YNR012W / URK1

Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR012W / URK1

Click on Significant Values for Screen Details ID:SGTC_34|Compound:0469-0683|FD-Score:3.44|P-value:4.28E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.91|P-value:5.99E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:3.27|P-value:7.85E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.28|P-value:7.46E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.31|P-value:5.42E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.55|P-value:2.96E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.98|P-value:6.74E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.78|P-value:9.67E-5 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:5.18|P-value:2.40E-7 ID:SGTC_569|Compound:4130-2812|FD-Score:-4.29|P-value:1.20E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:3.22|P-value:9.15E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:5.16|P-value:2.69E-7 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.57|P-value:2.72E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.32|P-value:5.37E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:7.52|P-value:1.29E-13 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.40|P-value:4.97E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.54|P-value:3.07E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:6.88|P-value:1.10E-11 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.77|P-value:1.82E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.84|P-value:7.91E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.47|P-value:3.84E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.20|P-value:9.83E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.87|P-value:8.89E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.50|P-value:3.50E-4 ID:SGTC_1606|Compound:st000094|FD-Score:-3.19|P-value:8.24E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-4.22|P-value:1.66E-5 ID:SGTC_1633|Compound:st005664|FD-Score:3.48|P-value:3.81E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.39|P-value:5.17E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-4.19|P-value:1.82E-5 ID:SGTC_1745|Compound:st081495|FD-Score:7.31|P-value:5.62E-13 ID:SGTC_1792|Compound:st045773|FD-Score:3.23|P-value:8.90E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.28|P-value:7.47E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.88|P-value:8.39E-5 ID:SGTC_1859|Compound:st055998|FD-Score:-3.38|P-value:4.34E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-3.45|P-value:3.39E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.48|P-value:6.81E-6 ID:SGTC_2120|Compound:5538279|FD-Score:-3.28|P-value:6.12E-4 ID:SGTC_2192|Compound:5915882|FD-Score:7.09|P-value:2.60E-12 ID:SGTC_2280|Compound:7785178|FD-Score:-3.35|P-value:4.74E-4 ID:SGTC_2363|Compound:9053361|FD-Score:4.06|P-value:4.05E-5 ID:SGTC_2367|Compound:9070478|FD-Score:5.61|P-value:2.52E-8 ID:SGTC_2378|Compound:9074213|FD-Score:4.00|P-value:5.19E-5 ID:SGTC_2387|Compound:9077560|FD-Score:3.38|P-value:5.33E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.68|P-value:1.79E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.58|P-value:2.62E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.68|P-value:2.76E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:5.99|P-value:2.80E-9 ID:SGTC_2885|Compound:9057732|FD-Score:-3.84|P-value:7.72E-5 ID:SGTC_2970|Compound:9090938|FD-Score:4.84|P-value:1.28E-6 ID:SGTC_3010|Compound:9080089|FD-Score:3.25|P-value:8.40E-4 ID:SGTC_3341|Compound:9147222|FD-Score:4.59|P-value:4.22E-6 ID:SGTC_3351|Compound:9150312|FD-Score:5.72|P-value:1.34E-8 ID:SGTC_34|Compound:0469-0683|FD-Score:3.44|P-value:4.28E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.91|P-value:5.99E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:3.27|P-value:7.85E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.28|P-value:7.46E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.31|P-value:5.42E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.55|P-value:2.96E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.98|P-value:6.74E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.78|P-value:9.67E-5 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:5.18|P-value:2.40E-7 ID:SGTC_569|Compound:4130-2812|FD-Score:-4.29|P-value:1.20E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:3.22|P-value:9.15E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:5.16|P-value:2.69E-7 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.57|P-value:2.72E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.32|P-value:5.37E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:7.52|P-value:1.29E-13 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.40|P-value:4.97E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.54|P-value:3.07E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:6.88|P-value:1.10E-11 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.77|P-value:1.82E-6 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.84|P-value:7.91E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.47|P-value:3.84E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.20|P-value:9.83E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.87|P-value:8.89E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.50|P-value:3.50E-4 ID:SGTC_1606|Compound:st000094|FD-Score:-3.19|P-value:8.24E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-4.22|P-value:1.66E-5 ID:SGTC_1633|Compound:st005664|FD-Score:3.48|P-value:3.81E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.39|P-value:5.17E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-4.19|P-value:1.82E-5 ID:SGTC_1745|Compound:st081495|FD-Score:7.31|P-value:5.62E-13 ID:SGTC_1792|Compound:st045773|FD-Score:3.23|P-value:8.90E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.28|P-value:7.47E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.88|P-value:8.39E-5 ID:SGTC_1859|Compound:st055998|FD-Score:-3.38|P-value:4.34E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-3.45|P-value:3.39E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.48|P-value:6.81E-6 ID:SGTC_2120|Compound:5538279|FD-Score:-3.28|P-value:6.12E-4 ID:SGTC_2192|Compound:5915882|FD-Score:7.09|P-value:2.60E-12 ID:SGTC_2280|Compound:7785178|FD-Score:-3.35|P-value:4.74E-4 ID:SGTC_2363|Compound:9053361|FD-Score:4.06|P-value:4.05E-5 ID:SGTC_2367|Compound:9070478|FD-Score:5.61|P-value:2.52E-8 ID:SGTC_2378|Compound:9074213|FD-Score:4.00|P-value:5.19E-5 ID:SGTC_2387|Compound:9077560|FD-Score:3.38|P-value:5.33E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.68|P-value:1.79E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.58|P-value:2.62E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.68|P-value:2.76E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:5.99|P-value:2.80E-9 ID:SGTC_2885|Compound:9057732|FD-Score:-3.84|P-value:7.72E-5 ID:SGTC_2970|Compound:9090938|FD-Score:4.84|P-value:1.28E-6 ID:SGTC_3010|Compound:9080089|FD-Score:3.25|P-value:8.40E-4 ID:SGTC_3341|Compound:9147222|FD-Score:4.59|P-value:4.22E-6 ID:SGTC_3351|Compound:9150312|FD-Score:5.72|P-value:1.34E-8

Top fitness defect scores for YNR012W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1175 0741-0056 7.52 27.6 µM 1.29E-13 1 2.83E-14
2 SGTC_1745 st081495 7.31 74.0 µM 5.62E-13 RNA processing & uracil transport 16 1.33E-13
3 SGTC_2192 5915882 7.09 198.5 µM 2.60E-12 RNA processing & uracil transport 7 6.65E-13
4 SGTC_1261 0712-0010 6.88 12.7 µM 1.10E-11 RNA processing & uracil transport 2 3.03E-12
5 SGTC_2584 androsterone 5.99 48.7 µM 2.80E-9 cell wall 59 1.02E-9
6 SGTC_3351 9150312 5.72 21.6 µM 1.34E-8 cell wall 9 5.29E-9
7 SGTC_2367 9070478 5.61 135.4 µM 2.52E-8 cell wall 13 1.03E-8
8 SGTC_494 Boc-Gly-Val-Val-CHO 5.18 140.0 µM 2.40E-7 1 1.10E-7
9 SGTC_957 1187-1561 5.16 14.1 µM 2.69E-7 7 1.24E-7
10 SGTC_453 enantio-paf c16 4.98 10.0 µM 6.74E-7 88 3.25E-7
11 SGTC_2970 9090938 4.84 41.9 µM 1.28E-6 RNA processing & uracil transport 13 6.41E-7
12 SGTC_1351 1496-0003 4.77 46.5 µM 1.82E-6 10 9.24E-7
13 SGTC_2569 tetrandrine 4.68 100.0 µM 2.76E-6 10 1.43E-6
14 SGTC_3341 9147222 4.59 25.9 µM 4.22E-6 RNA processing & uracil transport 4 2.24E-6
15 SGTC_2042 p-Dimethylaminoacetophenone 4.48 200.0 µM 6.81E-6 9 3.70E-6
16 SGTC_2363 9053361 4.06 176.0 µM 4.05E-5 Golgi 28 2.41E-5
17 SGTC_2378 9074213 4.00 121.4 µM 5.19E-5 RSC complex & mRNA processing 18 3.13E-5
18 SGTC_1851 st056236 3.88 18.9 µM 8.39E-5 16 5.19E-5
19 SGTC_1489 4065-0444 3.87 182.0 µM 8.89E-5 22 5.52E-5
20 SGTC_2390 9097792 3.68 176.6 µM 1.79E-4 20 1.15E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.163 2.40E-21 YLR420W URA4 hom Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
0.162 3.20E-21 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.151 1.35E-18 YNL307C MCK1 hom Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family
0.147 9.65E-18 YDR289C RTT103 hom Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
0.140 4.05E-16 YDR290W_d YDR290W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103
0.138 1.17E-15 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.136 2.90E-15 YLR014C PPR1 hom Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p
0.135 3.31E-15 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.133 1.12E-14 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.125 3.18E-13 YDR020C_p DAS2_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases
0.119 5.57E-12 YDR253C MET32 hom Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication
0.116 1.90E-11 YDR280W RRP45 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.113 4.78E-11 YDL173W PAR32 hom Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene
0.113 5.01E-11 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.111 1.24E-10 YML109W ZDS2 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication