YOR231W / MKK1

MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR231W / MKK1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:24.40|P-value:1.08E-138 ID:SGTC_138|Compound:0850-0259|FD-Score:3.25|P-value:4.59E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:8.10|P-value:5.45E-17 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.05|P-value:9.14E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-3.61|P-value:9.78E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.10|P-value:7.70E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.69|P-value:8.02E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.16|P-value:5.66E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.26|P-value:4.36E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:6.37|P-value:3.60E-11 ID:SGTC_716|Compound:1683-5115|FD-Score:-3.11|P-value:6.61E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:6.74|P-value:2.63E-12 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.28|P-value:3.64E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-3.74|P-value:5.84E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:3.57|P-value:1.34E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:-3.23|P-value:4.37E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.03|P-value:9.87E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.80|P-value:5.19E-5 ID:SGTC_904|Compound:1141-0088|FD-Score:3.67|P-value:8.93E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:3.22|P-value:5.10E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.33|P-value:4.67E-6 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.73|P-value:6.05E-5 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.89|P-value:3.46E-5 ID:SGTC_1410|Compound:3909-8106|FD-Score:-3.07|P-value:7.67E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.75|P-value:6.41E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-3.00|P-value:9.73E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.42|P-value:2.34E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.29|P-value:3.83E-4 ID:SGTC_2007|Compound:4011539|FD-Score:6.81|P-value:1.52E-12 ID:SGTC_2009|Compound:4012297|FD-Score:5.04|P-value:1.26E-7 ID:SGTC_2015|Compound:5119600|FD-Score:-3.17|P-value:5.36E-4 ID:SGTC_2075|Compound:5212009|FD-Score:-3.20|P-value:4.84E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.50|P-value:1.76E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.84|P-value:4.26E-5 ID:SGTC_2171|Compound:5739187|FD-Score:3.05|P-value:9.37E-4 ID:SGTC_2203|Compound:7227154|FD-Score:3.93|P-value:2.90E-5 ID:SGTC_2213|Compound:7173844|FD-Score:3.41|P-value:2.52E-4 ID:SGTC_2334|Compound:9017922|FD-Score:4.43|P-value:2.88E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.42|P-value:1.48E-8 ID:SGTC_2880|Compound:9042983|FD-Score:3.38|P-value:2.74E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-3.46|P-value:1.82E-4 ID:SGTC_2992|Compound:9074591|FD-Score:3.60|P-value:1.19E-4 ID:SGTC_2998|Compound:9066762|FD-Score:7.13|P-value:1.45E-13 ID:SGTC_3089|Compound:9117425|FD-Score:3.76|P-value:6.17E-5 ID:SGTC_3107|Compound:9121808|FD-Score:-3.96|P-value:2.27E-5 ID:SGTC_3165|Compound:9101544|FD-Score:4.44|P-value:2.84E-6 ID:SGTC_3166|Compound:9102297|FD-Score:3.88|P-value:3.66E-5 ID:SGTC_3168|Compound:9103419|FD-Score:-3.39|P-value:2.39E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-5.90|P-value:6.29E-10 ID:SGTC_3172|Compound:9105863|FD-Score:4.47|P-value:2.40E-6 ID:SGTC_3179|Compound:9107801|FD-Score:-3.54|P-value:1.33E-4 ID:SGTC_3208|Compound:9114115|FD-Score:4.21|P-value:8.38E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:24.40|P-value:1.08E-138 ID:SGTC_138|Compound:0850-0259|FD-Score:3.25|P-value:4.59E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:8.10|P-value:5.45E-17 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.05|P-value:9.14E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-3.61|P-value:9.78E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.10|P-value:7.70E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.69|P-value:8.02E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.16|P-value:5.66E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.26|P-value:4.36E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:6.37|P-value:3.60E-11 ID:SGTC_716|Compound:1683-5115|FD-Score:-3.11|P-value:6.61E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:6.74|P-value:2.63E-12 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.28|P-value:3.64E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-3.74|P-value:5.84E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:3.57|P-value:1.34E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:-3.23|P-value:4.37E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.03|P-value:9.87E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.80|P-value:5.19E-5 ID:SGTC_904|Compound:1141-0088|FD-Score:3.67|P-value:8.93E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:3.22|P-value:5.10E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.33|P-value:4.67E-6 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.73|P-value:6.05E-5 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.89|P-value:3.46E-5 ID:SGTC_1410|Compound:3909-8106|FD-Score:-3.07|P-value:7.67E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.75|P-value:6.41E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-3.00|P-value:9.73E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.42|P-value:2.34E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.29|P-value:3.83E-4 ID:SGTC_2007|Compound:4011539|FD-Score:6.81|P-value:1.52E-12 ID:SGTC_2009|Compound:4012297|FD-Score:5.04|P-value:1.26E-7 ID:SGTC_2015|Compound:5119600|FD-Score:-3.17|P-value:5.36E-4 ID:SGTC_2075|Compound:5212009|FD-Score:-3.20|P-value:4.84E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.50|P-value:1.76E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.84|P-value:4.26E-5 ID:SGTC_2171|Compound:5739187|FD-Score:3.05|P-value:9.37E-4 ID:SGTC_2203|Compound:7227154|FD-Score:3.93|P-value:2.90E-5 ID:SGTC_2213|Compound:7173844|FD-Score:3.41|P-value:2.52E-4 ID:SGTC_2334|Compound:9017922|FD-Score:4.43|P-value:2.88E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.42|P-value:1.48E-8 ID:SGTC_2880|Compound:9042983|FD-Score:3.38|P-value:2.74E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-3.46|P-value:1.82E-4 ID:SGTC_2992|Compound:9074591|FD-Score:3.60|P-value:1.19E-4 ID:SGTC_2998|Compound:9066762|FD-Score:7.13|P-value:1.45E-13 ID:SGTC_3089|Compound:9117425|FD-Score:3.76|P-value:6.17E-5 ID:SGTC_3107|Compound:9121808|FD-Score:-3.96|P-value:2.27E-5 ID:SGTC_3165|Compound:9101544|FD-Score:4.44|P-value:2.84E-6 ID:SGTC_3166|Compound:9102297|FD-Score:3.88|P-value:3.66E-5 ID:SGTC_3168|Compound:9103419|FD-Score:-3.39|P-value:2.39E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-5.90|P-value:6.29E-10 ID:SGTC_3172|Compound:9105863|FD-Score:4.47|P-value:2.40E-6 ID:SGTC_3179|Compound:9107801|FD-Score:-3.54|P-value:1.33E-4 ID:SGTC_3208|Compound:9114115|FD-Score:4.21|P-value:8.38E-6

Top fitness defect scores for YOR231W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 24.40 9.0 µM 1.08E-138 cell wall 4 5.30E-132
2 SGTC_255 tunicamycin 8.10 200.5 nM 5.45E-17 unfolded protein response 17 2.78E-16
3 SGTC_2998 9066762 7.13 71.4 µM 1.45E-13 RPP1 & pyrimidine depletion 2 5.09E-13
4 SGTC_2007 4011539 6.81 71.8 µM 1.52E-12 cell wall signaling 19 4.77E-12
5 SGTC_783 0848-0141 6.74 92.7 µM 2.63E-12 RSC & ERG11 2 8.04E-12
6 SGTC_663 1486-0733 6.37 13.9 µM 3.60E-11 cell wall signaling 17 9.72E-11
7 SGTC_2582 agaric acid 5.42 100.0 µM 1.48E-8 redox potentiating 197 3.02E-8
8 SGTC_2009 4012297 5.04 12.1 µM 1.26E-7 cell wall signaling 35 2.33E-7
9 SGTC_3172 9105863 4.47 49.5 µM 2.40E-6 ERG2 4 3.88E-6
10 SGTC_3165 9101544 4.44 49.5 µM 2.84E-6 9 4.55E-6
11 SGTC_2334 9017922 4.43 200.0 µM 2.88E-6 14 4.61E-6
12 SGTC_1000 4048-0884 4.33 8.7 µM 4.67E-6 copper-dependent oxidative stress 26 7.31E-6
13 SGTC_3208 9114115 4.21 49.5 µM 8.38E-6 28 1.28E-5
14 SGTC_2203 7227154 3.93 166.4 µM 2.90E-5 14 4.18E-5
15 SGTC_1025 k007-0731 3.89 70.0 µM 3.46E-5 13 4.95E-5
16 SGTC_3166 9102297 3.88 49.5 µM 3.66E-5 Golgi 33 5.22E-5
17 SGTC_2091 4-phenylthiadiazole 3.84 200.0 µM 4.26E-5 17 6.04E-5
18 SGTC_892 0929-0076 3.80 29.0 µM 5.19E-5 TRP & mitochondrial translation 45 7.29E-5
19 SGTC_3089 9117425 3.76 49.5 µM 6.17E-5 29 8.61E-5
20 SGTC_1442 4112-3290 3.75 3.0 µM 6.41E-5 20 8.92E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.481 8.13E-194 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.456 3.27E-172 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.451 1.44E-167 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.441 1.86E-159 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.408 1.59E-134 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.407 2.35E-134 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.389 1.53E-121 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.387 2.55E-120 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.384 3.84E-118 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.377 7.07E-114 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.365 1.92E-106 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.363 2.44E-105 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.359 1.28E-102 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.353 1.06E-98 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.348 4.49E-96 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together