Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene; relative distribution within the vacuolar membrane changes upon DNA replication stress

Zygosity: Homozygous strain
Profile for YMR160W / YMR160W

Click on Significant Values for Screen Details

Top fitness defect scores for YMR160W deletion by condition

RankScreen IDConditionFD ScoreConc
1 SGTC_1727 st034309 6.51 9.9 µM 1.10E-10 4 3.79E-11
2 SGTC_1495 4469-0029 5.78 237.0 µM 8.61E-9 56 3.79E-9
3 SGTC_1674 st016616 5.39 23.6 µM 7.24E-8 4 3.59E-8
4 SGTC_665 3914-0008 5.34 307.0 µM 9.04E-8 2 4.53E-8
5 SGTC_2634 4'-methoxyflavone 5.13 100.0 µM 2.67E-7 13 1.42E-7
6 SGTC_2697 mebhydrolin 5.07 72.4 µM 3.67E-7 NEO1 44 1.99E-7
7 SGTC_2081 5214970 4.74 32.3 µM 1.83E-6 10 1.08E-6
8 SGTC_2837 9008476 4.56 45.5 µM 4.09E-6 18 2.52E-6
9 SGTC_646 4092-0839 4.44 27.3 µM 7.06E-6 plasma membrane duress 16 4.48E-6
10 SGTC_1725 st036284 4.19 20.6 µM 2.12E-5 23 1.42E-5
11 SGTC_1421 4029-0249 4.14 71.4 µM 2.55E-5 12 1.73E-5
12 SGTC_1650 st011916 4.02 45.8 µM 4.26E-5 13 2.97E-5
13 SGTC_460 trequinsin 4.00 123.0 µM 4.61E-5 2 3.23E-5
14 SGTC_1744 st037937 3.89 38.9 µM 7.01E-5 30 5.02E-5
15 SGTC_2691 st077356 3.88 60.2 µM 7.29E-5 30 5.23E-5
16 SGTC_3265 9137266 3.79 49.5 µM 1.05E-4 11 7.63E-5
17 SGTC_3119 9125183 3.71 49.5 µM 1.42E-4 10 1.05E-4
18 SGTC_3104 9120930 3.70 49.5 µM 1.45E-4 16 1.08E-4
19 SGTC_2211 7117706 3.69 200.0 µM 1.54E-4 17 1.14E-4
20 SGTC_1644 st010134 3.68 20.9 µM 1.57E-4 mitochondrial processes 15 1.17E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 4.43E-11 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.108 3.32E-10 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.098 1.46E-8 YJL214W HXT8 hom Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
0.093 6.66E-8 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.089 2.46E-7 YEL063C CAN1 hom Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication
0.087 4.50E-7 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.085 8.50E-7 YHR097C_p YHR097C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
0.083 1.69E-6 YJR087W_d YJR087W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2
0.082 1.79E-6 YBR150C TBS1 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication
0.080 3.36E-6 YMR003W AIM34 hom Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss
0.080 3.54E-6 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.079 4.26E-6 YJR041C URB2 het Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
0.078 6.80E-6 YOR229W WTM2 hom Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats
0.076 9.25E-6 YOR140W SFL1 hom Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
0.073 2.50E-5 YPL163C SVS1 hom Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication