YOR243C / PUS7

Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR243C / PUS7

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.41|P-value:7.68E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.66|P-value:3.41E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.40|P-value:6.90E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.70|P-value:2.48E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.34|P-value:9.79E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:-3.71|P-value:2.46E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:-3.40|P-value:6.84E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.62|P-value:3.91E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.77|P-value:4.55E-6 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.43|P-value:6.26E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.71|P-value:2.91E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:6.43|P-value:1.08E-9 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.87|P-value:3.00E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.97|P-value:9.38E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:5.84|P-value:2.79E-8 ID:SGTC_625|Compound:k213-0058|FD-Score:5.61|P-value:9.02E-8 ID:SGTC_789|Compound:1309-1135|FD-Score:3.56|P-value:4.72E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.30|P-value:9.42E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.80|P-value:2.09E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:3.48|P-value:6.16E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.43|P-value:6.33E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.79|P-value:1.83E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.56|P-value:4.02E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.52|P-value:5.47E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.34|P-value:9.82E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.63|P-value:8.27E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.42|P-value:7.53E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.64|P-value:3.60E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.00|P-value:1.02E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.78|P-value:4.46E-6 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.62|P-value:8.94E-6 ID:SGTC_1559|Compound:coumarin 343|FD-Score:-3.55|P-value:4.15E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.42|P-value:7.56E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.99|P-value:8.92E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.35|P-value:9.54E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.56|P-value:4.71E-4 ID:SGTC_1799|Compound:st045822|FD-Score:5.38|P-value:2.77E-7 ID:SGTC_1887|Compound:st057648|FD-Score:3.42|P-value:7.64E-4 ID:SGTC_1904|Compound:st060225|FD-Score:3.34|P-value:9.63E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.71|P-value:2.89E-4 ID:SGTC_1931|Compound:st074438|FD-Score:7.12|P-value:1.65E-11 ID:SGTC_1952|Compound:st077036|FD-Score:4.13|P-value:6.28E-5 ID:SGTC_2043|Compound:5101342|FD-Score:3.38|P-value:8.56E-4 ID:SGTC_2087|Compound:5276107|FD-Score:4.72|P-value:5.66E-6 ID:SGTC_2144|Compound:5628481|FD-Score:3.61|P-value:4.01E-4 ID:SGTC_2205|Compound:7238770|FD-Score:3.90|P-value:1.49E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:4.46|P-value:1.68E-5 ID:SGTC_2245|Compound:6637752|FD-Score:6.78|P-value:1.42E-10 ID:SGTC_2285|Compound:7945142|FD-Score:4.30|P-value:3.23E-5 ID:SGTC_2286|Compound:7945697|FD-Score:-3.84|P-value:1.54E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.79|P-value:2.14E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.53|P-value:5.31E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.51|P-value:5.59E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.62|P-value:6.81E-8 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.73|P-value:2.25E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.99|P-value:1.07E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.84|P-value:1.79E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:4.44|P-value:1.89E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.69|P-value:2.58E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.95|P-value:1.25E-4 ID:SGTC_2995|Compound:9067767|FD-Score:5.03|P-value:1.46E-6 ID:SGTC_3148|Compound:9097893|FD-Score:5.92|P-value:1.82E-8 ID:SGTC_3299|Compound:9121982|FD-Score:4.59|P-value:1.01E-5 ID:SGTC_3329|Compound:9141233|FD-Score:4.04|P-value:8.63E-5 ID:SGTC_3339|Compound:9145883|FD-Score:5.02|P-value:1.50E-6 ID:SGTC_6|Compound:0844-0013|FD-Score:3.41|P-value:7.68E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.66|P-value:3.41E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.40|P-value:6.90E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.70|P-value:2.48E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.34|P-value:9.79E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:-3.71|P-value:2.46E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:-3.40|P-value:6.84E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.62|P-value:3.91E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.77|P-value:4.55E-6 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.43|P-value:6.26E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.71|P-value:2.91E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:6.43|P-value:1.08E-9 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.87|P-value:3.00E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.97|P-value:9.38E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:5.84|P-value:2.79E-8 ID:SGTC_625|Compound:k213-0058|FD-Score:5.61|P-value:9.02E-8 ID:SGTC_789|Compound:1309-1135|FD-Score:3.56|P-value:4.72E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.30|P-value:9.42E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.80|P-value:2.09E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:3.48|P-value:6.16E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.43|P-value:6.33E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.79|P-value:1.83E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.56|P-value:4.02E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.52|P-value:5.47E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.34|P-value:9.82E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.63|P-value:8.27E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.42|P-value:7.53E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.64|P-value:3.60E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.00|P-value:1.02E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.78|P-value:4.46E-6 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.62|P-value:8.94E-6 ID:SGTC_1559|Compound:coumarin 343|FD-Score:-3.55|P-value:4.15E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.42|P-value:7.56E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.99|P-value:8.92E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.35|P-value:9.54E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.56|P-value:4.71E-4 ID:SGTC_1799|Compound:st045822|FD-Score:5.38|P-value:2.77E-7 ID:SGTC_1887|Compound:st057648|FD-Score:3.42|P-value:7.64E-4 ID:SGTC_1904|Compound:st060225|FD-Score:3.34|P-value:9.63E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.71|P-value:2.89E-4 ID:SGTC_1931|Compound:st074438|FD-Score:7.12|P-value:1.65E-11 ID:SGTC_1952|Compound:st077036|FD-Score:4.13|P-value:6.28E-5 ID:SGTC_2043|Compound:5101342|FD-Score:3.38|P-value:8.56E-4 ID:SGTC_2087|Compound:5276107|FD-Score:4.72|P-value:5.66E-6 ID:SGTC_2144|Compound:5628481|FD-Score:3.61|P-value:4.01E-4 ID:SGTC_2205|Compound:7238770|FD-Score:3.90|P-value:1.49E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:4.46|P-value:1.68E-5 ID:SGTC_2245|Compound:6637752|FD-Score:6.78|P-value:1.42E-10 ID:SGTC_2285|Compound:7945142|FD-Score:4.30|P-value:3.23E-5 ID:SGTC_2286|Compound:7945697|FD-Score:-3.84|P-value:1.54E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.79|P-value:2.14E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.53|P-value:5.31E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.51|P-value:5.59E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.62|P-value:6.81E-8 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.73|P-value:2.25E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.99|P-value:1.07E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.84|P-value:1.79E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:4.44|P-value:1.89E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.69|P-value:2.58E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.95|P-value:1.25E-4 ID:SGTC_2995|Compound:9067767|FD-Score:5.03|P-value:1.46E-6 ID:SGTC_3148|Compound:9097893|FD-Score:5.92|P-value:1.82E-8 ID:SGTC_3299|Compound:9121982|FD-Score:4.59|P-value:1.01E-5 ID:SGTC_3329|Compound:9141233|FD-Score:4.04|P-value:8.63E-5 ID:SGTC_3339|Compound:9145883|FD-Score:5.02|P-value:1.50E-6

Top fitness defect scores for YOR243C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1931 st074438 7.12 57.1 µM 1.65E-11 2 5.25E-13
2 SGTC_2245 6637752 6.78 200.0 µM 1.42E-10 6 6.19E-12
3 SGTC_422 cantharidin 6.43 155.0 µM 1.08E-9 cell wall signaling 17 6.37E-11
4 SGTC_3148 9097893 5.92 49.5 µM 1.82E-8 12 1.62E-9
5 SGTC_617 3770-0098 5.84 35.0 µM 2.79E-8 exosome 4 2.63E-9
6 SGTC_625 k213-0058 5.61 121.0 µM 9.02E-8 translation 45 1.01E-8
7 SGTC_1799 st045822 5.38 46.1 µM 2.77E-7 3 3.65E-8
8 SGTC_2995 9067767 5.03 71.4 µM 1.46E-6 10 2.45E-7
9 SGTC_3339 9145883 5.02 14.9 µM 1.50E-6 5 2.54E-7
10 SGTC_423 5-fluorouracil 4.87 457.0 µM 3.00E-6 exosome 9 5.60E-7
11 SGTC_1445 4239-0156 4.78 97.7 µM 4.46E-6 11 8.83E-7
12 SGTC_102 gallobenzophenone 4.77 83.6 µM 4.55E-6 redox potentiating 27 9.02E-7
13 SGTC_2087 5276107 4.72 200.0 µM 5.66E-6 7 1.16E-6
14 SGTC_1131 3454-3128 4.63 32.3 µM 8.27E-6 20 1.79E-6
15 SGTC_1534 6-azauridine 4.62 81.6 µM 8.94E-6 RNA pol III & RNase P/MRP 10 1.96E-6
16 SGTC_3299 9121982 4.59 43.1 µM 1.01E-5 13 2.24E-6
17 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 4.46 122.8 µM 1.68E-5 3 4.04E-6
18 SGTC_2766 oltipraz 4.44 83.9 µM 1.89E-5 heme requiring 17 4.60E-6
19 SGTC_2285 7945142 4.30 200.0 µM 3.23E-5 14 8.52E-6
20 SGTC_1952 st077036 4.13 64.1 µM 6.28E-5 31 1.82E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 3.10E-9 YGL151W NUT1 hom Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
0.097 2.13E-8 YGL236C MTO1 hom Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
0.091 1.19E-7 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.091 1.41E-7 YER131W RPS26B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication
0.091 1.45E-7 YDR443C SSN2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation
0.090 1.60E-7 YMR056C AAC1 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.089 2.12E-7 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.089 2.32E-7 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.087 3.87E-7 YGL057C GEP7 hom Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.087 4.26E-7 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.083 1.42E-6 YGR185C TYS1 het Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress
0.081 2.98E-6 YER016W BIM1 hom Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
0.080 3.22E-6 YNL140C_p YNL140C_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
0.078 6.56E-6 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.078 6.60E-6 YMR191W SPG5 hom Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources