YOR025W / HST3

Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR025W / HST3

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.47|P-value:2.96E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.12|P-value:8.71E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:5.25|P-value:7.41E-8 ID:SGTC_159|Compound:3970-0959|FD-Score:4.58|P-value:2.32E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:3.71|P-value:1.01E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.48|P-value:2.41E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:4.00|P-value:3.09E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:3.63|P-value:1.37E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.16|P-value:8.92E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.88|P-value:5.94E-5 ID:SGTC_565|Compound:1418-0001|FD-Score:3.43|P-value:2.92E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.32|P-value:4.40E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.50|P-value:2.63E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.45|P-value:2.74E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.86|P-value:5.53E-5 ID:SGTC_1079|Compound:idarubicin|FD-Score:4.12|P-value:1.81E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:5.00|P-value:2.77E-7 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.47|P-value:2.50E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.30|P-value:4.62E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.73|P-value:9.22E-5 ID:SGTC_1640|Compound:st009078|FD-Score:-3.41|P-value:3.62E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.92|P-value:4.33E-5 ID:SGTC_1779|Compound:st039427|FD-Score:4.11|P-value:1.91E-5 ID:SGTC_1809|Compound:st050081|FD-Score:3.54|P-value:1.96E-4 ID:SGTC_1979|Compound:st071809|FD-Score:-3.16|P-value:8.95E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-4.48|P-value:4.47E-6 ID:SGTC_2212|Compound:7123476|FD-Score:4.16|P-value:1.57E-5 ID:SGTC_2308|Compound:7584454|FD-Score:-7.92|P-value:1.80E-15 ID:SGTC_2309|Compound:7664088|FD-Score:6.96|P-value:1.79E-12 ID:SGTC_2310|Compound:7668677|FD-Score:-9.24|P-value:2.05E-20 ID:SGTC_2315|Compound:7733312|FD-Score:-3.56|P-value:2.15E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.71|P-value:1.00E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-4.00|P-value:3.74E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.57|P-value:1.72E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.62|P-value:1.40E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-3.72|P-value:1.14E-4 ID:SGTC_2523|Compound:spermine|FD-Score:4.77|P-value:9.13E-7 ID:SGTC_2719|Compound:novobiocin|FD-Score:-3.17|P-value:8.53E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.26|P-value:6.34E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.13|P-value:9.78E-4 ID:SGTC_3144|Compound:9087057|FD-Score:3.54|P-value:1.92E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-4.53|P-value:3.52E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.47|P-value:2.96E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.12|P-value:8.71E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:5.25|P-value:7.41E-8 ID:SGTC_159|Compound:3970-0959|FD-Score:4.58|P-value:2.32E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:3.71|P-value:1.01E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.48|P-value:2.41E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:4.00|P-value:3.09E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:3.63|P-value:1.37E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.16|P-value:8.92E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.88|P-value:5.94E-5 ID:SGTC_565|Compound:1418-0001|FD-Score:3.43|P-value:2.92E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.32|P-value:4.40E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.50|P-value:2.63E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.45|P-value:2.74E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.86|P-value:5.53E-5 ID:SGTC_1079|Compound:idarubicin|FD-Score:4.12|P-value:1.81E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:5.00|P-value:2.77E-7 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.47|P-value:2.50E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.30|P-value:4.62E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.73|P-value:9.22E-5 ID:SGTC_1640|Compound:st009078|FD-Score:-3.41|P-value:3.62E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.92|P-value:4.33E-5 ID:SGTC_1779|Compound:st039427|FD-Score:4.11|P-value:1.91E-5 ID:SGTC_1809|Compound:st050081|FD-Score:3.54|P-value:1.96E-4 ID:SGTC_1979|Compound:st071809|FD-Score:-3.16|P-value:8.95E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-4.48|P-value:4.47E-6 ID:SGTC_2212|Compound:7123476|FD-Score:4.16|P-value:1.57E-5 ID:SGTC_2308|Compound:7584454|FD-Score:-7.92|P-value:1.80E-15 ID:SGTC_2309|Compound:7664088|FD-Score:6.96|P-value:1.79E-12 ID:SGTC_2310|Compound:7668677|FD-Score:-9.24|P-value:2.05E-20 ID:SGTC_2315|Compound:7733312|FD-Score:-3.56|P-value:2.15E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.71|P-value:1.00E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-4.00|P-value:3.74E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.57|P-value:1.72E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.62|P-value:1.40E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-3.72|P-value:1.14E-4 ID:SGTC_2523|Compound:spermine|FD-Score:4.77|P-value:9.13E-7 ID:SGTC_2719|Compound:novobiocin|FD-Score:-3.17|P-value:8.53E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.26|P-value:6.34E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.13|P-value:9.78E-4 ID:SGTC_3144|Compound:9087057|FD-Score:3.54|P-value:1.92E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-4.53|P-value:3.52E-6

Top fitness defect scores for YOR025W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2309 7664088 6.96 163.9 µM 1.79E-12 2 1.74E-12
2 SGTC_127 0180-0333 5.25 59.1 µM 7.41E-8 mitochondrial response to ROS 12 7.50E-8
3 SGTC_1195 1502-0147 5.00 41.1 µM 2.77E-7 9 2.81E-7
4 SGTC_2523 spermine 4.77 47.7 µM 9.13E-7 calcium & mitochondrial duress 17 9.32E-7
5 SGTC_159 3970-0959 4.58 50.0 µM 2.32E-6 50 2.37E-6
6 SGTC_2212 7123476 4.16 200.0 µM 1.57E-5 3 1.61E-5
7 SGTC_1079 idarubicin 4.12 2.4 µM 1.81E-5 DNA damage response 20 1.86E-5
8 SGTC_1779 st039427 4.11 55.0 µM 1.91E-5 23 1.97E-5
9 SGTC_261 5-fluorouridine 4.00 15.4 µM 3.09E-5 exosome 8 3.18E-5
10 SGTC_1707 st032323 3.92 6.3 µM 4.33E-5 DNA damage response 58 4.46E-5
11 SGTC_1019 4262-0212 3.86 3.4 µM 5.53E-5 ergosterol depletion effects on membrane 64 5.70E-5
12 SGTC_1625 st003711 3.73 30.1 µM 9.22E-5 calcium & mitochondrial duress 43 9.51E-5
13 SGTC_2384 9036245 3.71 200.0 µM 1.00E-4 36 1.03E-4
14 SGTC_165 k038-0023 3.71 64.4 µM 1.01E-4 ubiquinone biosynthesis & proteasome 93 1.04E-4
15 SGTC_381 3461-2219 3.63 42.7 µM 1.37E-4 copper-dependent oxidative stress 24 1.41E-4
16 SGTC_2495 cafestol 3.62 54.5 µM 1.40E-4 Golgi 30 1.45E-4
17 SGTC_2488 5268135 3.57 45.7 µM 1.72E-4 64 1.78E-4
18 SGTC_3144 9087057 3.54 49.5 µM 1.92E-4 26 1.99E-4
19 SGTC_1809 st050081 3.54 57.6 µM 1.96E-4 25 2.03E-4
20 SGTC_184 1494-0393 3.48 24.7 µM 2.41E-4 83 2.49E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 4.02E-12 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.108 3.16E-10 YKL183W LOT5 hom Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress
0.107 5.94E-10 YER044C-A MEI4 hom Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores
0.104 1.47E-9 YDR050C TPI1 het Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease
0.104 1.73E-9 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.098 1.10E-8 YNL063W MTQ1 hom S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene
0.095 3.82E-8 YLR071C RGR1 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation
0.094 5.20E-8 YDR075W PPH3 hom Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes
0.091 1.28E-7 YDR516C EMI2 hom Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.090 1.63E-7 YPL096W PNG1 hom Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p
0.090 1.98E-7 YCL011C GBP2 hom Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication
0.087 4.79E-7 YOR023C AHC1 hom Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
0.084 1.02E-6 YJL079C PRY1 hom Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY2; may be involved in detoxification of hydrophobic compounds; PRY1 has a paralog, PRY2, that arose from the whole genome duplication
0.083 1.49E-6 YLR415C_p YLR415C_p hom Putative protein of unknown function; YLR415C is not an essential gene
0.081 2.89E-6 YKL034W TUL1 hom Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1