YOL103W / ITR2

Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL103W / ITR2

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:-3.71|P-value:9.67E-5 ID:SGTC_252|Compound:miconazole|FD-Score:5.42|P-value:2.99E-8 ID:SGTC_591|Compound:4299-0174|FD-Score:3.36|P-value:3.94E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:-3.62|P-value:1.39E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.91|P-value:4.63E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:3.26|P-value:5.64E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:4.03|P-value:2.91E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.44|P-value:4.66E-6 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.71|P-value:1.06E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.47|P-value:2.70E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.24|P-value:6.02E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.32|P-value:4.21E-4 ID:SGTC_1548|Compound:st061468|FD-Score:3.44|P-value:2.96E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.22|P-value:6.58E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.77|P-value:9.32E-7 ID:SGTC_1995|Compound:st072814|FD-Score:3.30|P-value:4.87E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.60|P-value:1.66E-4 ID:SGTC_2168|Compound:5727979|FD-Score:3.16|P-value:8.17E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.61|P-value:1.54E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.87|P-value:5.68E-5 ID:SGTC_2764|Compound:methyldopa|FD-Score:-3.79|P-value:7.09E-5 ID:SGTC_2859|Compound:9028643|FD-Score:3.10|P-value:9.91E-4 ID:SGTC_2910|Compound:7948405|FD-Score:-3.17|P-value:7.31E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.08|P-value:2.26E-5 ID:SGTC_2983|Compound:9022671|FD-Score:-5.15|P-value:1.16E-7 ID:SGTC_3150|Compound:9097574|FD-Score:-4.00|P-value:2.93E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-4.13|P-value:1.71E-5 ID:SGTC_3316|Compound:9136639|FD-Score:3.16|P-value:7.97E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.19|P-value:7.26E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.35|P-value:4.13E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.71|P-value:9.67E-5 ID:SGTC_252|Compound:miconazole|FD-Score:5.42|P-value:2.99E-8 ID:SGTC_591|Compound:4299-0174|FD-Score:3.36|P-value:3.94E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:-3.62|P-value:1.39E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.91|P-value:4.63E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:3.26|P-value:5.64E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:4.03|P-value:2.91E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.44|P-value:4.66E-6 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.71|P-value:1.06E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.47|P-value:2.70E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.24|P-value:6.02E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.32|P-value:4.21E-4 ID:SGTC_1548|Compound:st061468|FD-Score:3.44|P-value:2.96E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.22|P-value:6.58E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.77|P-value:9.32E-7 ID:SGTC_1995|Compound:st072814|FD-Score:3.30|P-value:4.87E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.60|P-value:1.66E-4 ID:SGTC_2168|Compound:5727979|FD-Score:3.16|P-value:8.17E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.61|P-value:1.54E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.87|P-value:5.68E-5 ID:SGTC_2764|Compound:methyldopa|FD-Score:-3.79|P-value:7.09E-5 ID:SGTC_2859|Compound:9028643|FD-Score:3.10|P-value:9.91E-4 ID:SGTC_2910|Compound:7948405|FD-Score:-3.17|P-value:7.31E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.08|P-value:2.26E-5 ID:SGTC_2983|Compound:9022671|FD-Score:-5.15|P-value:1.16E-7 ID:SGTC_3150|Compound:9097574|FD-Score:-4.00|P-value:2.93E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-4.13|P-value:1.71E-5 ID:SGTC_3316|Compound:9136639|FD-Score:3.16|P-value:7.97E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.19|P-value:7.26E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.35|P-value:4.13E-4

Top fitness defect scores for YOL103W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_252 miconazole 5.42 1.3 nM 2.99E-8 ergosterol depletion effects on membrane 21 2.93E-8
2 SGTC_1942 st076330 4.77 65.2 µM 9.32E-7 14 9.12E-7
3 SGTC_1018 4259-0013 4.44 28.1 µM 4.66E-6 10 4.55E-6
4 SGTC_2926 9010726 4.08 65.2 µM 2.26E-5 31 2.21E-5
5 SGTC_885 0865-0106 4.03 16.8 µM 2.91E-5 TSC3-RPN4 27 2.84E-5
6 SGTC_663 1486-0733 3.91 13.9 µM 4.63E-5 cell wall signaling 51 4.53E-5
7 SGTC_2762 leflunomide 3.87 42.1 µM 5.68E-5 33 5.55E-5
8 SGTC_1020 4335-0961 3.71 93.3 µM 1.06E-4 22 1.03E-4
9 SGTC_2585 alliin 3.61 100.0 µM 1.54E-4 40 1.51E-4
10 SGTC_2118 5526350 3.60 200.0 µM 1.66E-4 23 1.62E-4
11 SGTC_1046 2001-0062 3.47 216.0 µM 2.70E-4 31 2.64E-4
12 SGTC_1548 st061468 3.44 90.8 µM 2.96E-4 18 2.89E-4
13 SGTC_591 4299-0174 3.36 154.0 µM 3.94E-4 20 3.85E-4
14 SGTC_3331 9141060 3.35 2.0 µM 4.13E-4 cell wall 48 4.03E-4
15 SGTC_1995 st072814 3.30 61.1 µM 4.87E-4 29 4.76E-4
16 SGTC_753 1322-0200 3.26 289.0 µM 5.64E-4 46 5.52E-4
17 SGTC_1208 2323-2347 3.24 50.3 µM 6.02E-4 28 5.88E-4
18 SGTC_1588 farnesol 3.22 29.9 µM 6.58E-4 33 6.43E-4
19 SGTC_3329 9141233 3.19 27.6 µM 7.26E-4 30 7.10E-4
20 SGTC_3316 9136639 3.16 10.6 µM 7.97E-4 39 7.78E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 8.50E-13 YGR263C SAY1 hom Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.110 1.46E-10 YPR031W NTO1 hom Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3
0.087 4.56E-7 YNR030W ALG12 hom Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation
0.077 7.02E-6 YDL123W SNA4 hom Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated
0.076 1.11E-5 YBR213W MET8 hom Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.075 1.28E-5 YPR140W TAZ1 hom Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome
0.075 1.48E-5 YGL125W MET13 hom Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
0.075 1.55E-5 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.072 2.81E-5 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.071 3.54E-5 YPR167C MET16 hom 3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism
0.071 4.33E-5 YER008C SEC3 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress
0.070 4.64E-5 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.070 5.07E-5 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.069 6.30E-5 YDR165W TRM82 hom Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.069 6.39E-5 YML005W TRM12 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA