YOR094W / ARF3

Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR094W / ARF3

Click on Significant Values for Screen Details ID:SGTC_80|Compound:0159-0065|FD-Score:2.74|P-value:9.22E-4 ID:SGTC_111|Compound:0083-0039|FD-Score:3.30|P-value:8.58E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.27|P-value:9.88E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:-2.87|P-value:5.50E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.33|P-value:7.63E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:-3.42|P-value:4.88E-5 ID:SGTC_644|Compound:1498-1197|FD-Score:-3.02|P-value:3.00E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-3.11|P-value:1.98E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:2.96|P-value:3.84E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:-2.75|P-value:8.66E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.49|P-value:3.65E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.89|P-value:4.79E-6 ID:SGTC_938|Compound:3126-1755|FD-Score:3.20|P-value:1.34E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.50|P-value:3.37E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.90|P-value:4.64E-6 ID:SGTC_1328|Compound:1441-0025|FD-Score:-2.88|P-value:5.19E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:-3.21|P-value:1.31E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.96|P-value:8.60E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.67|P-value:5.44E-8 ID:SGTC_1563|Compound:conessine|FD-Score:3.13|P-value:1.89E-4 ID:SGTC_1571|Compound:st070080|FD-Score:-2.74|P-value:9.08E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.74|P-value:1.05E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.24|P-value:1.15E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:2.99|P-value:3.43E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.30|P-value:8.56E-5 ID:SGTC_2012|Compound:4023501|FD-Score:-3.12|P-value:1.94E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.09|P-value:2.24E-4 ID:SGTC_2316|Compound:5844804|FD-Score:2.72|P-value:9.97E-4 ID:SGTC_2338|Compound:7999974|FD-Score:2.87|P-value:5.41E-4 ID:SGTC_2384|Compound:9036245|FD-Score:2.81|P-value:7.03E-4 ID:SGTC_2398|Compound:5228213|FD-Score:2.96|P-value:3.80E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.11|P-value:1.99E-4 ID:SGTC_3018|Compound:9082602|FD-Score:2.86|P-value:5.79E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:2.74|P-value:9.22E-4 ID:SGTC_111|Compound:0083-0039|FD-Score:3.30|P-value:8.58E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.27|P-value:9.88E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:-2.87|P-value:5.50E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.33|P-value:7.63E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:-3.42|P-value:4.88E-5 ID:SGTC_644|Compound:1498-1197|FD-Score:-3.02|P-value:3.00E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-3.11|P-value:1.98E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:2.96|P-value:3.84E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:-2.75|P-value:8.66E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.49|P-value:3.65E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.89|P-value:4.79E-6 ID:SGTC_938|Compound:3126-1755|FD-Score:3.20|P-value:1.34E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.50|P-value:3.37E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.90|P-value:4.64E-6 ID:SGTC_1328|Compound:1441-0025|FD-Score:-2.88|P-value:5.19E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:-3.21|P-value:1.31E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.96|P-value:8.60E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.67|P-value:5.44E-8 ID:SGTC_1563|Compound:conessine|FD-Score:3.13|P-value:1.89E-4 ID:SGTC_1571|Compound:st070080|FD-Score:-2.74|P-value:9.08E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.74|P-value:1.05E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.24|P-value:1.15E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:2.99|P-value:3.43E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.30|P-value:8.56E-5 ID:SGTC_2012|Compound:4023501|FD-Score:-3.12|P-value:1.94E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.09|P-value:2.24E-4 ID:SGTC_2316|Compound:5844804|FD-Score:2.72|P-value:9.97E-4 ID:SGTC_2338|Compound:7999974|FD-Score:2.87|P-value:5.41E-4 ID:SGTC_2384|Compound:9036245|FD-Score:2.81|P-value:7.03E-4 ID:SGTC_2398|Compound:5228213|FD-Score:2.96|P-value:3.80E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.11|P-value:1.99E-4 ID:SGTC_3018|Compound:9082602|FD-Score:2.86|P-value:5.79E-4

Top fitness defect scores for YOR094W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1586 deoxycorticosterone acetate 3.74 53.7 µM 1.05E-5 15 9.17E-5
2 SGTC_1200 1643-0193 3.50 18.4 µM 3.37E-5 28 2.29E-4
3 SGTC_739 1486-1183 3.49 203.0 µM 3.65E-5 29 2.44E-4
4 SGTC_111 0083-0039 3.30 52.5 µM 8.58E-5 11 4.77E-4
5 SGTC_1587 estradiol valerate 3.24 56.1 µM 1.15E-4 35 6.01E-4
6 SGTC_938 3126-1755 3.20 342.0 µM 1.34E-4 30 6.77E-4
7 SGTC_1563 conessine 3.13 56.1 µM 1.89E-4 45 8.87E-4
8 SGTC_2584 androsterone 3.11 48.7 µM 1.99E-4 cell wall 204 9.21E-4
9 SGTC_2309 7664088 3.09 163.9 µM 2.24E-4 95 0.00101
10 SGTC_1601 4'-hydroxyflavanone 2.99 55.5 µM 3.43E-4 RPP1 & pyrimidine depletion 73 0.00141
11 SGTC_2398 5228213 2.96 48.8 µM 3.80E-4 iron homeostasis 109 0.00153
12 SGTC_669 0108-0021 2.96 26.2 µM 3.84E-4 fatty acid desaturase (OLE1) 155 0.00155
13 SGTC_2338 7999974 2.87 200.0 µM 5.41E-4 75 0.00203
14 SGTC_3018 9082602 2.86 49.5 µM 5.79E-4 84 0.00214
15 SGTC_2384 9036245 2.81 200.0 µM 7.03E-4 86 0.00249
16 SGTC_80 0159-0065 2.74 512.2 µM 9.22E-4 27 0.00309
17 SGTC_2316 5844804 2.72 197.4 µM 9.97E-4 123 0.00328
18 SGTC_1503 4585-0012 2.71 61.3 µM 0.00102 82 0.00333
19 SGTC_774 k060-0086 2.65 136.0 µM 0.00127 96 0.00398
20 SGTC_1450 4112-4260 2.60 37.6 µM 0.00158 calcium & mitochondrial duress 101 0.00471

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.308 1.84E-74 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.301 3.24E-71 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.296 5.27E-69 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.285 1.32E-63 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.272 5.98E-58 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.257 9.27E-52 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.257 1.30E-51 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.252 1.07E-49 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.236 1.27E-43 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.232 3.95E-42 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.230 1.70E-41 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.230 1.98E-41 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.229 4.32E-41 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.229 2.70E-41 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.227 1.37E-40 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress