YMR207C / HFA1

Mitochondrial acetyl-coenzyme A carboxylase; catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR207C / HFA1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:4.13|P-value:1.06E-5 ID:SGTC_18|Compound:0111-0177|FD-Score:5.02|P-value:1.23E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:6.17|P-value:1.17E-10 ID:SGTC_73|Compound:0327-0325|FD-Score:3.24|P-value:4.17E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.56|P-value:1.20E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.11|P-value:8.21E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.56|P-value:1.32E-6 ID:SGTC_285|Compound:1486-1325|FD-Score:3.30|P-value:3.35E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.88|P-value:3.22E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:3.62|P-value:9.66E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.00|P-value:1.90E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:3.13|P-value:6.20E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.14|P-value:5.91E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.75|P-value:5.64E-5 ID:SGTC_1092|Compound:toremifene|FD-Score:3.71|P-value:6.59E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.54|P-value:1.34E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.65|P-value:8.34E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.81|P-value:5.46E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.37|P-value:2.55E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.28|P-value:3.53E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.86|P-value:3.49E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.07|P-value:9.42E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:-3.17|P-value:6.58E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-3.18|P-value:6.38E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.94|P-value:2.41E-5 ID:SGTC_1567|Compound:st069303|FD-Score:-3.31|P-value:3.97E-4 ID:SGTC_1594|Compound:piperine|FD-Score:5.23|P-value:3.71E-8 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.03|P-value:2.11E-5 ID:SGTC_1714|Compound:st033236|FD-Score:-4.63|P-value:1.25E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.85|P-value:4.75E-5 ID:SGTC_1755|Compound:st041960|FD-Score:-4.35|P-value:4.90E-6 ID:SGTC_1790|Compound:st045711|FD-Score:3.21|P-value:4.67E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.13|P-value:6.17E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.15|P-value:7.17E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.19|P-value:4.89E-4 ID:SGTC_2158|Compound:5657123|FD-Score:3.89|P-value:3.02E-5 ID:SGTC_2432|Compound:5630864|FD-Score:3.36|P-value:2.68E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.28|P-value:3.53E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.26|P-value:3.91E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:6.08|P-value:2.10E-10 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-5.61|P-value:5.54E-9 ID:SGTC_2788|Compound:5282734|FD-Score:4.25|P-value:5.95E-6 ID:SGTC_2899|Compound:9053889|FD-Score:-3.82|P-value:5.37E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-4.10|P-value:1.59E-5 ID:SGTC_2946|Compound:9065502|FD-Score:-3.89|P-value:3.87E-5 ID:SGTC_3048|Compound:9093155|FD-Score:-3.09|P-value:8.83E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.28|P-value:3.64E-4 ID:SGTC_3055|Compound:9094636|FD-Score:-3.56|P-value:1.49E-4 ID:SGTC_3175|Compound:9106517|FD-Score:-3.31|P-value:3.90E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-4.97|P-value:2.13E-7 ID:SGTC_3181|Compound:9108277|FD-Score:-5.72|P-value:3.01E-9 ID:SGTC_3211|Compound:9128781|FD-Score:3.19|P-value:5.05E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:4.13|P-value:1.06E-5 ID:SGTC_18|Compound:0111-0177|FD-Score:5.02|P-value:1.23E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:6.17|P-value:1.17E-10 ID:SGTC_73|Compound:0327-0325|FD-Score:3.24|P-value:4.17E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.56|P-value:1.20E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.11|P-value:8.21E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.56|P-value:1.32E-6 ID:SGTC_285|Compound:1486-1325|FD-Score:3.30|P-value:3.35E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.88|P-value:3.22E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:3.62|P-value:9.66E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.00|P-value:1.90E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:3.13|P-value:6.20E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.14|P-value:5.91E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.75|P-value:5.64E-5 ID:SGTC_1092|Compound:toremifene|FD-Score:3.71|P-value:6.59E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.54|P-value:1.34E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.65|P-value:8.34E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.81|P-value:5.46E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.37|P-value:2.55E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.28|P-value:3.53E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.86|P-value:3.49E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.07|P-value:9.42E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:-3.17|P-value:6.58E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-3.18|P-value:6.38E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.94|P-value:2.41E-5 ID:SGTC_1567|Compound:st069303|FD-Score:-3.31|P-value:3.97E-4 ID:SGTC_1594|Compound:piperine|FD-Score:5.23|P-value:3.71E-8 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.03|P-value:2.11E-5 ID:SGTC_1714|Compound:st033236|FD-Score:-4.63|P-value:1.25E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.85|P-value:4.75E-5 ID:SGTC_1755|Compound:st041960|FD-Score:-4.35|P-value:4.90E-6 ID:SGTC_1790|Compound:st045711|FD-Score:3.21|P-value:4.67E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.13|P-value:6.17E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.15|P-value:7.17E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.19|P-value:4.89E-4 ID:SGTC_2158|Compound:5657123|FD-Score:3.89|P-value:3.02E-5 ID:SGTC_2432|Compound:5630864|FD-Score:3.36|P-value:2.68E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.28|P-value:3.53E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.26|P-value:3.91E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:6.08|P-value:2.10E-10 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-5.61|P-value:5.54E-9 ID:SGTC_2788|Compound:5282734|FD-Score:4.25|P-value:5.95E-6 ID:SGTC_2899|Compound:9053889|FD-Score:-3.82|P-value:5.37E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-4.10|P-value:1.59E-5 ID:SGTC_2946|Compound:9065502|FD-Score:-3.89|P-value:3.87E-5 ID:SGTC_3048|Compound:9093155|FD-Score:-3.09|P-value:8.83E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.28|P-value:3.64E-4 ID:SGTC_3055|Compound:9094636|FD-Score:-3.56|P-value:1.49E-4 ID:SGTC_3175|Compound:9106517|FD-Score:-3.31|P-value:3.90E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-4.97|P-value:2.13E-7 ID:SGTC_3181|Compound:9108277|FD-Score:-5.72|P-value:3.01E-9 ID:SGTC_3211|Compound:9128781|FD-Score:3.19|P-value:5.05E-4

Top fitness defect scores for YMR207C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_59 0330-0160 6.17 1.3 µM 1.17E-10 35 3.46E-10
2 SGTC_2630 antimycin a 6.08 100.0 µM 2.10E-10 mitochondrial processes 10 6.06E-10
3 SGTC_1594 piperine 5.23 70.1 µM 3.71E-8 3 8.38E-8
4 SGTC_18 0111-0177 5.02 500.0 nM 1.23E-7 36 2.62E-7
5 SGTC_163 1327-0036 4.56 7.5 µM 1.32E-6 82 2.52E-6
6 SGTC_2788 5282734 4.25 71.4 µM 5.95E-6 32 1.05E-5
7 SGTC_7 0192-1582 4.13 4.2 µM 1.06E-5 53 1.82E-5
8 SGTC_920 mycophenolic acid 4.00 780.4 nM 1.90E-5 27 3.19E-5
9 SGTC_1564 D-Arginine 3.94 115.0 µM 2.41E-5 28 4.00E-5
10 SGTC_2158 5657123 3.89 3.6 µM 3.02E-5 7 4.94E-5
11 SGTC_787 4152-0075 3.88 138.0 µM 3.22E-5 24 5.26E-5
12 SGTC_1379 2144-0755 3.86 36.5 µM 3.49E-5 28 5.67E-5
13 SGTC_982 1491-0518 3.75 27.5 µM 5.64E-5 16 8.96E-5
14 SGTC_1092 toremifene 3.71 6.3 µM 6.59E-5 26 1.04E-4
15 SGTC_1162 k048-0130 3.65 20.1 µM 8.34E-5 Golgi 27 1.30E-4
16 SGTC_808 0711-0032 3.62 135.0 µM 9.66E-5 22 1.50E-4
17 SGTC_100 0086-0128 3.56 49.6 µM 1.20E-4 copper-dependent oxidative stress 71 1.84E-4
18 SGTC_1132 3456-3614 3.54 2.5 µM 1.34E-4 tubulin folding & SWR complex 74 2.04E-4
19 SGTC_1260 0700-1617 3.37 7.8 µM 2.55E-4 calcium & mitochondrial duress 51 3.77E-4
20 SGTC_2432 5630864 3.36 12.2 µM 2.68E-4 51 3.95E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.194 9.46E-30 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.182 2.94E-26 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.178 2.63E-25 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.154 3.32E-19 YBR221C PDB1 hom E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria
0.151 1.08E-18 YER061C CEM1 hom Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
0.131 2.30E-14 YNL071W LAT1 hom Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
0.127 1.58E-13 YLR044C PDC1 hom Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
0.127 1.69E-13 YGR208W SER2 hom Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
0.115 2.13E-11 YLR436C ECM30 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm
0.104 1.77E-9 YNL056W OCA2 hom Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
0.101 4.90E-9 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.099 7.87E-9 YMR216C SKY1 hom SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1
0.098 1.12E-8 YPR120C CLB5 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
0.098 1.31E-8 YLR095C IOC2 hom Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif
0.097 1.61E-8 YFL018C LPD1 hom Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes