YOL075C_p

Putative ABC transporter

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL075C / YOL075C

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:5.10|P-value:7.48E-10 ID:SGTC_57|Compound:miconazole|FD-Score:2.81|P-value:4.33E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:2.86|P-value:3.43E-4 ID:SGTC_83|Compound:0170-0301|FD-Score:3.01|P-value:1.81E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:2.92|P-value:2.71E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.19|P-value:8.06E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.40|P-value:2.87E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:3.40|P-value:2.82E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:2.78|P-value:4.78E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:-2.75|P-value:5.63E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:2.83|P-value:3.90E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.71|P-value:5.40E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:2.63|P-value:9.13E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.11|P-value:1.13E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.23|P-value:6.48E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:2.64|P-value:8.75E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.04|P-value:1.56E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.01|P-value:1.81E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:2.69|P-value:7.09E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:-2.68|P-value:7.49E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:2.88|P-value:3.22E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:-2.96|P-value:2.24E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-2.95|P-value:2.38E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.07|P-value:1.40E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-4.42|P-value:8.05E-8 ID:SGTC_1730|Compound:st033808|FD-Score:-3.42|P-value:2.62E-5 ID:SGTC_1733|Compound:st037357|FD-Score:-4.46|P-value:6.50E-8 ID:SGTC_2241|Compound:6772625|FD-Score:-3.87|P-value:2.27E-6 ID:SGTC_2293|Compound:7624732|FD-Score:-2.71|P-value:6.73E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.37|P-value:3.23E-5 ID:SGTC_2355|Compound:9061122|FD-Score:2.74|P-value:5.66E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.05|P-value:1.48E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.68|P-value:7.57E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.08|P-value:1.30E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-2.70|P-value:6.95E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-2.95|P-value:2.40E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.73|P-value:4.76E-6 ID:SGTC_3201|Compound:9113999|FD-Score:3.58|P-value:1.11E-5 ID:SGTC_3208|Compound:9114115|FD-Score:-2.94|P-value:2.51E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.03|P-value:1.68E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-5.45|P-value:5.35E-11 ID:SGTC_8|Compound:0354-0001|FD-Score:5.10|P-value:7.48E-10 ID:SGTC_57|Compound:miconazole|FD-Score:2.81|P-value:4.33E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:2.86|P-value:3.43E-4 ID:SGTC_83|Compound:0170-0301|FD-Score:3.01|P-value:1.81E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:2.92|P-value:2.71E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.19|P-value:8.06E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.40|P-value:2.87E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:3.40|P-value:2.82E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:2.78|P-value:4.78E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:-2.75|P-value:5.63E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:2.83|P-value:3.90E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.71|P-value:5.40E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:2.63|P-value:9.13E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.11|P-value:1.13E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.23|P-value:6.48E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:2.64|P-value:8.75E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.04|P-value:1.56E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.01|P-value:1.81E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:2.69|P-value:7.09E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:-2.68|P-value:7.49E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:2.88|P-value:3.22E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:-2.96|P-value:2.24E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-2.95|P-value:2.38E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.07|P-value:1.40E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-4.42|P-value:8.05E-8 ID:SGTC_1730|Compound:st033808|FD-Score:-3.42|P-value:2.62E-5 ID:SGTC_1733|Compound:st037357|FD-Score:-4.46|P-value:6.50E-8 ID:SGTC_2241|Compound:6772625|FD-Score:-3.87|P-value:2.27E-6 ID:SGTC_2293|Compound:7624732|FD-Score:-2.71|P-value:6.73E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.37|P-value:3.23E-5 ID:SGTC_2355|Compound:9061122|FD-Score:2.74|P-value:5.66E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.05|P-value:1.48E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.68|P-value:7.57E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.08|P-value:1.30E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-2.70|P-value:6.95E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-2.95|P-value:2.40E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.73|P-value:4.76E-6 ID:SGTC_3201|Compound:9113999|FD-Score:3.58|P-value:1.11E-5 ID:SGTC_3208|Compound:9114115|FD-Score:-2.94|P-value:2.51E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.03|P-value:1.68E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-5.45|P-value:5.35E-11

Top fitness defect scores for YOL075C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_8 0354-0001 5.10 70.0 µM 7.48E-10 41 1.72E-7
2 SGTC_2803 7707263 3.73 71.4 µM 4.76E-6 31 9.45E-5
3 SGTC_696 1560-0013 3.71 611.0 µM 5.40E-6 28 1.04E-4
4 SGTC_3201 9113999 3.58 49.5 µM 1.11E-5 51 1.75E-4
5 SGTC_188 3229-0966 3.40 278.5 µM 2.82E-5 48 3.43E-4
6 SGTC_827 3253-0474 3.23 693.0 µM 6.48E-5 47 6.26E-4
7 SGTC_739 1486-1183 3.11 203.0 µM 1.13E-4 43 9.36E-4
8 SGTC_2409 alverine citrate 3.08 64.0 µM 1.30E-4 101 0.00104
9 SGTC_2356 9061756 3.05 189.0 µM 1.48E-4 31 0.00114
10 SGTC_1210 3013-0140 3.04 750.0 nM 1.56E-4 34 0.00119
11 SGTC_1224 0823-0416 3.01 294.0 µM 1.81E-4 54 0.00132
12 SGTC_83 0170-0301 3.01 39.0 µM 1.81E-4 endomembrane recycling 16 0.00132
13 SGTC_127 0180-0333 2.92 59.1 µM 2.71E-4 mitochondrial response to ROS 119 0.00177
14 SGTC_1395 3486-0190 2.88 4.3 µM 3.22E-4 66 0.00201
15 SGTC_82 0054-0107 2.86 293.8 µM 3.43E-4 41 0.00211
16 SGTC_627 1391-0720 2.83 175.0 µM 3.90E-4 59 0.00231
17 SGTC_57 miconazole 2.81 162.5 nM 4.33E-4 ergosterol depletion effects on membrane 73 0.00250
18 SGTC_360 0957-0399 2.78 1.0 µM 4.78E-4 cell wall 118 0.00268
19 SGTC_2355 9061122 2.74 103.1 µM 5.66E-4 54 0.00304
20 SGTC_1304 1165-0502 2.69 251.0 µM 7.09E-4 139 0.00358

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.176 1.13E-24 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.171 2.01E-23 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.144 6.03E-17 YBR197C YBR197C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication
0.144 6.46E-17 YGR051C_d YGR051C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
0.137 1.37E-15 YDR109C_p YDR109C_p hom Putative kinase
0.128 8.34E-14 YDR262W_p YDR262W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
0.123 1.05E-12 YLR416C_d YLR416C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.122 1.52E-12 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.119 4.28E-12 YDR273W DON1 hom Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II
0.117 1.21E-11 YPR011C_p YPR011C_p hom Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.115 2.26E-11 YGR067C_p YGR067C_p hom Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
0.114 3.57E-11 YDR218C SPR28 hom Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation
0.112 8.59E-11 YGL249W ZIP2 hom Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.112 9.20E-11 YDL175C AIR2 hom RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication
0.108 3.77E-10 YAL062W GDH3 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication