YML117W / NAB6

Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP

Zygosity: Homozygous strain
fixedexpanded
Profile for YML117W / NAB6

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:13.80|P-value:7.89E-45 ID:SGTC_138|Compound:0850-0259|FD-Score:12.30|P-value:7.80E-36 ID:SGTC_147|Compound:4466-0538|FD-Score:3.90|P-value:3.82E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:3.60|P-value:1.32E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.14|P-value:7.38E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.40|P-value:4.01E-6 ID:SGTC_305|Compound:1682-2595|FD-Score:3.24|P-value:5.10E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.54|P-value:2.12E-6 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.32|P-value:3.87E-4 ID:SGTC_397|Compound:arbidol|FD-Score:5.87|P-value:1.38E-9 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.89|P-value:4.03E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:-3.07|P-value:9.45E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.82|P-value:5.44E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.61|P-value:1.26E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:10.10|P-value:4.37E-25 ID:SGTC_467|Compound:ro 31-8220|FD-Score:6.86|P-value:1.84E-12 ID:SGTC_514|Compound:4466-0038|FD-Score:10.10|P-value:9.74E-25 ID:SGTC_542|Compound:3381-0244|FD-Score:6.60|P-value:1.15E-11 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.47|P-value:2.21E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:5.02|P-value:1.83E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:9.19|P-value:6.30E-21 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.81|P-value:5.60E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:-3.26|P-value:4.85E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.79|P-value:6.08E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.39|P-value:3.02E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.16|P-value:6.78E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:8.58|P-value:1.69E-18 ID:SGTC_1081|Compound:sertraline|FD-Score:3.17|P-value:6.57E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:4.00|P-value:2.50E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.21|P-value:5.67E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:5.47|P-value:1.50E-8 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.16|P-value:6.76E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.07|P-value:9.18E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.25|P-value:4.94E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.71|P-value:8.67E-5 ID:SGTC_1515|Compound:3460-0031|FD-Score:-4.56|P-value:1.97E-6 ID:SGTC_1518|Compound:st038567|FD-Score:-5.90|P-value:1.16E-9 ID:SGTC_1590|Compound:st077108|FD-Score:3.82|P-value:5.40E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-5.47|P-value:1.50E-8 ID:SGTC_1682|Compound:st012968|FD-Score:3.59|P-value:1.35E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-4.05|P-value:2.04E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-4.24|P-value:8.63E-6 ID:SGTC_2245|Compound:6637752|FD-Score:3.51|P-value:1.84E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.10|P-value:1.60E-5 ID:SGTC_2289|Compound:7946404|FD-Score:4.31|P-value:6.32E-6 ID:SGTC_2312|Compound:7706453|FD-Score:-4.99|P-value:2.18E-7 ID:SGTC_2316|Compound:5844804|FD-Score:8.96|P-value:5.50E-20 ID:SGTC_2320|Compound:7373003|FD-Score:-6.57|P-value:1.41E-11 ID:SGTC_2367|Compound:9070478|FD-Score:10.20|P-value:2.97E-25 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.40|P-value:4.15E-6 ID:SGTC_2416|Compound:tofa|FD-Score:-4.26|P-value:8.00E-6 ID:SGTC_2460|Compound:5552655|FD-Score:-3.35|P-value:3.43E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-3.53|P-value:1.74E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.24|P-value:5.38E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:7.14|P-value:2.31E-13 ID:SGTC_2619|Compound:obliquin|FD-Score:10.70|P-value:6.80E-28 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.40|P-value:4.09E-6 ID:SGTC_2693|Compound:st077581|FD-Score:3.53|P-value:1.72E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.36|P-value:3.27E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.42|P-value:2.62E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:-3.86|P-value:4.57E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:4.24|P-value:8.45E-6 ID:SGTC_2790|Compound:5423970|FD-Score:4.11|P-value:1.52E-5 ID:SGTC_2823|Compound:7987624|FD-Score:3.10|P-value:8.49E-4 ID:SGTC_2848|Compound:9016370|FD-Score:5.20|P-value:6.98E-8 ID:SGTC_2864|Compound:9034755|FD-Score:-3.68|P-value:9.51E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-3.80|P-value:5.84E-5 ID:SGTC_3160|Compound:9100216|FD-Score:3.08|P-value:9.07E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.10|P-value:8.31E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.15|P-value:7.21E-4 ID:SGTC_3266|Compound:9136860|FD-Score:4.09|P-value:1.70E-5 ID:SGTC_3311|Compound:9131146|FD-Score:3.51|P-value:1.89E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.84|P-value:4.60E-7 ID:SGTC_3351|Compound:9150312|FD-Score:9.13|P-value:1.09E-20 ID:SGTC_58|Compound:0957-0393|FD-Score:13.80|P-value:7.89E-45 ID:SGTC_138|Compound:0850-0259|FD-Score:12.30|P-value:7.80E-36 ID:SGTC_147|Compound:4466-0538|FD-Score:3.90|P-value:3.82E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:3.60|P-value:1.32E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.14|P-value:7.38E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.40|P-value:4.01E-6 ID:SGTC_305|Compound:1682-2595|FD-Score:3.24|P-value:5.10E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.54|P-value:2.12E-6 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.32|P-value:3.87E-4 ID:SGTC_397|Compound:arbidol|FD-Score:5.87|P-value:1.38E-9 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.89|P-value:4.03E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:-3.07|P-value:9.45E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.82|P-value:5.44E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.61|P-value:1.26E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:10.10|P-value:4.37E-25 ID:SGTC_467|Compound:ro 31-8220|FD-Score:6.86|P-value:1.84E-12 ID:SGTC_514|Compound:4466-0038|FD-Score:10.10|P-value:9.74E-25 ID:SGTC_542|Compound:3381-0244|FD-Score:6.60|P-value:1.15E-11 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.47|P-value:2.21E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:5.02|P-value:1.83E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:9.19|P-value:6.30E-21 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.81|P-value:5.60E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:-3.26|P-value:4.85E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.79|P-value:6.08E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.39|P-value:3.02E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.16|P-value:6.78E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:8.58|P-value:1.69E-18 ID:SGTC_1081|Compound:sertraline|FD-Score:3.17|P-value:6.57E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:4.00|P-value:2.50E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.21|P-value:5.67E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:5.47|P-value:1.50E-8 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.16|P-value:6.76E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.07|P-value:9.18E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.25|P-value:4.94E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.71|P-value:8.67E-5 ID:SGTC_1515|Compound:3460-0031|FD-Score:-4.56|P-value:1.97E-6 ID:SGTC_1518|Compound:st038567|FD-Score:-5.90|P-value:1.16E-9 ID:SGTC_1590|Compound:st077108|FD-Score:3.82|P-value:5.40E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-5.47|P-value:1.50E-8 ID:SGTC_1682|Compound:st012968|FD-Score:3.59|P-value:1.35E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-4.05|P-value:2.04E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-4.24|P-value:8.63E-6 ID:SGTC_2245|Compound:6637752|FD-Score:3.51|P-value:1.84E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.10|P-value:1.60E-5 ID:SGTC_2289|Compound:7946404|FD-Score:4.31|P-value:6.32E-6 ID:SGTC_2312|Compound:7706453|FD-Score:-4.99|P-value:2.18E-7 ID:SGTC_2316|Compound:5844804|FD-Score:8.96|P-value:5.50E-20 ID:SGTC_2320|Compound:7373003|FD-Score:-6.57|P-value:1.41E-11 ID:SGTC_2367|Compound:9070478|FD-Score:10.20|P-value:2.97E-25 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.40|P-value:4.15E-6 ID:SGTC_2416|Compound:tofa|FD-Score:-4.26|P-value:8.00E-6 ID:SGTC_2460|Compound:5552655|FD-Score:-3.35|P-value:3.43E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-3.53|P-value:1.74E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.24|P-value:5.38E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:7.14|P-value:2.31E-13 ID:SGTC_2619|Compound:obliquin|FD-Score:10.70|P-value:6.80E-28 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.40|P-value:4.09E-6 ID:SGTC_2693|Compound:st077581|FD-Score:3.53|P-value:1.72E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.36|P-value:3.27E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.42|P-value:2.62E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:-3.86|P-value:4.57E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:4.24|P-value:8.45E-6 ID:SGTC_2790|Compound:5423970|FD-Score:4.11|P-value:1.52E-5 ID:SGTC_2823|Compound:7987624|FD-Score:3.10|P-value:8.49E-4 ID:SGTC_2848|Compound:9016370|FD-Score:5.20|P-value:6.98E-8 ID:SGTC_2864|Compound:9034755|FD-Score:-3.68|P-value:9.51E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-3.80|P-value:5.84E-5 ID:SGTC_3160|Compound:9100216|FD-Score:3.08|P-value:9.07E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.10|P-value:8.31E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.15|P-value:7.21E-4 ID:SGTC_3266|Compound:9136860|FD-Score:4.09|P-value:1.70E-5 ID:SGTC_3311|Compound:9131146|FD-Score:3.51|P-value:1.89E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.84|P-value:4.60E-7 ID:SGTC_3351|Compound:9150312|FD-Score:9.13|P-value:1.09E-20

Top fitness defect scores for YML117W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 13.80 9.0 µM 7.89E-45 cell wall 35 1.03E-43
2 SGTC_138 0850-0259 12.30 40.9 µM 7.80E-36 cell wall 26 5.98E-35
3 SGTC_2619 obliquin 10.70 87.9 µM 6.80E-28 cell wall 18 3.25E-27
4 SGTC_2367 9070478 10.20 135.4 µM 2.97E-25 cell wall 2 1.21E-24
5 SGTC_453 enantio-paf c16 10.10 10.0 µM 4.37E-25 6 1.77E-24
6 SGTC_514 4466-0038 10.10 2.6 nM 9.74E-25 cell wall 21 3.86E-24
7 SGTC_690 glyoxal 9.19 20.3 µM 6.30E-21 20 1.99E-20
8 SGTC_3351 9150312 9.13 21.6 µM 1.09E-20 cell wall 2 3.40E-20
9 SGTC_2316 5844804 8.96 197.4 µM 5.50E-20 1 1.64E-19
10 SGTC_916 4466-0038 8.58 42.0 nM 1.69E-18 cell wall 10 4.63E-18
11 SGTC_2584 androsterone 7.14 48.7 µM 2.31E-13 cell wall 35 4.67E-13
12 SGTC_467 ro 31-8220 6.86 72.8 µM 1.84E-12 calcium & mitochondrial duress 25 3.52E-12
13 SGTC_542 3381-0244 6.60 89.3 µM 1.15E-11 13 2.09E-11
14 SGTC_397 arbidol 5.87 50.0 µM 1.38E-9 cell wall 2 2.24E-9
15 SGTC_1282 0886-0010 5.47 32.4 µM 1.50E-8 endomembrane recycling 14 2.28E-8
16 SGTC_2582 agaric acid 5.24 100.0 µM 5.38E-8 redox potentiating 210 7.91E-8
17 SGTC_2848 9016370 5.20 26.0 µM 6.98E-8 8 1.02E-7
18 SGTC_666 0272-0154 5.02 136.0 µM 1.83E-7 cell wall 31 2.61E-7
19 SGTC_3350 9150499 4.84 3.6 µM 4.60E-7 cell wall 28 6.40E-7
20 SGTC_379 3970-0972 4.54 5.9 µM 2.12E-6 tubulin folding & SWR complex 20 2.85E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.496 9.11E-208 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.456 1.90E-171 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.449 5.34E-166 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.448 2.06E-165 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.394 2.19E-124 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.371 1.27E-109 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.359 1.12E-102 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.356 2.28E-100 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.355 5.32E-100 YLL021W SPA2 hom Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
0.353 1.32E-98 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.348 6.29E-96 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.344 1.45E-93 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.339 4.36E-91 YOR051C ETT1 hom Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough
0.332 4.42E-87 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.332 5.87E-87 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi