YNL118C / DCP2

Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex; removes the 5' cap structure from mRNAs prior to their degradation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL118C / DCP2

Click on Significant Values for Screen Details ID:SGTC_914|Compound:3820-6779|FD-Score:3.64|P-value:9.23E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:3.41|P-value:2.30E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.50|P-value:1.63E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-4.37|P-value:3.18E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.14|P-value:1.06E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-6.70|P-value:2.24E-12 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.66|P-value:8.62E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.39|P-value:2.23E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:-4.66|P-value:7.10E-7 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.12|P-value:6.74E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.37|P-value:3.57E-6 ID:SGTC_1285|Compound:0929-0069|FD-Score:5.11|P-value:7.53E-8 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.02|P-value:9.73E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.89|P-value:3.23E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.48|P-value:1.79E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.79|P-value:4.91E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.71|P-value:6.90E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.43|P-value:2.68E-6 ID:SGTC_1911|Compound:st060208|FD-Score:3.54|P-value:1.40E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.30|P-value:3.57E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.02|P-value:9.66E-4 ID:SGTC_1968|Compound:st069590|FD-Score:4.79|P-value:4.33E-7 ID:SGTC_1978|Compound:st071761|FD-Score:3.54|P-value:1.40E-4 ID:SGTC_2020|Compound:4017018|FD-Score:4.14|P-value:1.06E-5 ID:SGTC_2052|Compound:5265182|FD-Score:3.30|P-value:3.55E-4 ID:SGTC_2057|Compound:5236571|FD-Score:4.79|P-value:4.33E-7 ID:SGTC_2160|Compound:5660466|FD-Score:3.37|P-value:2.70E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.22|P-value:7.25E-6 ID:SGTC_2255|Compound:7941087|FD-Score:3.59|P-value:1.14E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.33|P-value:2.84E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.07|P-value:8.02E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.06|P-value:8.53E-4 ID:SGTC_2808|Compound:7946468|FD-Score:4.64|P-value:9.22E-7 ID:SGTC_3127|Compound:9126946|FD-Score:3.42|P-value:2.26E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.91|P-value:2.96E-5 ID:SGTC_3330|Compound:9141424|FD-Score:3.49|P-value:1.68E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.64|P-value:9.23E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:3.41|P-value:2.30E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.50|P-value:1.63E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-4.37|P-value:3.18E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.14|P-value:1.06E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-6.70|P-value:2.24E-12 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.66|P-value:8.62E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.39|P-value:2.23E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:-4.66|P-value:7.10E-7 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.12|P-value:6.74E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.37|P-value:3.57E-6 ID:SGTC_1285|Compound:0929-0069|FD-Score:5.11|P-value:7.53E-8 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.02|P-value:9.73E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.89|P-value:3.23E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.48|P-value:1.79E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.79|P-value:4.91E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.71|P-value:6.90E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.43|P-value:2.68E-6 ID:SGTC_1911|Compound:st060208|FD-Score:3.54|P-value:1.40E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.30|P-value:3.57E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.02|P-value:9.66E-4 ID:SGTC_1968|Compound:st069590|FD-Score:4.79|P-value:4.33E-7 ID:SGTC_1978|Compound:st071761|FD-Score:3.54|P-value:1.40E-4 ID:SGTC_2020|Compound:4017018|FD-Score:4.14|P-value:1.06E-5 ID:SGTC_2052|Compound:5265182|FD-Score:3.30|P-value:3.55E-4 ID:SGTC_2057|Compound:5236571|FD-Score:4.79|P-value:4.33E-7 ID:SGTC_2160|Compound:5660466|FD-Score:3.37|P-value:2.70E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.22|P-value:7.25E-6 ID:SGTC_2255|Compound:7941087|FD-Score:3.59|P-value:1.14E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.33|P-value:2.84E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.07|P-value:8.02E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.06|P-value:8.53E-4 ID:SGTC_2808|Compound:7946468|FD-Score:4.64|P-value:9.22E-7 ID:SGTC_3127|Compound:9126946|FD-Score:3.42|P-value:2.26E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.91|P-value:2.96E-5 ID:SGTC_3330|Compound:9141424|FD-Score:3.49|P-value:1.68E-4

Top fitness defect scores for YNL118C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1285 0929-0069 5.11 65.5 µM 7.53E-8 1 1.63E-7 0.98
2 SGTC_2057 5236571 4.79 38.3 µM 4.33E-7 RPP1 & pyrimidine depletion 10 8.51E-7 0.16
3 SGTC_1968 st069590 4.79 43.6 µM 4.33E-7 12 8.51E-7 0.60
4 SGTC_2808 7946468 4.64 45.5 µM 9.22E-7 2 1.74E-6 0.22
5 SGTC_1883 5-benzylidenerhodanine 4.43 20.0 µM 2.68E-6 TRP & mitochondrial translation 5 4.77E-6 0.32
6 SGTC_1254 0550-0035 4.37 264.0 µM 3.57E-6 6 6.26E-6 0.30
7 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 4.22 49.5 µM 7.25E-6 18 1.22E-5 0.00
8 SGTC_2020 4017018 4.14 200.0 µM 1.06E-5 6 1.75E-5 0.09
9 SGTC_1047 2043-3044 4.14 82.0 µM 1.06E-5 5 1.76E-5 0.09
10 SGTC_3137 9097352 3.91 49.5 µM 2.96E-5 6 4.63E-5 0.04
11 SGTC_1479 0549-0158 3.89 134.0 µM 3.23E-5 4 5.03E-5 0.07
12 SGTC_1724 st037281 3.79 8.3 µM 4.91E-5 16 7.48E-5 0.01
13 SGTC_1874 staurosporine 3.71 7.6 µM 6.90E-5 cell wall signaling 5 1.03E-4 0.22
14 SGTC_1055 3448-0672 3.66 86.0 µM 8.62E-5 17 1.27E-4 0.13
15 SGTC_914 3820-6779 3.64 408.0 µM 9.23E-5 5 1.36E-4 0.15
16 SGTC_2255 7941087 3.59 197.4 µM 1.14E-4 7 1.66E-4 0.08
17 SGTC_1978 st071761 3.54 42.0 µM 1.40E-4 TSC3-RPN4 10 2.02E-4 0.27
18 SGTC_1911 st060208 3.54 74.3 µM 1.40E-4 12 2.02E-4 0.29
19 SGTC_994 3910-0338 3.50 138.0 µM 1.63E-4 calcium & mitochondrial duress 21 2.33E-4 0.09
20 SGTC_3330 9141424 3.49 71.4 µM 1.68E-4 amide catabolism 6 2.40E-4 0.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 1.22E-13 YMR247C RKR1 hom RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice
0.108 2.98E-10 YMR204C INP1 hom Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane
0.108 4.59E-10 YFL010C WWM1 hom WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1
0.105 9.33E-10 YOR149C SMP3 het Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
0.097 1.53E-8 YJR141W_p YJR141W_p het Essential protein of unknown function
0.096 2.46E-8 YDR477W SNF1 hom AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation
0.088 2.94E-7 YAL030W SNC1 hom Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication
0.083 1.35E-6 YPL031C PHO85 hom Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle
0.082 1.97E-6 YOR080W DIA2 hom Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.081 2.30E-6 YPL187W MF(ALPHA)1 hom Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor
0.081 2.50E-6 YDR091C RLI1 het Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase; forms a complex with Lto1p and Yae1p that may be involved in protection of the ribosome from damage due to reactive oxygen species
0.078 5.74E-6 YGL053W PRM8 hom Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
0.077 9.05E-6 YDL141W BPL1 het Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation
0.075 1.26E-5 YDR409W SIZ1 hom SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring
0.074 1.63E-5 YGR186W TFG1 het TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74