YMR055C / BUB2

Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR055C / BUB2

Click on Significant Values for Screen Details ID:SGTC_199|Compound:4063-0024|FD-Score:4.38|P-value:1.74E-6 ID:SGTC_204|Compound:1543-0184|FD-Score:-3.67|P-value:4.74E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.79|P-value:2.93E-5 ID:SGTC_297|Compound:0986-0032|FD-Score:3.10|P-value:5.13E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.56|P-value:7.53E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.13|P-value:4.37E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:6.15|P-value:3.53E-11 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-2.98|P-value:7.69E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.79|P-value:2.93E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.12|P-value:4.55E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.37|P-value:1.75E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.04|P-value:6.43E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:4.20|P-value:4.27E-6 ID:SGTC_730|Compound:1436-0052|FD-Score:3.21|P-value:3.36E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.03|P-value:9.72E-6 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.03|P-value:6.65E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-4.31|P-value:2.32E-6 ID:SGTC_1324|Compound:1418-0026|FD-Score:4.11|P-value:6.77E-6 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.72|P-value:4.10E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.54|P-value:7.61E-7 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.21|P-value:3.35E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.50|P-value:9.66E-5 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.90|P-value:1.05E-7 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:-3.35|P-value:1.83E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.07|P-value:5.63E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-3.15|P-value:4.09E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.07|P-value:5.68E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.02|P-value:6.99E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.49|P-value:1.07E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.53|P-value:9.36E-5 ID:SGTC_1867|Compound:st057372|FD-Score:2.92|P-value:9.87E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.59|P-value:7.21E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.11|P-value:6.62E-6 ID:SGTC_2133|Compound:5320837|FD-Score:-3.00|P-value:7.01E-4 ID:SGTC_2257|Compound:7960413|FD-Score:3.47|P-value:1.19E-4 ID:SGTC_2290|Compound:7904846|FD-Score:4.78|P-value:1.97E-7 ID:SGTC_2335|Compound:9018011|FD-Score:3.12|P-value:4.74E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.38|P-value:1.68E-4 ID:SGTC_2356|Compound:9061756|FD-Score:-3.10|P-value:4.80E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.50|P-value:1.03E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.41|P-value:1.51E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.50|P-value:1.04E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.71|P-value:4.21E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.43|P-value:1.22E-6 ID:SGTC_2576|Compound:guaiol|FD-Score:3.38|P-value:1.73E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.10|P-value:7.04E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.52|P-value:9.78E-5 ID:SGTC_2652|Compound:actinonin|FD-Score:3.03|P-value:6.63E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.01|P-value:7.07E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.55|P-value:8.50E-5 ID:SGTC_3003|Compound:9075612|FD-Score:5.24|P-value:1.41E-8 ID:SGTC_3028|Compound:9087778|FD-Score:3.79|P-value:2.91E-5 ID:SGTC_3111|Compound:9122088|FD-Score:4.18|P-value:4.76E-6 ID:SGTC_3114|Compound:9122766|FD-Score:3.09|P-value:5.41E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.52|P-value:8.36E-7 ID:SGTC_199|Compound:4063-0024|FD-Score:4.38|P-value:1.74E-6 ID:SGTC_204|Compound:1543-0184|FD-Score:-3.67|P-value:4.74E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.79|P-value:2.93E-5 ID:SGTC_297|Compound:0986-0032|FD-Score:3.10|P-value:5.13E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.56|P-value:7.53E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.13|P-value:4.37E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:6.15|P-value:3.53E-11 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-2.98|P-value:7.69E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.79|P-value:2.93E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.12|P-value:4.55E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.37|P-value:1.75E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.04|P-value:6.43E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:4.20|P-value:4.27E-6 ID:SGTC_730|Compound:1436-0052|FD-Score:3.21|P-value:3.36E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.03|P-value:9.72E-6 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.03|P-value:6.65E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-4.31|P-value:2.32E-6 ID:SGTC_1324|Compound:1418-0026|FD-Score:4.11|P-value:6.77E-6 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.72|P-value:4.10E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.54|P-value:7.61E-7 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.21|P-value:3.35E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.50|P-value:9.66E-5 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.90|P-value:1.05E-7 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:-3.35|P-value:1.83E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.07|P-value:5.63E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-3.15|P-value:4.09E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.07|P-value:5.68E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.02|P-value:6.99E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.49|P-value:1.07E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.53|P-value:9.36E-5 ID:SGTC_1867|Compound:st057372|FD-Score:2.92|P-value:9.87E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.59|P-value:7.21E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.11|P-value:6.62E-6 ID:SGTC_2133|Compound:5320837|FD-Score:-3.00|P-value:7.01E-4 ID:SGTC_2257|Compound:7960413|FD-Score:3.47|P-value:1.19E-4 ID:SGTC_2290|Compound:7904846|FD-Score:4.78|P-value:1.97E-7 ID:SGTC_2335|Compound:9018011|FD-Score:3.12|P-value:4.74E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.38|P-value:1.68E-4 ID:SGTC_2356|Compound:9061756|FD-Score:-3.10|P-value:4.80E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.50|P-value:1.03E-4 ID:SGTC_2369|Compound:9071472|FD-Score:3.41|P-value:1.51E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.50|P-value:1.04E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.71|P-value:4.21E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.43|P-value:1.22E-6 ID:SGTC_2576|Compound:guaiol|FD-Score:3.38|P-value:1.73E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.10|P-value:7.04E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.52|P-value:9.78E-5 ID:SGTC_2652|Compound:actinonin|FD-Score:3.03|P-value:6.63E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.01|P-value:7.07E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.55|P-value:8.50E-5 ID:SGTC_3003|Compound:9075612|FD-Score:5.24|P-value:1.41E-8 ID:SGTC_3028|Compound:9087778|FD-Score:3.79|P-value:2.91E-5 ID:SGTC_3111|Compound:9122088|FD-Score:4.18|P-value:4.76E-6 ID:SGTC_3114|Compound:9122766|FD-Score:3.09|P-value:5.41E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.52|P-value:8.36E-7

Top fitness defect scores for YMR055C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_436 n,n-dimethylsphingosine 6.15 3.3 µM 3.53E-11 2 3.92E-10
2 SGTC_3003 9075612 5.24 71.4 µM 1.41E-8 7 8.19E-8
3 SGTC_1539 benzyladenosine 4.90 56.0 µM 1.05E-7 3 4.88E-7
4 SGTC_2290 7904846 4.78 200.0 µM 1.97E-7 11 8.56E-7
5 SGTC_1341 1486-1360 4.54 280.0 µM 7.61E-7 13 2.87E-6
6 SGTC_3142 9086498 4.52 49.5 µM 8.36E-7 iron homeostasis 22 3.12E-6
7 SGTC_199 4063-0024 4.38 41.6 µM 1.74E-6 2 6.01E-6
8 SGTC_718 1130-0073 4.20 349.0 µM 4.27E-6 14 1.34E-5
9 SGTC_3111 9122088 4.18 49.5 µM 4.76E-6 3 1.47E-5
10 SGTC_2129 girgensonine 4.11 121.0 µM 6.62E-6 heme biosynthesis & mitochondrial translocase 25 1.98E-5
11 SGTC_1324 1418-0026 4.11 34.4 µM 6.77E-6 9 2.02E-5
12 SGTC_2612 dictamnine 4.10 15.5 µM 7.04E-6 RNA pol III & RNase P/MRP 41 2.09E-5
13 SGTC_934 2950-0684 4.03 338.0 µM 9.72E-6 21 2.79E-5
14 SGTC_3028 9087778 3.79 49.5 µM 2.91E-5 17 7.42E-5
15 SGTC_489 paxilline 3.79 115.0 µM 2.93E-5 PDR1 17 7.46E-5
16 SGTC_241 5hr heat shock (37°C) + cantharidin 3.79 155.4 µM 2.93E-5 cell wall signaling 80 7.47E-5
17 SGTC_1340 1486-1359 3.72 257.0 µM 4.10E-5 27 1.01E-4
18 SGTC_2485 5633444 3.71 17.8 µM 4.21E-5 redox potentiating 54 1.03E-4
19 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 3.59 14.9 µM 7.21E-5 17 1.67E-4
20 SGTC_2993 9054257 3.55 71.4 µM 8.50E-5 fatty acid desaturase (OLE1) 59 1.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.094 4.71E-8 YNL214W PEX17 hom Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis
0.094 5.09E-8 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.090 1.63E-7 YML017W PSP2 hom Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing
0.085 7.37E-7 YFL050C ALR2 hom Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition
0.081 2.76E-6 YKL163W PIR3 hom O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; PIR3 has a paralog, HSP150, that arose from the whole genome duplication
0.080 3.43E-6 YOL111C MDY2 hom Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes
0.079 5.07E-6 YOR117W RPT5 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1
0.078 5.44E-6 YMR194C-B CMC4 hom Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs
0.076 9.52E-6 YEL068C_p YEL068C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.075 1.39E-5 YOR080W DIA2 hom Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.075 1.43E-5 YBR185C MBA1 hom Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane
0.071 3.88E-5 YGR230W BNS1 hom Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis
0.070 4.80E-5 YLR449W FPR4 hom Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
0.069 6.14E-5 YIL096C_p YIL096C_p hom Putative S-adenosylmethionine-dependent methyltransferase; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis
0.069 7.07E-5 YHR019C DED81 het Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA