YNL216W / RAP1

Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL216W / RAP1

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:4.97|P-value:1.40E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.31|P-value:8.65E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:12.30|P-value:1.49E-31 ID:SGTC_168|Compound:3970-0862|FD-Score:5.48|P-value:1.16E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.35|P-value:7.51E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.97|P-value:9.02E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.31|P-value:9.00E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.42|P-value:6.29E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:5.75|P-value:2.97E-8 ID:SGTC_336|Compound:4111-0029|FD-Score:3.42|P-value:6.41E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.81|P-value:1.53E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.41|P-value:6.61E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.61|P-value:3.33E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.96|P-value:9.30E-5 ID:SGTC_482|Compound:fipronil|FD-Score:3.40|P-value:6.74E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.41|P-value:6.48E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.69|P-value:2.54E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.67|P-value:5.37E-6 ID:SGTC_594|Compound:1487-1584|FD-Score:6.74|P-value:9.93E-11 ID:SGTC_682|Compound:0kpi-0099|FD-Score:7.15|P-value:7.30E-12 ID:SGTC_756|Compound:0508-1999|FD-Score:-4.04|P-value:6.58E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:4.26|P-value:2.98E-5 ID:SGTC_847|Compound:0342-0274|FD-Score:3.67|P-value:2.76E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:-3.51|P-value:4.38E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:4.17|P-value:4.22E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.61|P-value:3.11E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.52|P-value:4.60E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.52|P-value:4.59E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.32|P-value:8.82E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.33|P-value:8.60E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.57|P-value:3.83E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:7.06|P-value:1.36E-11 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.59|P-value:3.60E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.74|P-value:2.10E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.54|P-value:9.26E-6 ID:SGTC_1234|Compound:0326-0494|FD-Score:-3.90|P-value:1.12E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.32|P-value:8.87E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.57|P-value:3.89E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.64|P-value:2.97E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.14|P-value:4.70E-5 ID:SGTC_1604|Compound:st002052|FD-Score:3.84|P-value:1.48E-4 ID:SGTC_1643|Compound:st009866|FD-Score:4.76|P-value:3.51E-6 ID:SGTC_1661|Compound:st013063|FD-Score:14.20|P-value:2.00E-41 ID:SGTC_1752|Compound:st044819|FD-Score:4.40|P-value:1.67E-5 ID:SGTC_1773|Compound:st048542|FD-Score:12.70|P-value:1.82E-33 ID:SGTC_1922|Compound:5578187|FD-Score:4.07|P-value:6.27E-5 ID:SGTC_1923|Compound:st058458|FD-Score:4.55|P-value:8.99E-6 ID:SGTC_1935|Compound:st074532|FD-Score:-4.10|P-value:5.12E-5 ID:SGTC_1975|Compound:st070967|FD-Score:4.73|P-value:4.10E-6 ID:SGTC_2035|Compound:5154463|FD-Score:3.59|P-value:3.64E-4 ID:SGTC_2051|Compound:5263410|FD-Score:4.03|P-value:7.35E-5 ID:SGTC_2151|Compound:5563267|FD-Score:3.37|P-value:7.41E-4 ID:SGTC_2241|Compound:6772625|FD-Score:6.18|P-value:2.72E-9 ID:SGTC_2337|Compound:9009472|FD-Score:3.85|P-value:1.42E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.31|P-value:9.07E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.48|P-value:5.26E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.30|P-value:9.39E-4 ID:SGTC_2601|Compound:securinine|FD-Score:5.10|P-value:7.64E-7 ID:SGTC_2648|Compound:atorvastatin|FD-Score:4.34|P-value:2.09E-5 ID:SGTC_2701|Compound:st077767|FD-Score:4.45|P-value:1.37E-5 ID:SGTC_2783|Compound:7738165|FD-Score:3.30|P-value:9.30E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.83|P-value:1.52E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.68|P-value:2.65E-4 ID:SGTC_2862|Compound:9027634|FD-Score:3.37|P-value:7.57E-4 ID:SGTC_2903|Compound:5923464|FD-Score:-3.68|P-value:2.41E-4 ID:SGTC_2916|Compound:7875993|FD-Score:4.46|P-value:1.32E-5 ID:SGTC_2935|Compound:9038016|FD-Score:4.25|P-value:3.10E-5 ID:SGTC_2988|Compound:9073640|FD-Score:3.50|P-value:4.92E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-3.72|P-value:2.16E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.39|P-value:7.07E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.08|P-value:6.05E-5 ID:SGTC_3173|Compound:9105693|FD-Score:3.81|P-value:1.66E-4 ID:SGTC_3175|Compound:9106517|FD-Score:4.64|P-value:6.16E-6 ID:SGTC_3187|Compound:9109394|FD-Score:3.77|P-value:1.90E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.62|P-value:3.20E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.35|P-value:8.00E-4 ID:SGTC_3282|Compound:9108498|FD-Score:4.91|P-value:1.83E-6 ID:SGTC_3331|Compound:9141060|FD-Score:-3.50|P-value:4.49E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:4.97|P-value:1.40E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.31|P-value:8.65E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:12.30|P-value:1.49E-31 ID:SGTC_168|Compound:3970-0862|FD-Score:5.48|P-value:1.16E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.35|P-value:7.51E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.97|P-value:9.02E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.31|P-value:9.00E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.42|P-value:6.29E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:5.75|P-value:2.97E-8 ID:SGTC_336|Compound:4111-0029|FD-Score:3.42|P-value:6.41E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.81|P-value:1.53E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.41|P-value:6.61E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.61|P-value:3.33E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.96|P-value:9.30E-5 ID:SGTC_482|Compound:fipronil|FD-Score:3.40|P-value:6.74E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.41|P-value:6.48E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.69|P-value:2.54E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.67|P-value:5.37E-6 ID:SGTC_594|Compound:1487-1584|FD-Score:6.74|P-value:9.93E-11 ID:SGTC_682|Compound:0kpi-0099|FD-Score:7.15|P-value:7.30E-12 ID:SGTC_756|Compound:0508-1999|FD-Score:-4.04|P-value:6.58E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:4.26|P-value:2.98E-5 ID:SGTC_847|Compound:0342-0274|FD-Score:3.67|P-value:2.76E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:-3.51|P-value:4.38E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:4.17|P-value:4.22E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.61|P-value:3.11E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.52|P-value:4.60E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.52|P-value:4.59E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.32|P-value:8.82E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.33|P-value:8.60E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.57|P-value:3.83E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:7.06|P-value:1.36E-11 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.59|P-value:3.60E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.74|P-value:2.10E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.54|P-value:9.26E-6 ID:SGTC_1234|Compound:0326-0494|FD-Score:-3.90|P-value:1.12E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.32|P-value:8.87E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.57|P-value:3.89E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.64|P-value:2.97E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.14|P-value:4.70E-5 ID:SGTC_1604|Compound:st002052|FD-Score:3.84|P-value:1.48E-4 ID:SGTC_1643|Compound:st009866|FD-Score:4.76|P-value:3.51E-6 ID:SGTC_1661|Compound:st013063|FD-Score:14.20|P-value:2.00E-41 ID:SGTC_1752|Compound:st044819|FD-Score:4.40|P-value:1.67E-5 ID:SGTC_1773|Compound:st048542|FD-Score:12.70|P-value:1.82E-33 ID:SGTC_1922|Compound:5578187|FD-Score:4.07|P-value:6.27E-5 ID:SGTC_1923|Compound:st058458|FD-Score:4.55|P-value:8.99E-6 ID:SGTC_1935|Compound:st074532|FD-Score:-4.10|P-value:5.12E-5 ID:SGTC_1975|Compound:st070967|FD-Score:4.73|P-value:4.10E-6 ID:SGTC_2035|Compound:5154463|FD-Score:3.59|P-value:3.64E-4 ID:SGTC_2051|Compound:5263410|FD-Score:4.03|P-value:7.35E-5 ID:SGTC_2151|Compound:5563267|FD-Score:3.37|P-value:7.41E-4 ID:SGTC_2241|Compound:6772625|FD-Score:6.18|P-value:2.72E-9 ID:SGTC_2337|Compound:9009472|FD-Score:3.85|P-value:1.42E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.31|P-value:9.07E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.48|P-value:5.26E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.30|P-value:9.39E-4 ID:SGTC_2601|Compound:securinine|FD-Score:5.10|P-value:7.64E-7 ID:SGTC_2648|Compound:atorvastatin|FD-Score:4.34|P-value:2.09E-5 ID:SGTC_2701|Compound:st077767|FD-Score:4.45|P-value:1.37E-5 ID:SGTC_2783|Compound:7738165|FD-Score:3.30|P-value:9.30E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.83|P-value:1.52E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.68|P-value:2.65E-4 ID:SGTC_2862|Compound:9027634|FD-Score:3.37|P-value:7.57E-4 ID:SGTC_2903|Compound:5923464|FD-Score:-3.68|P-value:2.41E-4 ID:SGTC_2916|Compound:7875993|FD-Score:4.46|P-value:1.32E-5 ID:SGTC_2935|Compound:9038016|FD-Score:4.25|P-value:3.10E-5 ID:SGTC_2988|Compound:9073640|FD-Score:3.50|P-value:4.92E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-3.72|P-value:2.16E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.39|P-value:7.07E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.08|P-value:6.05E-5 ID:SGTC_3173|Compound:9105693|FD-Score:3.81|P-value:1.66E-4 ID:SGTC_3175|Compound:9106517|FD-Score:4.64|P-value:6.16E-6 ID:SGTC_3187|Compound:9109394|FD-Score:3.77|P-value:1.90E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.62|P-value:3.20E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.35|P-value:8.00E-4 ID:SGTC_3282|Compound:9108498|FD-Score:4.91|P-value:1.83E-6 ID:SGTC_3331|Compound:9141060|FD-Score:-3.50|P-value:4.49E-4

Top fitness defect scores for YNL216W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1661 st013063 14.20 9.7 µM 2.00E-41 2 3.32E-46 3.94
2 SGTC_1773 st048542 12.70 73.6 µM 1.82E-33 1 2.73E-37 2.23
3 SGTC_159 3970-0959 12.30 50.0 µM 1.49E-31 2 3.79E-35 2.98
4 SGTC_682 0kpi-0099 7.15 17.0 µM 7.30E-12 12 4.20E-13 4.07E-5
5 SGTC_1023 4482-3888 7.06 16.0 µM 1.36E-11 TSC3-RPN4 1 8.44E-13 0.95
6 SGTC_594 1487-1584 6.74 10.8 µM 9.93E-11 2 7.79E-12 1.34
7 SGTC_2241 6772625 6.18 37.8 µM 2.72E-9 3 3.16E-10 1.36
8 SGTC_332 4112-0506 5.75 40.9 µM 2.97E-8 12 4.58E-9 0.59
9 SGTC_168 3970-0862 5.48 530.5 µM 1.16E-7 21 2.11E-8 0.05
10 SGTC_2601 securinine 5.10 100.0 µM 7.64E-7 8 1.72E-7 0.17
11 SGTC_12 0849-0099 4.97 9.3 µM 1.40E-6 3 3.39E-7 0.49
12 SGTC_3282 9108498 4.91 15.5 µM 1.83E-6 7 4.57E-7 0.04
13 SGTC_1643 st009866 4.76 20.2 µM 3.51E-6 17 9.48E-7 0.02
14 SGTC_1975 st070967 4.73 30.8 µM 4.10E-6 7 1.13E-6 0.21
15 SGTC_580 1123-0028 4.67 41.0 µM 5.37E-6 DNA damage response 14 1.52E-6 0.02
16 SGTC_3175 9106517 4.64 49.5 µM 6.16E-6 iron homeostasis 4 1.78E-6 0.32
17 SGTC_1923 st058458 4.55 19.1 µM 8.99E-6 8 2.71E-6 0.14
18 SGTC_1191 1487-1166 4.54 10.6 µM 9.26E-6 azole & statin 2 2.80E-6 0.37
19 SGTC_2916 7875993 4.46 68.8 µM 1.32E-5 2 4.16E-6 0.07
20 SGTC_2701 st077767 4.45 14.7 µM 1.37E-5 6 4.34E-6 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.204 8.32E-33 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.190 1.02E-28 YJR073C OPI3 hom Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis
0.179 1.75E-25 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.163 2.42E-21 YAL024C LTE1 hom Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
0.162 3.33E-21 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.142 1.15E-16 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.137 1.72E-15 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.134 6.39E-15 YDR005C MAF1 hom Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions
0.134 7.98E-15 YBR058C-A TSC3 hom Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
0.130 4.67E-14 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.123 7.61E-13 YOR262W GPN2 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion
0.119 5.54E-12 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.117 1.13E-11 YHR062C RPP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.115 2.10E-11 YNR006W VPS27 hom Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
0.115 2.83E-11 YMR185W RTP1 het Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene