YNL225C / CNM67

Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL225C / CNM67

Click on Significant Values for Screen Details ID:SGTC_29|Compound:0299-0004|FD-Score:-3.67|P-value:5.86E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.73|P-value:5.19E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.82|P-value:1.52E-7 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.58|P-value:7.60E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:-4.96|P-value:5.65E-6 ID:SGTC_133|Compound:0724-0033|FD-Score:3.86|P-value:3.41E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:9.00|P-value:1.07E-15 ID:SGTC_354|Compound:2783-3500|FD-Score:3.79|P-value:4.36E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.85|P-value:3.25E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.77|P-value:4.22E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.72|P-value:5.36E-4 ID:SGTC_493|Compound:zm226600|FD-Score:4.28|P-value:8.22E-5 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:4.57|P-value:2.95E-5 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.89|P-value:2.87E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.85|P-value:9.73E-6 ID:SGTC_724|Compound:3910-0327|FD-Score:4.36|P-value:6.37E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:4.68|P-value:1.89E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:4.72|P-value:1.66E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:3.80|P-value:4.16E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:4.62|P-value:2.38E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:3.77|P-value:4.63E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.08|P-value:1.66E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.79|P-value:4.37E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.01|P-value:2.13E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.64|P-value:6.95E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.53|P-value:9.57E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:6.04|P-value:5.24E-8 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.39|P-value:5.59E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:-3.50|P-value:9.74E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.25|P-value:9.26E-5 ID:SGTC_1623|Compound:st003709|FD-Score:3.61|P-value:7.60E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-4.93|P-value:6.38E-6 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.99|P-value:5.65E-6 ID:SGTC_1749|Compound:st037932|FD-Score:5.26|P-value:1.85E-6 ID:SGTC_1831|Compound:st055328|FD-Score:3.74|P-value:5.11E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.96|P-value:2.48E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.76|P-value:1.40E-5 ID:SGTC_1999|Compound:st074831|FD-Score:3.94|P-value:2.63E-4 ID:SGTC_2013|Compound:4024628|FD-Score:6.15|P-value:3.03E-8 ID:SGTC_2035|Compound:5154463|FD-Score:4.48|P-value:4.12E-5 ID:SGTC_2089|Compound:5281248|FD-Score:4.42|P-value:5.01E-5 ID:SGTC_2210|Compound:7115885|FD-Score:6.35|P-value:1.15E-8 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.19|P-value:1.14E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:3.89|P-value:3.10E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-4.02|P-value:1.87E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.29|P-value:8.04E-5 ID:SGTC_2323|Compound:6148992|FD-Score:4.59|P-value:2.68E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.20|P-value:1.10E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.86|P-value:3.41E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:-4.66|P-value:1.84E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:4.90|P-value:8.21E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.52|P-value:9.75E-4 ID:SGTC_2694|Compound:st077685|FD-Score:3.87|P-value:3.33E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.83|P-value:3.75E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.80|P-value:4.12E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.73|P-value:5.22E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-6.00|P-value:5.57E-8 ID:SGTC_2821|Compound:7996764|FD-Score:-6.46|P-value:5.75E-9 ID:SGTC_2822|Compound:7994718|FD-Score:8.20|P-value:2.58E-13 ID:SGTC_2851|Compound:9015922|FD-Score:3.97|P-value:2.38E-4 ID:SGTC_3094|Compound:9117742|FD-Score:5.96|P-value:7.60E-8 ID:SGTC_3159|Compound:9100096|FD-Score:3.69|P-value:5.96E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.69|P-value:5.92E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.63|P-value:7.10E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.67|P-value:5.86E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.73|P-value:5.19E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.82|P-value:1.52E-7 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.58|P-value:7.60E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:-4.96|P-value:5.65E-6 ID:SGTC_133|Compound:0724-0033|FD-Score:3.86|P-value:3.41E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:9.00|P-value:1.07E-15 ID:SGTC_354|Compound:2783-3500|FD-Score:3.79|P-value:4.36E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.85|P-value:3.25E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.77|P-value:4.22E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.72|P-value:5.36E-4 ID:SGTC_493|Compound:zm226600|FD-Score:4.28|P-value:8.22E-5 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:4.57|P-value:2.95E-5 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.89|P-value:2.87E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.85|P-value:9.73E-6 ID:SGTC_724|Compound:3910-0327|FD-Score:4.36|P-value:6.37E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:4.68|P-value:1.89E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:4.72|P-value:1.66E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:3.80|P-value:4.16E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:4.62|P-value:2.38E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:3.77|P-value:4.63E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.08|P-value:1.66E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.79|P-value:4.37E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.01|P-value:2.13E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.64|P-value:6.95E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.53|P-value:9.57E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:6.04|P-value:5.24E-8 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.39|P-value:5.59E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:-3.50|P-value:9.74E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.25|P-value:9.26E-5 ID:SGTC_1623|Compound:st003709|FD-Score:3.61|P-value:7.60E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-4.93|P-value:6.38E-6 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.99|P-value:5.65E-6 ID:SGTC_1749|Compound:st037932|FD-Score:5.26|P-value:1.85E-6 ID:SGTC_1831|Compound:st055328|FD-Score:3.74|P-value:5.11E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.96|P-value:2.48E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.76|P-value:1.40E-5 ID:SGTC_1999|Compound:st074831|FD-Score:3.94|P-value:2.63E-4 ID:SGTC_2013|Compound:4024628|FD-Score:6.15|P-value:3.03E-8 ID:SGTC_2035|Compound:5154463|FD-Score:4.48|P-value:4.12E-5 ID:SGTC_2089|Compound:5281248|FD-Score:4.42|P-value:5.01E-5 ID:SGTC_2210|Compound:7115885|FD-Score:6.35|P-value:1.15E-8 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.19|P-value:1.14E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:3.89|P-value:3.10E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-4.02|P-value:1.87E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.29|P-value:8.04E-5 ID:SGTC_2323|Compound:6148992|FD-Score:4.59|P-value:2.68E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.20|P-value:1.10E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.86|P-value:3.41E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:-4.66|P-value:1.84E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:4.90|P-value:8.21E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.52|P-value:9.75E-4 ID:SGTC_2694|Compound:st077685|FD-Score:3.87|P-value:3.33E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.83|P-value:3.75E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.80|P-value:4.12E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.73|P-value:5.22E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-6.00|P-value:5.57E-8 ID:SGTC_2821|Compound:7996764|FD-Score:-6.46|P-value:5.75E-9 ID:SGTC_2822|Compound:7994718|FD-Score:8.20|P-value:2.58E-13 ID:SGTC_2851|Compound:9015922|FD-Score:3.97|P-value:2.38E-4 ID:SGTC_3094|Compound:9117742|FD-Score:5.96|P-value:7.60E-8 ID:SGTC_3159|Compound:9100096|FD-Score:3.69|P-value:5.96E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.69|P-value:5.92E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.63|P-value:7.10E-4

Top fitness defect scores for YNL225C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_138 0850-0259 9.00 40.9 µM 1.07E-15 cell wall 54 1.09E-19
2 SGTC_2822 7994718 8.20 71.4 µM 2.58E-13 1 1.23E-16
3 SGTC_2210 7115885 6.35 190.4 µM 1.15E-8 cell wall signaling 9 1.10E-10
4 SGTC_2013 4024628 6.15 200.0 µM 3.03E-8 15 3.82E-10
5 SGTC_1489 4065-0444 6.04 182.0 µM 5.24E-8 3 7.71E-10
6 SGTC_3094 9117742 5.96 49.5 µM 7.60E-8 5 1.24E-9
7 SGTC_58 0957-0393 5.82 9.0 µM 1.52E-7 cell wall 221 3.00E-9
8 SGTC_1749 st037932 5.26 54.2 µM 1.85E-6 13 7.29E-8
9 SGTC_1681 tripelennamine 4.99 100.0 µM 5.65E-6 8 3.04E-7
10 SGTC_2533 agelasine 4.90 13.7 µM 8.21E-6 ERG2 27 4.89E-7
11 SGTC_602 3130-1533 4.85 38.1 µM 9.73E-6 4 6.07E-7
12 SGTC_1933 st074711 4.76 15.9 µM 1.40E-5 23 9.67E-7
13 SGTC_839 0122-0028 4.72 230.0 µM 1.66E-5 RSC complex & mRNA processing 18 1.20E-6
14 SGTC_831 k061-1017 4.68 217.0 µM 1.89E-5 translation 28 1.42E-6
15 SGTC_927 2425-1185 4.62 123.0 µM 2.38E-5 17 1.90E-6
16 SGTC_2323 6148992 4.59 148.3 µM 2.68E-5 19 2.20E-6
17 SGTC_494 Boc-Gly-Val-Val-CHO 4.57 140.0 µM 2.95E-5 4 2.50E-6
18 SGTC_2035 5154463 4.48 94.6 µM 4.12E-5 8 3.82E-6
19 SGTC_2089 5281248 4.42 129.7 µM 5.01E-5 superoxide 13 4.90E-6
20 SGTC_1495 4469-0029 4.39 237.0 µM 5.59E-5 88 5.63E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 2.86E-24 YLL021W SPA2 hom Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
0.173 6.81E-24 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.170 3.70E-23 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.160 1.12E-20 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.155 2.04E-19 YNL233W BNI4 hom Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p
0.146 2.17E-17 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.145 2.51E-17 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.145 2.96E-17 YOR051C ETT1 hom Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough
0.144 4.69E-17 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.143 1.01E-16 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.140 3.64E-16 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.138 8.66E-16 YNL059C ARP5 hom Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.138 9.52E-16 YDR540C IRC4 hom Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.137 1.49E-15 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.137 1.89E-15 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication