YOR162C / YRR1

Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR162C / YRR1

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:10.70|P-value:8.79E-21 ID:SGTC_4|Compound:0960-0234|FD-Score:4.33|P-value:1.07E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.27|P-value:1.30E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:5.27|P-value:2.93E-6 ID:SGTC_21|Compound:0849-0113|FD-Score:21.50|P-value:2.57E-79 ID:SGTC_38|Compound:0929-0051|FD-Score:6.48|P-value:1.13E-8 ID:SGTC_44|Compound:0929-0055|FD-Score:11.00|P-value:3.90E-22 ID:SGTC_50|Compound:0929-0078|FD-Score:6.32|P-value:2.41E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:14.70|P-value:7.96E-38 ID:SGTC_124|Compound:0136-0217|FD-Score:7.40|P-value:7.75E-11 ID:SGTC_145|Compound:3737-0113|FD-Score:7.09|P-value:4.50E-10 ID:SGTC_149|Compound:3970-0822|FD-Score:4.00|P-value:3.12E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:5.51|P-value:1.07E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:3.65|P-value:9.39E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.46|P-value:8.76E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:4.25|P-value:1.37E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:7.73|P-value:1.09E-11 ID:SGTC_204|Compound:1543-0184|FD-Score:4.00|P-value:3.13E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:8.09|P-value:1.23E-12 ID:SGTC_324|Compound:1315-0088|FD-Score:4.38|P-value:8.94E-5 ID:SGTC_331|Compound:k048-0133|FD-Score:4.62|P-value:3.70E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:5.16|P-value:4.58E-6 ID:SGTC_362|Compound:0310-0100|FD-Score:4.11|P-value:2.20E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.16|P-value:1.89E-4 ID:SGTC_441|Compound:propafenone|FD-Score:3.83|P-value:5.39E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:7.14|P-value:3.30E-10 ID:SGTC_534|Compound:k292-0788|FD-Score:-3.81|P-value:2.93E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.63|P-value:5.18E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:15.70|P-value:7.27E-43 ID:SGTC_566|Compound:0958-0068|FD-Score:6.30|P-value:2.68E-8 ID:SGTC_572|Compound:0960-0087|FD-Score:6.66|P-value:4.36E-9 ID:SGTC_574|Compound:1315-0397|FD-Score:4.80|P-value:1.89E-5 ID:SGTC_590|Compound:k048-0076|FD-Score:5.01|P-value:8.45E-6 ID:SGTC_619|Compound:1652-1634|FD-Score:4.50|P-value:5.85E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:3.63|P-value:9.85E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.17|P-value:1.82E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:7.58|P-value:2.70E-11 ID:SGTC_783|Compound:0848-0141|FD-Score:4.12|P-value:2.14E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:5.68|P-value:4.88E-7 ID:SGTC_867|Compound:0518-0118|FD-Score:3.86|P-value:4.88E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:4.77|P-value:2.14E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:3.90|P-value:4.36E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:4.75|P-value:2.33E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:4.25|P-value:1.37E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:5.24|P-value:3.32E-6 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.92|P-value:4.10E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.76|P-value:6.66E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:4.24|P-value:1.43E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.23|P-value:1.50E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.53|P-value:7.07E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.92|P-value:4.10E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.64|P-value:9.51E-4 ID:SGTC_1694|Compound:st024011|FD-Score:4.64|P-value:3.40E-5 ID:SGTC_1731|Compound:st035964|FD-Score:4.36|P-value:9.39E-5 ID:SGTC_1953|Compound:st076800|FD-Score:-4.24|P-value:6.69E-5 ID:SGTC_1975|Compound:st070967|FD-Score:-4.31|P-value:5.25E-5 ID:SGTC_1976|Compound:st070609|FD-Score:3.70|P-value:8.17E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-7.24|P-value:5.56E-11 ID:SGTC_2129|Compound:girgensonine|FD-Score:6.08|P-value:7.95E-8 ID:SGTC_2157|Compound:5649910|FD-Score:4.00|P-value:3.11E-4 ID:SGTC_2160|Compound:5660466|FD-Score:-4.10|P-value:1.12E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.73|P-value:7.29E-4 ID:SGTC_2239|Compound:6685329|FD-Score:6.56|P-value:7.44E-9 ID:SGTC_2248|Compound:tofa|FD-Score:4.32|P-value:1.10E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:5.68|P-value:4.94E-7 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-4.40|P-value:3.75E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.65|P-value:5.70E-7 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:25.50|P-value:1.01E-110 ID:SGTC_2661|Compound:dactinomycin|FD-Score:5.56|P-value:8.48E-7 ID:SGTC_2701|Compound:st077767|FD-Score:5.56|P-value:8.44E-7 ID:SGTC_2703|Compound:st077852|FD-Score:-4.29|P-value:5.64E-5 ID:SGTC_2828|Compound:7998861|FD-Score:4.24|P-value:1.44E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.83|P-value:2.77E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.71|P-value:7.71E-4 ID:SGTC_3217|Compound:9129673|FD-Score:-4.04|P-value:1.36E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-3.57|P-value:6.19E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:10.70|P-value:8.79E-21 ID:SGTC_4|Compound:0960-0234|FD-Score:4.33|P-value:1.07E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.27|P-value:1.30E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:5.27|P-value:2.93E-6 ID:SGTC_21|Compound:0849-0113|FD-Score:21.50|P-value:2.57E-79 ID:SGTC_38|Compound:0929-0051|FD-Score:6.48|P-value:1.13E-8 ID:SGTC_44|Compound:0929-0055|FD-Score:11.00|P-value:3.90E-22 ID:SGTC_50|Compound:0929-0078|FD-Score:6.32|P-value:2.41E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:14.70|P-value:7.96E-38 ID:SGTC_124|Compound:0136-0217|FD-Score:7.40|P-value:7.75E-11 ID:SGTC_145|Compound:3737-0113|FD-Score:7.09|P-value:4.50E-10 ID:SGTC_149|Compound:3970-0822|FD-Score:4.00|P-value:3.12E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:5.51|P-value:1.07E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:3.65|P-value:9.39E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.46|P-value:8.76E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:4.25|P-value:1.37E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:7.73|P-value:1.09E-11 ID:SGTC_204|Compound:1543-0184|FD-Score:4.00|P-value:3.13E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:8.09|P-value:1.23E-12 ID:SGTC_324|Compound:1315-0088|FD-Score:4.38|P-value:8.94E-5 ID:SGTC_331|Compound:k048-0133|FD-Score:4.62|P-value:3.70E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:5.16|P-value:4.58E-6 ID:SGTC_362|Compound:0310-0100|FD-Score:4.11|P-value:2.20E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.16|P-value:1.89E-4 ID:SGTC_441|Compound:propafenone|FD-Score:3.83|P-value:5.39E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:7.14|P-value:3.30E-10 ID:SGTC_534|Compound:k292-0788|FD-Score:-3.81|P-value:2.93E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.63|P-value:5.18E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:15.70|P-value:7.27E-43 ID:SGTC_566|Compound:0958-0068|FD-Score:6.30|P-value:2.68E-8 ID:SGTC_572|Compound:0960-0087|FD-Score:6.66|P-value:4.36E-9 ID:SGTC_574|Compound:1315-0397|FD-Score:4.80|P-value:1.89E-5 ID:SGTC_590|Compound:k048-0076|FD-Score:5.01|P-value:8.45E-6 ID:SGTC_619|Compound:1652-1634|FD-Score:4.50|P-value:5.85E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:3.63|P-value:9.85E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.17|P-value:1.82E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:7.58|P-value:2.70E-11 ID:SGTC_783|Compound:0848-0141|FD-Score:4.12|P-value:2.14E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:5.68|P-value:4.88E-7 ID:SGTC_867|Compound:0518-0118|FD-Score:3.86|P-value:4.88E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:4.77|P-value:2.14E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:3.90|P-value:4.36E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:4.75|P-value:2.33E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:4.25|P-value:1.37E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:5.24|P-value:3.32E-6 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.92|P-value:4.10E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.76|P-value:6.66E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:4.24|P-value:1.43E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.23|P-value:1.50E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.53|P-value:7.07E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.92|P-value:4.10E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.64|P-value:9.51E-4 ID:SGTC_1694|Compound:st024011|FD-Score:4.64|P-value:3.40E-5 ID:SGTC_1731|Compound:st035964|FD-Score:4.36|P-value:9.39E-5 ID:SGTC_1953|Compound:st076800|FD-Score:-4.24|P-value:6.69E-5 ID:SGTC_1975|Compound:st070967|FD-Score:-4.31|P-value:5.25E-5 ID:SGTC_1976|Compound:st070609|FD-Score:3.70|P-value:8.17E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-7.24|P-value:5.56E-11 ID:SGTC_2129|Compound:girgensonine|FD-Score:6.08|P-value:7.95E-8 ID:SGTC_2157|Compound:5649910|FD-Score:4.00|P-value:3.11E-4 ID:SGTC_2160|Compound:5660466|FD-Score:-4.10|P-value:1.12E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.73|P-value:7.29E-4 ID:SGTC_2239|Compound:6685329|FD-Score:6.56|P-value:7.44E-9 ID:SGTC_2248|Compound:tofa|FD-Score:4.32|P-value:1.10E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:5.68|P-value:4.94E-7 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-4.40|P-value:3.75E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.65|P-value:5.70E-7 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:25.50|P-value:1.01E-110 ID:SGTC_2661|Compound:dactinomycin|FD-Score:5.56|P-value:8.48E-7 ID:SGTC_2701|Compound:st077767|FD-Score:5.56|P-value:8.44E-7 ID:SGTC_2703|Compound:st077852|FD-Score:-4.29|P-value:5.64E-5 ID:SGTC_2828|Compound:7998861|FD-Score:4.24|P-value:1.44E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.83|P-value:2.77E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.71|P-value:7.71E-4 ID:SGTC_3217|Compound:9129673|FD-Score:-4.04|P-value:1.36E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-3.57|P-value:6.19E-4

Top fitness defect scores for YOR162C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2615 purpurogallin-4-carboxylic acid 25.50 100.0 µM 1.01E-110 redox potentiating 1 3.52E-144
2 SGTC_21 0849-0113 21.50 23.0 µM 2.57E-79 1 2.91E-103
3 SGTC_537 1334-0398 15.70 209.0 µM 7.27E-43 1 9.86E-56
4 SGTC_119 0121-0043 14.70 24.8 µM 7.96E-38 mitochondrial stress 3 3.72E-49
5 SGTC_44 0929-0055 11.00 61.2 µM 3.90E-22 1 1.15E-28
6 SGTC_3 0833-0587 10.70 95.6 µM 8.79E-21 redox potentiating 2 6.76E-27
7 SGTC_288 1315-0019 8.09 35.1 µM 1.23E-12 RSC & ERG11 1 3.07E-16
8 SGTC_203 k066-0004 7.73 30.9 µM 1.09E-11 RSC & ERG11 1 5.31E-15
9 SGTC_767 0929-0023 7.58 86.0 µM 2.70E-11 TRP & mitochondrial translation 13 1.74E-14
10 SGTC_124 0136-0217 7.40 7.1 µM 7.75E-11 mitochondrial stress 12 6.92E-14
11 SGTC_518 1021-0119 7.14 62.6 µM 3.30E-10 ERG2 5 4.61E-13
12 SGTC_145 3737-0113 7.09 38.4 µM 4.50E-10 DNA intercalators 15 6.92E-13
13 SGTC_572 0960-0087 6.66 17.7 µM 4.36E-9 2 1.35E-11
14 SGTC_2239 6685329 6.56 187.6 µM 7.44E-9 2 2.73E-11
15 SGTC_38 0929-0051 6.48 58.3 µM 1.13E-8 3 4.74E-11
16 SGTC_50 0929-0078 6.32 56.4 µM 2.41E-8 22 1.27E-10
17 SGTC_566 0958-0068 6.30 16.5 µM 2.68E-8 RSC & ERG11 4 1.46E-10
18 SGTC_2129 girgensonine 6.08 121.0 µM 7.95E-8 heme biosynthesis & mitochondrial translocase 12 6.08E-10
19 SGTC_855 0428-0020 5.68 25.0 µM 4.88E-7 Golgi 5 6.55E-9
20 SGTC_2513 baicalein 5.68 25.6 µM 4.94E-7 calcium & mitochondrial duress 9 6.67E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.267 9.98E-56 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.188 4.73E-28 YBL059W_p YBL059W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication
0.166 3.99E-22 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.157 6.37E-20 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.153 4.33E-19 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.150 2.28E-18 YGL008C PMA1 het Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]
0.147 1.32E-17 YGL007W_d BRP1_d hom Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1
0.144 5.50E-17 YOR164C GET4 hom Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20
0.143 9.97E-17 YGR280C PXR1 het Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
0.139 5.46E-16 YBR151W APD1 hom Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
0.137 1.52E-15 YBR157C ICS2 hom Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
0.135 4.91E-15 YLR304C ACO1 hom Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
0.134 7.56E-15 YDR173C ARG82 hom Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
0.132 1.52E-14 YLL040C VPS13 hom Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.121 2.03E-12 YPL222W_p FMP40_p hom Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies