YOR004W / UTP23

Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR004W / UTP23

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.83|P-value:4.24E-6 ID:SGTC_18|Compound:0111-0177|FD-Score:3.10|P-value:1.57E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:2.88|P-value:4.24E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-4.90|P-value:4.40E-9 ID:SGTC_42|Compound:0133-0086|FD-Score:4.16|P-value:6.59E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.39|P-value:3.28E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:5.34|P-value:2.59E-10 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.28|P-value:5.72E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:5.83|P-value:5.39E-12 ID:SGTC_360|Compound:0957-0399|FD-Score:2.87|P-value:4.32E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:-2.66|P-value:8.71E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.60|P-value:1.12E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:3.80|P-value:5.06E-6 ID:SGTC_542|Compound:3381-0244|FD-Score:2.82|P-value:5.35E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.37|P-value:3.62E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:2.80|P-value:5.70E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:2.71|P-value:8.21E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:2.67|P-value:9.83E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.58|P-value:1.58E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:-3.43|P-value:2.72E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.21|P-value:7.78E-5 ID:SGTC_771|Compound:0250-0039|FD-Score:-2.82|P-value:4.46E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:-2.75|P-value:5.92E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.20|P-value:8.45E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.15|P-value:1.02E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.04|P-value:2.05E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:2.73|P-value:7.64E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.29|P-value:6.72E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.16|P-value:1.20E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.70|P-value:8.81E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.33|P-value:5.53E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:2.68|P-value:9.52E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:-2.91|P-value:3.09E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.58|P-value:1.57E-5 ID:SGTC_1606|Compound:st000094|FD-Score:3.95|P-value:2.13E-6 ID:SGTC_1648|Compound:st011736|FD-Score:-2.80|P-value:4.77E-4 ID:SGTC_1717|Compound:st033143|FD-Score:2.76|P-value:6.88E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-2.67|P-value:8.28E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.12|P-value:1.45E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.27|P-value:7.17E-5 ID:SGTC_1896|Compound:st058441|FD-Score:-3.96|P-value:1.60E-6 ID:SGTC_1899|Compound:st063254|FD-Score:-3.10|P-value:1.30E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.08|P-value:1.74E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-2.79|P-value:5.07E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.01|P-value:1.95E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.26|P-value:7.72E-5 ID:SGTC_2292|Compound:7671323|FD-Score:5.08|P-value:1.70E-9 ID:SGTC_2406|Compound:ethylparaben|FD-Score:5.24|P-value:5.15E-10 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.21|P-value:9.67E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.65|P-value:8.62E-6 ID:SGTC_2417|Compound:cerulenin|FD-Score:-2.65|P-value:8.91E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-2.82|P-value:4.53E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-2.62|P-value:9.89E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-2.70|P-value:7.28E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:2.96|P-value:2.99E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.27|P-value:6.09E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:2.97|P-value:2.89E-4 ID:SGTC_2794|Compound:7785382|FD-Score:5.42|P-value:1.38E-10 ID:SGTC_2812|Compound:7970281|FD-Score:-3.63|P-value:9.99E-6 ID:SGTC_3215|Compound:9129942|FD-Score:4.26|P-value:3.60E-7 ID:SGTC_3220|Compound:9131269|FD-Score:-2.65|P-value:9.10E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-2.92|P-value:2.88E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.83|P-value:4.24E-6 ID:SGTC_18|Compound:0111-0177|FD-Score:3.10|P-value:1.57E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:2.88|P-value:4.24E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-4.90|P-value:4.40E-9 ID:SGTC_42|Compound:0133-0086|FD-Score:4.16|P-value:6.59E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.39|P-value:3.28E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:5.34|P-value:2.59E-10 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.28|P-value:5.72E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:5.83|P-value:5.39E-12 ID:SGTC_360|Compound:0957-0399|FD-Score:2.87|P-value:4.32E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:-2.66|P-value:8.71E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.60|P-value:1.12E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:3.80|P-value:5.06E-6 ID:SGTC_542|Compound:3381-0244|FD-Score:2.82|P-value:5.35E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.37|P-value:3.62E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:2.80|P-value:5.70E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:2.71|P-value:8.21E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:2.67|P-value:9.83E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.58|P-value:1.58E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:-3.43|P-value:2.72E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.21|P-value:7.78E-5 ID:SGTC_771|Compound:0250-0039|FD-Score:-2.82|P-value:4.46E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:-2.75|P-value:5.92E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.20|P-value:8.45E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.15|P-value:1.02E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.04|P-value:2.05E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:2.73|P-value:7.64E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.29|P-value:6.72E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.16|P-value:1.20E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.70|P-value:8.81E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.33|P-value:5.53E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:2.68|P-value:9.52E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:-2.91|P-value:3.09E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.58|P-value:1.57E-5 ID:SGTC_1606|Compound:st000094|FD-Score:3.95|P-value:2.13E-6 ID:SGTC_1648|Compound:st011736|FD-Score:-2.80|P-value:4.77E-4 ID:SGTC_1717|Compound:st033143|FD-Score:2.76|P-value:6.88E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-2.67|P-value:8.28E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.12|P-value:1.45E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.27|P-value:7.17E-5 ID:SGTC_1896|Compound:st058441|FD-Score:-3.96|P-value:1.60E-6 ID:SGTC_1899|Compound:st063254|FD-Score:-3.10|P-value:1.30E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.08|P-value:1.74E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-2.79|P-value:5.07E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.01|P-value:1.95E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.26|P-value:7.72E-5 ID:SGTC_2292|Compound:7671323|FD-Score:5.08|P-value:1.70E-9 ID:SGTC_2406|Compound:ethylparaben|FD-Score:5.24|P-value:5.15E-10 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.21|P-value:9.67E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.65|P-value:8.62E-6 ID:SGTC_2417|Compound:cerulenin|FD-Score:-2.65|P-value:8.91E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-2.82|P-value:4.53E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-2.62|P-value:9.89E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-2.70|P-value:7.28E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:2.96|P-value:2.99E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.27|P-value:6.09E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:2.97|P-value:2.89E-4 ID:SGTC_2794|Compound:7785382|FD-Score:5.42|P-value:1.38E-10 ID:SGTC_2812|Compound:7970281|FD-Score:-3.63|P-value:9.99E-6 ID:SGTC_3215|Compound:9129942|FD-Score:4.26|P-value:3.60E-7 ID:SGTC_3220|Compound:9131269|FD-Score:-2.65|P-value:9.10E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-2.92|P-value:2.88E-4

Top fitness defect scores for YOR004W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_359 0081-0058 5.83 15.9 µM 5.39E-12 60S ribosome export 4 2.71E-9 0.10
2 SGTC_2794 7785382 5.42 27.3 µM 1.38E-10 6 2.98E-8 0.00
3 SGTC_65 0798-0905 5.34 35.0 µM 2.59E-10 calcium & mitochondrial duress 2 4.75E-8 0.50
4 SGTC_2406 ethylparaben 5.24 405.7 µM 5.15E-10 1 7.90E-8 0.49
5 SGTC_2292 7671323 5.08 168.1 µM 1.70E-9 RNA processing & uracil transport 5 1.91E-7 0.21
6 SGTC_3215 9129942 4.26 49.5 µM 3.60E-7 4 1.02E-5 0.47
7 SGTC_42 0133-0086 4.16 60.6 µM 6.59E-7 6 1.60E-5 0.03
8 SGTC_1606 st000094 3.95 49.2 µM 2.13E-6 60S ribosome export 7 3.84E-5 0.24
9 SGTC_7 0192-1582 3.83 4.2 µM 4.24E-6 3 6.41E-5 0.05
10 SGTC_535 2293-4129 3.80 48.2 µM 5.06E-6 NEO1 11 7.31E-5 0.09
11 SGTC_1506 4226-2149 3.58 212.0 µM 1.57E-5 7 1.70E-4 0.01
12 SGTC_699 0375-0592 3.58 111.0 µM 1.58E-5 iron homeostasis 5 1.71E-4 0.24
13 SGTC_1305 1181-0477 3.33 144.0 µM 5.53E-5 11 4.37E-4 0.23
14 SGTC_1242 0402-0103 3.29 60.1 µM 6.72E-5 12 5.06E-4 0.02
15 SGTC_1894 3',6'-dihydroxyflavone 3.27 78.7 µM 7.17E-5 11 5.31E-4 0.02
16 SGTC_2167 5876490 3.26 200.0 µM 7.72E-5 2 5.61E-4 0.12
17 SGTC_2407 paclitaxel 3.21 400.0 µM 9.67E-5 13 6.65E-4 0.01
18 SGTC_1251 0490-5699 3.16 265.0 µM 1.20E-4 15 7.80E-4 0.03
19 SGTC_1779 st039427 3.12 55.0 µM 1.45E-4 8 8.98E-4 0.19
20 SGTC_18 0111-0177 3.10 500.0 nM 1.57E-4 10 9.58E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 1.02E-21 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.158 3.00E-20 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.153 5.65E-19 YGR208W SER2 hom Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
0.148 5.46E-18 YJR017C ESS1 het Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3
0.141 2.93E-16 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.133 9.96E-15 YER157W COG3 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.128 8.92E-14 YAL014C SYN8 hom Endosomal SNARE related to mammalian syntaxin 8
0.122 1.06E-12 YOR149C SMP3 het Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
0.113 5.37E-11 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.113 5.65E-11 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.113 5.46E-11 YHL032C GUT1 hom Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
0.110 1.86E-10 YBR051W_d YBR051W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
0.106 7.27E-10 YOR071C NRT1 hom High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
0.106 7.39E-10 YGR148C RPL24B hom Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication
0.104 1.63E-9 YOR016C ERP4 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport