YOR098C / NUP1

FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR098C / NUP1

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:3.28|P-value:6.18E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:2.98|P-value:2.53E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:2.75|P-value:6.52E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:2.88|P-value:3.85E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:2.91|P-value:3.32E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:6.45|P-value:2.45E-14 ID:SGTC_592|Compound:k241-0073|FD-Score:3.26|P-value:6.95E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:3.28|P-value:6.27E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:-2.84|P-value:4.65E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.57|P-value:1.54E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.44|P-value:1.06E-7 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.10|P-value:8.19E-7 ID:SGTC_1350|Compound:1495-0454|FD-Score:-3.51|P-value:2.18E-5 ID:SGTC_1526|Compound:st051518|FD-Score:3.06|P-value:1.70E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.34|P-value:5.06E-5 ID:SGTC_1590|Compound:st077108|FD-Score:-3.29|P-value:6.19E-5 ID:SGTC_1591|Compound:genipin|FD-Score:-2.82|P-value:5.09E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.41|P-value:3.39E-5 ID:SGTC_1711|Compound:st032263|FD-Score:-3.55|P-value:1.78E-5 ID:SGTC_1746|Compound:st038117|FD-Score:-3.09|P-value:1.55E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-2.68|P-value:9.10E-4 ID:SGTC_1907|Compound:st060210|FD-Score:2.93|P-value:3.09E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.22|P-value:8.28E-5 ID:SGTC_2052|Compound:5265182|FD-Score:4.93|P-value:4.16E-9 ID:SGTC_2104|Compound:5389443|FD-Score:3.33|P-value:5.01E-5 ID:SGTC_2237|Compound:6667747|FD-Score:2.66|P-value:9.29E-4 ID:SGTC_2243|Compound:6634756|FD-Score:3.48|P-value:2.35E-5 ID:SGTC_2306|Compound:7482397|FD-Score:3.71|P-value:7.25E-6 ID:SGTC_2435|Compound:5706476|FD-Score:2.80|P-value:5.29E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.42|P-value:3.15E-5 ID:SGTC_2483|Compound:5729050|FD-Score:4.26|P-value:3.15E-7 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.73|P-value:6.84E-6 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.14|P-value:1.24E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-3.34|P-value:4.95E-5 ID:SGTC_2703|Compound:st077852|FD-Score:3.11|P-value:1.37E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.21|P-value:8.60E-5 ID:SGTC_2969|Compound:9091408|FD-Score:2.69|P-value:8.38E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.40|P-value:3.47E-5 ID:SGTC_3009|Compound:9080819|FD-Score:2.70|P-value:8.04E-4 ID:SGTC_3157|Compound:9099274|FD-Score:2.69|P-value:8.17E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.27|P-value:6.60E-5 ID:SGTC_3335|Compound:9143315|FD-Score:-2.80|P-value:5.45E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:3.28|P-value:6.18E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:2.98|P-value:2.53E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:2.75|P-value:6.52E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:2.88|P-value:3.85E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:2.91|P-value:3.32E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:6.45|P-value:2.45E-14 ID:SGTC_592|Compound:k241-0073|FD-Score:3.26|P-value:6.95E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:3.28|P-value:6.27E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:-2.84|P-value:4.65E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.57|P-value:1.54E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.44|P-value:1.06E-7 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.10|P-value:8.19E-7 ID:SGTC_1350|Compound:1495-0454|FD-Score:-3.51|P-value:2.18E-5 ID:SGTC_1526|Compound:st051518|FD-Score:3.06|P-value:1.70E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.34|P-value:5.06E-5 ID:SGTC_1590|Compound:st077108|FD-Score:-3.29|P-value:6.19E-5 ID:SGTC_1591|Compound:genipin|FD-Score:-2.82|P-value:5.09E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.41|P-value:3.39E-5 ID:SGTC_1711|Compound:st032263|FD-Score:-3.55|P-value:1.78E-5 ID:SGTC_1746|Compound:st038117|FD-Score:-3.09|P-value:1.55E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-2.68|P-value:9.10E-4 ID:SGTC_1907|Compound:st060210|FD-Score:2.93|P-value:3.09E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.22|P-value:8.28E-5 ID:SGTC_2052|Compound:5265182|FD-Score:4.93|P-value:4.16E-9 ID:SGTC_2104|Compound:5389443|FD-Score:3.33|P-value:5.01E-5 ID:SGTC_2237|Compound:6667747|FD-Score:2.66|P-value:9.29E-4 ID:SGTC_2243|Compound:6634756|FD-Score:3.48|P-value:2.35E-5 ID:SGTC_2306|Compound:7482397|FD-Score:3.71|P-value:7.25E-6 ID:SGTC_2435|Compound:5706476|FD-Score:2.80|P-value:5.29E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.42|P-value:3.15E-5 ID:SGTC_2483|Compound:5729050|FD-Score:4.26|P-value:3.15E-7 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.73|P-value:6.84E-6 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.14|P-value:1.24E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-3.34|P-value:4.95E-5 ID:SGTC_2703|Compound:st077852|FD-Score:3.11|P-value:1.37E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.21|P-value:8.60E-5 ID:SGTC_2969|Compound:9091408|FD-Score:2.69|P-value:8.38E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.40|P-value:3.47E-5 ID:SGTC_3009|Compound:9080819|FD-Score:2.70|P-value:8.04E-4 ID:SGTC_3157|Compound:9099274|FD-Score:2.69|P-value:8.17E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.27|P-value:6.60E-5 ID:SGTC_3335|Compound:9143315|FD-Score:-2.80|P-value:5.45E-4

Top fitness defect scores for YOR098C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_372 0155-0182 6.45 15.9 µM 2.45E-14 mitochondrial response to ROS 2 5.54E-11 0.85
2 SGTC_2052 5265182 4.93 7.1 µM 4.16E-9 3 4.07E-7 0.50
3 SGTC_1132 3456-3614 4.44 2.5 µM 1.06E-7 tubulin folding & SWR complex 9 4.48E-6 0.20
4 SGTC_2483 5729050 4.26 27.2 µM 3.15E-7 6 1.00E-5 0.20
5 SGTC_1255 0566-0045 4.10 221.0 µM 8.19E-7 excess fatty acid 13 2.04E-5 0.02
6 SGTC_2306 7482397 3.71 179.5 µM 7.25E-6 RPP1 & pyrimidine depletion 12 1.03E-4 0.15
7 SGTC_951 1171-0579 3.57 82.7 µM 1.54E-5 cell wall 29 1.81E-4 0.05
8 SGTC_2243 6634756 3.48 200.0 µM 2.35E-5 5 2.48E-4 0.19
9 SGTC_2479 5617353 3.42 43.9 µM 3.15E-5 12 3.09E-4 0.02
10 SGTC_1599 8-chlro-1-tetrahydronorharmanone 3.41 90.6 µM 3.39E-5 12 3.26E-4 0.13
11 SGTC_2995 9067767 3.40 71.4 µM 3.47E-5 5 3.32E-4 0.17
12 SGTC_2104 5389443 3.33 200.0 µM 5.01E-5 12 4.36E-4 0.21
13 SGTC_49 0717-0965 3.28 32.1 µM 6.18E-5 60S ribosome export 17 5.10E-4 0.05
14 SGTC_934 2950-0684 3.28 338.0 µM 6.27E-5 12 5.16E-4 0.15
15 SGTC_3235 9132602 3.27 49.5 µM 6.60E-5 9 5.36E-4 0.03
16 SGTC_592 k241-0073 3.26 46.5 µM 6.95E-5 6 5.57E-4 0.03
17 SGTC_1967 st070177 3.22 51.4 µM 8.28E-5 17 6.35E-4 0.13
18 SGTC_2769 toremifene 3.21 3.7 µM 8.60E-5 14 6.53E-4 0.03
19 SGTC_2663 amphotericin b 3.14 100.0 µM 1.24E-4 15 8.57E-4 0.02
20 SGTC_2703 st077852 3.11 53.4 µM 1.37E-4 15 9.26E-4 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.30E-10 YLR063W_p YLR063W_p hom Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
0.109 2.85E-10 YHR040W BCD1 het Essential protein required for the accumulation of box C/D snoRNA
0.108 2.97E-10 YEL068C_p YEL068C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.107 4.35E-10 YJR008W MHO1 hom Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility
0.104 1.72E-9 YBR153W RIB7 het Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway
0.104 1.76E-9 YLR247C IRC20 hom Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
0.103 2.68E-9 YNL145W MFA2 hom Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1
0.102 3.49E-9 YLR216C CPR6 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress
0.100 7.02E-9 YLR001C_p YLR001C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated
0.097 2.05E-8 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.094 5.68E-8 YBR054W YRO2 hom Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p; YRO2 has a paralog, MRH1, that arose from the whole genome duplication
0.092 8.36E-8 YIL024C_p YIL024C_p hom Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
0.084 1.17E-6 YLR350W ORM2 hom Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress
0.083 1.47E-6 YAL014C SYN8 hom Endosomal SNARE related to mammalian syntaxin 8
0.083 1.60E-6 YIR019C FLO11 hom GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); required for the formation of fibrous interconnections between cells in a colony of a wild S. cerevisiae strain