YOR248W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR248W / YOR248W

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:-3.10|P-value:4.52E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:-2.91|P-value:9.38E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.15|P-value:3.76E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:4.31|P-value:2.40E-6 ID:SGTC_253|Compound:dyclonine|FD-Score:3.57|P-value:7.82E-5 ID:SGTC_287|Compound:k060-0039|FD-Score:2.99|P-value:7.73E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.35|P-value:1.73E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.57|P-value:7.84E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.05|P-value:5.51E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.66|P-value:4.50E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:2.98|P-value:8.14E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:-3.48|P-value:1.01E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.03|P-value:6.67E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.13|P-value:4.55E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.28|P-value:2.58E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:10.90|P-value:4.30E-31 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.86|P-value:2.15E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:7.07|P-value:2.87E-14 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.29|P-value:2.21E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.88|P-value:1.98E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.74|P-value:3.75E-5 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.79|P-value:2.90E-5 ID:SGTC_1672|Compound:st016598|FD-Score:3.18|P-value:3.82E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-2.91|P-value:9.16E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.10|P-value:5.11E-4 ID:SGTC_1717|Compound:st033143|FD-Score:2.98|P-value:8.09E-4 ID:SGTC_1999|Compound:st074831|FD-Score:2.92|P-value:9.92E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.03|P-value:6.60E-4 ID:SGTC_2083|Compound:5306046|FD-Score:3.73|P-value:3.77E-5 ID:SGTC_2162|Compound:5663267|FD-Score:3.11|P-value:5.00E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.32|P-value:2.14E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.00|P-value:7.51E-4 ID:SGTC_2373|Compound:9071805|FD-Score:4.11|P-value:6.68E-6 ID:SGTC_2378|Compound:9074213|FD-Score:-3.64|P-value:4.93E-5 ID:SGTC_2389|Compound:9091542|FD-Score:-3.52|P-value:8.43E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:4.29|P-value:2.64E-6 ID:SGTC_2594|Compound:a-mangostin|FD-Score:6.13|P-value:3.88E-11 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.63|P-value:5.24E-5 ID:SGTC_2744|Compound:captopril|FD-Score:3.20|P-value:3.54E-4 ID:SGTC_2818|Compound:7996756|FD-Score:3.18|P-value:3.81E-4 ID:SGTC_2862|Compound:9027634|FD-Score:4.10|P-value:6.80E-6 ID:SGTC_2872|Compound:9044037|FD-Score:3.26|P-value:2.81E-4 ID:SGTC_2876|Compound:9059903|FD-Score:-7.17|P-value:1.03E-14 ID:SGTC_2912|Compound:7964298|FD-Score:5.35|P-value:6.81E-9 ID:SGTC_2913|Compound:7966556|FD-Score:3.58|P-value:7.37E-5 ID:SGTC_3054|Compound:9094397|FD-Score:3.40|P-value:1.55E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.40|P-value:1.59E-4 ID:SGTC_3114|Compound:9122766|FD-Score:4.10|P-value:6.93E-6 ID:SGTC_3167|Compound:9103034|FD-Score:3.75|P-value:3.53E-5 ID:SGTC_3170|Compound:9103054|FD-Score:3.48|P-value:1.12E-4 ID:SGTC_3187|Compound:9109394|FD-Score:-3.30|P-value:2.12E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.21|P-value:3.35E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.10|P-value:4.52E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:-2.91|P-value:9.38E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.15|P-value:3.76E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:4.31|P-value:2.40E-6 ID:SGTC_253|Compound:dyclonine|FD-Score:3.57|P-value:7.82E-5 ID:SGTC_287|Compound:k060-0039|FD-Score:2.99|P-value:7.73E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.35|P-value:1.73E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.57|P-value:7.84E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.05|P-value:5.51E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.66|P-value:4.50E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:2.98|P-value:8.14E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:-3.48|P-value:1.01E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.03|P-value:6.67E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.13|P-value:4.55E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.28|P-value:2.58E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:10.90|P-value:4.30E-31 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.86|P-value:2.15E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:7.07|P-value:2.87E-14 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.29|P-value:2.21E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.88|P-value:1.98E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.74|P-value:3.75E-5 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.79|P-value:2.90E-5 ID:SGTC_1672|Compound:st016598|FD-Score:3.18|P-value:3.82E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-2.91|P-value:9.16E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.10|P-value:5.11E-4 ID:SGTC_1717|Compound:st033143|FD-Score:2.98|P-value:8.09E-4 ID:SGTC_1999|Compound:st074831|FD-Score:2.92|P-value:9.92E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.03|P-value:6.60E-4 ID:SGTC_2083|Compound:5306046|FD-Score:3.73|P-value:3.77E-5 ID:SGTC_2162|Compound:5663267|FD-Score:3.11|P-value:5.00E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.32|P-value:2.14E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.00|P-value:7.51E-4 ID:SGTC_2373|Compound:9071805|FD-Score:4.11|P-value:6.68E-6 ID:SGTC_2378|Compound:9074213|FD-Score:-3.64|P-value:4.93E-5 ID:SGTC_2389|Compound:9091542|FD-Score:-3.52|P-value:8.43E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:4.29|P-value:2.64E-6 ID:SGTC_2594|Compound:a-mangostin|FD-Score:6.13|P-value:3.88E-11 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.63|P-value:5.24E-5 ID:SGTC_2744|Compound:captopril|FD-Score:3.20|P-value:3.54E-4 ID:SGTC_2818|Compound:7996756|FD-Score:3.18|P-value:3.81E-4 ID:SGTC_2862|Compound:9027634|FD-Score:4.10|P-value:6.80E-6 ID:SGTC_2872|Compound:9044037|FD-Score:3.26|P-value:2.81E-4 ID:SGTC_2876|Compound:9059903|FD-Score:-7.17|P-value:1.03E-14 ID:SGTC_2912|Compound:7964298|FD-Score:5.35|P-value:6.81E-9 ID:SGTC_2913|Compound:7966556|FD-Score:3.58|P-value:7.37E-5 ID:SGTC_3054|Compound:9094397|FD-Score:3.40|P-value:1.55E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.40|P-value:1.59E-4 ID:SGTC_3114|Compound:9122766|FD-Score:4.10|P-value:6.93E-6 ID:SGTC_3167|Compound:9103034|FD-Score:3.75|P-value:3.53E-5 ID:SGTC_3170|Compound:9103054|FD-Score:3.48|P-value:1.12E-4 ID:SGTC_3187|Compound:9109394|FD-Score:-3.30|P-value:2.12E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.21|P-value:3.35E-4

Top fitness defect scores for YOR248W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_944 3370-0224 10.90 231.0 µM 4.30E-31 1 9.51E-28
2 SGTC_1017 4239-0030 7.07 168.0 µM 2.87E-14 1 7.49E-13
3 SGTC_2594 a-mangostin 6.13 100.0 µM 3.88E-11 10 4.48E-10
4 SGTC_2912 7964298 5.35 10.9 µM 6.81E-9 cell wall 59 4.39E-8
5 SGTC_203 k066-0004 4.31 30.9 µM 2.40E-6 RSC & ERG11 14 8.08E-6
6 SGTC_2539 epi(13)torulosol 4.29 80.0 µM 2.64E-6 18 8.79E-6
7 SGTC_2373 9071805 4.11 200.0 µM 6.68E-6 10 2.01E-5
8 SGTC_2862 9027634 4.10 71.4 µM 6.80E-6 ERG2 27 2.04E-5
9 SGTC_3114 9122766 4.10 49.5 µM 6.93E-6 13 2.08E-5
10 SGTC_1213 1315-0166 3.88 115.0 µM 1.98E-5 32 5.30E-5
11 SGTC_1010 4112-3296 3.86 15.2 µM 2.15E-5 18 5.69E-5
12 SGTC_1476 4112-3294 3.79 3.3 µM 2.90E-5 60S ribosome export 20 7.43E-5
13 SGTC_3167 9103034 3.75 49.5 µM 3.53E-5 RPP1 & pyrimidine depletion 8 8.85E-5
14 SGTC_1268 0828-0275 3.74 2.5 µM 3.75E-5 27 9.35E-5
15 SGTC_2083 5306046 3.73 65.9 µM 3.77E-5 35 9.40E-5
16 SGTC_2913 7966556 3.58 36.6 µM 7.37E-5 60S ribosome export 21 1.71E-4
17 SGTC_253 dyclonine 3.57 31.2 µM 7.82E-5 amide catabolism 39 1.80E-4
18 SGTC_485 niflumic acid 3.57 177.0 µM 7.84E-5 15 1.81E-4
19 SGTC_3170 9103054 3.48 49.5 µM 1.12E-4 60S ribosome export 29 2.47E-4
20 SGTC_3054 9094397 3.40 49.5 µM 1.55E-4 fatty acid desaturase (OLE1) 51 3.31E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 8.59E-10 YGR041W BUD9 hom Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole
0.097 1.75E-8 YBL060W YEL1 hom Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip
0.096 2.61E-8 YGR205W TDA10 hom ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele
0.094 5.11E-8 YNL306W MRPS18 het Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins
0.092 1.09E-7 YER129W SAK1 hom Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
0.088 3.90E-7 YFR017C IGD1 hom Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication
0.087 4.86E-7 YOR032C HMS1 hom Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
0.086 7.08E-7 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.085 7.70E-7 YOR255W OSW1 hom Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p
0.085 8.68E-7 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.082 1.96E-6 YLR432W IMD3 hom Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
0.077 7.29E-6 YOL039W RPP2A hom Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.076 9.57E-6 YKR027W BCH2 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication
0.075 1.28E-5 YBR271W EFM2 hom S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis
0.075 1.50E-5 YPR135W CTF4 hom Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion