YNL202W / SPS19

Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL202W / SPS19

Click on Significant Values for Screen Details ID:SGTC_93|Compound:0109-0045|FD-Score:5.44|P-value:1.74E-7 ID:SGTC_94|Compound:0334-0113|FD-Score:5.29|P-value:3.55E-7 ID:SGTC_97|Compound:0535-0701|FD-Score:4.59|P-value:8.78E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:3.74|P-value:2.36E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.61|P-value:3.67E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.44|P-value:6.63E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.03|P-value:8.26E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:3.61|P-value:3.66E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:4.01|P-value:8.96E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.98|P-value:1.00E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.39|P-value:7.81E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.95|P-value:1.09E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.62|P-value:3.62E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.93|P-value:1.17E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.48|P-value:5.78E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.90|P-value:1.31E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.47|P-value:5.90E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.44|P-value:6.47E-4 ID:SGTC_1481|Compound:3346-2004|FD-Score:3.39|P-value:7.63E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.53|P-value:4.79E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.73|P-value:2.43E-4 ID:SGTC_1758|Compound:st042942|FD-Score:-3.82|P-value:1.47E-4 ID:SGTC_1831|Compound:st055328|FD-Score:-3.27|P-value:9.66E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.74|P-value:2.37E-4 ID:SGTC_1987|Compound:st072290|FD-Score:4.13|P-value:5.57E-5 ID:SGTC_2085|Compound:5307070|FD-Score:3.59|P-value:3.90E-4 ID:SGTC_2127|Compound:5253358|FD-Score:4.36|P-value:2.22E-5 ID:SGTC_2185|Compound:6113692|FD-Score:3.89|P-value:1.37E-4 ID:SGTC_2246|Compound:7293507|FD-Score:4.52|P-value:1.16E-5 ID:SGTC_2268|Compound:7933382|FD-Score:3.59|P-value:3.95E-4 ID:SGTC_2352|Compound:9027995|FD-Score:3.91|P-value:1.27E-4 ID:SGTC_2397|Compound:5161689|FD-Score:8.05|P-value:2.08E-14 ID:SGTC_2402|Compound:5553605|FD-Score:3.95|P-value:1.09E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.58|P-value:3.38E-10 ID:SGTC_2495|Compound:cafestol|FD-Score:3.50|P-value:5.33E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.04|P-value:6.51E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.90|P-value:1.32E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.50|P-value:5.40E-4 ID:SGTC_2938|Compound:9059746|FD-Score:4.25|P-value:3.43E-5 ID:SGTC_2943|Compound:9068529|FD-Score:5.59|P-value:8.08E-8 ID:SGTC_2985|Compound:9022375|FD-Score:-4.65|P-value:5.25E-6 ID:SGTC_3008|Compound:9078912|FD-Score:4.07|P-value:7.06E-5 ID:SGTC_3196|Compound:9111891|FD-Score:4.42|P-value:1.77E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:5.44|P-value:1.74E-7 ID:SGTC_94|Compound:0334-0113|FD-Score:5.29|P-value:3.55E-7 ID:SGTC_97|Compound:0535-0701|FD-Score:4.59|P-value:8.78E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:3.74|P-value:2.36E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.61|P-value:3.67E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.44|P-value:6.63E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.03|P-value:8.26E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:3.61|P-value:3.66E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:4.01|P-value:8.96E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.98|P-value:1.00E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.39|P-value:7.81E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.95|P-value:1.09E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.62|P-value:3.62E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.93|P-value:1.17E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.48|P-value:5.78E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.90|P-value:1.31E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.47|P-value:5.90E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.44|P-value:6.47E-4 ID:SGTC_1481|Compound:3346-2004|FD-Score:3.39|P-value:7.63E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.53|P-value:4.79E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.73|P-value:2.43E-4 ID:SGTC_1758|Compound:st042942|FD-Score:-3.82|P-value:1.47E-4 ID:SGTC_1831|Compound:st055328|FD-Score:-3.27|P-value:9.66E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.74|P-value:2.37E-4 ID:SGTC_1987|Compound:st072290|FD-Score:4.13|P-value:5.57E-5 ID:SGTC_2085|Compound:5307070|FD-Score:3.59|P-value:3.90E-4 ID:SGTC_2127|Compound:5253358|FD-Score:4.36|P-value:2.22E-5 ID:SGTC_2185|Compound:6113692|FD-Score:3.89|P-value:1.37E-4 ID:SGTC_2246|Compound:7293507|FD-Score:4.52|P-value:1.16E-5 ID:SGTC_2268|Compound:7933382|FD-Score:3.59|P-value:3.95E-4 ID:SGTC_2352|Compound:9027995|FD-Score:3.91|P-value:1.27E-4 ID:SGTC_2397|Compound:5161689|FD-Score:8.05|P-value:2.08E-14 ID:SGTC_2402|Compound:5553605|FD-Score:3.95|P-value:1.09E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.58|P-value:3.38E-10 ID:SGTC_2495|Compound:cafestol|FD-Score:3.50|P-value:5.33E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.04|P-value:6.51E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.90|P-value:1.32E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.50|P-value:5.40E-4 ID:SGTC_2938|Compound:9059746|FD-Score:4.25|P-value:3.43E-5 ID:SGTC_2943|Compound:9068529|FD-Score:5.59|P-value:8.08E-8 ID:SGTC_2985|Compound:9022375|FD-Score:-4.65|P-value:5.25E-6 ID:SGTC_3008|Compound:9078912|FD-Score:4.07|P-value:7.06E-5 ID:SGTC_3196|Compound:9111891|FD-Score:4.42|P-value:1.77E-5

Top fitness defect scores for YNL202W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2397 5161689 8.05 200.0 µM 2.08E-14 3 4.10E-16
2 SGTC_2408 sulbentine 6.58 18.4 µM 3.38E-10 17 2.33E-11
3 SGTC_2943 9068529 5.59 45.3 µM 8.08E-8 3 1.13E-8
4 SGTC_93 0109-0045 5.44 59.2 µM 1.74E-7 DNA damage response 16 2.68E-8
5 SGTC_94 0334-0113 5.29 514.8 µM 3.55E-7 5 6.01E-8
6 SGTC_97 0535-0701 4.59 19.1 µM 8.78E-6 60S ribosome export 9 2.25E-6
7 SGTC_2246 7293507 4.52 91.6 µM 1.16E-5 22 3.09E-6
8 SGTC_3196 9111891 4.42 49.5 µM 1.77E-5 mitochondrial processes 12 4.95E-6
9 SGTC_2127 5253358 4.36 187.9 µM 2.22E-5 18 6.40E-6
10 SGTC_2938 9059746 4.25 27.3 µM 3.43E-5 fatty acid desaturase (OLE1) 35 1.05E-5
11 SGTC_1987 st072290 4.13 61.9 µM 5.57E-5 13 1.81E-5
12 SGTC_3008 9078912 4.07 71.4 µM 7.06E-5 14 2.36E-5
13 SGTC_580 1123-0028 4.03 41.0 µM 8.26E-5 DNA damage response 33 2.82E-5
14 SGTC_756 0508-1999 4.01 28.3 µM 8.96E-5 RPP1 & pyrimidine depletion 23 3.09E-5
15 SGTC_920 mycophenolic acid 3.98 780.4 nM 1.00E-4 28 3.51E-5
16 SGTC_2402 5553605 3.95 200.0 µM 1.09E-4 25 3.84E-5
17 SGTC_966 1300-0360 3.95 30.2 µM 1.09E-4 heme requiring 24 3.85E-5
18 SGTC_1097 itavastatin 3.93 7.2 µM 1.17E-4 azole & statin 21 4.17E-5
19 SGTC_2352 9027995 3.91 87.8 µM 1.27E-4 tubulin folding & SWR complex 31 4.57E-5
20 SGTC_1280 0880-0253 3.90 10.1 µM 1.31E-4 18 4.72E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 8.81E-14 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.118 6.99E-12 YPL171C OYE3 hom Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death
0.114 3.83E-11 YBR098W MMS4 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.106 8.70E-10 YLR262C-A TMA7 hom Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.104 1.37E-9 YKR091W SRL3 hom Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate
0.095 3.48E-8 YDL069C CBS1 hom Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
0.089 2.20E-7 YGL160W AIM14 hom NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p
0.087 3.90E-7 YGR049W SCM4 hom Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation
0.080 3.43E-6 YOR257W CDC31 het Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation
0.080 3.74E-6 YDR004W RAD57 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
0.078 6.42E-6 YOR174W MED4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.078 6.92E-6 YHR058C MED6 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress
0.077 8.24E-6 YDL037C BSC1 hom Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.076 9.51E-6 YPL155C KIP2 hom Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle
0.076 1.05E-5 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p