YMR263W / SAP30

Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR263W / SAP30

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:4.24|P-value:4.47E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.79|P-value:4.87E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:5.32|P-value:4.44E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:3.49|P-value:6.33E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.01|P-value:1.06E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.89|P-value:1.67E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:6.94|P-value:7.19E-11 ID:SGTC_165|Compound:k038-0023|FD-Score:4.63|P-value:9.72E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:3.99|P-value:1.16E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:3.84|P-value:1.97E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:4.20|P-value:5.37E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:4.67|P-value:8.16E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.23|P-value:4.37E-9 ID:SGTC_455|Compound:paf C-16|FD-Score:4.42|P-value:2.21E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.58|P-value:4.44E-4 ID:SGTC_459|Compound:nigericin|FD-Score:4.22|P-value:4.93E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:4.26|P-value:4.28E-5 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.52|P-value:5.30E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:5.33|P-value:4.32E-7 ID:SGTC_671|Compound:0560-0003|FD-Score:3.61|P-value:4.40E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.39|P-value:8.89E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.85|P-value:1.91E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.23|P-value:4.81E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:3.37|P-value:9.33E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:4.43|P-value:2.17E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.73|P-value:2.62E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.92|P-value:2.79E-6 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.69|P-value:3.36E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:5.74|P-value:5.83E-8 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.36|P-value:2.86E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.64|P-value:3.91E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:4.19|P-value:5.42E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.36|P-value:9.68E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.33|P-value:9.90E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.90|P-value:1.60E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.59|P-value:4.68E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.39|P-value:8.98E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:4.66|P-value:8.52E-6 ID:SGTC_1430|Compound:4049-0248|FD-Score:4.28|P-value:3.90E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.48|P-value:6.67E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:4.53|P-value:1.46E-5 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:-3.38|P-value:8.48E-4 ID:SGTC_1659|Compound:st012954|FD-Score:4.13|P-value:6.85E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.70|P-value:3.24E-4 ID:SGTC_1715|Compound:st032160|FD-Score:4.52|P-value:1.53E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.52|P-value:5.83E-4 ID:SGTC_1797|Compound:st048695|FD-Score:3.38|P-value:9.14E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.59|P-value:4.71E-4 ID:SGTC_1994|Compound:st072947|FD-Score:4.32|P-value:3.37E-5 ID:SGTC_2007|Compound:4011539|FD-Score:7.36|P-value:5.06E-12 ID:SGTC_2009|Compound:4012297|FD-Score:8.51|P-value:1.88E-15 ID:SGTC_2129|Compound:girgensonine|FD-Score:6.40|P-value:1.64E-9 ID:SGTC_2162|Compound:5663267|FD-Score:3.70|P-value:3.21E-4 ID:SGTC_2191|Compound:5911152|FD-Score:4.46|P-value:1.92E-5 ID:SGTC_2221|Compound:6807166|FD-Score:4.09|P-value:8.02E-5 ID:SGTC_2347|Compound:9049783|FD-Score:3.82|P-value:2.14E-4 ID:SGTC_2391|Compound:6285546|FD-Score:4.09|P-value:8.05E-5 ID:SGTC_2486|Compound:5283202|FD-Score:3.62|P-value:4.26E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:5.52|P-value:1.72E-7 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:5.02|P-value:1.79E-6 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:5.61|P-value:1.07E-7 ID:SGTC_2602|Compound:kawain|FD-Score:4.52|P-value:1.51E-5 ID:SGTC_2825|Compound:7998094|FD-Score:3.70|P-value:3.24E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.62|P-value:3.85E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-3.36|P-value:9.07E-4 ID:SGTC_2997|Compound:9067075|FD-Score:5.44|P-value:2.51E-7 ID:SGTC_3108|Compound:9121785|FD-Score:3.59|P-value:4.63E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.50|P-value:6.20E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.80|P-value:2.08E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.60|P-value:4.41E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-3.77|P-value:2.34E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:4.24|P-value:4.47E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.79|P-value:4.87E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:5.32|P-value:4.44E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:3.49|P-value:6.33E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.01|P-value:1.06E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.89|P-value:1.67E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:6.94|P-value:7.19E-11 ID:SGTC_165|Compound:k038-0023|FD-Score:4.63|P-value:9.72E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:3.99|P-value:1.16E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:3.84|P-value:1.97E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:4.20|P-value:5.37E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:4.67|P-value:8.16E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.23|P-value:4.37E-9 ID:SGTC_455|Compound:paf C-16|FD-Score:4.42|P-value:2.21E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.58|P-value:4.44E-4 ID:SGTC_459|Compound:nigericin|FD-Score:4.22|P-value:4.93E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:4.26|P-value:4.28E-5 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.52|P-value:5.30E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:5.33|P-value:4.32E-7 ID:SGTC_671|Compound:0560-0003|FD-Score:3.61|P-value:4.40E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.39|P-value:8.89E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.85|P-value:1.91E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.23|P-value:4.81E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:3.37|P-value:9.33E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:4.43|P-value:2.17E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.73|P-value:2.62E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.92|P-value:2.79E-6 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.69|P-value:3.36E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:5.74|P-value:5.83E-8 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.36|P-value:2.86E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.64|P-value:3.91E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:4.19|P-value:5.42E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.36|P-value:9.68E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.33|P-value:9.90E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.90|P-value:1.60E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.59|P-value:4.68E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.39|P-value:8.98E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:4.66|P-value:8.52E-6 ID:SGTC_1430|Compound:4049-0248|FD-Score:4.28|P-value:3.90E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.48|P-value:6.67E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:4.53|P-value:1.46E-5 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:-3.38|P-value:8.48E-4 ID:SGTC_1659|Compound:st012954|FD-Score:4.13|P-value:6.85E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.70|P-value:3.24E-4 ID:SGTC_1715|Compound:st032160|FD-Score:4.52|P-value:1.53E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.52|P-value:5.83E-4 ID:SGTC_1797|Compound:st048695|FD-Score:3.38|P-value:9.14E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.59|P-value:4.71E-4 ID:SGTC_1994|Compound:st072947|FD-Score:4.32|P-value:3.37E-5 ID:SGTC_2007|Compound:4011539|FD-Score:7.36|P-value:5.06E-12 ID:SGTC_2009|Compound:4012297|FD-Score:8.51|P-value:1.88E-15 ID:SGTC_2129|Compound:girgensonine|FD-Score:6.40|P-value:1.64E-9 ID:SGTC_2162|Compound:5663267|FD-Score:3.70|P-value:3.21E-4 ID:SGTC_2191|Compound:5911152|FD-Score:4.46|P-value:1.92E-5 ID:SGTC_2221|Compound:6807166|FD-Score:4.09|P-value:8.02E-5 ID:SGTC_2347|Compound:9049783|FD-Score:3.82|P-value:2.14E-4 ID:SGTC_2391|Compound:6285546|FD-Score:4.09|P-value:8.05E-5 ID:SGTC_2486|Compound:5283202|FD-Score:3.62|P-value:4.26E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:5.52|P-value:1.72E-7 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:5.02|P-value:1.79E-6 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:5.61|P-value:1.07E-7 ID:SGTC_2602|Compound:kawain|FD-Score:4.52|P-value:1.51E-5 ID:SGTC_2825|Compound:7998094|FD-Score:3.70|P-value:3.24E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.62|P-value:3.85E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-3.36|P-value:9.07E-4 ID:SGTC_2997|Compound:9067075|FD-Score:5.44|P-value:2.51E-7 ID:SGTC_3108|Compound:9121785|FD-Score:3.59|P-value:4.63E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.50|P-value:6.20E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.80|P-value:2.08E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.60|P-value:4.41E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-3.77|P-value:2.34E-4

Top fitness defect scores for YMR263W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2009 4012297 8.51 12.1 µM 1.88E-15 cell wall signaling 11 9.06E-18
2 SGTC_2007 4011539 7.36 71.8 µM 5.06E-12 cell wall signaling 18 9.00E-14
3 SGTC_158 k038-0087 6.94 26.4 µM 7.19E-11 ubiquinone biosynthesis & proteasome 55 1.98E-12
4 SGTC_2129 girgensonine 6.40 121.0 µM 1.64E-9 heme biosynthesis & mitochondrial translocase 11 7.56E-11
5 SGTC_453 enantio-paf c16 6.23 10.0 µM 4.37E-9 38 2.37E-10
6 SGTC_1079 idarubicin 5.74 2.4 µM 5.83E-8 DNA damage response 8 4.85E-9
7 SGTC_2597 laccaic acid a 5.61 100.0 µM 1.07E-7 10 9.88E-9
8 SGTC_2500 5-alpha-androstan-3,17-dione 5.52 61.4 µM 1.72E-7 15 1.71E-8
9 SGTC_2997 9067075 5.44 71.4 µM 2.51E-7 unfolded protein response 25 2.65E-8
10 SGTC_642 0335-0876 5.33 158.0 µM 4.32E-7 ubiquinone biosynthesis & proteasome 18 4.98E-8
11 SGTC_64 000l-0018 5.32 272.1 µM 4.44E-7 ubiquinone biosynthesis & proteasome 98 5.15E-8
12 SGTC_2536 dehydroabietamide 5.02 32.0 µM 1.79E-6 7 2.60E-7
13 SGTC_976 1348-1067 4.92 47.6 µM 2.79E-6 60S ribosome export 11 4.36E-7
14 SGTC_58 0957-0393 4.79 9.0 µM 4.87E-6 cell wall 307 8.33E-7
15 SGTC_310 1273-0058 4.67 1.1 µM 8.16E-6 mitochondrial stress 197 1.52E-6
16 SGTC_1401 3807-4679 4.66 7.6 µM 8.52E-6 tubulin folding & SWR complex 11 1.60E-6
17 SGTC_165 k038-0023 4.63 64.4 µM 9.72E-6 ubiquinone biosynthesis & proteasome 56 1.86E-6
18 SGTC_1486 3970-0793 4.53 4.5 µM 1.46E-5 5 2.99E-6
19 SGTC_2602 kawain 4.52 100.0 µM 1.51E-5 15 3.11E-6
20 SGTC_1715 st032160 4.52 10.2 µM 1.53E-5 31 3.15E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.243 3.21E-46 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.221 2.45E-38 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.219 1.44E-37 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.217 3.53E-37 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.216 9.20E-37 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.212 1.80E-35 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.210 8.53E-35 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.203 1.67E-32 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.203 1.68E-32 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.199 1.91E-31 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.196 2.59E-30 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.190 1.59E-28 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.186 1.68E-27 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.185 2.55E-27 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.185 4.09E-27 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance