YMR304W / UBP15

Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR304W / UBP15

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:4.89|P-value:8.89E-6 ID:SGTC_79|Compound:0052-0007|FD-Score:5.37|P-value:1.18E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:7.33|P-value:5.69E-11 ID:SGTC_90|Compound:0870-0863|FD-Score:4.23|P-value:1.02E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:6.80|P-value:1.15E-9 ID:SGTC_129|Compound:0088-0017|FD-Score:7.31|P-value:6.44E-11 ID:SGTC_136|Compound:0097-0015|FD-Score:4.23|P-value:1.04E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.68|P-value:6.34E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.66|P-value:3.33E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:5.95|P-value:8.56E-8 ID:SGTC_397|Compound:arbidol|FD-Score:3.99|P-value:2.34E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.52|P-value:9.01E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:4.57|P-value:3.01E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:3.53|P-value:9.90E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:-3.79|P-value:3.91E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.03|P-value:1.81E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:11.80|P-value:2.29E-25 ID:SGTC_916|Compound:4466-0038|FD-Score:-7.83|P-value:2.33E-12 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:5.26|P-value:1.95E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:5.22|P-value:2.28E-6 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.74|P-value:5.26E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.74|P-value:5.13E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:6.70|P-value:1.93E-9 ID:SGTC_1570|Compound:verbenone|FD-Score:-6.30|P-value:1.29E-8 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.77|P-value:1.44E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:6.50|P-value:5.68E-9 ID:SGTC_1805|Compound:st050013|FD-Score:-3.49|P-value:9.94E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:-4.24|P-value:8.60E-5 ID:SGTC_1861|Compound:st057647|FD-Score:-3.77|P-value:4.16E-4 ID:SGTC_2046|Compound:4110841|FD-Score:-3.65|P-value:6.05E-4 ID:SGTC_2143|Compound:5623677|FD-Score:-4.07|P-value:1.57E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.51|P-value:3.79E-5 ID:SGTC_2430|Compound:5571206|FD-Score:-3.50|P-value:9.46E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.26|P-value:9.36E-5 ID:SGTC_2791|Compound:5663188|FD-Score:-3.53|P-value:8.83E-4 ID:SGTC_2843|Compound:9000894|FD-Score:-3.69|P-value:5.34E-4 ID:SGTC_2847|Compound:9005661|FD-Score:-3.94|P-value:2.43E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.89|P-value:8.89E-6 ID:SGTC_79|Compound:0052-0007|FD-Score:5.37|P-value:1.18E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:7.33|P-value:5.69E-11 ID:SGTC_90|Compound:0870-0863|FD-Score:4.23|P-value:1.02E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:6.80|P-value:1.15E-9 ID:SGTC_129|Compound:0088-0017|FD-Score:7.31|P-value:6.44E-11 ID:SGTC_136|Compound:0097-0015|FD-Score:4.23|P-value:1.04E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.68|P-value:6.34E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.66|P-value:3.33E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:5.95|P-value:8.56E-8 ID:SGTC_397|Compound:arbidol|FD-Score:3.99|P-value:2.34E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.52|P-value:9.01E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:4.57|P-value:3.01E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:3.53|P-value:9.90E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:-3.79|P-value:3.91E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.03|P-value:1.81E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:11.80|P-value:2.29E-25 ID:SGTC_916|Compound:4466-0038|FD-Score:-7.83|P-value:2.33E-12 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:5.26|P-value:1.95E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:5.22|P-value:2.28E-6 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.74|P-value:5.26E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.74|P-value:5.13E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:6.70|P-value:1.93E-9 ID:SGTC_1570|Compound:verbenone|FD-Score:-6.30|P-value:1.29E-8 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.77|P-value:1.44E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:6.50|P-value:5.68E-9 ID:SGTC_1805|Compound:st050013|FD-Score:-3.49|P-value:9.94E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:-4.24|P-value:8.60E-5 ID:SGTC_1861|Compound:st057647|FD-Score:-3.77|P-value:4.16E-4 ID:SGTC_2046|Compound:4110841|FD-Score:-3.65|P-value:6.05E-4 ID:SGTC_2143|Compound:5623677|FD-Score:-4.07|P-value:1.57E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.51|P-value:3.79E-5 ID:SGTC_2430|Compound:5571206|FD-Score:-3.50|P-value:9.46E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.26|P-value:9.36E-5 ID:SGTC_2791|Compound:5663188|FD-Score:-3.53|P-value:8.83E-4 ID:SGTC_2843|Compound:9000894|FD-Score:-3.69|P-value:5.34E-4 ID:SGTC_2847|Compound:9005661|FD-Score:-3.94|P-value:2.43E-4

Top fitness defect scores for YMR304W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_914 3820-6779 11.80 408.0 µM 2.29E-25 1 3.41E-32
2 SGTC_87 0100-0052 7.33 35.5 µM 5.69E-11 16 1.11E-13
3 SGTC_129 0088-0017 7.31 176.6 µM 6.44E-11 21 1.30E-13
4 SGTC_127 0180-0333 6.80 59.1 µM 1.15E-9 mitochondrial response to ROS 5 5.29E-12
5 SGTC_1564 D-Arginine 6.70 115.0 µM 1.93E-9 5 1.03E-11
6 SGTC_1575 cyproterone acetate 6.50 48.0 µM 5.68E-9 1 4.09E-11
7 SGTC_236 1509-0011 5.95 5.3 µM 8.56E-8 295 1.33E-9
8 SGTC_221 trifluoperazine 5.66 10.3 µM 3.33E-7 NEO1-PIK1 134 7.57E-9
9 SGTC_79 0052-0007 5.37 94.1 µM 1.18E-6 14 3.84E-8
10 SGTC_920 mycophenolic acid 5.26 780.4 nM 1.95E-6 6 7.28E-8
11 SGTC_1045 1348-1485 5.22 165.0 µM 2.28E-6 9 8.89E-8
12 SGTC_46 0329-0187a 4.89 2.2 µM 8.89E-6 40 5.08E-7
13 SGTC_1574 spiramycin 4.77 23.7 µM 1.44E-5 13 9.42E-7
14 SGTC_642 0335-0876 4.57 158.0 µM 3.01E-5 ubiquinone biosynthesis & proteasome 26 2.41E-6
15 SGTC_2368 9071271 4.51 200.0 µM 3.79E-5 19 3.24E-6
16 SGTC_2582 agaric acid 4.26 100.0 µM 9.36E-5 redox potentiating 286 1.03E-5
17 SGTC_90 0870-0863 4.23 4.6 µM 1.02E-4 39 1.15E-5
18 SGTC_136 0097-0015 4.23 404.5 µM 1.04E-4 60S ribosome export 13 1.18E-5
19 SGTC_397 arbidol 3.99 50.0 µM 2.34E-4 cell wall 19 3.31E-5
20 SGTC_1562 morin hydrate 3.74 59.1 µM 5.13E-4 21 9.02E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.185 4.24E-27 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.184 6.78E-27 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.183 1.14E-26 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
0.179 1.16E-25 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.178 2.80E-25 YDL107W MSS2 hom Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
0.177 3.88E-25 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.176 1.17E-24 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.174 3.42E-24 YER086W ILV1 hom Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
0.169 5.17E-23 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.168 1.28E-22 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.168 1.66E-22 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.164 1.13E-21 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.162 3.01E-21 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.160 1.30E-20 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.160 1.52E-20 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes