-7 0.04
8 SGTC_1019 4262-0212 4.70 3.4 µM 1.06E-6 ergosterol depletion effects on membrane 10 1.27E-6 0.62
9 SGTC_167 3672-0051 4.48 66.2 µM 3.23E-6 6 3.81E-6 0.23
10 SGTC_1616 st002734 4.19 56.1 µM 1.18E-5 4 1.37E-5 0.09
11 SGTC_902 1120-0002 3.88 2.1 µM 4.58E-5 azole & statin 19 5.20E-5 0.12
12 SGTC_996 3970-0799 3.85 1.8 µM 5.11E-5 22 5.79E-5 0.29
13 SGTC_1574 spiramycin 3.83 23.7 µM 5.66E-5 6 6.41E-5 0.09
14 SGTC_514 4466-0038 3.79 2.6 nM 6.70E-5 cell wall 43 7.57E-5 4.16E-4
15 SGTC_2479 5617353 3.74 43.9 µM 8.00E-5 8 9.02E-5 0.10
16 SGTC_299 1273-0059 3.63 1.4 µM 1.25E-4 11 1.40E-4 0.05
17 SGTC_368 fentichlor 3.53 4.6 µM 1.84E-4 9 2.05E-4 0.41
18 SGTC_408 cantharidin 3.53 100.0 µM 1.88E-4 cell wall signaling 12 2.10E-4 0.10
19 SGTC_363 0455-0021 3.50 3.1 µM 2.07E-4 azole & statin 24 2.31E-4 0.11
20 SGTC_1844 rapamycin 3.47 4.0 nM 2.35E-4 64 2.61E-4 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.25E-17 YGL112C TAF6 het Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
0.143 1.03E-16 YBR198C TAF5 het Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
0.139 6.31E-16 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.136 2.83E-15 YOR194C TOA1 het TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA
0.135 3.51E-15 YGL113W SLD3 het Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress
0.133 9.66E-15 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.126 2.36E-13 YOR043W WHI2 hom Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression
0.125 3.74E-13 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.123 7.19E-13 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.121 1.90E-12 YLR415C_p YLR415C_p hom Putative protein of unknown function; YLR415C is not an essential gene
0.120 2.95E-12 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.120 3.69E-12 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
0.115 2.24E-11 YDR042C_p YDR042C_p hom Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
0.113 5.24E-11 YIL087C AIM19 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth
0.112 7.19E-11 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane