YML115C / VAN1

Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant

Zygosity: Homozygous strain
fixedexpanded
Profile for YML115C / VAN1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-8.53|P-value:1.33E-14 ID:SGTC_70|Compound:0141-0289|FD-Score:4.06|P-value:2.46E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.77|P-value:1.98E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.77|P-value:6.25E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.71|P-value:7.42E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.07|P-value:1.15E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.21|P-value:1.49E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-4.19|P-value:7.53E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:3.74|P-value:6.77E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:6.24|P-value:3.28E-8 ID:SGTC_708|Compound:3448-5400|FD-Score:5.16|P-value:4.20E-6 ID:SGTC_743|Compound:1275-0778|FD-Score:-3.61|P-value:5.25E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.94|P-value:3.60E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:-3.44|P-value:8.79E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.65|P-value:8.93E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.18|P-value:1.64E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.60|P-value:3.71E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:5.69|P-value:4.22E-7 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.09|P-value:2.24E-4 ID:SGTC_1615|Compound:st002656|FD-Score:4.50|P-value:5.38E-5 ID:SGTC_1623|Compound:st003709|FD-Score:4.71|P-value:2.50E-5 ID:SGTC_1624|Compound:st003710|FD-Score:3.76|P-value:6.30E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.77|P-value:1.97E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.71|P-value:7.39E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.60|P-value:5.19E-9 ID:SGTC_1991|Compound:st073000|FD-Score:5.41|P-value:1.45E-6 ID:SGTC_2007|Compound:4011539|FD-Score:3.67|P-value:8.27E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.04|P-value:2.63E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.85|P-value:2.43E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-4.82|P-value:7.08E-6 ID:SGTC_2055|Compound:5235184|FD-Score:-3.97|P-value:1.64E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.32|P-value:1.01E-4 ID:SGTC_2194|Compound:5927483|FD-Score:4.14|P-value:1.90E-4 ID:SGTC_2199|Compound:6590217|FD-Score:4.69|P-value:2.69E-5 ID:SGTC_2242|Compound:6630449|FD-Score:4.08|P-value:2.32E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.15|P-value:1.84E-4 ID:SGTC_2283|Compound:7944793|FD-Score:5.19|P-value:3.67E-6 ID:SGTC_2286|Compound:7945697|FD-Score:3.80|P-value:5.68E-4 ID:SGTC_2289|Compound:7946404|FD-Score:8.79|P-value:9.97E-15 ID:SGTC_2345|Compound:9052315|FD-Score:4.67|P-value:2.86E-5 ID:SGTC_2357|Compound:9067248|FD-Score:3.73|P-value:7.09E-4 ID:SGTC_2472|Compound:5377652|FD-Score:4.60|P-value:3.78E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.11|P-value:2.07E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.44|P-value:1.17E-8 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.69|P-value:4.16E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.29|P-value:1.11E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:6.39|P-value:1.54E-8 ID:SGTC_2695|Compound:st077686|FD-Score:5.41|P-value:1.47E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.94|P-value:1.02E-5 ID:SGTC_2715|Compound:st079500|FD-Score:3.84|P-value:5.02E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.31|P-value:2.24E-6 ID:SGTC_2821|Compound:7996764|FD-Score:4.89|P-value:1.26E-5 ID:SGTC_2824|Compound:7998404|FD-Score:-5.27|P-value:1.08E-6 ID:SGTC_2832|Compound:7992762|FD-Score:4.14|P-value:1.87E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.28|P-value:1.18E-4 ID:SGTC_2927|Compound:9011802|FD-Score:4.20|P-value:1.55E-4 ID:SGTC_2983|Compound:9022671|FD-Score:5.37|P-value:1.70E-6 ID:SGTC_2985|Compound:9022375|FD-Score:3.84|P-value:4.94E-4 ID:SGTC_3152|Compound:9099253|FD-Score:5.35|P-value:1.87E-6 ID:SGTC_3153|Compound:9100258|FD-Score:4.21|P-value:1.48E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.78|P-value:5.93E-4 ID:SGTC_3245|Compound:9134821|FD-Score:4.45|P-value:6.44E-5 ID:SGTC_3248|Compound:9135562|FD-Score:3.75|P-value:6.48E-4 ID:SGTC_3277|Compound:9138724|FD-Score:3.87|P-value:4.48E-4 ID:SGTC_3281|Compound:9140613|FD-Score:4.45|P-value:6.38E-5 ID:SGTC_3289|Compound:9119912|FD-Score:4.38|P-value:8.11E-5 ID:SGTC_3293|Compound:9120939|FD-Score:-3.54|P-value:6.53E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-8.53|P-value:1.33E-14 ID:SGTC_70|Compound:0141-0289|FD-Score:4.06|P-value:2.46E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.77|P-value:1.98E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.77|P-value:6.25E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.71|P-value:7.42E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.07|P-value:1.15E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.21|P-value:1.49E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-4.19|P-value:7.53E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:3.74|P-value:6.77E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:6.24|P-value:3.28E-8 ID:SGTC_708|Compound:3448-5400|FD-Score:5.16|P-value:4.20E-6 ID:SGTC_743|Compound:1275-0778|FD-Score:-3.61|P-value:5.25E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.94|P-value:3.60E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:-3.44|P-value:8.79E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.65|P-value:8.93E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.18|P-value:1.64E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.60|P-value:3.71E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:5.69|P-value:4.22E-7 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.09|P-value:2.24E-4 ID:SGTC_1615|Compound:st002656|FD-Score:4.50|P-value:5.38E-5 ID:SGTC_1623|Compound:st003709|FD-Score:4.71|P-value:2.50E-5 ID:SGTC_1624|Compound:st003710|FD-Score:3.76|P-value:6.30E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.77|P-value:1.97E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.71|P-value:7.39E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.60|P-value:5.19E-9 ID:SGTC_1991|Compound:st073000|FD-Score:5.41|P-value:1.45E-6 ID:SGTC_2007|Compound:4011539|FD-Score:3.67|P-value:8.27E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.04|P-value:2.63E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.85|P-value:2.43E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-4.82|P-value:7.08E-6 ID:SGTC_2055|Compound:5235184|FD-Score:-3.97|P-value:1.64E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.32|P-value:1.01E-4 ID:SGTC_2194|Compound:5927483|FD-Score:4.14|P-value:1.90E-4 ID:SGTC_2199|Compound:6590217|FD-Score:4.69|P-value:2.69E-5 ID:SGTC_2242|Compound:6630449|FD-Score:4.08|P-value:2.32E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.15|P-value:1.84E-4 ID:SGTC_2283|Compound:7944793|FD-Score:5.19|P-value:3.67E-6 ID:SGTC_2286|Compound:7945697|FD-Score:3.80|P-value:5.68E-4 ID:SGTC_2289|Compound:7946404|FD-Score:8.79|P-value:9.97E-15 ID:SGTC_2345|Compound:9052315|FD-Score:4.67|P-value:2.86E-5 ID:SGTC_2357|Compound:9067248|FD-Score:3.73|P-value:7.09E-4 ID:SGTC_2472|Compound:5377652|FD-Score:4.60|P-value:3.78E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.11|P-value:2.07E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.44|P-value:1.17E-8 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.69|P-value:4.16E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.29|P-value:1.11E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:6.39|P-value:1.54E-8 ID:SGTC_2695|Compound:st077686|FD-Score:5.41|P-value:1.47E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.94|P-value:1.02E-5 ID:SGTC_2715|Compound:st079500|FD-Score:3.84|P-value:5.02E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.31|P-value:2.24E-6 ID:SGTC_2821|Compound:7996764|FD-Score:4.89|P-value:1.26E-5 ID:SGTC_2824|Compound:7998404|FD-Score:-5.27|P-value:1.08E-6 ID:SGTC_2832|Compound:7992762|FD-Score:4.14|P-value:1.87E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.28|P-value:1.18E-4 ID:SGTC_2927|Compound:9011802|FD-Score:4.20|P-value:1.55E-4 ID:SGTC_2983|Compound:9022671|FD-Score:5.37|P-value:1.70E-6 ID:SGTC_2985|Compound:9022375|FD-Score:3.84|P-value:4.94E-4 ID:SGTC_3152|Compound:9099253|FD-Score:5.35|P-value:1.87E-6 ID:SGTC_3153|Compound:9100258|FD-Score:4.21|P-value:1.48E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.78|P-value:5.93E-4 ID:SGTC_3245|Compound:9134821|FD-Score:4.45|P-value:6.44E-5 ID:SGTC_3248|Compound:9135562|FD-Score:3.75|P-value:6.48E-4 ID:SGTC_3277|Compound:9138724|FD-Score:3.87|P-value:4.48E-4 ID:SGTC_3281|Compound:9140613|FD-Score:4.45|P-value:6.38E-5 ID:SGTC_3289|Compound:9119912|FD-Score:4.38|P-value:8.11E-5 ID:SGTC_3293|Compound:9120939|FD-Score:-3.54|P-value:6.53E-4

Top fitness defect scores for YML115C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2289 7946404 8.79 165.1 µM 9.97E-15 10 7.78E-19
2 SGTC_1873 rapamycin 6.60 2.0 nM 5.19E-9 25 2.06E-11
3 SGTC_2582 agaric acid 6.44 100.0 µM 1.17E-8 redox potentiating 143 5.93E-11
4 SGTC_2689 tacrolimus 6.39 100.0 µM 1.54E-8 9 8.46E-11
5 SGTC_658 3253-0951 6.24 102.0 µM 3.28E-8 calcium & mitochondrial duress 12 2.26E-10
6 SGTC_1473 k844-0725 5.69 134.0 µM 4.22E-7 2 6.25E-9
7 SGTC_1991 st073000 5.41 8.9 µM 1.45E-6 NEO1 45 3.10E-8
8 SGTC_2695 st077686 5.41 52.0 µM 1.47E-6 13 3.17E-8
9 SGTC_2983 9022671 5.37 13.0 µM 1.70E-6 60S ribosome export 3 3.83E-8
10 SGTC_3152 9099253 5.35 49.5 µM 1.87E-6 NEO1-PIK1 71 4.33E-8
11 SGTC_2737 bleomycin 5.31 30.5 nM 2.24E-6 Golgi 39 5.47E-8
12 SGTC_2283 7944793 5.19 200.0 µM 3.67E-6 15 1.04E-7
13 SGTC_708 3448-5400 5.16 146.0 µM 4.20E-6 15 1.24E-7
14 SGTC_2697 mebhydrolin 4.94 72.4 µM 1.02E-5 NEO1 46 3.91E-7
15 SGTC_2821 7996764 4.89 71.4 µM 1.26E-5 17 5.16E-7
16 SGTC_1627 st003713 4.77 25.6 µM 1.97E-5 calcium & mitochondrial duress 45 9.24E-7
17 SGTC_146 3448-8650 4.77 53.1 µM 1.98E-5 NEO1-PIK1 95 9.29E-7
18 SGTC_1623 st003709 4.71 20.3 µM 2.50E-5 calcium & mitochondrial duress 38 1.26E-6
19 SGTC_2199 6590217 4.69 200.0 µM 2.69E-5 mitochondrial processes 2 1.39E-6
20 SGTC_2345 9052315 4.67 157.4 µM 2.86E-5 10 1.50E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.206 1.61E-33 YOR002W ALG6 hom Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease
0.198 4.67E-31 YLR342W FKS1 hom Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling
0.181 5.42E-26 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.172 1.33E-23 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.168 1.38E-22 YDL117W CYK3 hom SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants
0.167 1.83E-22 YDR525W_d API2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology
0.167 1.89E-22 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.165 6.16E-22 YGL027C CWH41 hom Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress
0.165 6.68E-22 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.163 1.82E-21 YML019W OST6 hom Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p
0.159 2.07E-20 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.151 1.75E-18 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.150 2.87E-18 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.149 4.36E-18 YAL058W CNE1 hom Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.148 6.19E-18 YEL036C ANP1 hom Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol