YMR056C / AAC1

Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR056C / AAC1

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:3.94|P-value:2.13E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:3.05|P-value:7.56E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.16|P-value:5.11E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.95|P-value:1.98E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:4.92|P-value:1.59E-7 ID:SGTC_617|Compound:3770-0098|FD-Score:8.38|P-value:1.75E-18 ID:SGTC_618|Compound:k072-0232|FD-Score:-3.05|P-value:8.23E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:4.03|P-value:1.41E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:3.43|P-value:1.80E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:5.73|P-value:1.33E-9 ID:SGTC_632|Compound:0781-2353|FD-Score:3.72|P-value:5.59E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.18|P-value:5.04E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.26|P-value:4.84E-6 ID:SGTC_647|Compound:0140-0236|FD-Score:3.09|P-value:6.60E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.11|P-value:6.49E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.20|P-value:4.37E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.18|P-value:5.04E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.47|P-value:1.70E-6 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.70|P-value:5.91E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:5.13|P-value:5.11E-8 ID:SGTC_1286|Compound:0929-0070|FD-Score:4.92|P-value:1.64E-7 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.31|P-value:2.89E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.83|P-value:3.36E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.13|P-value:4.83E-8 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.83|P-value:3.49E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.65|P-value:7.39E-5 ID:SGTC_1678|Compound:st019265|FD-Score:3.67|P-value:6.69E-5 ID:SGTC_1729|Compound:st035615|FD-Score:3.06|P-value:7.29E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.09|P-value:6.55E-4 ID:SGTC_1795|Compound:st049545|FD-Score:5.25|P-value:2.53E-8 ID:SGTC_1834|Compound:st055981|FD-Score:3.02|P-value:8.30E-4 ID:SGTC_1837|Compound:st055472|FD-Score:4.41|P-value:2.36E-6 ID:SGTC_1925|Compound:st057770|FD-Score:5.57|P-value:3.62E-9 ID:SGTC_1931|Compound:st074438|FD-Score:7.31|P-value:1.67E-14 ID:SGTC_1933|Compound:st074711|FD-Score:3.51|P-value:1.31E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.93|P-value:2.19E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.60|P-value:9.00E-5 ID:SGTC_2260|Compound:7964312|FD-Score:4.33|P-value:3.39E-6 ID:SGTC_2309|Compound:7664088|FD-Score:4.15|P-value:8.17E-6 ID:SGTC_2313|Compound:7726885|FD-Score:-4.51|P-value:1.54E-6 ID:SGTC_2429|Compound:5902844|FD-Score:-3.35|P-value:2.67E-4 ID:SGTC_2432|Compound:5630864|FD-Score:2.98|P-value:9.53E-4 ID:SGTC_2445|Compound:5742597|FD-Score:-3.15|P-value:5.77E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.35|P-value:3.08E-6 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.29|P-value:3.40E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.94|P-value:2.32E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-3.75|P-value:5.35E-5 ID:SGTC_2702|Compound:st077768|FD-Score:3.71|P-value:5.73E-5 ID:SGTC_2709|Compound:st078560|FD-Score:-3.56|P-value:1.19E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.55|P-value:1.13E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.28|P-value:4.29E-6 ID:SGTC_2799|Compound:7812892|FD-Score:3.35|P-value:2.45E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.55|P-value:1.12E-4 ID:SGTC_2850|Compound:9015429|FD-Score:3.06|P-value:7.30E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.77|P-value:4.49E-5 ID:SGTC_3174|Compound:9107204|FD-Score:3.08|P-value:6.68E-4 ID:SGTC_3177|Compound:9107506|FD-Score:3.07|P-value:6.96E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.95|P-value:2.05E-5 ID:SGTC_47|Compound:0149-0135|FD-Score:3.94|P-value:2.13E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:3.05|P-value:7.56E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.16|P-value:5.11E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.95|P-value:1.98E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:4.92|P-value:1.59E-7 ID:SGTC_617|Compound:3770-0098|FD-Score:8.38|P-value:1.75E-18 ID:SGTC_618|Compound:k072-0232|FD-Score:-3.05|P-value:8.23E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:4.03|P-value:1.41E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:3.43|P-value:1.80E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:5.73|P-value:1.33E-9 ID:SGTC_632|Compound:0781-2353|FD-Score:3.72|P-value:5.59E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.18|P-value:5.04E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.26|P-value:4.84E-6 ID:SGTC_647|Compound:0140-0236|FD-Score:3.09|P-value:6.60E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.11|P-value:6.49E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.20|P-value:4.37E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.18|P-value:5.04E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.47|P-value:1.70E-6 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.70|P-value:5.91E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:5.13|P-value:5.11E-8 ID:SGTC_1286|Compound:0929-0070|FD-Score:4.92|P-value:1.64E-7 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.31|P-value:2.89E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.83|P-value:3.36E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.13|P-value:4.83E-8 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.83|P-value:3.49E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.65|P-value:7.39E-5 ID:SGTC_1678|Compound:st019265|FD-Score:3.67|P-value:6.69E-5 ID:SGTC_1729|Compound:st035615|FD-Score:3.06|P-value:7.29E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.09|P-value:6.55E-4 ID:SGTC_1795|Compound:st049545|FD-Score:5.25|P-value:2.53E-8 ID:SGTC_1834|Compound:st055981|FD-Score:3.02|P-value:8.30E-4 ID:SGTC_1837|Compound:st055472|FD-Score:4.41|P-value:2.36E-6 ID:SGTC_1925|Compound:st057770|FD-Score:5.57|P-value:3.62E-9 ID:SGTC_1931|Compound:st074438|FD-Score:7.31|P-value:1.67E-14 ID:SGTC_1933|Compound:st074711|FD-Score:3.51|P-value:1.31E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.93|P-value:2.19E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.60|P-value:9.00E-5 ID:SGTC_2260|Compound:7964312|FD-Score:4.33|P-value:3.39E-6 ID:SGTC_2309|Compound:7664088|FD-Score:4.15|P-value:8.17E-6 ID:SGTC_2313|Compound:7726885|FD-Score:-4.51|P-value:1.54E-6 ID:SGTC_2429|Compound:5902844|FD-Score:-3.35|P-value:2.67E-4 ID:SGTC_2432|Compound:5630864|FD-Score:2.98|P-value:9.53E-4 ID:SGTC_2445|Compound:5742597|FD-Score:-3.15|P-value:5.77E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.35|P-value:3.08E-6 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.29|P-value:3.40E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.94|P-value:2.32E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-3.75|P-value:5.35E-5 ID:SGTC_2702|Compound:st077768|FD-Score:3.71|P-value:5.73E-5 ID:SGTC_2709|Compound:st078560|FD-Score:-3.56|P-value:1.19E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.55|P-value:1.13E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.28|P-value:4.29E-6 ID:SGTC_2799|Compound:7812892|FD-Score:3.35|P-value:2.45E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.55|P-value:1.12E-4 ID:SGTC_2850|Compound:9015429|FD-Score:3.06|P-value:7.30E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.77|P-value:4.49E-5 ID:SGTC_3174|Compound:9107204|FD-Score:3.08|P-value:6.68E-4 ID:SGTC_3177|Compound:9107506|FD-Score:3.07|P-value:6.96E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.95|P-value:2.05E-5

Top fitness defect scores for YMR056C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_617 3770-0098 8.38 35.0 µM 1.75E-18 exosome 3 2.69E-17
2 SGTC_1931 st074438 7.31 57.1 µM 1.67E-14 1 1.36E-13
3 SGTC_629 3448-6466 5.73 76.7 µM 1.33E-9 1 4.97E-9
4 SGTC_1925 st057770 5.57 10.1 µM 3.62E-9 TSC3-RPN4 4 1.26E-8
5 SGTC_1795 st049545 5.25 62.3 µM 2.53E-8 TSC3-RPN4 4 7.72E-8
6 SGTC_1495 4469-0029 5.13 237.0 µM 4.83E-8 65 1.41E-7
7 SGTC_1280 0880-0253 5.13 10.1 µM 5.11E-8 2 1.49E-7
8 SGTC_609 0986-0026 4.92 86.3 µM 1.59E-7 calcium & mitochondrial duress 12 4.28E-7
9 SGTC_1286 0929-0070 4.92 131.0 µM 1.64E-7 10 4.42E-7
10 SGTC_1197 1601-0112 4.47 267.0 µM 1.70E-6 7 3.89E-6
11 SGTC_1837 st055472 4.41 66.5 µM 2.36E-6 13 5.28E-6
12 SGTC_2451 5856223 4.35 45.7 µM 3.08E-6 16 6.78E-6
13 SGTC_2260 7964312 4.33 200.0 µM 3.39E-6 8 7.40E-6
14 SGTC_2759 disulfiram 4.28 3.4 µM 4.29E-6 18 9.22E-6
15 SGTC_644 1498-1197 4.26 63.3 µM 4.84E-6 13 1.03E-5
16 SGTC_2309 7664088 4.15 163.9 µM 8.17E-6 21 1.68E-5
17 SGTC_619 1652-1634 4.03 108.0 µM 1.41E-5 PDR1 19 2.80E-5
18 SGTC_594 1487-1584 3.95 10.8 µM 1.98E-5 24 3.83E-5
19 SGTC_3309 9129340 3.95 25.8 µM 2.05E-5 14 3.96E-5
20 SGTC_47 0149-0135 3.94 24.2 µM 2.13E-5 TSC3-RPN4 20 4.10E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 1.26E-13 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.098 1.33E-8 YLR222C UTP13 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.098 1.52E-8 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.097 2.12E-8 YNL140C_p YNL140C_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
0.096 2.78E-8 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.091 1.48E-7 YDR105C TMS1 hom Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance
0.090 1.60E-7 YOR243C PUS7 hom Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria
0.090 1.89E-7 YGR224W AZR1 hom Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole
0.088 3.02E-7 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.085 7.14E-7 YLR051C FCF2 het Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon
0.083 1.51E-6 YCR057C PWP2 het Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis
0.083 1.52E-6 YGR109C CLB6 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1
0.083 1.51E-6 YGL256W ADH4 hom Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency
0.083 1.52E-6 YAL029C MYO4 hom Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication
0.076 1.11E-5 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres