YOR087W / YVC1

Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR087W / YVC1

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.67|P-value:3.70E-5 ID:SGTC_260|Compound:nsc-65238|FD-Score:-2.84|P-value:9.39E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:-2.95|P-value:6.03E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:-3.13|P-value:3.03E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:-2.95|P-value:6.17E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:-3.37|P-value:1.11E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:3.81|P-value:1.94E-5 ID:SGTC_336|Compound:4111-0029|FD-Score:3.13|P-value:3.73E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.09|P-value:3.52E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.09|P-value:3.59E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.08|P-value:3.71E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.74|P-value:2.66E-5 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-3.45|P-value:8.11E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.17|P-value:2.63E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.82|P-value:1.89E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.59|P-value:2.59E-7 ID:SGTC_752|Compound:1896-0090|FD-Score:-3.20|P-value:2.30E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:2.94|P-value:7.77E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:-4.00|P-value:6.04E-6 ID:SGTC_1477|Compound:0139-0234|FD-Score:-2.94|P-value:6.27E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.05|P-value:4.08E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-4.03|P-value:5.23E-6 ID:SGTC_1912|Compound:st060209|FD-Score:2.89|P-value:9.41E-4 ID:SGTC_1960|Compound:st011366|FD-Score:-2.87|P-value:8.13E-4 ID:SGTC_2202|Compound:7226349|FD-Score:-3.15|P-value:2.83E-4 ID:SGTC_2287|Compound:7945887|FD-Score:-3.01|P-value:4.87E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-5.08|P-value:1.45E-8 ID:SGTC_2311|Compound:7694451|FD-Score:3.47|P-value:9.19E-5 ID:SGTC_2435|Compound:5706476|FD-Score:3.28|P-value:2.03E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.37|P-value:1.13E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:5.17|P-value:1.14E-8 ID:SGTC_2755|Compound:lomerizine|FD-Score:-4.89|P-value:4.74E-8 ID:SGTC_2760|Compound:etidronate|FD-Score:-5.16|P-value:8.58E-9 ID:SGTC_2810|Compound:7959871|FD-Score:-3.65|P-value:3.26E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:3.67|P-value:3.70E-5 ID:SGTC_260|Compound:nsc-65238|FD-Score:-2.84|P-value:9.39E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:-2.95|P-value:6.03E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:-3.13|P-value:3.03E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:-2.95|P-value:6.17E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:-3.37|P-value:1.11E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:3.81|P-value:1.94E-5 ID:SGTC_336|Compound:4111-0029|FD-Score:3.13|P-value:3.73E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.09|P-value:3.52E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.09|P-value:3.59E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.08|P-value:3.71E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.74|P-value:2.66E-5 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-3.45|P-value:8.11E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.17|P-value:2.63E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.82|P-value:1.89E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.59|P-value:2.59E-7 ID:SGTC_752|Compound:1896-0090|FD-Score:-3.20|P-value:2.30E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:2.94|P-value:7.77E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:-4.00|P-value:6.04E-6 ID:SGTC_1477|Compound:0139-0234|FD-Score:-2.94|P-value:6.27E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.05|P-value:4.08E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-4.03|P-value:5.23E-6 ID:SGTC_1912|Compound:st060209|FD-Score:2.89|P-value:9.41E-4 ID:SGTC_1960|Compound:st011366|FD-Score:-2.87|P-value:8.13E-4 ID:SGTC_2202|Compound:7226349|FD-Score:-3.15|P-value:2.83E-4 ID:SGTC_2287|Compound:7945887|FD-Score:-3.01|P-value:4.87E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-5.08|P-value:1.45E-8 ID:SGTC_2311|Compound:7694451|FD-Score:3.47|P-value:9.19E-5 ID:SGTC_2435|Compound:5706476|FD-Score:3.28|P-value:2.03E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.37|P-value:1.13E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:5.17|P-value:1.14E-8 ID:SGTC_2755|Compound:lomerizine|FD-Score:-4.89|P-value:4.74E-8 ID:SGTC_2760|Compound:etidronate|FD-Score:-5.16|P-value:8.58E-9 ID:SGTC_2810|Compound:7959871|FD-Score:-3.65|P-value:3.26E-5

Top fitness defect scores for YOR087W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2750 bromebric acid 5.17 70.2 µM 1.14E-8 10 1.18E-7
2 SGTC_425 3825-7017 3.82 13.1 µM 1.89E-5 25 6.76E-5
3 SGTC_334 1502-1024 3.81 68.5 µM 1.94E-5 14 6.91E-5
4 SGTC_402 epigallocatechin gallate 3.74 10.0 µM 2.66E-5 34 9.06E-5
5 SGTC_65 0798-0905 3.67 35.0 µM 3.70E-5 calcium & mitochondrial duress 104 1.20E-4
6 SGTC_2311 7694451 3.47 200.0 µM 9.19E-5 35 2.63E-4
7 SGTC_2435 5706476 3.28 10.6 µM 2.03E-4 47 5.21E-4
8 SGTC_336 4111-0029 3.13 111.0 µM 3.73E-4 22 8.80E-4
9 SGTC_1174 0739-0097 2.94 51.1 µM 7.77E-4 redox potentiating 84 0.00166
10 SGTC_1912 st060209 2.89 90.8 µM 9.41E-4 90 0.00195
11 SGTC_737 1950-0117 2.83 57.9 µM 0.00116 72 0.00234
12 SGTC_1748 st037455 2.82 53.6 µM 0.00121 101 0.00244
13 SGTC_263 alizarin 2.81 107.9 µM 0.00126 iron homeostasis 152 0.00251
14 SGTC_605 1315-0399 2.77 119.0 µM 0.00144 Golgi 88 0.00282
15 SGTC_337 1315-0038 2.75 354.0 µM 0.00155 amide catabolism 81 0.00300
16 SGTC_739 1486-1183 2.74 203.0 µM 0.00156 68 0.00303
17 SGTC_2295 7971645 2.69 200.0 µM 0.00187 101 0.00354
18 SGTC_2583 asiatic acid 2.64 100.0 µM 0.00225 103 0.00415
19 SGTC_1449 4112-4002 2.63 201.0 µM 0.00232 RPP1 & pyrimidine depletion 79 0.00427
20 SGTC_1086 cerivastatin 2.62 2.2 µM 0.00244 azole & statin 63 0.00445

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.241 2.04E-45 YNL312W RFA2 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.238 2.15E-44 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.188 3.42E-28 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.156 9.21E-20 YNL260C LTO1 het Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
0.146 1.45E-17 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.132 1.91E-14 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.128 8.65E-14 YDR534C FIT1 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.126 2.01E-13 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.123 8.09E-13 YHR106W TRR2 hom Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication
0.121 2.02E-12 YPR010C RPA135 het RNA polymerase I second largest subunit A135
0.113 4.46E-11 YEL066W HPA3 hom D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
0.112 7.45E-11 YGR082W TOM20 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
0.109 2.48E-10 YJR109C CPA2 hom Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor
0.107 5.46E-10 YKL187C FAT3 hom Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
0.107 5.37E-10 YDR531W CAB1 het Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element