YOL128C / YGK3

Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation

Zygosity: Homozygous strain
fixedexpanded
Profile for YOL128C / YGK3

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.65|P-value:2.97E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:3.48|P-value:5.13E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.27|P-value:9.99E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.71|P-value:2.40E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:5.52|P-value:1.24E-7 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.74|P-value:3.70E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.55|P-value:4.10E-4 ID:SGTC_389|Compound:tpck|FD-Score:-3.68|P-value:4.50E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.55|P-value:4.12E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.04|P-value:7.41E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:6.19|P-value:3.67E-9 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.54|P-value:4.30E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.30|P-value:2.67E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.35|P-value:2.22E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.62|P-value:3.22E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.95|P-value:1.01E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.31|P-value:8.92E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.90|P-value:1.22E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:4.11|P-value:5.58E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.55|P-value:4.06E-4 ID:SGTC_1602|Compound:st001878|FD-Score:4.45|P-value:1.50E-5 ID:SGTC_1625|Compound:st003711|FD-Score:5.78|P-value:3.25E-8 ID:SGTC_1638|Compound:st008370|FD-Score:-4.13|P-value:9.54E-5 ID:SGTC_1767|Compound:st044992|FD-Score:4.02|P-value:7.94E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:6.99|P-value:3.51E-11 ID:SGTC_1958|Compound:st076513|FD-Score:-3.63|P-value:5.31E-4 ID:SGTC_1981|Compound:st071826|FD-Score:-4.55|P-value:1.91E-5 ID:SGTC_2022|Compound:5136654|FD-Score:-4.94|P-value:3.64E-6 ID:SGTC_2253|Compound:7938677|FD-Score:3.67|P-value:2.71E-4 ID:SGTC_2254|Compound:7938975|FD-Score:-4.26|P-value:5.75E-5 ID:SGTC_2264|Compound:7948757|FD-Score:3.77|P-value:1.94E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.43|P-value:6.03E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.02|P-value:7.74E-5 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.33|P-value:8.47E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.52|P-value:7.60E-4 ID:SGTC_2556|Compound:citropten|FD-Score:-4.41|P-value:3.24E-5 ID:SGTC_2801|Compound:7907800|FD-Score:3.62|P-value:3.30E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.72|P-value:2.33E-4 ID:SGTC_2870|Compound:9038528|FD-Score:-3.76|P-value:3.42E-4 ID:SGTC_2879|Compound:9041815|FD-Score:-4.01|P-value:1.44E-4 ID:SGTC_2900|Compound:5328528|FD-Score:4.28|P-value:2.90E-5 ID:SGTC_2916|Compound:7875993|FD-Score:-4.63|P-value:1.34E-5 ID:SGTC_2947|Compound:9072639|FD-Score:3.29|P-value:9.49E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.74|P-value:2.19E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.72|P-value:2.27E-4 ID:SGTC_3132|Compound:9126706|FD-Score:4.11|P-value:5.73E-5 ID:SGTC_3212|Compound:9128307|FD-Score:4.08|P-value:6.39E-5 ID:SGTC_3223|Compound:9129970|FD-Score:-3.83|P-value:2.67E-4 ID:SGTC_3268|Compound:9137683|FD-Score:3.54|P-value:4.28E-4 ID:SGTC_3294|Compound:9122953|FD-Score:4.17|P-value:4.43E-5 ID:SGTC_3323|Compound:9138564|FD-Score:-4.47|P-value:2.63E-5 ID:SGTC_3325|Compound:9138760|FD-Score:-4.44|P-value:2.85E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:3.65|P-value:2.97E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:3.48|P-value:5.13E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.27|P-value:9.99E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.71|P-value:2.40E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:5.52|P-value:1.24E-7 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.74|P-value:3.70E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.55|P-value:4.10E-4 ID:SGTC_389|Compound:tpck|FD-Score:-3.68|P-value:4.50E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.55|P-value:4.12E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.04|P-value:7.41E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:6.19|P-value:3.67E-9 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.54|P-value:4.30E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.30|P-value:2.67E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.35|P-value:2.22E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.62|P-value:3.22E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.95|P-value:1.01E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.31|P-value:8.92E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.90|P-value:1.22E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:4.11|P-value:5.58E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.55|P-value:4.06E-4 ID:SGTC_1602|Compound:st001878|FD-Score:4.45|P-value:1.50E-5 ID:SGTC_1625|Compound:st003711|FD-Score:5.78|P-value:3.25E-8 ID:SGTC_1638|Compound:st008370|FD-Score:-4.13|P-value:9.54E-5 ID:SGTC_1767|Compound:st044992|FD-Score:4.02|P-value:7.94E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:6.99|P-value:3.51E-11 ID:SGTC_1958|Compound:st076513|FD-Score:-3.63|P-value:5.31E-4 ID:SGTC_1981|Compound:st071826|FD-Score:-4.55|P-value:1.91E-5 ID:SGTC_2022|Compound:5136654|FD-Score:-4.94|P-value:3.64E-6 ID:SGTC_2253|Compound:7938677|FD-Score:3.67|P-value:2.71E-4 ID:SGTC_2254|Compound:7938975|FD-Score:-4.26|P-value:5.75E-5 ID:SGTC_2264|Compound:7948757|FD-Score:3.77|P-value:1.94E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.43|P-value:6.03E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.02|P-value:7.74E-5 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.33|P-value:8.47E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.52|P-value:7.60E-4 ID:SGTC_2556|Compound:citropten|FD-Score:-4.41|P-value:3.24E-5 ID:SGTC_2801|Compound:7907800|FD-Score:3.62|P-value:3.30E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.72|P-value:2.33E-4 ID:SGTC_2870|Compound:9038528|FD-Score:-3.76|P-value:3.42E-4 ID:SGTC_2879|Compound:9041815|FD-Score:-4.01|P-value:1.44E-4 ID:SGTC_2900|Compound:5328528|FD-Score:4.28|P-value:2.90E-5 ID:SGTC_2916|Compound:7875993|FD-Score:-4.63|P-value:1.34E-5 ID:SGTC_2947|Compound:9072639|FD-Score:3.29|P-value:9.49E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.74|P-value:2.19E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.72|P-value:2.27E-4 ID:SGTC_3132|Compound:9126706|FD-Score:4.11|P-value:5.73E-5 ID:SGTC_3212|Compound:9128307|FD-Score:4.08|P-value:6.39E-5 ID:SGTC_3223|Compound:9129970|FD-Score:-3.83|P-value:2.67E-4 ID:SGTC_3268|Compound:9137683|FD-Score:3.54|P-value:4.28E-4 ID:SGTC_3294|Compound:9122953|FD-Score:4.17|P-value:4.43E-5 ID:SGTC_3323|Compound:9138564|FD-Score:-4.47|P-value:2.63E-5 ID:SGTC_3325|Compound:9138760|FD-Score:-4.44|P-value:2.85E-5

Top fitness defect scores for YOL128C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1926 methyl fluorone black 6.99 53.6 µM 3.51E-11 DNA intercalators 12 1.34E-12
2 SGTC_1007 4101-0031 6.19 70.0 µM 3.67E-9 2 2.94E-10
3 SGTC_1625 st003711 5.78 30.1 µM 3.25E-8 calcium & mitochondrial duress 11 3.66E-9
4 SGTC_184 1494-0393 5.52 24.7 µM 1.24E-7 19 1.72E-8
5 SGTC_1602 st001878 4.45 87.6 µM 1.50E-5 13 4.33E-6
6 SGTC_1128 3448-9350 4.35 235.0 µM 2.22E-5 18 6.82E-6
7 SGTC_1014 4130-3005 4.30 69.3 µM 2.67E-5 9 8.41E-6
8 SGTC_2900 5328528 4.28 85.3 µM 2.90E-5 Golgi 23 9.24E-6
9 SGTC_3294 9122953 4.17 26.3 µM 4.43E-5 tubulin folding & SWR complex 25 1.51E-5
10 SGTC_1297 1068-0111 4.11 14.1 µM 5.58E-5 8 1.96E-5
11 SGTC_3132 9126706 4.11 49.5 µM 5.73E-5 19 2.02E-5
12 SGTC_3212 9128307 4.08 49.5 µM 6.39E-5 41 2.29E-5
13 SGTC_922 1866-0035 4.04 480.0 µM 7.41E-5 excess fatty acid 54 2.72E-5
14 SGTC_2418 pentamidine 4.02 31.7 µM 7.74E-5 mitochondrial processes 40 2.85E-5
15 SGTC_1767 st044992 4.02 70.3 µM 7.94E-5 19 2.94E-5
16 SGTC_1220 1838-0075 3.95 193.0 µM 1.01E-4 9 3.86E-5
17 SGTC_1290 0986-0249 3.90 10.2 µM 1.22E-4 DNA intercalators 22 4.83E-5
18 SGTC_2264 7948757 3.77 110.8 µM 1.94E-4 21 8.19E-5
19 SGTC_2997 9067075 3.74 71.4 µM 2.19E-4 unfolded protein response 60 9.38E-5
20 SGTC_3089 9117425 3.72 49.5 µM 2.27E-4 32 9.78E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.18E-17 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.138 1.27E-15 YDR458C HEH2 hom Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle
0.136 2.76E-15 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.135 4.25E-15 YJL085W EXO70 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.134 6.97E-15 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.133 1.16E-14 YMR044W IOC4 hom Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing
0.126 2.39E-13 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.124 5.79E-13 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.118 6.82E-12 YPR059C_d YPR059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W
0.117 1.24E-11 YER099C PRS2 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication
0.114 3.43E-11 YPL197C_d YPL197C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
0.113 4.93E-11 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.106 6.69E-10 YMR208W ERG12 het Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
0.105 1.13E-9 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.104 1.68E-9 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene