YOR080W / DIA2

Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR080W / DIA2

Click on Significant Values for Screen Details ID:SGTC_316|Compound:k060-0003|FD-Score:3.36|P-value:5.85E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.99|P-value:5.27E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:3.94|P-value:6.85E-5 ID:SGTC_694|Compound:1315-0438|FD-Score:3.74|P-value:1.49E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:-3.33|P-value:6.12E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:4.24|P-value:2.06E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.08|P-value:4.14E-7 ID:SGTC_911|Compound:3456-4043|FD-Score:5.03|P-value:5.66E-7 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.53|P-value:3.23E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-5.37|P-value:9.00E-8 ID:SGTC_925|Compound:2064-1272|FD-Score:7.77|P-value:2.55E-14 ID:SGTC_931|Compound:2812-0076|FD-Score:3.72|P-value:1.58E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.30|P-value:7.17E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-6.25|P-value:6.46E-10 ID:SGTC_1111|Compound:tnp00062|FD-Score:-4.99|P-value:6.20E-7 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.85|P-value:9.65E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:6.41|P-value:2.69E-10 ID:SGTC_1615|Compound:st002656|FD-Score:3.72|P-value:1.58E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.85|P-value:9.84E-5 ID:SGTC_1650|Compound:st011916|FD-Score:3.68|P-value:1.86E-4 ID:SGTC_1795|Compound:st049545|FD-Score:-3.23|P-value:8.52E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.43|P-value:4.58E-4 ID:SGTC_2403|Compound:6032726|FD-Score:4.39|P-value:1.06E-5 ID:SGTC_2404|Compound:5161160|FD-Score:-4.13|P-value:3.04E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.42|P-value:4.44E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.40|P-value:1.01E-5 ID:SGTC_2912|Compound:7964298|FD-Score:4.01|P-value:5.12E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-4.64|P-value:3.35E-6 ID:SGTC_2940|Compound:9060638|FD-Score:3.87|P-value:9.16E-5 ID:SGTC_3003|Compound:9075612|FD-Score:6.66|P-value:5.45E-11 ID:SGTC_3320|Compound:9137005|FD-Score:-3.54|P-value:2.87E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:3.36|P-value:5.85E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.99|P-value:5.27E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:3.94|P-value:6.85E-5 ID:SGTC_694|Compound:1315-0438|FD-Score:3.74|P-value:1.49E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:-3.33|P-value:6.12E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:4.24|P-value:2.06E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.08|P-value:4.14E-7 ID:SGTC_911|Compound:3456-4043|FD-Score:5.03|P-value:5.66E-7 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.53|P-value:3.23E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-5.37|P-value:9.00E-8 ID:SGTC_925|Compound:2064-1272|FD-Score:7.77|P-value:2.55E-14 ID:SGTC_931|Compound:2812-0076|FD-Score:3.72|P-value:1.58E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.30|P-value:7.17E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-6.25|P-value:6.46E-10 ID:SGTC_1111|Compound:tnp00062|FD-Score:-4.99|P-value:6.20E-7 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.85|P-value:9.65E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:6.41|P-value:2.69E-10 ID:SGTC_1615|Compound:st002656|FD-Score:3.72|P-value:1.58E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.85|P-value:9.84E-5 ID:SGTC_1650|Compound:st011916|FD-Score:3.68|P-value:1.86E-4 ID:SGTC_1795|Compound:st049545|FD-Score:-3.23|P-value:8.52E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.43|P-value:4.58E-4 ID:SGTC_2403|Compound:6032726|FD-Score:4.39|P-value:1.06E-5 ID:SGTC_2404|Compound:5161160|FD-Score:-4.13|P-value:3.04E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.42|P-value:4.44E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.40|P-value:1.01E-5 ID:SGTC_2912|Compound:7964298|FD-Score:4.01|P-value:5.12E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-4.64|P-value:3.35E-6 ID:SGTC_2940|Compound:9060638|FD-Score:3.87|P-value:9.16E-5 ID:SGTC_3003|Compound:9075612|FD-Score:6.66|P-value:5.45E-11 ID:SGTC_3320|Compound:9137005|FD-Score:-3.54|P-value:2.87E-4

Top fitness defect scores for YOR080W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_925 2064-1272 7.77 59.6 µM 2.55E-14 1 3.85E-15
2 SGTC_3003 9075612 6.66 71.4 µM 5.45E-11 3 1.34E-11
3 SGTC_1514 1189-1591 6.41 158.0 µM 2.69E-10 11 7.31E-11
4 SGTC_911 3456-4043 5.03 236.0 µM 5.66E-7 mitochondrial processes 10 2.49E-7
5 SGTC_2628 lathosterol 4.40 100.0 µM 1.01E-5 21 5.30E-6
6 SGTC_2403 6032726 4.39 181.2 µM 1.06E-5 28 5.59E-6
7 SGTC_745 0469-0705 4.24 296.0 µM 2.06E-5 mitochondrial processes 15 1.14E-5
8 SGTC_2912 7964298 4.01 10.9 µM 5.12E-5 cell wall 94 2.99E-5
9 SGTC_619 1652-1634 3.94 108.0 µM 6.85E-5 PDR1 21 4.07E-5
10 SGTC_2940 9060638 3.87 45.9 µM 9.16E-5 amide catabolism 26 5.54E-5
11 SGTC_1466 k213-0079 3.85 57.5 µM 9.65E-5 20 5.86E-5
12 SGTC_1622 st003707 3.85 19.4 µM 9.84E-5 calcium & mitochondrial duress 43 5.98E-5
13 SGTC_694 1315-0438 3.74 43.2 µM 1.49E-4 15 9.26E-5
14 SGTC_1615 st002656 3.72 86.5 µM 1.58E-4 redox potentiating 17 9.89E-5
15 SGTC_931 2812-0076 3.72 566.0 µM 1.58E-4 30 9.92E-5
16 SGTC_1650 st011916 3.68 45.8 µM 1.86E-4 18 1.18E-4
17 SGTC_920 mycophenolic acid 3.53 780.4 nM 3.23E-4 46 2.11E-4
18 SGTC_2027 5150920 3.43 200.0 µM 4.58E-4 24 3.06E-4
19 SGTC_316 k060-0003 3.36 58.6 µM 5.85E-4 31 3.97E-4
20 SGTC_1049 3226-0134 3.30 66.0 µM 7.17E-4 58 4.92E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.66E-16 YNL305C BXI1 hom Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p
0.132 1.70E-14 YPL112C PEX25 hom Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
0.121 1.67E-12 YLL051C FRE6 hom Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels
0.104 1.37E-9 YIR038C GTT1 hom ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p
0.103 1.94E-9 YIR005W IST3 hom Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing
0.102 3.52E-9 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.099 7.91E-9 YOL098C_p YOL098C_p hom Putative metalloprotease
0.099 9.92E-9 YMR269W TMA23 hom Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan
0.099 1.03E-8 YEL068C_p YEL068C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.096 2.29E-8 YHR097C_p YHR097C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
0.092 1.07E-7 YPL009C TAE2 hom Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.090 1.77E-7 YGR266W YGR266W hom Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress
0.090 1.84E-7 YBR082C UBC4 hom Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication
0.085 7.09E-7 YPR088C SRP54 het Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
0.085 9.05E-7 YPR161C SGV1 het Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins