YMR068W / AVO2

Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR068W / AVO2

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:3.29|P-value:4.90E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:-3.42|P-value:2.02E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.57|P-value:1.75E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.09|P-value:9.98E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.03|P-value:8.41E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.29|P-value:3.32E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.78|P-value:4.79E-5 ID:SGTC_446|Compound:go6976|FD-Score:3.44|P-value:2.91E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.16|P-value:8.00E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.89|P-value:4.25E-7 ID:SGTC_687|Compound:k029-0044|FD-Score:-3.79|P-value:4.64E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.47|P-value:1.69E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:3.24|P-value:5.94E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.11|P-value:9.50E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.29|P-value:5.00E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.32|P-value:4.39E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.37|P-value:5.60E-6 ID:SGTC_1101|Compound:ebselen|FD-Score:-3.55|P-value:1.22E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.01|P-value:2.88E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.15|P-value:8.31E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.67|P-value:1.15E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.44|P-value:1.90E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.25|P-value:3.93E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.26|P-value:5.50E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.84|P-value:5.91E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:4.08|P-value:2.07E-5 ID:SGTC_1682|Compound:st012968|FD-Score:4.16|P-value:1.50E-5 ID:SGTC_1684|Compound:st024538|FD-Score:3.78|P-value:7.57E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-3.14|P-value:5.87E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.14|P-value:8.46E-4 ID:SGTC_1952|Compound:st077036|FD-Score:3.16|P-value:7.90E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.27|P-value:3.58E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-3.93|P-value:2.49E-5 ID:SGTC_2077|Compound:5212015|FD-Score:-3.44|P-value:1.89E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-3.51|P-value:1.44E-4 ID:SGTC_2266|Compound:7929956|FD-Score:4.67|P-value:1.33E-6 ID:SGTC_2367|Compound:9070478|FD-Score:3.56|P-value:1.79E-4 ID:SGTC_2413|Compound:inermin|FD-Score:-4.90|P-value:2.29E-7 ID:SGTC_2449|Compound:5812982|FD-Score:3.33|P-value:4.37E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.11|P-value:9.48E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.19|P-value:4.76E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.58|P-value:1.08E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.29|P-value:3.30E-4 ID:SGTC_2789|Compound:5281112|FD-Score:6.05|P-value:5.32E-10 ID:SGTC_2798|Compound:7813637|FD-Score:3.75|P-value:8.60E-5 ID:SGTC_2829|Compound:7992743|FD-Score:5.74|P-value:3.62E-9 ID:SGTC_2925|Compound:9010536|FD-Score:4.06|P-value:2.35E-5 ID:SGTC_3065|Compound:9113888|FD-Score:-3.02|P-value:8.83E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.56|P-value:1.78E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-4.31|P-value:4.58E-6 ID:SGTC_3292|Compound:9120825|FD-Score:-4.27|P-value:5.39E-6 ID:SGTC_3304|Compound:9125678|FD-Score:6.79|P-value:3.57E-12 ID:SGTC_3306|Compound:9127676|FD-Score:5.43|P-value:2.22E-8 ID:SGTC_23|Compound:0213-0011|FD-Score:3.29|P-value:4.90E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:-3.42|P-value:2.02E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.57|P-value:1.75E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.09|P-value:9.98E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.03|P-value:8.41E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.29|P-value:3.32E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.78|P-value:4.79E-5 ID:SGTC_446|Compound:go6976|FD-Score:3.44|P-value:2.91E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.16|P-value:8.00E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.89|P-value:4.25E-7 ID:SGTC_687|Compound:k029-0044|FD-Score:-3.79|P-value:4.64E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.47|P-value:1.69E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:3.24|P-value:5.94E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.11|P-value:9.50E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.29|P-value:5.00E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.32|P-value:4.39E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.37|P-value:5.60E-6 ID:SGTC_1101|Compound:ebselen|FD-Score:-3.55|P-value:1.22E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.01|P-value:2.88E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.15|P-value:8.31E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.67|P-value:1.15E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.44|P-value:1.90E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.25|P-value:3.93E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.26|P-value:5.50E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.84|P-value:5.91E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:4.08|P-value:2.07E-5 ID:SGTC_1682|Compound:st012968|FD-Score:4.16|P-value:1.50E-5 ID:SGTC_1684|Compound:st024538|FD-Score:3.78|P-value:7.57E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-3.14|P-value:5.87E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.14|P-value:8.46E-4 ID:SGTC_1952|Compound:st077036|FD-Score:3.16|P-value:7.90E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.27|P-value:3.58E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-3.93|P-value:2.49E-5 ID:SGTC_2077|Compound:5212015|FD-Score:-3.44|P-value:1.89E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-3.51|P-value:1.44E-4 ID:SGTC_2266|Compound:7929956|FD-Score:4.67|P-value:1.33E-6 ID:SGTC_2367|Compound:9070478|FD-Score:3.56|P-value:1.79E-4 ID:SGTC_2413|Compound:inermin|FD-Score:-4.90|P-value:2.29E-7 ID:SGTC_2449|Compound:5812982|FD-Score:3.33|P-value:4.37E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.11|P-value:9.48E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.19|P-value:4.76E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.58|P-value:1.08E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.29|P-value:3.30E-4 ID:SGTC_2789|Compound:5281112|FD-Score:6.05|P-value:5.32E-10 ID:SGTC_2798|Compound:7813637|FD-Score:3.75|P-value:8.60E-5 ID:SGTC_2829|Compound:7992743|FD-Score:5.74|P-value:3.62E-9 ID:SGTC_2925|Compound:9010536|FD-Score:4.06|P-value:2.35E-5 ID:SGTC_3065|Compound:9113888|FD-Score:-3.02|P-value:8.83E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.56|P-value:1.78E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-4.31|P-value:4.58E-6 ID:SGTC_3292|Compound:9120825|FD-Score:-4.27|P-value:5.39E-6 ID:SGTC_3304|Compound:9125678|FD-Score:6.79|P-value:3.57E-12 ID:SGTC_3306|Compound:9127676|FD-Score:5.43|P-value:2.22E-8

Top fitness defect scores for YMR068W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3304 9125678 6.79 46.1 µM 3.57E-12 9 5.52E-12
2 SGTC_2789 5281112 6.05 71.4 µM 5.32E-10 5 7.26E-10
3 SGTC_2829 7992743 5.74 58.4 µM 3.62E-9 10 4.71E-9
4 SGTC_3306 9127676 5.43 59.8 µM 2.22E-8 5 2.76E-8
5 SGTC_674 0498-0004 4.89 451.0 µM 4.25E-7 heme requiring 9 4.95E-7
6 SGTC_2266 7929956 4.67 200.0 µM 1.33E-6 15 1.51E-6
7 SGTC_1016 4226-1401 4.37 38.0 µM 5.60E-6 RNA pol III & RNase P/MRP 11 6.16E-6
8 SGTC_1682 st012968 4.16 530.0 nM 1.50E-5 11 1.62E-5
9 SGTC_1543 azetidyl-2-carboxylic acid 4.08 198.0 µM 2.07E-5 10 2.22E-5
10 SGTC_2925 9010536 4.06 32.5 µM 2.35E-5 azole & statin 43 2.50E-5
11 SGTC_1193 1488-0126 4.01 41.5 µM 2.88E-5 25 3.06E-5
12 SGTC_1395 3486-0190 3.84 4.3 µM 5.91E-5 13 6.20E-5
13 SGTC_1684 st024538 3.78 14.6 µM 7.57E-5 7 7.89E-5
14 SGTC_2798 7813637 3.75 45.5 µM 8.60E-5 38 8.94E-5
15 SGTC_1199 1638-0010 3.67 4.5 µM 1.15E-4 endomembrane recycling 38 1.19E-4
16 SGTC_50 0929-0078 3.57 56.4 µM 1.75E-4 63 1.80E-4
17 SGTC_3166 9102297 3.56 49.5 µM 1.78E-4 Golgi 40 1.83E-4
18 SGTC_2367 9070478 3.56 135.4 µM 1.79E-4 cell wall 50 1.84E-4
19 SGTC_446 go6976 3.44 132.0 µM 2.91E-4 26 2.96E-4
20 SGTC_2449 5812982 3.33 45.8 µM 4.37E-4 20 4.41E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.177 5.13E-25 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.169 6.08E-23 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.148 7.03E-18 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.146 2.39E-17 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.140 3.27E-16 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.133 1.18E-14 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.105 1.05E-9 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.104 1.30E-9 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.093 6.48E-8 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.093 6.27E-8 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.090 2.06E-7 YLR230W_d YLR230W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity
0.088 3.65E-7 YMR090W_p YMR090W_p hom Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability
0.087 5.06E-7 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.086 5.22E-7 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.083 1.37E-6 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication