YOR202W / HIS3

Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR202W / HIS3

Click on Significant Values for Screen Details ID:SGTC_183|Compound:3914-0051|FD-Score:3.14|P-value:2.31E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-2.94|P-value:5.88E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.38|P-value:8.18E-5 ID:SGTC_300|Compound:r073-0011|FD-Score:-3.36|P-value:1.04E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.19|P-value:1.89E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.46|P-value:5.77E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:3.35|P-value:9.59E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:-2.88|P-value:7.64E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.28|P-value:1.50E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.35|P-value:1.08E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.44|P-value:6.30E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:-2.98|P-value:5.16E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.56|P-value:3.63E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.86|P-value:7.18E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.57|P-value:3.54E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.81|P-value:1.10E-5 ID:SGTC_1711|Compound:st032263|FD-Score:3.09|P-value:2.90E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.24|P-value:1.53E-4 ID:SGTC_1741|Compound:st038134|FD-Score:9.57|P-value:1.13E-26 ID:SGTC_1749|Compound:st037932|FD-Score:3.66|P-value:2.30E-5 ID:SGTC_1750|Compound:st081859|FD-Score:5.67|P-value:1.50E-10 ID:SGTC_1864|Compound:st057645|FD-Score:-3.18|P-value:2.29E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.21|P-value:1.73E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.10|P-value:3.17E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.16|P-value:2.17E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:2.88|P-value:6.63E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.13|P-value:2.44E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.47|P-value:5.54E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:8.68|P-value:2.74E-22 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.68|P-value:1.20E-7 ID:SGTC_2784|Compound:7567673|FD-Score:-3.17|P-value:2.39E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.23|P-value:1.83E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-3.42|P-value:7.97E-5 ID:SGTC_2805|Compound:7950783|FD-Score:4.76|P-value:5.96E-8 ID:SGTC_2832|Compound:7992762|FD-Score:-3.80|P-value:1.39E-5 ID:SGTC_2871|Compound:9038510|FD-Score:3.01|P-value:3.95E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.12|P-value:2.32E-6 ID:SGTC_3006|Compound:9075424|FD-Score:3.57|P-value:3.55E-5 ID:SGTC_3290|Compound:9121031|FD-Score:3.88|P-value:7.86E-6 ID:SGTC_3292|Compound:9120825|FD-Score:3.82|P-value:1.07E-5 ID:SGTC_3320|Compound:9137005|FD-Score:-3.65|P-value:2.82E-5 ID:SGTC_3323|Compound:9138564|FD-Score:3.38|P-value:8.39E-5 ID:SGTC_3327|Compound:9140648|FD-Score:2.88|P-value:6.52E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.14|P-value:2.31E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-2.94|P-value:5.88E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.38|P-value:8.18E-5 ID:SGTC_300|Compound:r073-0011|FD-Score:-3.36|P-value:1.04E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.19|P-value:1.89E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.46|P-value:5.77E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:3.35|P-value:9.59E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:-2.88|P-value:7.64E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.28|P-value:1.50E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.35|P-value:1.08E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.44|P-value:6.30E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:-2.98|P-value:5.16E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.56|P-value:3.63E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.86|P-value:7.18E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.57|P-value:3.54E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.81|P-value:1.10E-5 ID:SGTC_1711|Compound:st032263|FD-Score:3.09|P-value:2.90E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.24|P-value:1.53E-4 ID:SGTC_1741|Compound:st038134|FD-Score:9.57|P-value:1.13E-26 ID:SGTC_1749|Compound:st037932|FD-Score:3.66|P-value:2.30E-5 ID:SGTC_1750|Compound:st081859|FD-Score:5.67|P-value:1.50E-10 ID:SGTC_1864|Compound:st057645|FD-Score:-3.18|P-value:2.29E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.21|P-value:1.73E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.10|P-value:3.17E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.16|P-value:2.17E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:2.88|P-value:6.63E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.13|P-value:2.44E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.47|P-value:5.54E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:8.68|P-value:2.74E-22 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.68|P-value:1.20E-7 ID:SGTC_2784|Compound:7567673|FD-Score:-3.17|P-value:2.39E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.23|P-value:1.83E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-3.42|P-value:7.97E-5 ID:SGTC_2805|Compound:7950783|FD-Score:4.76|P-value:5.96E-8 ID:SGTC_2832|Compound:7992762|FD-Score:-3.80|P-value:1.39E-5 ID:SGTC_2871|Compound:9038510|FD-Score:3.01|P-value:3.95E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.12|P-value:2.32E-6 ID:SGTC_3006|Compound:9075424|FD-Score:3.57|P-value:3.55E-5 ID:SGTC_3290|Compound:9121031|FD-Score:3.88|P-value:7.86E-6 ID:SGTC_3292|Compound:9120825|FD-Score:3.82|P-value:1.07E-5 ID:SGTC_3320|Compound:9137005|FD-Score:-3.65|P-value:2.82E-5 ID:SGTC_3323|Compound:9138564|FD-Score:3.38|P-value:8.39E-5 ID:SGTC_3327|Compound:9140648|FD-Score:2.88|P-value:6.52E-4

Top fitness defect scores for YOR202W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1741 st038134 9.57 10.2 µM 1.13E-26 1 5.29E-22
2 SGTC_2588 indole-3-carbinol 8.68 100.0 µM 2.74E-22 4 1.97E-18
3 SGTC_1750 st081859 5.67 2.4 µM 1.50E-10 endomembrane recycling 116 7.29E-9
4 SGTC_2805 7950783 4.76 58.4 µM 5.96E-8 11 9.65E-7
5 SGTC_2930 9013230 4.12 14.9 µM 2.32E-6 heme biosynthesis & mitochondrial translocase 28 1.93E-5
6 SGTC_3290 9121031 3.88 71.4 µM 7.86E-6 13 5.23E-5
7 SGTC_3292 9120825 3.82 59.8 µM 1.07E-5 13 6.76E-5
8 SGTC_1592 4',5'-dihydroxyflavone 3.81 8.8 µM 1.10E-5 60S ribosome export 15 6.91E-5
9 SGTC_1749 st037932 3.66 54.2 µM 2.30E-5 36 1.26E-4
10 SGTC_1525 8-methoxypsoralen 3.57 92.5 µM 3.54E-5 DNA damage response 46 1.80E-4
11 SGTC_3006 9075424 3.57 71.4 µM 3.55E-5 17 1.80E-4
12 SGTC_1180 1193-0155 3.56 285.0 µM 3.63E-5 21 1.83E-4
13 SGTC_2584 androsterone 3.47 48.7 µM 5.54E-5 cell wall 160 2.59E-4
14 SGTC_686 1319-0111 3.46 510.0 µM 5.77E-5 60S ribosome export 43 2.68E-4
15 SGTC_1172 0370-0043 3.44 85.0 µM 6.30E-5 37 2.88E-4
16 SGTC_266 formosanin C 3.38 406.0 nM 8.18E-5 sphingolipid biosynthesis & PDR1 86 3.57E-4
17 SGTC_3323 9138564 3.38 53.9 µM 8.39E-5 38 3.64E-4
18 SGTC_815 1582-0027 3.35 36.9 µM 9.59E-5 59 4.06E-4
19 SGTC_1738 st035555 3.24 74.0 µM 1.53E-4 TSC3-RPN4 63 5.96E-4
20 SGTC_2012 4023501 3.21 200.0 µM 1.73E-4 62 6.59E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.183 1.28E-26 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.167 1.71E-22 YBR259W YBR259W hom Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress
0.164 1.33E-21 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.151 1.27E-18 YFL051C_p YFL051C_p hom Putative protein of unknown function; YFL051C is not an essential gene
0.150 2.20E-18 YPR153W YPR153W hom Putative protein of unknown function
0.149 5.05E-18 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.146 1.65E-17 YOL160W_d YOL160W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.133 1.29E-14 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.131 2.95E-14 YJL026W RNR2 het Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
0.128 1.07E-13 YCL046W_d YCL046W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
0.121 2.28E-12 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.118 5.87E-12 YGL166W CUP2 hom Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication
0.118 5.82E-12 YMR317W_p YMR317W_p hom Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene
0.117 1.04E-11 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.117 1.13E-11 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi