YML116W / ATR1

Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YML116W / ATR1

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:5.34|P-value:1.02E-10 ID:SGTC_41|Compound:0478-0632|FD-Score:4.97|P-value:1.70E-9 ID:SGTC_65|Compound:0798-0905|FD-Score:4.38|P-value:8.94E-8 ID:SGTC_209|Compound:4077-0173|FD-Score:2.65|P-value:7.80E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.25|P-value:5.38E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:2.97|P-value:1.91E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.23|P-value:7.12E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:2.81|P-value:3.96E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:2.80|P-value:4.04E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.32|P-value:4.75E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.53|P-value:1.61E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.46|P-value:2.32E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:-2.91|P-value:3.16E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.43|P-value:2.15E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.03|P-value:1.84E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:2.62|P-value:8.72E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.23|P-value:5.90E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.45|P-value:5.85E-8 ID:SGTC_1250|Compound:0485-0349|FD-Score:2.82|P-value:3.71E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:2.64|P-value:8.14E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-2.67|P-value:8.47E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-2.87|P-value:3.68E-4 ID:SGTC_2043|Compound:5101342|FD-Score:-3.36|P-value:3.87E-5 ID:SGTC_2110|Compound:5483698|FD-Score:3.35|P-value:3.22E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.71|P-value:6.02E-4 ID:SGTC_2189|Compound:6047310|FD-Score:-2.80|P-value:4.97E-4 ID:SGTC_2237|Compound:6667747|FD-Score:2.93|P-value:2.35E-4 ID:SGTC_2255|Compound:7941087|FD-Score:2.67|P-value:7.11E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.17|P-value:7.73E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-2.76|P-value:5.84E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.37|P-value:2.92E-5 ID:SGTC_2692|Compound:st077426|FD-Score:4.43|P-value:6.41E-8 ID:SGTC_2693|Compound:st077581|FD-Score:6.11|P-value:1.93E-13 ID:SGTC_2695|Compound:st077686|FD-Score:-3.23|P-value:7.40E-5 ID:SGTC_2956|Compound:9076196|FD-Score:-2.63|P-value:9.95E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:5.34|P-value:1.02E-10 ID:SGTC_41|Compound:0478-0632|FD-Score:4.97|P-value:1.70E-9 ID:SGTC_65|Compound:0798-0905|FD-Score:4.38|P-value:8.94E-8 ID:SGTC_209|Compound:4077-0173|FD-Score:2.65|P-value:7.80E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.25|P-value:5.38E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:2.97|P-value:1.91E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.23|P-value:7.12E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:2.81|P-value:3.96E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:2.80|P-value:4.04E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.32|P-value:4.75E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.53|P-value:1.61E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.46|P-value:2.32E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:-2.91|P-value:3.16E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.43|P-value:2.15E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.03|P-value:1.84E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:2.62|P-value:8.72E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.23|P-value:5.90E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.45|P-value:5.85E-8 ID:SGTC_1250|Compound:0485-0349|FD-Score:2.82|P-value:3.71E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:2.64|P-value:8.14E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-2.67|P-value:8.47E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-2.87|P-value:3.68E-4 ID:SGTC_2043|Compound:5101342|FD-Score:-3.36|P-value:3.87E-5 ID:SGTC_2110|Compound:5483698|FD-Score:3.35|P-value:3.22E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.71|P-value:6.02E-4 ID:SGTC_2189|Compound:6047310|FD-Score:-2.80|P-value:4.97E-4 ID:SGTC_2237|Compound:6667747|FD-Score:2.93|P-value:2.35E-4 ID:SGTC_2255|Compound:7941087|FD-Score:2.67|P-value:7.11E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.17|P-value:7.73E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-2.76|P-value:5.84E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.37|P-value:2.92E-5 ID:SGTC_2692|Compound:st077426|FD-Score:4.43|P-value:6.41E-8 ID:SGTC_2693|Compound:st077581|FD-Score:6.11|P-value:1.93E-13 ID:SGTC_2695|Compound:st077686|FD-Score:-3.23|P-value:7.40E-5 ID:SGTC_2956|Compound:9076196|FD-Score:-2.63|P-value:9.95E-4

Top fitness defect scores for YML116W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2693 st077581 6.11 40.7 µM 1.93E-13 5 5.13E-10
2 SGTC_39 0986-0283 5.34 58.4 µM 1.02E-10 calcium & mitochondrial duress 11 4.56E-8
3 SGTC_41 0478-0632 4.97 82.6 µM 1.70E-9 11 3.41E-7
4 SGTC_1203 3992-3522 4.45 103.0 µM 5.85E-8 17 4.32E-6
5 SGTC_2692 st077426 4.43 47.7 µM 6.41E-8 17 4.61E-6
6 SGTC_65 0798-0905 4.38 35.0 µM 8.94E-8 calcium & mitochondrial duress 69 5.86E-6
7 SGTC_1083 didemethylchlorpromazine sulfoxide 3.43 707.4 nM 2.15E-5 redox potentiating 112 3.02E-4
8 SGTC_2690 usnic acid 3.37 100.0 µM 2.92E-5 51 3.77E-4
9 SGTC_2110 5483698 3.35 200.0 µM 3.22E-5 TSC3-RPN4 39 4.05E-4
10 SGTC_773 4358-1457 3.25 44.6 µM 5.38E-5 64 5.86E-4
11 SGTC_1142 3253-1408 3.23 9.8 µM 5.90E-5 26 6.26E-4
12 SGTC_2438 5259590 3.17 200.0 µM 7.73E-5 40 7.62E-4
13 SGTC_808 0711-0032 2.97 135.0 µM 1.91E-4 55 0.00147
14 SGTC_2237 6667747 2.93 47.2 µM 2.35E-4 51 0.00170
15 SGTC_1250 0485-0349 2.82 40.2 µM 3.71E-4 95 0.00237
16 SGTC_916 4466-0038 2.81 42.0 nM 3.96E-4 cell wall 169 0.00249
17 SGTC_940 3232-1287 2.80 54.8 µM 4.04E-4 NEO1 98 0.00252
18 SGTC_2130 NSC 7 2.71 2.5 µM 6.02E-4 copper-dependent oxidative stress 127 0.00337
19 SGTC_2255 7941087 2.67 197.4 µM 7.11E-4 108 0.00380
20 SGTC_209 4077-0173 2.65 175.6 µM 7.80E-4 45 0.00406

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 1.10E-33 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.203 2.16E-32 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.190 1.03E-28 YOR020W-A_p YOR020W-A_p hom Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.184 4.66E-27 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.177 4.05E-25 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.176 1.04E-24 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.175 2.21E-24 YML101C CUE4 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication
0.155 1.51E-19 YDR305C HNT2 hom Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins
0.154 2.48E-19 YGR117C_p YGR117C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.154 3.13E-19 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.152 7.37E-19 YNL007C SIS1 het Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; has similarity to bacterial DnaJ proteins; protein abundance increases in response to DNA replication stress
0.149 3.81E-18 YKL187C FAT3 hom Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
0.149 4.38E-18 YDR246W TRS23 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4
0.146 1.46E-17 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.136 3.08E-15 YOL011W PLB3 hom Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro