YNL240C / NAR1

Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL240C / NAR1

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:3.60|P-value:1.27E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.87|P-value:4.41E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.65|P-value:1.11E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.25|P-value:5.01E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:-4.63|P-value:1.36E-6 ID:SGTC_595|Compound:3909-8003|FD-Score:5.05|P-value:1.46E-7 ID:SGTC_603|Compound:3794-0023|FD-Score:5.65|P-value:4.92E-9 ID:SGTC_615|Compound:k087-0205|FD-Score:-4.01|P-value:2.41E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:3.08|P-value:8.86E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:5.87|P-value:1.27E-9 ID:SGTC_698|Compound:k064-0052|FD-Score:3.14|P-value:7.08E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.24|P-value:8.13E-6 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.20|P-value:6.07E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.63|P-value:1.14E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.27|P-value:4.45E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.18|P-value:6.11E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.04|P-value:2.03E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:-4.33|P-value:5.76E-6 ID:SGTC_1299|Compound:1079-1439|FD-Score:-3.75|P-value:7.42E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.34|P-value:3.54E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:-3.77|P-value:6.59E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.22|P-value:5.37E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:5.83|P-value:1.60E-9 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.42|P-value:2.52E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.89|P-value:3.87E-5 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.94|P-value:3.14E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.07|P-value:8.91E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.61|P-value:1.20E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-4.63|P-value:1.35E-6 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-4.72|P-value:8.66E-7 ID:SGTC_1891|Compound:st059073|FD-Score:4.94|P-value:2.66E-7 ID:SGTC_1912|Compound:st060209|FD-Score:7.62|P-value:4.96E-15 ID:SGTC_1916|Compound:st067606|FD-Score:3.72|P-value:7.86E-5 ID:SGTC_2102|Compound:5377816|FD-Score:3.21|P-value:5.55E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-3.52|P-value:1.79E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.93|P-value:3.22E-5 ID:SGTC_2187|Compound:6125751|FD-Score:3.09|P-value:8.42E-4 ID:SGTC_2205|Compound:7238770|FD-Score:4.11|P-value:1.49E-5 ID:SGTC_2206|Compound:7254556|FD-Score:4.91|P-value:3.07E-7 ID:SGTC_2208|Compound:7283366|FD-Score:5.05|P-value:1.46E-7 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:5.06|P-value:1.41E-7 ID:SGTC_2211|Compound:7117706|FD-Score:4.17|P-value:1.12E-5 ID:SGTC_2285|Compound:7945142|FD-Score:4.09|P-value:1.63E-5 ID:SGTC_2338|Compound:7999974|FD-Score:4.13|P-value:1.34E-5 ID:SGTC_2371|Compound:9071574|FD-Score:3.30|P-value:3.98E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.28|P-value:4.30E-4 ID:SGTC_2416|Compound:tofa|FD-Score:4.61|P-value:1.41E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-3.20|P-value:5.90E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.05|P-value:9.63E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:5.01|P-value:1.80E-7 ID:SGTC_2704|Compound:st078022|FD-Score:3.11|P-value:7.87E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.43|P-value:2.45E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.99|P-value:2.56E-5 ID:SGTC_2875|Compound:9039966|FD-Score:3.12|P-value:7.48E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.28|P-value:4.35E-4 ID:SGTC_2977|Compound:9011197|FD-Score:3.12|P-value:7.59E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-3.65|P-value:1.09E-4 ID:SGTC_3009|Compound:9080819|FD-Score:3.36|P-value:3.24E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.13|P-value:7.22E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-4.92|P-value:3.15E-7 ID:SGTC_3141|Compound:9094609|FD-Score:3.16|P-value:6.67E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.15|P-value:6.75E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.72|P-value:7.78E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-3.44|P-value:2.52E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-3.26|P-value:4.74E-4 ID:SGTC_3356|Compound:9151811|FD-Score:-4.43|P-value:3.54E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:3.60|P-value:1.27E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.87|P-value:4.41E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.65|P-value:1.11E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.25|P-value:5.01E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:-4.63|P-value:1.36E-6 ID:SGTC_595|Compound:3909-8003|FD-Score:5.05|P-value:1.46E-7 ID:SGTC_603|Compound:3794-0023|FD-Score:5.65|P-value:4.92E-9 ID:SGTC_615|Compound:k087-0205|FD-Score:-4.01|P-value:2.41E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:3.08|P-value:8.86E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:5.87|P-value:1.27E-9 ID:SGTC_698|Compound:k064-0052|FD-Score:3.14|P-value:7.08E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.24|P-value:8.13E-6 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.20|P-value:6.07E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.63|P-value:1.14E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.27|P-value:4.45E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.18|P-value:6.11E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.04|P-value:2.03E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:-4.33|P-value:5.76E-6 ID:SGTC_1299|Compound:1079-1439|FD-Score:-3.75|P-value:7.42E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.34|P-value:3.54E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:-3.77|P-value:6.59E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.22|P-value:5.37E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:5.83|P-value:1.60E-9 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.42|P-value:2.52E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.89|P-value:3.87E-5 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.94|P-value:3.14E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.07|P-value:8.91E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.61|P-value:1.20E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-4.63|P-value:1.35E-6 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-4.72|P-value:8.66E-7 ID:SGTC_1891|Compound:st059073|FD-Score:4.94|P-value:2.66E-7 ID:SGTC_1912|Compound:st060209|FD-Score:7.62|P-value:4.96E-15 ID:SGTC_1916|Compound:st067606|FD-Score:3.72|P-value:7.86E-5 ID:SGTC_2102|Compound:5377816|FD-Score:3.21|P-value:5.55E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-3.52|P-value:1.79E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.93|P-value:3.22E-5 ID:SGTC_2187|Compound:6125751|FD-Score:3.09|P-value:8.42E-4 ID:SGTC_2205|Compound:7238770|FD-Score:4.11|P-value:1.49E-5 ID:SGTC_2206|Compound:7254556|FD-Score:4.91|P-value:3.07E-7 ID:SGTC_2208|Compound:7283366|FD-Score:5.05|P-value:1.46E-7 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:5.06|P-value:1.41E-7 ID:SGTC_2211|Compound:7117706|FD-Score:4.17|P-value:1.12E-5 ID:SGTC_2285|Compound:7945142|FD-Score:4.09|P-value:1.63E-5 ID:SGTC_2338|Compound:7999974|FD-Score:4.13|P-value:1.34E-5 ID:SGTC_2371|Compound:9071574|FD-Score:3.30|P-value:3.98E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.28|P-value:4.30E-4 ID:SGTC_2416|Compound:tofa|FD-Score:4.61|P-value:1.41E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-3.20|P-value:5.90E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.05|P-value:9.63E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:5.01|P-value:1.80E-7 ID:SGTC_2704|Compound:st078022|FD-Score:3.11|P-value:7.87E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.43|P-value:2.45E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.99|P-value:2.56E-5 ID:SGTC_2875|Compound:9039966|FD-Score:3.12|P-value:7.48E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.28|P-value:4.35E-4 ID:SGTC_2977|Compound:9011197|FD-Score:3.12|P-value:7.59E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-3.65|P-value:1.09E-4 ID:SGTC_3009|Compound:9080819|FD-Score:3.36|P-value:3.24E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.13|P-value:7.22E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-4.92|P-value:3.15E-7 ID:SGTC_3141|Compound:9094609|FD-Score:3.16|P-value:6.67E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.15|P-value:6.75E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.72|P-value:7.78E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-3.44|P-value:2.52E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-3.26|P-value:4.74E-4 ID:SGTC_3356|Compound:9151811|FD-Score:-4.43|P-value:3.54E-6

Top fitness defect scores for YNL240C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1912 st060209 7.62 90.8 µM 4.96E-15 1 1.23E-14 1.09
2 SGTC_680 0417-1641 5.87 114.0 µM 1.27E-9 RPP1 & pyrimidine depletion 2 2.21E-9 0.91
3 SGTC_1364 1653-0028 5.83 37.6 µM 1.60E-9 2 2.76E-9 1.57
4 SGTC_603 3794-0023 5.65 45.9 µM 4.92E-9 1 8.23E-9 1.84
5 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 5.06 122.8 µM 1.41E-7 2 2.15E-7 0.12
6 SGTC_595 3909-8003 5.05 73.7 µM 1.46E-7 2 2.21E-7 0.55
7 SGTC_2208 7283366 5.05 200.0 µM 1.46E-7 1 2.22E-7 1.98
8 SGTC_2516 gossypol 5.01 71.5 µM 1.80E-7 6 2.72E-7 0.17
9 SGTC_1891 st059073 4.94 26.2 µM 2.66E-7 TSC3-RPN4 2 3.97E-7 0.64
10 SGTC_2206 7254556 4.91 147.0 µM 3.07E-7 60S ribosome export 3 4.57E-7 1.24
11 SGTC_2416 tofa 4.61 880.0 nM 1.41E-6 sphingolipid biosynthesis & PDR1 3 2.00E-6 0.51
12 SGTC_710 3448-4187 4.24 58.0 µM 8.13E-6 fatty acid desaturase (OLE1) 7 1.10E-5 0.01
13 SGTC_2211 7117706 4.17 200.0 µM 1.12E-5 1 1.51E-5 0.49
14 SGTC_2338 7999974 4.13 200.0 µM 1.34E-5 6 1.79E-5 0.08
15 SGTC_2205 7238770 4.11 200.0 µM 1.49E-5 1 1.99E-5 0.67
16 SGTC_2285 7945142 4.09 200.0 µM 1.63E-5 8 2.16E-5 0.15
17 SGTC_1136 pergolide 4.04 1.1 µM 2.03E-5 13 2.68E-5 0.03
18 SGTC_2864 9034755 3.99 47.6 µM 2.56E-5 6 3.35E-5 0.52
19 SGTC_1429 4049-0205 3.94 9.5 µM 3.14E-5 1 4.10E-5 0.59
20 SGTC_2162 5663267 3.93 200.0 µM 3.22E-5 10 4.19E-5 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 4.53E-11 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.106 8.52E-10 YOL013C HRD1 hom Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon
0.087 3.90E-7 YHL046C PAU13 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock
0.085 9.45E-7 YPR079W MRL1 hom Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress
0.083 1.39E-6 YML065W ORC1 het Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity
0.083 1.64E-6 YHR038W RRF1 hom Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria
0.080 3.61E-6 YOR079C ATX2 hom Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation
0.076 1.03E-5 YOR243C PUS7 hom Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria
0.073 2.34E-5 YML069W POB3 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.072 3.05E-5 YNR004W_p SWM2_p hom Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds
0.070 4.68E-5 YBR019C GAL10 hom UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers
0.069 6.22E-5 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.069 6.31E-5 YOR302W YOR302W hom CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA
0.068 7.91E-5 YDL076C RXT3 hom Subunit of the RPD3L complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress
0.068 8.16E-5 YKL021C MAK11 het Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats